Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
JUDITH AKELLO
ID: UNCST-2024-R003967
Unpacking the Influence of Women's Economic Empowerment Initiatives through Uganda Women’s Entrepreneurship Program on Livelihoods and Cultural Dynamics, Amolatar Sub-Region
REFNo: SS2635ES

Main objective
To explore whether and how economic impact of women's entrepreneurship program initiatives, is influenced by cultural norms and traditions on their engagement in entrepreneurial activities, in Amolatar sub-region.
Specific objectives
1. Analyse the economic impact of women's entrepreneurship programme initiatives in Amolatar sub-region. This involves tracking changes in women's income levels, employment opportunities, and access to financial services as a result of participating in these programs. The study will also evaluate the sustainability of economic improvements over time.
2. Explore the influence of cultural norms and traditions on women's engagement in women entrepreneurship programme activities within Amolatar sub-region. This will involve interviews to understand how cultural beliefs, roles, and expectations shape women's economic opportunities and choices. This study will also examine any shifts in these norms resulting from entrepreneurship program initiatives.
3. Establish the complex interplay between women's entrepreneurship program initiatives and cultural dynamics in Amolatar sub-region. This objective will involve a comparative analysis of the data gathered under the first two objectives to identify areas of alignment and tension between economic empowerment efforts and cultural norms. Additionally, we will investigate the strategies and mechanisms used by empowerment programs to navigate and influence these cultural dynamics.

Uganda 2024-05-31 18:05:38 2027-05-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
ERIC WOBUDEYA
ID: UNCST-2019-R001047
Shortened RegiMen for Drug-susceptIbLE TB in Children
REFNo: HS4030ES

Primary
1. To determine if an 8-week HPZM regimen in children with presumed drug-susceptible TB disease has non-inferior efficacy to 8-weeks of HRZ(E) plus 8- or 16-weeks of HR(E) for achieving treatment success.
2. To evaluate the safety of the 8-week HPZM regimen in comparison to the 16- or 24- week HRZ(E) regimen among children with and without HIV.
Secondary
1. To evaluate the tolerability of the 8-week HPZM regimen in comparison to the 16- or 24- week HRZ(E) regimen among children with and without HIV.
2. To determine the weight-banded dosing of rifapentine and moxifloxacin taken as part of the HPZM regimen.
3. To evaluate the palatability and acceptability of the 8-week HPZM regimen in comparison to the 16- or 24-week HRZ(E) regimen among children with and without HIV.
4. To evaluate adherence to the 8-week HPZM regimen in comparison to the 16- or 24- week HRZ(E) regimen among children with and without HIV.
5. To evaluate clinical and laboratory characteristics and drug exposures associated with unsuccessful treatment outcomes (treatment failure or death).
6. To evaluate the cost and cost-effectiveness of the 8-week HPZM regimen relative to the 16- or 24-week HRZ(E) standard of care regimen, using a societal approach.
Exploratory
1. To characterize rifapentine and moxifloxacin PK parameters in malnourished children.
2. To evaluate the effect of rifapentine or rifampin, taken as part of the HPZM or HRZ(E) regimen, on the PK of dolutegravir.
3. To evaluate virologic control (less than 200 copies/mL) at 24- and 48-weeks among children with HIV taking a dolutegravir-based ARV treatment regimen co-administered with either HPZM or HRZ(E).
4. To collect and store biospecimens from consented participants for the purpose of future TB research.

Uganda 2024-05-31 18:02:19 2027-05-31 Medical and Health Sciences Clinical Trial Non-degree Award
Bernard Kikaire
ID:
Improving identification of new HIV infections and primary drug resistance among adolescents' girls, young women and their sexual partners in Uganda.
REFNo: HS4283ES

To improve identification of HIV infection, describe transmitted drug resistance mutations and HIV transmission network among AGYW and their sexual partners in Uganda.
Uganda 2024-05-31 17:57:30 2027-05-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Francis Eswap
ID:
Skepticism Over Refugee Quest to Realise the Right to Skills Development; the Case of South Sudan Adolescents in Adjumani-Uganda
REFNo: SS2659ES

1 To find out if adolescent refugees are accessing skills training programmes in a supportive social ecological system and if there are barriers and whether human rights legal regimes are effectively applied for their realisation of the right to skills development.
2 To assess skills training programmes for adolescent refugees to realise their right to skills development
3 To evaluate whether there is a Social Ecological System that supports adolescent refugees’ realisation of the right to Skills Development
4 To analyse the Barriers to adolescent refugees’ realisation of the right to skills development
5 To Examine the effectiveness of legal regimes in the Adolescent Refugee realisation of the Right to Skills Development

Uganda 2024-05-31 17:52:27 2027-05-31 Social Science and Humanities Non-Clinical Trial Degree Award
Ponsiano Ocama
ID: UNCST-2019-R001799
Assessment of Research Integrity Environment at Makerere University College of Health Sciences
REFNo: HS4131ES

To explore students and staff’s knowledge and attitudes towards research misconduct at MakCHS,To assess the magnitude of focus on research integrity issues among MakCHS regulatory structures,To determine the factors associated with research misconduct practices at MakCHS.,To identify the different types of research misconduct practices at MakCHS.,To assess the current research integrity frameworks at Makerere University College of Health Sciences and develop interventions to address research misconduct.,
Uganda 2024-05-31 17:48:32 2027-05-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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