Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Christine  Wiltshire Sekaggya
ID: UNCST-2019-R000578
PRIVATE HEALTH PROVIDERS POINT OF CARE TESTING FOR TUBERCULOSIS IN SELECTED URBAN PRIVATE FACILITIES IN UGANDA.
REFNo: HS7989ES

1. To evaluate whether use of near - point of care (NPOC) for tuberculosis (TB) testing using the oral and sputum-based swabs is feasible and acceptable in private health provider settings in Wakiso and Kampala districts. 2. To determine the effect of use of NPOC testing on time to TB diagnosis and time to treatment initiation following TB screening and testing at private health facilities in Wakiso and Kampala districts.
Uganda 2026-07-17 15:42:29 2029-07-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Abel  Kakuru
ID: UNCST-2022-R009193
Perennial Malaria Chemoprevention With Dihydroartemisinin-Piperaquine Versus Sulfadoxine-Pyrimethamine Plus Amodiaquine Versus No Chemoprevention: A Double Blind Randomised Controlled Trial
REFNo: HS7437ES

1. To compare the protective efficacy of combining R21 vaccination with PMC-DP or PMC-SPAQ vs R21 alone up to 5 years of age.
2. To compare the safety and tolerability of combining R21 vaccination with PMC-DP vs. PMC-SPAQ.
3. To determine the impact of PMC on the drug resistance landscape and R21-specific immunogenicity and durability.

Uganda 2026-07-16 20:29:47 2029-07-16 Medical and Health Sciences Clinical Trial Non-degree Award
Andrew Muhumuza
ID: UNCST-2022-R009010
CAN TOUCH HELP IDENTIFY PATIENTS WHO NEED AN IMMEDIATE FULL CLINICAL ASSESSMENT BY A PHYSICIAN?
REFNo: HS7768ES

To find out if touch can help identify patients who need an immediate full clinical assessment by a physician.,To compare the ability to predict 24-hour mortality by temperature and moisture subjectively assessed by touch in different parts of the body ,To compare the ability of temperature and moisture subjectively assessed by touch to predict 24-hour mortality with standard thermometry and the National Early Warning Score,
Uganda 2026-07-16 20:26:26 2029-07-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
MOREEN ASASIRA
ID: UNCST-2026-R023307
Climate Resilient Tea Innovations In Uganda: A Case of Nature-Based Strategies in The Tea Value Chain
REFNo: A775ES

1.To evaluate farmer awareness, perceptions, and attitudes about the use of nature-based innovations in tea production 2.Establish the probability of use of nature-based innovations in tea production 3.To map the Uganda tea value chain 4.Establish perceived actor preference of the resilient tea varieties among tea chain actors
Ugandan 2026-07-16 20:13:13 2029-07-16 Agricultural Sciences Non-Clinical Trial Degree Award
Faizo Mugerwa
ID: UNCST-2025-R021837
EVALUATION OF THE FEASIBILITY AND ACCEPTABILITY OF AN EXHALED BREATH CONDENSATE SAMPLING DEVICE TO COLLECT A RESPIRATORY SAMPLE FOR LIPOARABINOMANNAN TESTING AMONG SUSPECTED TUBERCULOSIS PATIENTS AT MBARARA REGIONAL REFERRAL HOSPITAL (EXHALE STUDY)
REFNo: HS7963ES

To determine the sensitivity, specificity, of the Alere LAM test if used to test the sample collected by the EBC device among suspected tuberculosis patients. To assess the feasibility and acceptability of the EBC sampling device by patients, and healthcare workers. To determine the positive and negative predictive values of the Alere LAM test if used to test the sample collected by the EBC device among suspected tuberculosis patients.
Uganda 2026-07-16 20:11:09 2029-07-16 Medical and Health Sciences Non-Clinical Trial Degree Award
Catriona  Waitt John
ID: UNCST-2019-R001068
PHASE IV HUMAN LACTATION STUDY TO DESCRIBE THE PHARMACOKINETICS OF SEMAGLUTIDE IN LACTATING MOTHER-INFANT PAIRS IN UGANDA
REFNo: HS7927ES

Primary Objective
To define the transfer of semaglutide from mother to
breastfed infant during the postpartum period.

Secondary Objectives
? To determine the effect of maternal semaglutide on
breastmilk composition
? To determine the effect of maternal semaglutide on
breastmilk volume and breastfeeding practice
(frequency, duration)
? To determine the effect of maternal semaglutide on
infant growth
? To determine the effect of maternal semaglutide on
maternal HbA1c
? To measure the effect of maternal semaglutide on
body composition (BMI, lipid profile, hip/waist
circ)
? To evaluate participant perceptions of semaglutide
use and the paradigm of postpartum initiation of
medication
? To calibrate semaglutide PBPK model to predict
untested clinical scenarios (infant oral bioavailability,
maternal dose, dose ranges, milk
characteristics/composition)
UK 2026-07-16 20:06:07 2029-07-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bridgious Walusimbi
ID: UNCST-2026-R026054
Genetic causes and epigenetic consequences of infection in childhood (GECo)
REFNo: HS8006ES

The project will use human genetic tools to understand why some children are at increased risk of infection and how childhood infection shapes immune cell function and long-term health. To deliver this, the project has 3 linked work packages:
1. Work Package 1: Genome-wide association studies of common infection in Ugandan children, addressing:
� What are the human genetic drivers of common childhood infections in Ugandan children?
2. Work Package 2: eQTL and epigenetic studies in immune cells across variable burdens of childhood infection, addressing:
� Whether the epigenetic and transcriptional landscape of monocytes is shaped by childhood infection.
3. Work Package 3: Define clonal haematopoeisis (CH) in genomic data from Ugandan adults, addressing:
� What is the frequency of CH in Ugandan adults?
� Is risk of CH influenced by lifetime infection burden?


Uganda 2026-07-16 20:04:22 2029-07-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Annet Kahunde
ID: UNCST-2025-R021768
Subject Inversion Constructions in Rutooro: A Morphosyntactic, Semantic and Information Structural Account
REFNo: SS5204ES

i. To describe the agreement patterns in Rutooro SICs.
ii. To examine the thematic restrictions on arguments and predicates in Rutooro SICs.
iii. To analyse the role of information structure in Rutooro SICs.

Uganda 2026-07-16 20:01:01 2029-07-16 Social Science and Humanities Non-Clinical Trial Degree Award
Grace Nalukwago Kakoola
ID: UNCST-2025-R022885
IMPLEMENTATION OF THE NON-MOTORIZED TRANSPORT PILOT CORRIDOR AND ITS EFFECTS ON ACTIVE MOBILITY IN KAMPALA UGANDA.
REFNo: HS7552ES

I. To explore the acceptability, inclusivity, and perceived barriers influencing the intended use of Kampala’s NMT pilot corridor. II. To examine the effect of the NMT pilot corridor on overall walking and cycling experiences in comparison to a motorized road. III. To compare walking-related physical activity levels between adults working along the NMT pilot corridor and those working along a motorized road in Kampala. IV. To examine the implementation of the NMT pilot corridor by examining the strategies adopted, and their outcomes over time during the post-construction phase (2021-2026).
Uganda 2026-07-16 19:58:26 2029-07-16 Medical and Health Sciences Non-Clinical Trial Degree Award
PRISCILLA NASOLO
ID: UNCST-2025-R021017
MANAGEMENT PRACTICES AND PERFORMANCE IN UGANDA REVENUE AUTHORITY AND UGANDA BROADCASTING CORPORATIONS IN UGANDA
REFNo: SS5228ES

1. To assess the effect of internal audit functions on the performance of URA and UBC in Uganda.
2. To evaluate the influence of corporate governance mechanisms on the performance of URA and UBC in Uganda.
3. To assess the extent to which strategic plan compliance affects the performance of URA and UBC in Uganda.
4. To determine the effect of capacity-building initiatives on the performance of URA and UBC in Uganda.
5. To examine the moderating effect of organizational culture on the relationship between selected management practices and the performance of URA and UBC in Uganda.

Uganda 2026-07-16 19:56:25 2029-07-16 Social Science and Humanities Non-Clinical Trial Degree Award
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