Sarah Kiguli
ID: UNCST-2021-R013020
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In-Hospital Mortality Among Sickle-Cell Disease Patients with and without SARS-CoV-2 co-Infection at Mulago National referral Hospital.
REFNo: HS4253ES
Genral OBJECTIVE
The overall objective of this study is to determine the in-hospital annual mortality rate among SCD patients over the 2010 to 2022 13 years period, and the association with SARS-CoV-2 infection-related morbidity and mortality in Uganda.
SPECIFIC OBJECTIVES
1.To determine prevalent SCD events and time-trend (annual) of in-hospital mortality rate before the COVID-19 pandemic (2010 to 20190) at Mulago National referral & Teaching Hospital
2. To assess probable-cause of death by adjudicating the diagnosis made at the time of death
3. To investigate the individual and health system factors (e.g., pediatricians with SCD expertise, pediatric ICU, oxygen supply, blood bank, and access to Hydroxyurea) associated with in-hospital mortality
4. To assess the prevalence of SARS-CoV-2 infection and any bidirectional effect between SARS-CoV-2 and SCD on mortality among those with vs. without SARS-CoV-2 or SCD admitted in hospital between 2020 and 2022.
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Uganda |
2024-07-26 15:47:47 |
2027-07-26 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Edgar Mulogo Mugema
ID: UNCST-2023-R008170
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Leveraging Molecular Technologies to Improve Diagnosis and Management of Pediatric Acute Respiratory Illness in Resource-Constrained Settings.
REFNo: HS4539ES
Refine existing host immune response classifiers for the differentiation of bacterial and viral causes of febrile ARI among children in Uganda. Determine the etiology of febrile ARI episodes using a diagnostic assessment that includes physician adjudication and is augmented by pathogen metagenomics. Develop and internally validate a host immune response signature that differentiates between causes of pediatric ARI in Uganda using previously identified gene transcripts. Develop novel clinical algorithms for pediatric ARI to inform antibiotic treatment decisions ,The objective of this proposal is to develop novel clinical algorithms for pediatric febrile ARI in sub-Saharan Africa to identify children with bacterial illness. To augment samples collected during a previous cohort study (MUST REC 14/03-19) to achieve sufficient sample size to develop a host gene expression signature that differentiates between viral and bacterial ARI, we will enroll 160 children presenting to St. Pauls Health Center IV with ARI and 20 healthy controls.,
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Uganda |
2024-07-26 15:44:44 |
2027-07-26 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Stephen Okoboi
ID: UNCST-2019-R001356
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UNDERSTANDING DRIVERS OF TB AND MALARIA PREVALENCE AND INCIDENCE, AND BARRIERS TO UPTAKE OF HEALTH SERVICES AND RETENTION IN CARE – COMMUNITY VOICE PERSPECTIVE IN NAMAYINGO DISTRICT
REFNo: SS2915ES
To collaboratively develop recommendations for driving sustainable impact and improving health outcomes in the context of TB and malaria.,To identify community-specific needs and gaps in current TB and malaria interventions and healthcare delivery systems.,To explore the socio-economic, cultural, and behavioral factors influencing the spread and persistence of TB and malaria within communities.,To engage directly with community members to understand their perspectives on the barriers and drivers of TB and malaria prevalence and incidence.,To understand the drivers of TB and malaria prevalence and incidence, as well as barriers to the uptake of health services and retention in care from a community voice perspective in Namayingo district,
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Uganda |
2024-07-26 15:43:11 |
2027-07-26 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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William Veness Andrew
ID:
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Assessing Causal Processes of Multi-Hazard Risk in the Rwenzori Region
REFNo: NS842ES
Generation of an evidence base for solutions through a multi-hazard risk assessment inthe Rwenzori Mountains
Hydrological characterisation of the highlands
Evidencing the mechanisms of landslides and potential for vegetative stabilisation
Evidencing geomorphological changes in river valleys
Assessment of whether water quality is being impacted by soil erosion
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UK |
2024-07-26 15:42:01 |
2027-07-26 |
Natural Sciences |
Non-Clinical Trial |
Degree Award |
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Ronald Angupale Jimmy
ID:
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Design, Development and Characterization of Drug Delivery Systems for Ugandan Antimalarial Plants - Artemisia annua, Vernonia amygdalina and Microglossa pyrifolia
REFNo: HS1886ES
4. To optimize the developed drug delivery system(s) with respect to the critical product quality attributes and assess their antimalarial efficacy and safety,3. To design and develop suitable herbal drug delivery systems (conventional and novel) for the plant extracts,2. To carry out preformulation studies (physicochemical properties) for the plant extracts,1. To determine in vivo antimalarial efficacy of selected combinations of A. annua, V. amygdalina and M. pyrifolia ,To design, develop and characterize drug delivery systems for selected Ugandan antimalarial plants – Artemisia annua, Vernonia amygdalina and Microglossa pyrifolia,
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Uganda |
2024-07-26 13:50:14 |
2027-07-26 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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