Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Nazarius Tumwesigye Mbona
ID: UNCST-2019-R000664
KOFIH/OPM BUSOGA WASH PROJECT ON WATERBORNE DISEASE REDUCTION AND PREVENTION -AN ENDLINE SURVEY
REFNo: HS8079ES

3.1 General Objective
Assess changes in WASH indicators and waterborne disease outcomes following implementation of project interventions
3.2 Specific objectives
i. Measure project outcomes against baseline data and defined performance indicators;
ii. Evaluate the effectiveness of interventions in improving access to clean water, sanitation, and hygiene practices;
iii. Identify successes, challenges, and gaps in project implementation;
iv. Provide evidence-based recommendations for sustainability, replication, and scaling of interventions;

Uganda 2026-07-17 17:12:16 2029-07-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mohammed Hamid Osman Ali
ID: UNCST-2026-R024137
Harnessing Borassus Fruits as a Sustainable Source of Biofuels: A Techno-Economic Feasibility Study at Soroti University
REFNo: SIR726ES

Overall Objective To evaluate and demonstrate the potential of Borassus tress as a sustainable source of renewable energy for Soroti University and its surrounding community by 2026. Smart Specific Objectives 1. To analyze the chemical composition (sugar content, metals, calorific value and moisture) of Borassus fruits and sap, and quantify their potential yield for biofuels production. 2. To conduct bench scale, high precision sap to biofuel conversion through fractional distillation and refining. 3. To conduct a techno-economic feasibility assessment comparing Borassus-derived energy with current energy sources (national electricity grid, firewood and charcoal) used in Soroti University.
Sudan 2026-07-17 17:09:06 2029-07-17 Engineering and Technology Non-Clinical Trial Non-degree Award
Sam Ononge
ID: UNCST-2020-R000328
Evaluation of a self-monitoring tool to detect early obstetric complications in the immediate postpartum period: A validation study of the ImPoWa tool
REFNo: HS7770ES

Main Objective
1. To evaluate the validity of the ImPoWA tool in facilitate self-monitoring for early warning signs of an obstetric complication during the immediate postpartum period by women and their birth companions
Specific Objectives
1. To explore the accuracy of the mothers’ and companions’ assessments when using the tool
2. To ?Explore the reliability of mothers’ and companions’ assessments when using the tool in different clinical contexts and time periods
Uganda 2026-07-17 17:05:51 2029-07-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Miriam Nakalembe
ID: UNCST-2021-R014040
A PHASE 3, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLINDED TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF A MULTIVALENT GROUP B STREPTOCOCCUS VACCINE IN HEALTHY PREGNANT WOMEN AND THEIR INFANTS (BEATRIX)
REFNo: HS8109ES

To describe GBS serotype-specific IgG concentrations measured from dried blood spots in a subset of infant participants at birth; To describe anti-GBS antibodies present in breast milk in a subset of maternal participants vaccinated with GBS6 To describe serum IgG responses to active immunization with diphtheria toxoid�containing vaccine and PCV in infant participants born to maternal participants vaccinated with GBS6 versus placebo. To describe PCV serotype-specific OPA titers after a toddler vaccination in infant participants born to maternal participants vaccinated with GBS6 or placebo. To additionally describe the immune responses to CPS elicited by GBS6 when administered to healthy pregnant women. To describe serum IgG responses to active immunization with diphtheria toxoid� containing vaccine and/or PCV in infant participants born to maternal participants vaccinated with GBS6 versus placebo.,To further describe the immunogenicity of GBS6 in maternal participants when administered to healthy pregnant women. To describe anti-CPS IgG antibody levels predicted to provide protection from invasive GBS EOD and LOD, separately, caused by the 6 individual vaccine serotypes (Ia, Ib, II, III, IV, and V) in infants when GBS6 is administered to healthy pregnant women,To assess the ability of GBS6 to induce opsonophagocytic activity (OPA) titers at birth in infant participants born to maternal participants vaccinated with GBS6,To describe anti-CPS IgG antibody levels in infant participants born to maternal participants vaccinated with GBS6. To describe anti-CPS IgG antibody levels predicted to provide protection from invasive GBS disease (all disease) caused by the 6 individual vaccine serotypes in infants when GBS6 is administered to healthy pregnant women,To evaluate the aggregate predicted VE combining all 6 serotypes in GBS6 to provide protection from invasive GBS EOD based on serotype-specific anti-CPS IgG concentrations measured in infants at birth,To evaluate the aggregate predicted VE combining all 6 serotypes in GBS6 to provide protection from invasive GBS LOD based on serotype-specific anti-CPS IgG concentrations measured in infants at birth. To assess the ability of GBS6 to induce anti-CPS IgG antibody levels predicted to provide protection from invasive GBS early-onset disease (EOD) caused by the 6 individual vaccine serotypes (Ia, Ib, II III, IV, and V) in infants when GBS6 is administered to healthy pregnant women,To assess the ability of GBS6 to induce anti-CPS IgG antibody levels predicted to provide protection from invasive GBS late-onset disease (LOD) caused by the 6 individual vaccine serotypes (Ia, Ib, II III, IV, and V) in infants when GBS6 is administered to healthy pregnant women,To assess the safety of maternal immunization in infant participants born to pregnant women who were vaccinated with GBS6 during pregnancy. To describe the safety and tolerability of GBS6 in maternal participants
Uganda 2026-07-17 17:00:50 2029-07-17 Medical and Health Sciences Clinical Trial Non-degree Award
Esther Nanfuka Kalule
ID:
EXPLORING ACCELERATING IMPACT FOR YOUNG WOMEN (AIM) PROGRAM COHORT # 2 AND # 3 LIVELIHOOD EXPERIENCES: A QUALITATIVE STUDY IN UGANDA
REFNo: SS5437ES

Main objective
This study seeks to explore the AIM financial inclusion journey for cohort #2 participants and progress thus far in the livelihoods pathway for those in cohort #3.


Specific objectives
1.To examine opportunities and challenges experienced by cohort #2 project participants and staff in transitioning participants to microfinance.
2.To identify opportunities and challenges experienced by cohort #3 project participants and staff during implementation of cost sharing and coaching elements of AIM 2.0.
3.To document cohort #2 and #3 participants’ perspectives on the impact of AIM on their lives.

Uganda 2026-07-17 16:20:28 2029-07-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
ConfiSign HCV Self-Test: Evaluation of Clinical Performance and Usability in the hands of untrained users.
REFNo: HS8059ES

The product design, instructions for use and usability of the ConfiSign HCV Self-Test for self-testing will be assessed by investigation of the following secondary objectives: - Clarity and usability of instructions and packaging � participant-reported ease of understanding and following instructions, collected via a structured questionnaire. - Occurrence of user errors � frequency and type of errors and/or deviations from the test procedure observed during the study - Invalid test results � proportion of tests yielding invalid results due to user errors.,The primary and overall objective of this study is to evaluate the performance and the usability of the ConfiSign HCV Self-Test in the hands of untrained users, recruited in a high prevalence HCV region (> 2%), who have no or limited experience in self-testing. ,
Uganda 2026-07-17 16:17:16 2029-07-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Herbert Muyinda
ID: UNCST-2019-R000373
Digital Humanitarianism: Governing Vulnerable Populations in an Age of Technological Innovation in Uganda
REFNo: SS5510ES

The general objective of this study is to provide an in-depth understanding of the role of digital innovations in (re)shaping the way humanitarian action is understood, conceived and practiced - how DTs are changing the face of Humanitarian Response in Uganda. The specific objectives are:

1. To analyze how DTs are tested on populations and how they influence conceptions of vulnerability and needs as well as solutions to address them

2. To examine how DTs are transforming humanitarian action among those displaced, the host communities, and the humanitarian workers tasked with safeguarding their rights of the refugees.

3. To identify the barriers in uptake and adaptation of DTs among refugees and the humanitarian workers

Uganda 2026-07-17 16:11:54 2029-07-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
Simplified Antenatal Integrated Testing,Partner inclusion and same day Hepatitis B prophylaxis to scale Prevention in Uganda
REFNo: HS8027ES

To determine the acceptability, feasibility, and patient-level costs of the chronic care model for HBV management at intervention sites. ,To determine the optimal linkage to chronic care pathways under the expanded WHO treatment criteria at intervention sites. ,To determine the acceptability, feasibility, and patient-level costs of family-based testing.,To ascertain the yield of family- and partner-based testing of index cases (number positive / number tested) at intervention sites. ,To evaluate the acceptability, feasibility, and patient-level costs of the test-and-prophylaxis approach for both patients and healthcare providers at the intervention sites.,To assess the effectiveness of the test-and-prophylaxis approach, measured through the PMTCT cascade (prophylaxis initiation, adherence, birth dose coverage, and infant HBV status at 9 months) at the intervention sites. ,To measure the change in uptake and completion rate of antiviral prophylaxis (AVP) among HBsAg-positive women in ANC in the intervention as compared to the comparison sites.,
Uganda 2026-07-17 16:09:55 2029-07-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Benson Nasasira
ID: UNCST-2025-R023111
Evaluating the Impact of Integrating Tuberculosis Screening into Routine Community-Based Child Health Services on Childhood Tuberculosis treatment coverage in Kalangala District, Uganda � A quasi-experimental study
REFNo: HS8056ES

Primary Objective To compare monthly childhood TB treatment coverage—defined as the proportion of National TB and Leprosy Program (NTLP) paediatric TB treatment targets achieved among children aged 0–14 years, before and after integration of TB screening into routine community-based child health outreach activities in Kalangala District. Secondary Objectives • To compare the monthly absolute number of presumptive paediatric TB cases identified before and after integration. • To compare the monthly proportion of presumptive paediatric TB cases completing diagnostic evaluation before and after integration. • To compare the monthly proportion of all TB cases that are children aged 0–14 years before and after integration. • To assess the feasibility and acceptability of integrating TB screening into routine child health outreaches from the perspectives of health workers and Village Health Team (VHT) members.
Uganda 2026-07-17 15:59:12 2029-07-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Laura LaBarge Rose
ID: UNCST-2025-R017293
Next-generation animal tracking for research and conservation the Mweya ATLAS project
REFNo: NS951ES

1. To obtain proof-of-principle for reverse-GPS tracking of wild mammals, using banded mongooses as a model system. 2. To test how group ranging behaviour is influenced by ecology and intergroup interactions. 3. To test the consequences of variation in group movement patterns for reproductive success and population dynamics. 4. To use ATLAS data to anticipate and record intergroup encounters and investigate the causes of intergroup aggression.
USA 2026-07-17 15:44:11 2029-07-17 Natural Sciences Non-Clinical Trial Non-degree Award
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