Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Jackson Mukonzo
ID: UNCST-2021-R013916
Safety and Efficacy of COVIDEX™ Therapy in Management of adult Covid-19 Patients in Uganda: A randomized double-blind placebo controlled adaptive phase 2 B clinical trial.
REFNo: HS2041ES

3. To determine the plasma concentration of berberine in COVID-19 patients receiving COVIDEX. ,2. To determine the efficacy of COVIDEXTm for treatment of COVID-19 among adults in Uganda.,To determine the efficacy of COVIDEXTm for treatment of COVID-19 among adults in Uganda.,To validate the safety and determine the efficacy of COVIDEXTm therapy for treatment of COVID-19 in adult Ugandans. ,
Uganda 2022-01-25 2025-01-25 Medical and Health Sciences Clinical Trial Non-degree Award
Timothy  Muwonge Ronald
ID: UNCST-2020-R014680
Evaluating the implementation of assisted partner notification for HIV in refugee settlements in West Nile Uganda: An implementation Science approach
REFNo: HS1970ES

AIM 2.To explore barriers and facilitators to APN for HIV in refugee settlements in West Nile using qualitative methods to evaluate each stage of RE-AIM, guided by the Consolidated Framework for Implementation Research (CFIR) domains. ,AIM 1. To assess the reach, effectiveness, adoption, implementation, and maintenance of APN for HIV in refugee settlements in West Nile utilizing the RE-AIM framework. ,
Uganda 2022-01-24 2025-01-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Esther Nanfuka Kalule
ID:
Resilience during and After quarantine: A qualitative study of people affected by Covid-19 in Uganda
REFNo: SS1047ES

1. To examine the socio-economic constraints faced during and after quarantine
2. To examine the psychological constraints faced during and after quarantine
3. To examine the protective factors that facilitated the successful management of the socio-economic and psychological risks faced during and after quarantine.

Uganda 2022-01-21 2025-01-21 Social Science and Humanities Non-Clinical Trial Non-degree Award
Justine  Komunyena Tumusiime
ID: UNCST-2023-R008465
Assessing willingness to pay for HIV self-testing and evaluation of distribution, linkages, and referral models for HIV self-testing in Uganda
REFNo: HS1982ES

1) To assess the knowledge and attitudes of the different categories of key populations with respect to HIV self-testing in the districts with STAR III project intervention (STAR III intervention districts) and selected districts without STAR project interventions (non-intervention districts)
2) To assess access and extent of use of different HIVST kits available in Ugandan market in districts with STAR III interventions and non-intervention districts
3) To understand respondents' preferences to blood-based and oral fluid-based HIVST kits in the districts selected (see section 2.2)
4) To assess willingness to pay and estimate the specific price points HIVST kit users and non-users are willing to pay for the different HIVST kits available in Uganda
5) To identify the constraints to HIVST adoption and WTP for HIVST kits in the districts selected
6) To assess and compare the different distribution models with respect to selected indicators of effectiveness and cost-effectiveness

Uganda 2022-01-20 2025-01-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
AGATHA NSHABOHURIRA
ID:
FACTORS INFLUENCING LOW UPTAKE OF DPT3 AMONG INFANTS AGED 16 TO 52 WEEKS IN RUBIRIZI TOWN, RUBIRIZI DISTRICT
REFNo: HS1513ES

General objective for the study
To explore factors influencing uptake of DPT 3 Immunization amongst infants aged 16-52 weeks in Rubirizi Town, Rubirizi District.
Specific objectives of the study
• To find out individual level perceptions influencing uptake of DPT 3 Immunization amongst parents/caretakers of infants aged16-52 weeks in Rubirizi Town, Rubirizi District.
• To examine community influencing factors associated with uptake of DPT 3 Immunization amongst infants 16-52 weeks in Rubirizi Town, Rubirizi District.
• To explore the health service related factors influencing uptake of DPT 3 Immunization amongst infants aged 16-52 weeks in Rubirizi Town, Rubirizi District.

Uganda 2022-01-20 2025-01-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Keneth Kananura
ID:
Hematological Recovery among People Living with HIV after Cotrimoxazole prophylaxis discontinuation at Infectious Diseases Institute in Uganda
REFNo: HS1908ES

1.To determine the proportion of PLHIV with hematological complications of anemia and neutropenia who experience hematological recovery following discontinuation of CTX prophylaxis. 2. To determine the factors associated with hematological recovery among PLHIV after discontinuation of cotrimoxazole prophylaxis.
Uganda 2022-01-20 2025-01-20 Medical and Health Sciences Non-Clinical Trial Degree Award
JAMES MULEME
ID: UNCST-2021-R012263
Reservoirs, transmission and antibiotic resistance profiles of Extended Spectrum Beta Lactamase-producing Escherichia Coli at the human-animal-environment interface among farming communities in Wakiso district, Uganda
REFNo: HS1919ES

General Objective
To decipher the reservoirs and transmission pathways for ESBL-PE at the human-animal-environment interface among farming communities in Wakiso district

Specific Objectives
1. To determine the comparative distribution of ESBL-PE from humans, animals and environment among selected households in Wakiso district.

2. To describe the antibiotic susceptibility profiles of the ESBL-PE isolates obtained from humans, animals and their immediate environment among selected households in Wakiso district

3. To assess the pathways and drivers of transmission of the ESBL-PE among humans, animals and environment in selected households of Wakiso district.  

4. To explore factors influencing occurrence, transmission and management of AMR caused by ESBL-PE at the human-animal-environment interface in Wakiso district, Uganda


Uganda 2022-01-20 2025-01-20 Medical and Health Sciences Non-Clinical Trial Degree Award
Cole Harris
ID:
Pentecostalism and Development: Explaining the Variation of Church-Led Community Programs in Kampala, Uganda
REFNo: SS1151ES

Complete program observation at the community programs of the three selected case study churches.,Create three Pentecostal-Charismatic church case studies that situate the churches within the broader Pentecostal movement.,Conduct interviews with church leaders regarding the availability of community programs and their selection of those programs.,Better understand Pentecostal leaders’ decision-making process in the selection of community programs.,Take an inventory of the availability of community programs offered by Pentecostal-Charismatic churches in Kampala, Uganda.,
USA 2022-01-19 2025-01-19 Social Science and Humanities Non-Clinical Trial Non-degree Award
Susanne Guidetti Gittel Eleonora
ID: UNCST-2021-R012422
Participation in everyday life - A randomized controlled trial of mobile phone-supported and family-centred rehabilitation after stroke in Uganda
REFNo: HS1528ES

General objective (Overall aim)
To implement and evaluate the effects a mobile phone supported and family-centred rehabilitation intervention F@ce 2.0 aiming to enable performance in daily activities and participation in everyday life among persons who have had a stroke and their family members both in urban (Kampala and its surroundings) and rural (Greater Masaka) areas.

Specific objectives
• To describe the perceived impact of stroke and perceived participation in everyday life in a sample of people with stroke in rural Uganda. (Study 1)
• To evaluate the effects of F@ce in comparison with ordinary rehabilitation among persons with stroke in urban and rural Uganda regarding a) self-efficacy b) perceived performance and participation in everyday activities c) independence in ADL, d) healthcare utilization and e)their families´ perceived participation in everyday activities.(Study 2)
• To explore and describe the experiences of people with stroke and family members of participating in the F@ce (Study 3)
• To evaluate the implementation process of F@ce and to gain knowledge on the mechanisms of impact as well as the contextual factors that might influence the implementation process and its outcome. (Study 4)
• To determine the cost of delivering the F@ce intervention in comparison with the usual rehabilitation (Study 5)

Sweden 2022-01-19 2025-01-19 Medical and Health Sciences Clinical Trial Non-degree Award
Churchill Akena
ID:
; RECALL ASSESSMENT STUDY; HOW EFFECTIVE IS IT TO CARRY OUT RECALL OF PHARMACEUTICALS IN THE PRIVATE SECTOR? A CROSS SECTIONAL CASE ASSESSMENT OF GYNOZOL, EPICEPHIN AND APIDONE
REFNo: HS1916ES

1. To determine the extent of distribution of common pharmaceutical products in Uganda using examples of epicephin, gynozol and apidone.
2. To find out the percentage of distributors/customers who respond in time to class I, class II and class III recall alerts for all levels of recall.
3. To find out the percentage of wholesalers and retailers who keep adequate record of the medicines they distribute/dispense to facilitate a successful recall.

Uganda 2022-01-19 2025-01-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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