Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Adam Hewitt Smith
ID: UNCST-2019-R001658
‘5 Rs to Rescue’ A quality improvement initiative with a cluster trial evaluation and embedded process evaluation
REFNo: HS5020ES

To evaluate the effect of the QI intervention on: 1. 30 day in-hospital mortality. 2. Duration of hospital stay.,To evaluate whether implementation of the ‘5 Rs to Rescue’ quality improvement intervention increases surveillance for patients at risk of ‘failure to rescue’ after surgery in hospitals in Africa.,
UK 2025-01-22 12:30:25 2028-01-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Immaculate  Nankya Lillian
ID: UNCST-2020-R014784
Interplay between Estrogen, immune activation and HIV persistence during pregnancy
REFNo: SS3319ES

To characterize the clonal dynamics and diversity within the circulating latent reservoir in pregnant women on ART who are experiencing low-level viremia, viral blips, and persistently non-suppressed virus. ,To measure fluctuations in inflammation and immune activation markers, estrogen, and reservoir dynamics in women during pregnancy. , The main goal of this protocol is to understand the interplay between estrogen, markers of immune activation and the reservoir dynamics among pregnant women.,
Uganda 2025-01-22 11:58:29 2028-01-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
JUDITH NASSAAZI
ID: UNCST-2023-R007664
Comparing in-person versus virtual postoperative review appointments for children following guided growth surgery at CORSU Hospital, Uganda
REFNo: HS5268ES

Study Objectives
Primary objectives
To compare the show-rates of in-person versus virtual/telehealth post-operative review appointments for children following guided growth surgery at CoRSU Hospital

Secondary objectives.
1.To compare parental satisfaction of in-person versus virtual appointments
2.To determine the factors that facilitate in-person and virtual appointments following guided growth surgery.
3.To compare the rate of post-operative complications following in-person follow-up versus virtual follow-up
Uganda 2025-01-22 10:12:27 2028-01-22 Medical and Health Sciences Clinical Trial Non-degree Award
SABRINA KITAKA BAKEERA
ID: UNCST-2020-R014290
GENERATING LOCAL DATA ON HPV VACCINATION IMPACT AND TRAINING NEEDS AT THE LEVEL OF VACCINE IMPLEMENTERS – A FEASIBILITY STUDY
REFNo: HS5219ES

1) generate local data on HPV vaccine induced immune response and HPV infection prevalence using first-void urine (FVU) in Uganda and assess feasibility of conducting such studies, 2) assess knowledge and training gaps among HCWs in Uganda and standardize HPV vaccine training barometer survey,
Uganda 2025-01-22 10:09:20 2028-01-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
MUSANA SAMSON ISRAEL
ID: UNCST-2024-R016481
RELIGIOUS MISSION FIELD RIVALRIES AND ITS IMPACT ON CHRISTIAN-MUSLIM PEACEFUL COEXISTENCE IN MBALE CITY, UGANDA
REFNo: SS3541ES

1) to investigate the root causes of religious mission field rivalries affecting Christian-Muslim peaceful coexistence. 2) to establish Christian and Muslim missionary methods being utilised in the
mission field; and 3) to ascertain the impact of Christian and Muslim missionary outreach
practices.
Uganda 2025-01-10 12:29:51 2028-01-10 Social Science and Humanities Non-Clinical Trial Degree Award
Venantius Bbaale Kirwana Bbaale
ID: UNCST-2024-R002370
Behind the Scenes: Young women and gender-based inequities in Africa’s Creative Sector -Uganda research project
REFNo: SS3483ES

iii. Provide evidence-based recommendations and best practices for key stakeholders that can support gender equity in Uganda\'s creative industries and workplaces.,ii. Map the Creative Sector in Uganda to understand its organization in terms of stakeholders, policies, potential, remuneration systems, accessibility to different categories of youth, challenges, conduct codes, job creation opportunities, funding, education, training, products, and services.,i. To generate and disseminate evidence on the nature, dynamics, and implications of gender-based inequities faced by young female creatives in Uganda and other countries in the project.,
Uganda 2025-01-10 12:12:15 2028-01-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Justine Namuli Diana
ID: UNCST-2021-R011844
ENHANCING COMPREHENSION OF INFORMED CONSENT IN RESEARCH INVOLVING PATIENTS WITH PSYCHOTIC DISORDERS USING AUDIO-VISUAL AIDS
REFNo: HS5358ES

To evaluate the comprehension of informed consent, identify key factors that are associated with comprehension of consent, determine the feasibility, acceptability, and preliminary effectiveness of audio-visual aids on enhancing the comprehension of consent information during the consenting process in research involving individuals with psychotic disorders
Uganda 2025-01-10 12:00:57 2028-01-10 Medical and Health Sciences Clinical Trial Degree Award
Baguma Deus Bagambana
ID: UNCST-2024-R002898
AGRONOMIC AND UTILIZATION POTENTIAL OF COCOYAM IN SOUTH WESTERN HIGHLANDS AGRO-ECOLOGICAL ZONE OF UGANDA
REFNo: NS888ES

1. To establish cocoyam production practices, constraints and trait preferences in the south western highlands agroecological zone of Uganda.
2. To establish the facilitators and barriers of cocoyam utilization by value chain end users in south western highlands agroecological zone of Uganda
3. To determine edaphoclimatic suitability of cocoyam production in the south western highlands agroecological zone of Uganda
4. To establish the feasibility of utilisation of cocoyam flour for production of cookies in south western highlands agroecological zone of Uganda

Uganda 2025-01-10 11:58:50 2028-01-10 Natural Sciences Non-Clinical Trial Degree Award
BAINA NAKANWAGI
ID: UNCST-2024-R002838
Financial Literacy and performance of Micro and small businesses owned by muslim women in Mbarara city,Uganda
REFNo: SS3493ES

i) To assess the effect of Islamic finance principles on performance of micro and small businesses owned by muslim women in Mbarara City
ii) To evaluate the impact of debt management on performance micro and small businesses owned by muslim women in Mbarara city
iii)To evaluate the impact of finance planning and budgeting on performance micro and small businesses owned by muslim women in Mbarara city
iv) To establish the moderating effect of access to finance on the relationship between financial literacy and performance of micro and small enterprise owned by muslim women in Mbarara city
1.5 Research Questions
i) What is the effect of Islamic finance principles on the performance of micro and small businesses owned by Muslim women in Mbarara City?
ii) What is the impact of debt management on the performance of micro and small businesses owned by Muslim women in Mbarara City?
iii) How does financial planning and budgeting affect the performance of micro and small businesses owned by Muslim women in Mbarara City?
iv) What is the moderating effect of access to finance on the relationship between financial literacy and the performance of micro and small enterprises owned by Muslim women in Mbarara City?

Uganda 2025-01-10 11:57:43 2028-01-10 Social Science and Humanities Non-Clinical Trial Degree Award
Ali Ndiwalana
ID: UNCST-2024-R015333
Evaluation of UNICEF’s contribution towards addressing equitable access to quality, inclusive education for vulnerable children and adolescents in Uganda 2021-2024
REFNo: SS3478ES

The evaluation that will assess the relevance and effectiveness of UNICEF's contributions towards achieving the goals set for the BEAD
programme under the CPD 2021-2025. The evaluation's findings are expected to guide the design of UNICEF's future learning and skilling programs in Uganda
Uganda 2025-01-10 11:56:23 2028-01-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jackline  Akello
ID: UNCST-2023-R005827
Sickle cell disease in pregnancy: Experiences in provision and access to care and adverse pregnancy outcomes at Mbale and Kawempe Referral Hospitals
REFNo: HS5315ES

4.To explore health providers experiences in providing care to pregnant women with SCD at Mbale and Kawempe referral hospitals. ,To explore experiences of pregnant women with SCD in accessing health care at Kawempe and Mbale referral Hospitals. ,2.To determine risk factors for adverse fetal outcomes among pregnant women with SCD at Mbale and Kawempe Referral Hospitals,To determine risk factors for adverse maternal outcomes among pregnant women with SCD at Mbale and Kawempe Referral Hospitals ,The general objective is to determine the adverse maternal and fetal outcomes associated with pregnancies complicated by SCD and explore experiences in access and provision of care at Mbale and Kawempe Referral Hospitals. ,
Uganda 2025-01-10 11:54:49 2028-01-10 Medical and Health Sciences Non-Clinical Trial Degree Award
BABTUNDE SAMUEL ADEBAYO
ID: UNCST-2024-R002460
The Endline Evaluation of CorpsAfrica's Community Development Interventions in Uganda (FY23/24)
REFNo: SS3428ES

The objective of the Endline Evaluation of CorpsAfrica's Community Development Interventions in Uganda (FY23/24) is to assess the impact, effectiveness, and sustainability of interventions implemented by CorpsAfrica volunteers across four districts—Buikwe, Lyantonde, Mpigi, and Kabarole. The evaluation aims to measure changes in community development outcomes, assess improvements in livelihoods, and document the role of volunteers in addressing the needs of these communities. Furthermore, the evaluation will capture lessons learned, identify best practices, explore community acceptance, and assess stakeholder contributions, ultimately providing valuable insights for improving and scaling similar community-led development initiatives in Uganda and beyond.
Nigeria 2025-01-10 11:53:04 2028-01-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
JUDITH NASSAAZI
ID: UNCST-2023-R007664
HIP SURVEILLANCE IN PAEDIATRIC PATIENTS WITH CEREBRAL PALSY AT CoRSU REHABILITATION HOSPITAL
REFNo: HS5220ES

Primary objective
1. To assess the feasibility of implementing a hip surveillance program in detecting early signs of displacement among cerebral palsy patients attending CoRSU hospital in 2024-2025
2. To determine the incidence of hip dislocation in patients with cerebral palsy seen at CoRSU hospital in 2024-2025
Secondary objectives
1. To assess changes in the QOL of life of children after joining the hip surveillance program on hip displacement among children with cerebral palsy seen at CoRSU hospital in 2024-2025

2. To develop a standard for frequency of pelvic x-rays for children with cerebral palsy seen at CoRSU hospital in 2024-2025

3. To evaluate the benefits and complications of early intervention measures on reducing hip displacement cerebral palsy seen at CoRSU hospital in 2024-2025

Uganda 2025-01-10 11:51:15 2028-01-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hannah Kibuuka
ID: UNCST-2020-R014355
Sub-Study D – Evaluation of Point-of-Care C-reactive Protein Assay Performed on the EnLiSense Rapid ElectroAnalytical Device (READ) Platform Among a Subset of Patients Enrolled in an Observational Study of Sepsis in Uganda
REFNo: HS5172ES

To validate the CRP assay performed on the READ platform by comparing it to a point-of-care conventional CRP assay previously cleared by the United States Food and Drug Administration (FDA). The results from this substudy are intended to be used for a FDA 510(k) submission for the EnLiSense READ device and CRP assay
Uganda 2025-01-10 11:49:48 2028-01-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ferdinand Nduwayo
ID: UNCST-2024-R004506
Development of Comprehensive Seismic Design Guidelines for Earthquake Resistant Design of Buildings in Uganda
REFNo: SIR390ES

(e) To develop comprehensive national structural design guidelines based on modern seismic design codes, aimed at providing engineering practitioners with practical seismic risk mitigation techniques; subsequently leading to sustainable growth and development,(d) To derive spectral displacement, elastic and design pseudo-acceleration spectra representing seismic action in the horizontal direction for key building typologies located in major cities in Uganda,(c) To develop reliable bespoke building exposure models for risk calculations by gathering data on building stock taxonomies and occupancy types,(b) To perform a stochastic event-based probabilistic seismic hazard analysis for Uganda which relies on the available data collected on the seismicity, geology and tectonics of the country,(a) To compile Uganda historical and instrumental earthquake catalogues required for homogenisation, removal of non-Poissonian events and completeness analyses,The main objective of this research proposal is to develop comprehensive earthquake-resistant building design guidelines specifically tailored for Uganda\'s unique geological, seismo-tectonic conditions and available construction materials. These guidelines will facilitate the construction of buildings that can withstand earthquakes, thereby reducing the potential for damage and casualties during seismic events.,
Burundi 2025-01-10 11:48:15 2028-01-10 Engineering and Technology Non-Clinical Trial Non-degree Award
Julius Okuni Boniface
ID: UNCST-2019-R000963
A One Health Survey of AMR and farming practices that drive Antimicrobial Resistance at Selected Animal-Human-environment Interface in Uganda
REFNo: A539ES

General Objective: To build capacity for antimicrobial resistance (AMR) surveillance and AMR stewardship using a One Health approach.

Specific Objectives:
1. To isolate the AMR resistant E coli and Salmonella from slaughtered chicken, slaughtered cattle and the environment. 2. To determine the phenotypic and genotypic characteristics of Salmonella and pathogenic E. coli present in selected human-animal interfaces in Uganda. 3. To determine the changes in the antimicrobial use by farmers and Veterinarians during COVID19 pandemic.
4. To determine the roles played by different livestock management practices and animal health interventions in escalating AMR in Uganda. 5. To identify and evaluate community based hygienic and disinfection practices that can reduce antibiotic/biocide use. 6. To determine the levels of antimicrobials and biocide residues in slaughtered chicken and cattle cecal samples and abattoir/market wastewater from the selected districts in the country. Secondary objectives: To harness the functions of various policy makers in government institution and build capacity and partnerships for AMR reduction with different organisations within Uganda.
Uganda 2025-01-10 11:46:51 2028-01-10 Agricultural Sciences Non-Clinical Trial Non-degree Award
Ilemobayo  Fasogbon Victor
ID: UNCST-2023-R008569
DEVELOPMENT AND EVALUATION OF AN APTAMER-BASED LATERAL FLOW BIOSENSOR FOR RAPID DETECTION OF Mycoplasma bovis P48 PROTEIN
REFNo: HS4931ES

Evaluation of the aptamer-based biosensor using M. bovis infected milk samples,Construction of the aptamer-based biosensor after optimizing the inherent conditions and components,Characterization of the binding affinity and specificity of the aptamer-target interactions,Selection and optimization of the most sensitive aptamer for application in the lateral flow biosensor through molecular interaction studies on previously reported P48 protein aptamers.,he research aim to develop and evaluate an aptamer-based lateral flow biosensor for the rapid and accurate detection of the Mycoplasma bovis P48 protein in infected samples,
Nigeria 2024-12-23 12:36:24 2027-12-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Paul Matovu
ID: UNCST-2024-R004929
The Phylogeny of East African Chlorophytum Ker-Gawl. (Asparagaceae), Phylogeography and Conservation of species found in Uganda
REFNo: NS756ES

1. To establish the phylogeny of Chlorophytum species in the FTEA region and put them in a global context.
2. To unravel the phylogenetic and morphological delimitation of problematic taxa and species complexes within Chlorophytum.
3. To establish the spatial phylogeny of Chlorophytum species that occur in Uganda
4. To establish the conservation status of Chlorophytum species in Uganda

Uganda 2024-12-23 12:34:57 2027-12-23 Natural Sciences Non-Clinical Trial Degree Award
Francis Ssali
ID: UNCST-2021-R012134
A5409: A Phase 2 Randomized, Adaptive, Dose-Ranging, Open-Label Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis (RAD-TB)
REFNo: HS4036ES

1.2 Primary Objectives

1.2.1 To compare MGIT liquid culture TTP slope over the first 6 weeks of treatment for each experimental treatment arm to the SOC arm.

1.2.2 To compare new Grade 3 or higher adverse events (AEs) (safety) over the first 8 weeks of treatment for each experimental treatment arm to the SOC arm.

1.3 Secondary Objectives

1.3.1 To compare time to stable culture conversion by MGIT liquid culture by week 8 for each experimental treatment arm to the SOC arm.

1.3.2 To compare MGIT liquid culture TTP slope over the first 8 weeks of treatment for each experimental treatment arm to the SOC arm.

1.3.3 To compare new Grade 3 or higher AEs (safety) over 26 weeks of treatment for each experimental treatment arm to the SOC arm.

1.3.4 To compare discontinuations of anti-TB drugs for any reason prior to 8 and 26 weeks of treatment for each experimental treatment arm to the SOC arm.

1.3.5 To determine the dose- and exposure-response relationships between experimental drug estimated pharmacokinetic (PK) parameters with safety and efficacy.

1.3.6 To compare a composite of efficacy and safety outcomes using a risk-benefit approach for each experimental treatment arm to the SOC arm.

1.3.7 To compare MGIT liquid culture TTP slope over the first 6 weeks of treatment for Arms 3A-3B and Arms 4A-4B compared to Arm 2.

1.3.8 To compare durable cure by 52 weeks after treatment initiation in each experimental treatment arm to the SOC arm.


Uganda 2024-12-23 12:34:14 2027-12-23 Medical and Health Sciences Clinical Trial Non-degree Award
Hakimu Sseviiri
ID: UNCST-2024-R004881
Formalizing and Elevating Workforce Visibility for Marginalized Sanitation Workers in Kampala, Uganda: Unravelling the intended and Unintended Consequences.
REFNo: SS2816ES

4. To co-design multi-stakeholder pathways towards effective formalization, integration and recognition of sanitation workers. ,3. To analyze the multi-dimensional intended and unintended impacts of formalizing and increasing the visibility of the workforce for the most marginalized workers. ,2. To identify and characterize actors involved in the formalization and visibility raising processes in Kampala city. ,1.To determine the different sanitation workers’ formalization and visibility raising initiatives overtime. ,To unravel the intended and unintended consequences of sanitation workers formalization and visibility enrichment in Kampala city, Uganda. ,
Uganda 2024-12-23 12:29:36 2027-12-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
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