Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Alfred Jatho
ID: UNCST-2021-R011710
Barriers to and Facilitators of Prostate Cancer Screening among Men in Uganda Prisons
REFNo: HS2128ES

The goal of this study is to examine the perceptions, attitudes and beliefs of men in Uganda Prisons regarding barriers to and facilitators of PCa screening. This will enable the research team to identify potential interventional strategies to promote PCa screening among men in Uganda prisons.,
Uganda 2022-04-01 2025-04-01 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joaniter Nankabirwa Immaculate
ID: UNCST-2021-R012896
Optimizing the use of SARS-Cov-2 antigen rapid diagnostic tests (Ag-RDT) for timely detection and effective response to COVID-19 in key border communities in Uganda
REFNo: HS2050ES

To evaluate the feasibility of active surveillance using the SARS-CoV-2 Ag-RDT in high-risk populations in border districts of Tororo and Busia.

To determine the yield of active surveillance using the SARS-CoV-2 Ag-RDT in high-risk populations in the border districts of Tororo and Busia districts

To assess the acceptability of active surveillance using the SARS-CoV-2 Ag-RDT in high-risk populations in border districts of Tororo and Busia.

Uganda 2022-04-01 2025-04-01 Medical and Health Sciences Non-Clinical Trial Non-degree Award
helen harrison
ID:
A grounded theory epistemological exploration of wellbeing for women with lived experience of conflict-affected trauma, based in Uganda
REFNo: HS2148ES

- To use thematic-induced analysis to develop a theory relating to the epistemology of wellbeing that is grounded in the interview data,- To conduct semi-structured interviews with six – eight female participants from each of the communities.,- To explore the epistemology of wellbeing for women from three specific Uganda-based communities, each of whom has lived experience of conflict-affected trauma, and who are linked through trauma counselling,
UK 2022-04-01 2025-04-01 Medical and Health Sciences Non-Clinical Trial Degree Award
Thereza Piloya Were
ID: UNCST-2019-R000491
Diabetes in African Youth: Improving Glucose Time-In-Range (DAY Time) Randomized Clinical Trial.
REFNo: HS2129ES

Primary Study Objectives
1. To determine if patient ability to continuously observe plasma glucose levels for 6 months using a flash intermittently scanned CGM improves glucose TIR compared to baseline. The change in glucose TIR while wearing the unblinded CGM will be compared to change in TIR in patients performing 3x/day SMBG (wearing a blinded CGM for endpoint measurement).
2. To perform a cost analysis on flash glucose monitoring compared to 3x/day SMBG, to determine whether this technology is cost effective in the setting of a low-resource nation.
Secondary Objectives: To assess the change-from-baseline impact of unblinded CGM on:
1. Percent time-in-range at 12 months
2. Percent time with glucose 180-250, >250, <70, and <54 mg/dl at 6 and 12 months
3. HbA1c at 6 and 12 months
4. Patient satisfaction and quality of life at 6 and 12 months
5. Glucose variability (coefficient of variation, CV) at 6 and 12 months

Uganda 2022-04-01 2025-04-01 Medical and Health Sciences Clinical Trial Non-degree Award
Pontiano  Kaleebu
ID: UNCST-2020-R019901
Performance evaluation of the CheckNOW™ HIV Self-Test study
REFNo: HS2170ES

1. To evaluate the performance (Sensitivity and specificity) of the CheckNOW™ HIV SELF TEST when compared to the Genscreen ULTRA HIV1/2 Ag/Ab EIA followed by the Murex diasorin HIV1/2 Ag/Ab combination (reference testing) in the laboratory and the national testing algorithm.

2. To describe the clinical performance (sensitivity and specificity) of the CheckNOW™ HIV SELF TEST, as obtained by the professional users, when compared to the reference testing and the national testing algorithm.

3. To describe the clinical performance (sensitivity and specificity) of the CheckNOW™ HIV SELF TEST, as obtained by the lay users, when compared to the reference testing and the national testing algorithm.

4. To assess the accuracy of the lay user interpretation of the HIVST result. This will be compared with the interpretation by the RA.
5. To assess the usability of the CheckNOW™ HIV SELF TEST. The usability of the test will be evaluated by questionnaires completed by the study staff observers and by the lay users.



Uganda 2022-04-01 2025-04-01 Medical and Health Sciences Clinical Trial Non-degree Award
Samson Okello
ID: UNCST-2019-R001580
Epidemiology of cardiac dysfunction in sub-Saharan Africa: Heart Failure Registry of HIV-infected and HIV-uninfected persons in Uganda and Zambia
REFNo: HS788ES

1. To describe the clinical characteristics, treatment outcomes, and predictors of all-cause and CV mortality among HIV-infected and HIV-uninfected heart failure adults hospitalized at Mbarara Regional Referral Hospital (Mbarara, Uganda) and University of Zambia Hospital (Lusaka, Zambia).
2. To describe echocardiographic etiology of heart failure among HIV-infected and uninfected adults hospitalized at Mbarara Regional Referral Hospital (Mbarara, Uganda) and University of Zambia Hospital (Lusaka, Zambia).
3. To determine the differences in the serum markers of cardiac fibrosis, cardiac injury, oxidative stress, and hypercoagulability in HIV-infected and HIV-uninfected individuals hospitalized with heart failure at Mbarara Regional Referral Hospital and the University of Zambia Hospital.

Uganda 2022-03-30 2025-03-30 Medical and Health Sciences Non-degree Award
Jennifer Ross
ID:
Modeling Approaches to Prioritize TB Prevention in Uganda
REFNo: HS1981ES

1. Estimate national, regional- or district-level patterns in prevalence, incidence, and mortality of TB and TBHIV using a geospatial model to identify geographic areas with higher versus lower infection burden.

2. Quantify the potential impact in disease burden and cost for PT scale-up in regionalized versus uniform implementation.

3. Engage stakeholders to inform model development and evaluate strategies to improve the acceptability and feasibility of modeled strategies for TB prevention.

USA 2022-03-30 2025-03-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bernard Kikaire
ID:
Utility of using C - reactive protein (CRP) in identifying bacteremia in children below five years presenting with fever at the Kawempe National Referral hospital.
REFNo: HS2038ES

1. To assess the performance of CRP in identifying bacterial infection among children less than 5 five years presenting with fever Kawempe National Referral Hospital
2. To assess the performance of Neutrophilia in identifying bacterial infection among children less than 5 five years presenting with fever Kawempe National Referral Hospital
3. To compare the two diagnostic criteria in identifying children with bacteremia at Kawempe National Referral Hospital

Uganda 2022-03-30 2025-03-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
HARRIET NANKYA
ID:
Toward effective community engagement for genomics research in Uganda
REFNo: SS1172ES

1. To assess Genomics Researchers’ perspectives and practices on CE for genomics research in Uganda.
2. To explore Community Stakeholders’ experiences and perspectives on CE for genomics research in Uganda.
3. To assess research regulators’ perspectives on what constitutes effective community engagement for genomics research in Uganda.
4. To develop a framework for effective community engagement for genomics research in Uganda.

Uganda 2022-03-30 2025-03-30 Social Science and Humanities Non-Clinical Trial Degree Award
Raymond Tweheyo
ID: UNCST-2020-R014507
Development and validation of a Medical Internship Experience Scale (MIES) for low- and middle-income countries.
REFNo: HS2062ES

4.2 General Objective
To develop and validate the Medical Internship Experiences Scale in Uganda, so as to contribute to the understanding of internship experiences for the health workforce in low- and middle-income countries.
4.3 Specific Objectives
1) To draft a Medical Internship Experiences Scale (MIES) for testing in Uganda alongside other LMICs.
2) To develop and test the Medical Internship Experiences Scale (MIES) among intern doctors in Uganda.
3) To evaluate the experiences of intern doctors and 3-year post internship doctors with their medical internship, using the MIES in Uganda.
4) To explore the perceptions of intern doctors, and intern doctor supervisors regarding the wellbeing of intern doctors during the medical internship training in Uganda.

UK 2022-03-30 2025-03-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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