Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
Search By Approval Date:
Clear Filter Total: 5,852
Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Timothy  Muwonge Ronald
ID: UNCST-2020-R014680
 Pharmacy Delivery of PrEP and HIVST for Adolescent Girls and Young Women seeking Emergency Contraception at Community Pharmacies in Uganda: Formative Research
REFNo: HS2037ES

Aim 1: To assess the willingness of providing HIV self-testing and PrEP to AGYW seeking emergency contraception at community pharmacies.
Approach: Using the social-ecological model, fig 2, we will conduct surveys with AGYW approximately 130 seeking EC at community pharmacies within a radius of 45km from the Infectious Diseases Institute-Kasangati (IDI-K) research center, to evaluate knowledge of HIVST and PrEP and acceptability of accessing HIVST and PrEP through a pharmacy. In addition, we will purposefully select a subsample of up to 30 to undergo in-depth interviews (IDIs) to explore potential barriers and facilitators of HIVST and PrEP delivery at community pharmacies.
Hypothesis: AGYW seeking EC at community pharmacies will be willing to use HIVST and PrEP and will highlight potential barriers and facilitators to accessing PrEP at community pharmacies
Aim 2: To identify readiness of pharmacy providers regarding AGYW sexual health and specifically HIVST, emergency contraception, and PrEP
Approach: To assess the readiness, knowledge gaps, and training needs of community pharmacists to deliver HIVST and PrEP alongside EC, we will conduct up to 20 IDIs with providers (pharmacy technicians, nurses, and pharmacists) from private pharmacies who under the pharmaceutical society of Uganda have agreed to be included in the study.
Hypothesis: Addressing knowledge gaps of pharmacy providers will inform delivery of sexual health services to AGYW.

Uganda 2022-05-13 9:02:19 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
John Mukisa
ID:
Host genetic variation and association with HIV disease progression among pediatric cohorts in Botswana and Uganda
REFNo: HS1841ES

1) To identify common host genetic variants associated with HIV disease progression among pediatric HIV cohorts from Botswana and Uganda. 2.) To evaluate the performance of genotype imputation methods with whole genome sequences as a gold standard for determining missing genotypes among samples from Botswana and Uganda. 3.) To identify and validate KIR genotypes among children with HIV in Botswana and Uganda. 4.) To determine the KIR haplotypes associated with HIV disease progression among children with HIV from Botswana, and Uganda.
Uganda 2022-05-13 7:48:00 2025-05-13 Medical and Health Sciences Non-Clinical Trial Degree Award
Agnes Kiragga
ID:
SARS-CoV-2 international biorepository and diagnostic test performance
REFNo: HS1808ES

Primary:
• To create a biorepository to test retrospectively the performance of investigational, emerging diagnostic technologies in the intended population or setting compared to a reference comparator for diagnosing SARS-CoV-2 infection using frozen samples.
Secondary
• To test prospectively the accuracy of investigational, emerging diagnostic technologies in the intended population or setting compared to a standard comparator for diagnosing SARS-CoV-2 infection
• To determine agreement between self-collected nasal swabs, saliva and clinician-collected nasopharyngeal swab samples for the diagnosis of SARS-CoV-2 using a reference test in Uganda.
• Determine the proportion of non-reportable results (unresolved, indeterminate and incomplete) and turn-around time compared to reference test.
• To assess acceptability of self-collected nasal swab tests and saliva for testing SARS-CoV-2 in both participants and healthcare workers in Uganda.
• To explore socio-demographic, behavioural and clinical factors associated with positive SARS-CoV-2 diagnosis.


Uganda 2022-05-13 7:45:44 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kristina Roesel
ID:
Boosting Uganda's investments in livestock development (BUILD)
REFNo: A139ES

The program is divided into four different components that will be aligned and integrated, especially on activities that involve national stakeholder engagement and capacity building. Component 1 on Peste de petits ruminants (PPR) combines socio-economic studies, vaccine targeting and delivery, regional Pan-African networking activities (e.g. PENAPH, PPR alliance GPRA) and capacity development at the Biosciences eastern and Central Africa (BecA)-Hub at ILRI Nairobi: Objective1: Develop a socio-economic framework to assess the impact of PPR interventions Activities: Household survey in different livestock production systems; Longitudinal study-sentinel households; System dynamic modeling; Focus group discussions Outputs: Livelihoods impacts of different PPR control options Objective 2: Update the epidemiological status of PPR to allow assessment of control options Activities: Cross-sectional survey in different livestock productions systems; Post vaccination sampling; Genetic characterization of PPRV isolates; Participatory disease search; Slaughter house surveillance; Develop PPR risk maps Outputs: Updated risk map of PPR, circulating PPR genotypes, other important SR diseases Objective 3: Capacity development Activities: Support review of National PPR control strategy; Review of animal health services; Multi-stakeholder platform for AH service delivery to discuss gaps and define new mechanisms for control and surveillance; Strengthen passive surveillance system; Awareness creation of farmers; Post vaccination sampling Outputs: Novel models of animal health service delivery, strengthened surveillance system, capacity enhanced Component 2 on Rift Valley fever (RVF) includes the characterization of animal and human samples from outbreaks in 2016 and 2018, socio-economics, development of a risk and vulnerability map for Uganda as a decision-making tool Objective 1: Improved knowledge on RVF epidemiology Activities: Genotyping (RVF and other viruses); Serology (establish Gn/Gc distribution); Outbreak response; Entomological studies; Risk mapping Objective 2: Socio-economic studies Activities: Ex-ante analyses of control options; KAP questionnaire surveys; Gender assessments – exposure and constraints on uptake of interventions Objective 3: Develop National action plans/policy work and extension Activities: Contingency plans/decision support tools; Community trainings Outputs: RVF risk map, genetic characterization of circulating strains (informs vaccine interventions), Improved RVF national action plans, Training and communication materials, capacity building, improved capacity on vector sampling/surveys and biological sampling; PhD/MSc training Component 3 on Antimicrobial resistance (AMR) will contribute to the finalization of the National AMR action plan, describe and quantify the use of antimicrobials in the peri-urban poultry value chain. Objective 1: Understand knowledge, attitude, practices, and incentives for AMU in poultry value chains in Uganda, and the role of formal and informal markets Activities: Literature review on AMR and AMU in the poultry sector in Uganda; Gender sensitive rapid appraisal with AMUSE tool; Identify possible intervention entry points to improve AMU Objective 2: Assess risks to humans from poultry-associated AMR: Research on AMR transmission risks at the human-animal-environmental interface in different poultry production systems (smallholder and commercial; rural and peri-urban) in Uganda Activities: Map possible transmission pathways within the production system; Conduct AMR and residue prevalence surveys; In-depth AMR transmission studies that include environmental samples, and farm workers, and samples from other animal species potentially housed together with poultry; Outline risk pathways for human exposure to AMR from poultry production Objective 3: Design and evaluate interventions to reduce AMU in poultry value chains in Uganda Activities: Design interventions (co-design with poultry producers), closely monitor implementation over time to understand incentives to motivate change; Establish drug use monitoring system in poultry farms to allow M&E; Qualitative and quantitative analysis of intervention impact Objective 4: Support evidence-based policy dialogue for antimicrobial surveillance and AMR strategies Activities: Organise multi-stakeholder workshops to discuss feasibility, challenges, and constraints in implementing NAP in poultry sector, involve representatives from other countries and support continued review of NAP Objective 5: Build capacity in value chain actors, implementers, researchers Activities: Conduct capacity development need assessment; Develop capacity development plan for different stakeholder groups Component 4 on Veterinary Public health (VPH) at the point of slaughter includes scaling of already piloted butcher training curricula and implementation of abattoir-based sentinel studies for animal disease surveillance Objective 1: development of curriculum for capacity building of meat handlers on good hygienic practices (slaughter house personnel, butchers, meat transporters); meat inspectors on carcass inspection and mobile reporting; Public engagement of consumers; laboratory personnel (GLP and quality assurance) Activities: Baseline assessment of meat handlers’ knowledge and practices; hygiene indicators, selected pathogens; Consolidation and adaptation of existing materials for training of butchers; assessment of suitability of consolidated training materials and delivery mode with stakeholders; delivery of the training; endline study to assess success of the intervention Objective 2: proof-of-concept slaughterhouses as sentinels for zoonotic disease Activities: Mapping slaughterhouses through key informants and GIS; grey and published literature review; prioritization of disease in slaughterhouses/ identification of critical control points – KII and FGD with vets, meat inspectors, public health staff; Ethnographic observation of slaughterhouses; biological survey in animals and humans
Germany 2022-05-13 7:44:12 2025-05-13 Agricultural Sciences Non-Clinical Trial Non-degree Award
REBECCA CLAIRE LUSOBYA
ID:
Knowledge, Attitudes and Practices of Pediatricians, Neonatal Nurses and Parents of Preterm Infants towards Retinopathy of Prematurity in Tertiary Hospitals Uganda.
REFNo: HS2228ES

To determine the attitudes and practice patterns regarding ROP and its risk factors among pediatricians, neonatal nurses and caregivers at Kawempe National Referral Hospital and Mulago Specialized Women’s and Neonatal Hospital.,2 To determine the level of knowledge of ROP and its risk factors among caregivers attending Kawempe National Referral Hospital and Mulago Specialized Women’s and Neonatal Hospital.,1. To determine the level of knowledge of ROP and its risk factors among pediatricians and neonatal nurses in Kawempe National Referral Hospital and Mulago Specialized Women’s and Neonatal Hospital.,To determine the knowledge, attitude and practice patterns regarding ROP among the pediatricians, neonatal nurses and the preterm caregivers at Kawempe National Referral Hospital and the Mulago Specialised Women’s and neonatal Hospital.,
 Uganda 2022-05-13 16:09:48 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JUSTUS BARAGEINE KAFUNJO
ID: UNCST-2020-R014150
 Identifying Opportunities for Prevention of Adverse Outcomes Following Female Genital Fistula Repair
REFNo: HS2033ES

Identify predictors of post-repair fistula breakdown and recurrence

Identify predictors and characteristics of post-repair incontinence

Identify feasible and acceptable strategies for modifying key risk factors of adverse
outcomes
 Uganda 2022-05-13 16:09:08 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel Rukundo NSHAKIRA
ID: UNCST-2021-R012277
 COVID-19 Risk,Electoral Violence and Civic Participation in the 2020/2021 Ugandan General Elections
REFNo: SS1218ES

To establish the extent to which COVID-19 fear affected civic participation in the 2021 elections,Compare the level of fear of Covid-19 and fear of electoral and post-electoral violence on voter turn-out,Assess the effect or concern and fear of COVID-19 affect voter turnout,Assess the effect of COVID-19 on campaign rally participation and candidate interface,
 Uganda 2022-05-13 15:52:13 2025-05-13 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jackson Orem
ID: UNCST-2021-R012016
 Factors that affect the timely diagnosis and treatment of neutropenic fever in Ugandan patients with cancer and HIV
REFNo: HS2175ES

1. To understand the current process of antibiotic initiation for patients with cancer and neutropenic fever at the UCI. 2. To identify factors that influence timely initiation of guideline-recommended antibiotics which can be addressed using targeted implementation strategies. 3. To identify the unique barriers to diagnosis and treatment of neutropenic fever for patients with HIV who are receiving treatment for cancer at UCI.
 Uganda 2022-05-13 10:09:59 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Charles Batte
ID: UNCST-2021-R013587
 Validation of the Chronic Obstructive Pulmonary Disease Assessment Tool (CAT) Among COPD patients in rural Uganda.
REFNo: HS2145ES

To validate CAT among COPD patients in Nakaseke, Uganda. Specific objectives: • To determine the validity of CAT in assessing quality of life among COPD patients in rural Uganda using Saint George Respiratory Questionnaire (SGRQ) as the gold standard • To determine the internal reliability of the CAT in diagnosis of QOL among COPD patients in rural Uganda. Secondary objective: • To determine factors associated with poor QoL among patients with COPD in rural Uganda.
Uganda 2022-05-13 10:05:27 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Claude Raisaro
ID:
Driving Behaviors, Monetary Incentives and Norms: Experimental Evidence from the Ugandan Transit Industry
REFNo: SS1217ES

• To better understanding the underlying mechanisms to understand and incentivize safe driving behaviors for bodaboda drivers
• Examine how financial incentives affect driving behavior and to which extent is road safety impacted on an individual basis?.
• To learn whether beliefs about safe driving change in the presence of financial incentives.

 Italy 2022-05-13 10:01:06 2025-05-13 Social Science and Humanities Non-Clinical Trial Degree Award
View Sort By:

"A prosperous Science and Technology Led Ugandan Society."

NRIMS