Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Grace Ahimbisibwe Miriam
ID: UNCST-2021-R012129
 Pediatric HIV Cure Collaborative Study Version 2.0 dated 16 Sep 2021
REFNo: HS2671ES

1. Identify correlates of susceptibility to proviral reactivation through immune profiling, which will be analyzed by multiparameter by flow cytometry methods, antibody profiling and transcriptomic analyses by bulk RNA-seq of PBMCs and CD4+ T cells in perinatal and adult infections.
2. To quantitatively and qualitatively characterize viral reservoirs, in children, adolescents and youth living with HIV compared with adults through determining and comparing the size, composition, and inducibility of the latent HIV reservoir in different geographic locations and subtypes, and characterizing their differences. The size will be determined by HIV DNA quantitative assays and inducibility by TILDA. The composition will be determined by near full-length sequencing for intact and defective genomes.
 Uganda 2023-05-26 8:39:02 2026-05-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eugene Kinyanda
ID: UNCST-2023-R008028
 Proposal to address the medium- to long-term EBOLA associated psychological Distress and psychosocial problems in Mubende District in central Uganda (Ebola+D Project)
REFNo: HS2870ES

To undertake a project to address the medium- to long-term EBOLA associated psychological Distress and psychosocial problems in Mubende District in central Uganda. Aims i) To develop, implement and evaluate the Ebola+D mental health intervention in Mubende district ii) To investigate the nature of mental health problems of community members accessing the Ebola+D mental health intervention and factors associated with treatment outcomes including immunological biomarkers iii) To explore the EVD associated negative beliefs and lived out experiences of affected members of the community (including health care workers)
 Uganda 2023-05-26 8:34:43 2026-05-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kamwine Monicah
ID:
MICROBIAL AND METAGENOMIC ANALYSIS OF BACTERIAL COMMUNITIES IN MILK PRODUCTS PRODUCED IN MBARARA CITY, UGANDA
REFNo: HS2673ES

General objective
To characterize bacterial communities in milk products produced in Mbarara City, Uganda using culture techniques and metagenomic analysis
Specific Objectives
1. To determine the presence, levels of overall bacterial contamination load and bacterial profile in different milk products produced in Mbarara city, Uganda
2. To characterize the predominant microbiota in each milk product, determine the percentage of relative abundance of main identified bacterial genera, in each of the milk products produced in Mbarara city, Uganda.
3. To determine Virulence factors of the isolated bacteria
4. To determine the antimicrobial susceptibility patterns of pathogenic bacteria isolated from milk products produced in Mbarara city, Uganda

 Uganda 2023-05-25 12:11:40 2026-05-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Deborah Ekusai-Sebatta
ID: UNCST-2021-R003878
 REGULATION OF DATA SHARING IN INTERNATIONAL GENOMIC RESEARCH: ETHICAL, SOCIAL AND LEGAL IMPLICATIONS
REFNo: SS1730ES

3. To evaluate the ethico-regulatory frameworks governing data sharing practices of genomic research in Uganda,2. To determine stakeholder knowledge, attitudes and practices (KAP) on sharing of data in collaborative genomic research in Uganda.,1. To establish the genomic data sharing practices and perceptions in collaborative human genomic research in Low and Middle Income Countries .,To comprehend the ELSI of the data sharing in international collaborative genomic research from a regulatory stand point. This will involve an evaluation the data sharing policies and explore the knowledge, perceptions and experiences of stakeholders involved in the conduct of international genomic research,
 Uganda 2023-05-25 12:10:10 2026-05-25 Social Science and Humanities Non-Clinical Trial Degree Award
juliet cheptoris
ID:
Experiences and perceptions of Intimate Partner Violence (IPV) among Adolescent Girls and Young Women (AGYW) enrolled in the DREAMS Project in Mukono District, Uganda, 2023
REFNo: SS1718ES

General study objective To explore experiences and perceptions of Intimate Partner Violence (IPV) among Adolescent Girls and Young Women (AGYW) 15-24 enrolled in the DREAMS Program in Mukono District Specific Objectives 1. To explore the knowledge and perceptions on IPV among Adolescent Girls and Young Women (AGYW) who are enrolled in the DREAMS program 2. To examine the experiences of IPV among AGYW before and after enrolling in the DREAMS program. 3. To determine the factors associated with Intimate Partner Violence among AGYW who enrolled in the DREAMS program.
Uganda 2023-05-25 12:08:46 2026-05-25 Social Science and Humanities Non-Clinical Trial Degree Award
Rosalind  Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
 HIV and sexually transmitted infection international biorepository and diagnostic test performance
REFNo: HS2724ES

• To create a biorepository to test retrospectively the performance of investigational, emerging diagnostic technologies in the intended population or setting compared to a reference comparator for diagnosing HIV/STIs using frozen samples.
• To test prospectively the accuracy of investigational, emerging diagnostic technologies in the intended population or setting compared to a standard comparator for diagnosing HIV/STI infection
• To determine agreement between self-collected swabs, saliva and clinician-collected swab samples for the diagnosis of STI using a reference test in Uganda.
• To determine agreement between self-collected blood, saliva and clinician-collected blood samples for the diagnosis of HIV using a reference test in Uganda.
• Determine the proportion of non-reportable results (unresolved, indeterminate and incomplete) and turn-around time compared to reference test.
• To assess acceptability of self-collected blood samples, swab tests, and saliva for testing HIV/STI in both participants and healthcare workers in Uganda.
• To explore socio-demographic, behavioural and clinical factors associated with positive HIV and other STI diagnosis

 UK 2023-05-25 12:07:08 2026-05-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Richard Idro
ID: UNCST-2021-R013599
 Dihydroartemisinin-piperaquine and azithromycin for the post-discharge management of children with severe anaemia in Malawi, Kenya and Uganda; A, multicentre, parallel-group, two-arm, randomised, double-blind superiority trial.
REFNo: HS2815ES

To determine if PDMC with four courses of monthly AZ treatment in combination with four months of weekly DP is superior to PDMC with weekly DP-alone in reducing non-malaria SCCV by six months post-discharge in children aged <5 years admitted with severe anaemia (Hb<5g/dl) who are ready to be discharged and are clinically stable and able to switch to oral medication,
 Uganda 2023-05-25 12:04:54 2026-05-25 Medical and Health Sciences Clinical Trial Non-degree Award
David Meya Bisagaya
ID: UNCST-2019-R000837
 Platform Trial For Cryptococcal Meningitis - PLATFORM-CM
REFNo: HS2649ES

The purpose of this study is to know whether this oral form of amphotericin (MAT2203) is safe and effective in the treatment of people sick with cryptococcal meningitis.
 Uganda 2023-05-25 12:01:51 2026-05-25 Medical and Health Sciences Clinical Trial Non-degree Award
CHRISTINE MBABAZI -MPYANGU
ID:
Freedom of Religion or Beliefs Leadership Network (FoRBLN): A case study of Tororo district in Uganda.
REFNo: SS1308ES

Overall goal To explore a new synthesis of theoretical models derived from a combination of work in cognitive anthropology with modes theory, social psychology with identity fusion, leadership psychology with barrier crossing leadership. The research aims to address the following research questions 1. What role do imagistic group experiences play in fostering identity fusion Vs group identification bonds directed at the ingroup vs outgroup. 2. How far attitudes towards and experiences of barrier crossing leadership lead to improved intergroup attitudes and behaviours. 3. Whether individual empathetic abilities moderate the effects of imagistic experiences and/ or barrier crossing leadership. 4. How far the evidence from the cross cultural sample supports the theoretical model outline by modes theory.
Uganda 2023-05-25 11:59:07 2026-05-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
JULIET MWANGA-AMUMPAIRE
ID: UNCST-2022-R009420
 Omuyambi: Traditional healer support to improve HIV viral suppression in rural Uganda
REFNo: HS2780ES

Aim 2: Evaluate implementation of the Omuyambi intervention using a convergent, mixed methods study design guided by the Consolidated Framework for Implementation Research (CFIR). Participants for this Aim will include TH and PLWH from Aim 1, in addition to staff from affiliated HIV clinics, and Ministry of Health (MoH) AIDS Control Division Officers who will be invited to participate in in- depth interviews and structured surveys. Following the convergent mixed methods approach38, quantitative and qualitative data – including validated survey instruments, in-depth interviews, and structured observations – will be collected to evaluate context pertinent to Omuyambi implementation over a 24-month period.,Aim 1: We will compare the Omuyambi intervention versus HIV clinic-based care (control) in a cluster randomized trial to assess the effectiveness of a community-based traditional healer (TH)-facilitated support program for people living with HIV (PLWH) in Mbarara District. We will conduct a CRT of Omuyambi versus TH’s referrals for clinic-based HIV care at 40 TH cluster sites over 33 months in Aim 1. The unit of randomization is the TH; each cluster includes TH and adult PLWH who are ART naïve or defaulted from HIV care. TH who are randomized to Omuyambi will facilitate HIV support for ART naïve or nonadherent PWLH receiving care at their practice.,We propose a parallel arm cluster randomized trial to compare the intervention (Omuyambi) to the control in Aim 1 to assess the effectiveness of the intervention and use a mixed methods approach to evaluate the implementation in Aim 2.,
 Uganda 2023-05-18 16:44:40 2026-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Gideon Nsubuga
ID:
Inflammageing and anti-inflammageing cytokines in the HIV-seropositive and HIV-seronegative geriatric populations in Uganda.
REFNo: HS2889ES

1) To determine the mean inflammageing and anti-inflammageing cytokine levels in HIV-seropositive compared to HIV-seronegative geriatric populations in Uganda. 2) To determine the risk factors for inflammageing and anti-inflammageing cytokines in the HIV-seropositive compared to the HIV-seronegative geriatric population in Uganda.
Uganda 2023-05-18 16:05:34 2026-05-18 Medical and Health Sciences Non-Clinical Trial Degree Award
Margaret Lubwama
ID: UNCST-2019-R000636
 Antimicrobial resistance training course for preclinical undergraduate health sciences students in Makerere University
REFNo: HS2831ES

Increase knowledge of AMR among preclinical undergraduate health sciences students at MakCHS,To develop and execute a blended AMR training course curriculum for preclinical undergraduate health sciences students at MakCHS,To determine the knowledge gap about AMR among clinical undergraduate health sciences students at MakCHS ,To improve knowledge about AMR among preclinical undergraduate health sciences students at MakCHS
 Uganda 2023-05-18 16:03:18 2026-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Justine Bukenya Nnakate
ID: UNCST-2021-R012503
 Multi-City Menstruation-Friendly Public Toilet (MFPT) Study
REFNo: HS2796ES

General objective
To describe public toilets in Kampala city and identify approaches to improve their menstrual health and hygiene (MHH) compatibility (or “friendliness”)

Specific objectives
• To describe public toilets and their menstrual health and hygiene (MHH) compatibility (or “friendliness”) in Kampala city.
• To identify approaches to improve their menstrual health and hygiene (MHH) compatibility (or “friendliness”) in Kampala city.

 Uganda 2023-05-18 16:02:21 2026-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Richard Wamimbi Wotti
ID:
DEMOCRACY HUMAN RIGHTS AND GOVERNNANCE LEARNING, EVALUATION, AND RESEARCH (DRG-LER) II ACTIVITY GENDER-BASED VIOLENCE PORTFOLIO PERFORMANCE EVALUATION
REFNo: SS1709ES

To understand what is working, challenges faced, knowledge gaps, and what can be improved in USAID/GenDev’s GBV portfolio - RISE Activity Cluster,
 Uganda 2023-05-18 16:01:29 2026-05-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Amon Kanyesigye
ID:
KNOWLEDGE OF SICKLE CELL DISEASE AND ASSOCIATED FACTORS AMONG UNDERGRADUATE STUDENTS AT MAKERERE UNIVERSITY
REFNo: HS2823ES

1.To determine knowledge and awareness levels of SCD among undergraduate students at
Makerere University.
2. To determine the factors associated with knowledge and awareness levels of SCD among
undergraduate students at Makerere University.
 Uganda 2023-05-18 16:00:11 2026-05-18 Medical and Health Sciences Non-Clinical Trial Degree Award
Yume Nomoto
ID:
A comparison of nutritional status among children under five years of age between refugee and host communities: A multi-sectoral cross-sectional study in Lamwo district, Uganda
REFNo: SS1640ES

To estimate determinants of nutritional status among children in refugee and host communities,To estimate the difference in the prevalence of malnutrition among children between refugee and host communities,To estimate the difference in nutritional status among children 0-59 months of age between refugee and host communities.,
 Japan 2023-05-18 15:50:51 2026-05-18 Social Science and Humanities Non-Clinical Trial Degree Award
Patrick Tumwine
ID:
An Exploration of How Education Stakeholders Perceive the Implication of Grade Repetition at a Secondary School Level in Western Uganda. A Qualitative Multiple-Case Study.
REFNo: SS1727ES

To establish the parents' and administrators' perceptions about the cost implications of grade repetition within the secondary education system in Western Uganda.

To describe the teachers' and administrators' perception of the current grade repetition system's impact on students' self-efficacy.

To establish the understanding of administrators and chairpersons of PTA on the impact of grade repetition on national examination pass rates and related social promotion policy implications.
 Uganda 2023-05-18 15:49:44 2026-05-18 Social Science and Humanities Non-Clinical Trial Degree Award
franck Sikakulya
ID: UNCST-2021-R013687
 Effectiveness of movement and respiratory rate monitoring device in early detection of vital sign deterioration and hospitalisation outcomes among patients admitted at Kitovu Hospital in Central Uganda
REFNo: HS2792ES

To determine the effectiveness of a non-invasive movement and respiratory rate monitoring device in predicting the outcome of medical patients admitted to Kitovu Hospital. To assess the effectiveness of a non-invasive movement and respiratory rate monitoring device in early detection of vital sign deterioration among patients admitted at Kitovu Hospital.
 Democratic Republic of Congo 2023-05-18 15:45:26 2026-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JENNIFER WILBURN
ID:
AMR STEWARDSHIP KNOWLEDGE, PERCEPTIONS AND PRACTICES AMONG DISPENSERS IN COMMUNITY DISPENSARY SETTINGS IN KAWEMPE, KAMPALA
REFNo: SS1814ES

1. Evaluate the level of knowledge of antimicrobial resistance and antimicrobial stewardship of individuals working and dispensing antimicrobials within public and private community settings where antibiotics are dispensed.

2. Gain an understanding into perceptions toward AMS of individuals working and dispensing antimicrobials within these settings.

3. Document self-reported practices towards AMS of individuals working and dispensing antimicrobials within these community dispensary settings.
 UK 2023-05-18 15:43:17 2026-05-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Ali Ssetaala
ID: UNCST-2021-R011817
 Multi-site study for Adolescent Girls and Young Women for future HIV vaccines and antibodies candidates for prevention (MAGY).
REFNo: HS2741ES

Aim 1: To investigate factors that influence the design and participation in
clinical trials of future HIV vaccine and bnAb product candidates for AGYW.
Aim 1.1. To understand AGYW, parent/guardians, community members
perspectives on the inclusion of AGYW in future trials to develop and test HIV
vaccine candidates and broadly neutralizing antibodies (bnAb) products.
Aim 1.2. To understand the factors that influence the perceptions (e.g., vaccine
confidence vs hesitancy) of future HIV vaccine and bnAb products among AGYW,
parents/guardians and community members.
Aim 2: Establish AGYW clinical trial preparedness cohorts for the evaluation
of enhanced broadly neutralizing antibodies as a long-acting injectable HIV
prevention product.
Aim 2.1. To establish cohorts of AGYW aged 15-24 years in eastern and southern
Africa using best practices for standard of care, child protection and linkage to
sexual reproductive health (SRH) and HIV services and care.
Aim 2.2. To understand HIV risk and incidence among AGYW aged 15-24 years to
support the calculation of a background HIV incidence counterfactual.
Aim 3: To characterize peripheral immune cells via the least invasive
sampling approaches for assessment or prediction of the suitability of HIV
vaccine candidates for AGYW.
Aim 3.1. To assess the feasibility and acceptability of different sampling techniques
for AGYW
Aim 3.2a. To assess or predict the suitability of HIV vaccine candidates for AGYW
ages 18+ years by characterizing peripheral blood samples and performing
immunological comparison to adults.
Aim 3.2b. To assess or predict the suitability of HIV vaccine candidates for AGYW
ages 15-17 years by characterizing peripheral blood samples and performing
immunological comparison to older adolescents and adults.
Aim 3.3. Examine the temporal relationships between immunological and microbial
factors associated with HIV susceptibility in the female genital tract of AGYW.


 Uganda 2023-05-18 15:31:35 2026-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Anna Nordén
ID:
Social Acceptance of a green Transition in East Africa
REFNo: SS1666ES

Civil servants and policy makers working with environmental related policies and policy instruments in East Africa.,Enhancing Evironmental related policies and policy instruments in East Africa.,
 Sweden 2023-05-18 15:05:28 2026-05-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Hannington Businge
ID: UNCST-2022-R009477
 Board Characteristics, Strategic Orientation and performance of Insurance Companies in Uganda UCUREC-2022-392
REFNo: SS1546ES

To examine the influence of strategic orientation on the relationship between board characteristics and performance of Insurance companies in Uganda.,To determine the influence of board characteristics on performance of Insurance companies in Uganda.,To establish the board practices of Insurance companies in Uganda.,The overall objective of the study will be to determine the influence of strategic orientation on the relationship between board characteristics, and performance of Insurance Companies in Uganda. ,
 Uganda 2023-05-18 15:00:59 2026-05-18 Social Science and Humanities Non-Clinical Trial Degree Award
Michael Mukiibi
ID:
Effectiveness of a Smartphone Application on the Accessibility to Information on Maternal, Newborn, and Child Health Care in Slum Settlements in Uganda
REFNo: HS2818ES

i To investigate whether, and how, a smartphone-based job aid used by CHWs improves women’s uptake of facility-based delivery and other maternal health services in Uganda. ii To establish the accessibility of infant and maternal healthcare information by New born and Child health care uptake of facility-based delivery and other maternal health services in Uganda iii To develop a mobile smartphone application to address the accessibility to the information on Maternal, Newborn, And Child Health Care in Slum Settlements in Uganda iv To pilot-test the application in the study area
 Uganda 2023-05-11 15:03:31 2026-05-11 Medical and Health Sciences Non-Clinical Trial Degree Award
Maxensia owor
ID: UNCST-2021-R014003
 Metabolic Impact of Dolutegravir based ART in Postpartum Women Living with HIV and their Infants” (MI-DART study)
REFNo: HS2809ES

Aim 1: To determine the impact of maternal HIV and DTG-ART on i) energy intake and expenditure, ii) metabolic profile and iii) body composition and weight in postpartum women.
Aim 2: To determine the impact of maternal HIV and DTG-ART on i) energy intake and expenditure, ii) metabolic profile and iii) body composition and growth of their HEU infants.

Uganda 2023-05-11 15:01:13 2026-05-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
James Russell Michael
ID:
Fire and Climate in the Rwenzori Mountain National Park
REFNo: NS531ES

To develop a long-term record of fire in high-elevation areas of the Rwenzori Mountain National Park. With this record, we will investigate the relationship between fire and climate change through time. Our ultimate objective is to determine whether changes in air temperature cause changes in fire frequency through time. This will allow us to better predict changes in fire regime in the future.
 USA 2023-05-11 15:00:00 2026-05-11 Natural Sciences Non-Clinical Trial Non-degree Award
George Kipaalu Bogere
ID:
Internal Audit Function and Public Funds Management in Uganda. A case of selected Local Governments in Busoga sub Region.
REFNo: SS1708ES

1. To establish the relationship of Internal Audit function and Internal Control System Evaluation in Uganda. A case of selected Local Governments of Busoga.
2. To determine the effect of Internal Control System Evaluation on Auditor Independency and Integrity in Uganda. A case of selected Local Governments of Busoga.
3. To evaluate the Correlation between Audit independency and integrity and public funds management in Uganda. A case of selected Local Governments of Busoga.
4. To establish the association between internal Audit function and public funds management in Uganda. A case of selected Local Governments of Busoga.

 Uganda 2023-05-11 14:59:17 2026-05-11 Social Science and Humanities Non-Clinical Trial Degree Award
MARBLE NASASIRA
ID: UNCST-2021-R012753
 INCIDENCE AND PREDICTORS OF QTC PROLONGATION AMONG DRUG RESISTANT TUBERCULOSIS PATIENTS RECEIVING BEDAQUILINE BASED REGIMEN IN UGANDA.
REFNo: HS2802ES

To develop and validate a clinical risk score To estimate the risk of QTc prolongation after initiation of BDQ-containing regimens among DR-TB patients,To determine the predictors of QTc prolongation among patients receiving drug resistant tuberculosis treatment in Uganda,To assess the incidence of QTc prolongation among patients receiving drug resistant tuberculosis treatment in Uganda.,To determine the incidence, factors associated with QTc prolongation, develop and validate risk score among patients receiving BDQ based regimen. ,
 Uganda 2023-05-11 14:57:53 2026-05-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
 Phase B SAPPHIRE
REFNo: HS2784ES

Reduce HIV incidence using innovative strategies for HIV prevention and
treatment to simultaneously reach persistent driver populations.

 Uganda 2023-05-11 14:55:58 2026-05-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adalbert Aineomucunguzi
ID:
Conservation Research to monitor Grey Crowned Cranes in Uganda
REFNo: NS518ES

1. Understand movement, long-term survival and landscape use of the Grey Crowned Cranes.
2. Provide data on Grey Crowned Crane populations and their distribution in Uganda
3. Advance our understanding of landscape use (particularly agriculture) and its influence on size and distribution of crane populations
4. Identify areas where the potential exists for crane conservation interventions

Uganda 2023-05-11 14:53:15 2026-05-11 Natural Sciences Non-Clinical Trial Non-degree Award
Ali Ssetaala
ID: UNCST-2021-R011817
 CHILI- Adaptation
REFNo: HS2758ES

To support development of a new screening test for Cervical Cancer detecting high risk HPV DNA phenotypes and cancer proteins biomarkers in low-income countries.

Specific Objectives
1. To collect and analyze self-samples
2. To identify high risk HPV DNA in the self-samples
3. To link the levels of proteins measured in the self-samples with the cervical cancer lessions detected by papsmear and VIA.
4. To evaluate the effect of confounding factors on the cervical cancer protein levels in the self-samples

2.To understand user’s perspectives regarding (self-) sampling

 Uganda 2023-05-11 14:52:00 2026-05-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Simon Kigozi Peter
ID: UNCST-2022-R009813
 Studying Incidence of Malaria from Routine Health Facility Reporting to Assess Impact of Targeted Control Interventions: Transforming Surveillance for Malaria Control
REFNo: HS2783ES

4. Investigate the level of residual burden of malaria missed by routine surveillance using randomised surveys.,3. Estimate the impact of targeted control intervention on incidence of malaria within health-facility-catchments.,2. Describe population spatial access to routinely reporting health facilities and estimate health facility catchments.,1. Evaluate the quality of routine HMIS data generated through the national surveillance system (DHIS-2) against facility register records.,To investigate the effectiveness of HMIS-based incidence in assessing the impact of targeted control interventions on malaria burden, through the following objectives.,
 Uganda 2023-05-11 14:50:40 2026-05-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Arthur  Mpimbaza
ID: UNCST-2022-R008866
 Malaria rapid diagnostic test (RDT) capture and reporting assessment (MaCRA): Uganda protocol
REFNo: HS2747ES

Primary
1. Measure agreement between HCW and panel RDT results in Uganda.
Secondary
2. Measure the association between key characteristics of HCWs, RDT guidelines, health systems, malaria epidemiology and patient demographics and type of agreement/disagreement between the HCW and panel RDT results.
3. Understand how characteristics of HCWs, RDT guidelines, health systems, malaria epidemiology, and patient demographics affect the ability of HCWs to accurately implement, interpret, use, record and report RDT results.
4. Assess the fidelity of data entry from health facility registers to the health management information system (HMIS).
5. Determine the degree of over- and under- treatment for malaria and associations with characteristics of HCWs, RDT guidelines, health systems, malaria epidemiology and patient demographics.
6. Determine whether there is an observer impact of the study on monthly test positivity rates (TPRs).
7. Develop a database of photos of results from various RDT brands that can be used to train an artificial intelligence application to automate the interpretation and reporting of RDTs.
8. Classify common unusual RDT results that appear in RDT photos and assess patterns of errors to guide NMP and PMI on issues related to RDT administration and case management practices.
9. Calculate the accuracy of HealthPulse (Audere, Seattle, WA), a smartphone-based application that uses artificial intelligence to interpret RDT results, compared to the panel RDT results after training on a random selection of RDT photographs.
10. Compare agreement of RDT results read at one week and one month after administration with the initial read to determine the durability of RDT results over time.

 Uganda 2023-05-11 14:45:16 2026-05-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Dominik Biesalski
ID:
The Drivers, Effects and Measurement of Time Use Among the Urban Poor: Evidence from Uganda
REFNo: SS1674ES

Get insights into the time use patterns of urban workers and understand their effects on productivity and well-being.
 Germany 2023-05-11 14:41:00 2026-05-11 Social Science and Humanities Clinical Trial Degree Award
Anthony  Batte
ID: UNCST-2022-R011127
 Malaria Associated Pathogenesis of Chronic Kidney Disease (MAP-CKD) Study
REFNo: HS2794ES

To define the impact of AKI and persistent kidney disease on morbidity, mortality, and health-related quality of life. ,To define host pathways associated with maladaptive kidney repair following severe malaria associated AKI. To determine risk factors for short-term and long-term kidney disease following severe malaria,
 Uganda 2023-05-11 14:33:58 2026-05-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ruth Obaikol
ID: UNCST-2021-R012513
 FACILITY-BASED MENTAL HEALTH CARE FOR VICTIMS OF GENDER-BASED VIOLENCE: CURRENT PRACTICE, DEVELOPMENT AND TESTING OF AN ICT MANAGEMENT SYSTEM
REFNo: HS2669ES

1. To establish the type and nature of psychological care offered to GBV victims reporting to hospitals in Kampala describe the current practice of mental health care for post-violence victims and test a novae approach in a Hospital setting in Ugandan. ,To determine the user satisfaction of patients and caregivers with TSM,To assess the feasibility and the effectiveness of a Hospital-Based Technology supported mental health care intervention (TSM) in management of mental Health effects of violence among adult women. To determine the experiences of healthcare providers in integrating psychological care in the case management of GBV victims who are receive care in Kampala.
 Uganda 2023-05-11 14:18:19 2026-05-11 Medical and Health Sciences Non-Clinical Trial Degree Award
John Bosco Alege
ID: UNCST-2020-R014831
 Effectiveness of Integrated Viral Hepatitis B, C, and HIV Care Model to Optimize Screening Uptake among mothers and newborns at health facilities in West Nile Region, Uganda
REFNo: HS2706ES

The overall aim of this study is to evaluate the effectiveness of integrated viral hepatitis B, and C Care Model to Optimize screening among mothers and newborns at health facilities in West Nile region, Uganda.
Uganda 2023-05-11 13:53:29 2026-05-11 Medical and Health Sciences Non-Clinical Trial Degree Award
Isabelle Clark Rae
ID: UNCST-2022-R010329
 Social development of infant and juvenile chimpanzees in two communities following permanent fission at Ngogo, Kibale National Park, Uganda
REFNo: NS413ES

To determine the demographic, social and individual-level factors shaping social development in two adjacent communities of different size and composition following a rare permanent fission.
 USA 2023-05-11 13:52:27 2026-05-11 Natural Sciences Non-Clinical Trial Degree Award
Joshua Musinguzi Bazaale
ID:
HIV Case Surveillance of Newly Diagnosed People Living with HIV at the time of diagnosis in Uganda
REFNo: HS2171ES

1)Identify and describe geographic locations associated with newly-diagnosed cases including recent infections to inform geographic prioritization of HIV prevention interventions;
2)Monitor and describe epidemiological trends in newly-diagnosed HIV cases by demographics, behavior, mode of transmission, and recency of HIV infection to inform prioritization of HIV prevention interventions to specific populations;
3)Monitor and describe trends of clinical status (WHO Stage, initial CD4, other opportunistic infections) at the time of diagnosis; and
4)Monitor and describe trends in linkage to services (e.g., same-day ART) at the time of diagnosis.

Uganda 2023-05-11 13:50:47 2026-05-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sarah Juster
ID: UNCST-2023-R007855
 Tree-Based Interventions in the Imvepi Refugee Settlement in Uganda
REFNo: NS544ES

Gain additional perspective on the role of NGO Tree-Based Interventions in Imvepi from staff of UNCHR, OPM through additional interviews and attending settlement Refugee Welfare Council and Local Council meetings,Gain additional perspective on the role of NGO Tree-Based Interventions in Imvepi from staff of UNCHR, OPM through additional interviews and attending settlement Environment and Livelihood sector meetings,Gain additional perspective on the role of NGO Tree-Based Interventions in Imvepi from Refugee Welfare Council and Local Council members,Gain overarching context for Tree-Based Intervention implementation in Imvepi ,Specifically code transcripts to synthesize themes related to NGO staff perspectives on the challenges of Tree-Based Intervention implementation and recommended programming adjustments,Employ content-analysis coding and axial coding of transcripts of staff interviews and organizational documents for qualitative synthesis of organizational activities and characteristics,Use a comparative table to specifically assess patterns in terms of overlap between Tree-Based Intervention activities and characteristics of the promoting NGO,Synthesize the characteristics and activities of four NGOs promoting Tree-Based Interventions in Imvepi,Compare the environmental characteristics of Tree-Based Interventions across four NGOs in Imvepi, including species choice and integration of TBI activities with local ecological features,Compare social dimensions of Tree-Based Interventions across four NGOs in Imvepi, including the integration of local perspectives and staff, focus on socioeconomic benefits of trees to participants, and inclusion of women as staff and program participants,Compare the nature, source, and duration of Tree-Based Intervention funding across four NGOs in Imvepi,Compare Tree-Based Intervention characteristics across four NGOs in the Imvepi refugee settlement,Identify which specific tree-based intervention activities (in the categories of conserving, planting, and facilitated re-sprouting trees) each of four NGOs in Imvepi are engaged with,Compare Tree-Based Intervention activities among four non-governmental organizations in the Imvepi refugee settlement,
 USA 2023-05-04 16:39:21 2026-05-04 Natural Sciences Non-Clinical Trial Degree Award
Michio Matsuba Kyle
ID: UNCST-2022-R009027
 Wang Oo Relit Project (WORP) Evaluation Study
REFNo: SS1716ES

1. To determine if youth who participate in the WORP program show improvement on measures of well-being, 2. To monitor the level of engagement of youth in WORP lessons and activities 3. To understand the benefits and challenges associated with the WORP program from the perspective of youth participants.
 Canada 2023-05-02 22:28:11 2026-05-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Fredrickson B Wasswa
ID: UNCST-2022-R008765
 MINION WHOLE GENOME SEQUENCING OF BLOOD FOR DIAGNOSIS OF MENINGITIS AT MBARARA REGIONAL REFERRAL HOSPITAL, UGANDA
REFNo: NS528ES

To determine the use of MinION WGS to identify antimicrobial resistant genes, virulence enzymatic genes and Single Nucloetide polymorphisms (SNPs) among patients with CM and TBM at MRRH, To compare the performance of full MinION flow cells with Flongle flow discs designed for smaller samples for detection of CM and TBM at MRRH. To determine the suitability of blood as an alternative to CSF for the detection Cryptococcus and MTB in patients CM and TBM using MinION WGS at MRRH,To compare Cryptococcus and TB detection from blood and CSF using MimION WGS from patients with CM and TBM at MRRH.,
 Uganda 2023-05-02 22:27:01 2026-05-02 Natural Sciences Non-Clinical Trial Degree Award
Nathan Kenya-Mugisha
ID: UNCST-2021-R013752
 Smart Discharges for Vulnerable Refugee Children: A Cohort Study to Validate Prognostic Algorithms for Post-discharge Readmission and Mortality among Children Living in Refugee Settings.
REFNo: HS2755ES

Primary Objective:

1. To validate, calibrate, and refine the Smart Discharges risk-prediction algorithm in a representative cohort of refugee children.

Secondary Objectives:

1. To describe the epidemiology of, and risk factors for, post-discharge mortality of children in the context of refugee settings.
2. To describe the post-discharge health seeking patterns of children in the context of refugee settings.

 Uganda 2023-05-02 22:24:41 2026-05-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
James Davis KATUMBA
ID:
Uncontrolled asthma among adolescents in selected secondary schools in Kampala City: Prevalence, associated factors, in-school needs, pathways to care and effectiveness of an mHealth Self-management app
REFNo: HS2791ES

To determine the effectiveness, acceptability and feasibility of the KmAsthma self-management app in improving the control of asthma among day scholar secondary school adolescents 12-19 years old in Kampala City Uganda.,To examine pathways to asthma care and their influence on asthma control among secondary school adolescents with asthma in Kampala City Uganda ,To establish the in-school needs associated with asthma control among adolescents in selected secondary schools in Kampala City Uganda ,To determine the prevalence of and factors associated with uncontrolled asthma among adolescents in selected secondary schools in Kampala City Uganda ,To establish the prevalence of and factors associated with uncontrolled asthma, in-school needs, pathways to asthma care, and effectiveness of KmAsthma Self-management app intervention to control asthma among adolescents in selected secondary schools in Kampala City Uganda,
 Uganda 2023-05-02 22:22:49 2026-05-02 Medical and Health Sciences Clinical Trial Degree Award
Martin Lukindu
ID: UNCST-2023-R008081
 One-Health analysis of CCHFV transmission risk patterns in Ugandan cattle corridor and arid Northern Kenya”
REFNo: A296ES

i) Identify tick spp diversity in diverse ecosystems of Ugandan cattle corridor
ii) Assess tick blood meal sources of potential vectors collected from unique spatial regions
iii) Delineate CCHFV infection rates of tick populations in diverse ecological units
iv) Characterize the tick virome of the Ugandan cattle corridor tick populations
v) Assess CCHFV genetic diversity at fine geographical and temporal scales across ecosystems

 Uganda 2023-05-02 22:19:16 2026-05-02 Agricultural Sciences Non-Clinical Trial Non-degree Award
Esau Tugume
ID: UNCST-2019-R000622
 Improving the Measurement of Productivity Dispersion and Misallocation in Developing Countries
REFNo: SS1698ES

6. Generate information and knowledge required to make informed policy decisions particularly in raising the productivity of small firms. ,Determine the role of firm-to-firm interactions, either as catalysts or hindrances to growth. ,Quantify the extent of resource misallocation across firms and the role of frictions in constraining firm growth.,Evaluate the strengths and weaknesses of existing empirical approaches to measuring misallocation. ,Verify whether existing estimates of productivity and marginal product dispersion are robust to improved measurement and the accounting of firm-to-firm interactions. If not, our data will identify the source of bias,Quantify three margins of allocative efficiency of firms: (i) the within-firm allocation of inputs across products, (ii) the allocation of resources across firms located in geographical proximity to each other, i.e., that operate within informal “clusters,” as widely documented in low-income country settings, and (iii) the sector-level allocation of resources across different geographic areas (or clusters).,The primary objective of this research project is to shed light on the organization of production in low-income countries and estimate firm-product level production functions. ,
 Uganda 2023-05-02 22:16:11 2026-05-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
John Kellett Gale
ID:
Can continuous non-invasive monitoring of movement predict and detect clinical deterioration of hospital patients earlier and more efficiently than traditional intermittent observations?
REFNo: HS2765ES

To determine if continuously collected accelerometer data can indicate and identify clinical deterioration of acutely ill hospitalised patients before intermittently collected vital signs.
 Ireland 2023-05-02 22:11:25 2026-05-02 Medical and Health Sciences Clinical Trial Non-degree Award
Stephen Pande Legesi
ID:
Sentinel Surveillance for Adverse Events of Special Interest after Vaccination with COVID-19 Vaccines-Uganda
REFNo: HS2370ES

Primary Objectives The overall aim of this surveillance protocol is to monitor the safety of COVID-19 vaccines in UGANDA in near real-time for pre-specified AESI conditions and evaluation to inform decision making to maintain public confidence in the vaccination program Specific Objective The specific objective of this evaluation is to assess the risk of pre-defined AESI following vaccination with a COVID-19 vaccine by brand. Secondary objectives 1.To strengthen Uganda’s active AEFI Surveillance system 2.To describe lessons learned from implementing active surveillance for various COVID 19 vaccine products.
 Uganda 2023-05-02 22:08:38 2026-05-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Dorcas Mandera Agatha
ID:
Accelerating Impact for Young Women in Africa (AIM) Project Process Evaluation
REFNo: SS1644ES

- To identify contextual factors and success drivers that influence the program reach and quality,- To ascertain the effectiveness of the project from the perspective of its beneficiaries.,- To assess the viability of the intervention strategy and its feasibility as assumed in the theory of change (ToC).,This process evaluation intends to assess the implementation of the AIM project to ascertain whether it works, why it works, how it works, and its potential replicability. ,
 Uganda 2023-04-28 23:54:42 2026-04-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
Lawrence Osuwat Obado
ID: UNCST-2023-R008389
 Assessing the Health Risk of Arsenic Burden in Human Beings and its Levels in Natural Water Sources Providing Domestic Water in Amuria District
REFNo: HS2770ES

To determine the arsenic concentration in hair samples taken from residents using water from sampled sources for domestic purposes,To determine the concentration of arsenic in the nails of residents using water from sampled sources for domestic purposes,To profile the arsenic levels of water from natural sources in areas of Amuria district in Eastern Uganda, and test for potential bioaccumulation of arsenic among the residents that use the water for domestic purposes,To determine the amount of arsenic in water collected from underground wells in Amuria District.
 Uganda 2023-04-26 11:43:03 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
SSEDYABANE FRANK
ID: UNCST-2022-R011175
 ASSOCIATION OF FOXP3, P16INK4A, CMYC AND SELECTED MICRO RNA SERUM EXPRESSION WITH GRADES, TREATMENT STRATEGIES AND OUTCOMES FOR CERVICAL SQUAMOUS INTRAEPITHELIAL LESIONS
REFNo: HS2722ES

1. To determine the prevalence of Cervical Intraepithelial Neoplasia among women attending the cervical cancer clinic at Mbarara Regional Referral Hospital.
2. To establish the individual and combined accuracy of FOXP3, P16ink4a, cMYC, and selected micro RNAs (miR-205, miR-9, miR-192 and miR-21) in detection of cervical squamous intraepithelial lesions among women attending the cervical cancer clinic at Mbarara Regional Referral Hospital.
3. To determine the association between serum levels of FOXP3, P16ink4a, cMYC, and selected micro RNAs (miR-205, miR-9, miR-192 and miR-21) with grades of cervical squamous intraepithelial lesions among women attending the cervical cancer clinic at Mbarara Regional Referral Hospital.
4. To determine the relationship between follow-up serum levels of FOXP3, P16ink4a, cMYC, and selected micro RNAs (miR-205, miR-9, miR-192 and miR-21) and treatment strategies as well as outcomes (clearance, persistence or progression) of cervical squamous intraepithelial lesions among women attending the cervical cancer clinic at Mbarara Regional Referral Hospital.

 Uganda 2023-04-26 11:42:24 2026-04-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Ronald Moses Galiwango
ID: UNCST-2024-R015239
 Assessing dynamics of heterosexual transmission of genital bacteria and coital impact on microbiome composition/stability in the female and male genital tracts in South-central Uganda
REFNo: HS2696ES

Primary objective
To elucidate the sexual transmission of genital bacteria and the determinants of the penile microbiome after sex.

Secondary objectives
A. To assess the strain variations of the triad and to characterize the different strains’ acquisition and carriage peri-coitus.
B. To identify abiotic and biotic factors from host (penile) and partner (vaginal) micro-environment that have a consistent and significant impact on penile microbiome composition.
C. To assess the short-term impact of standard anti-bacterial vaginosis (BV) treatment on the composition of the genital microbiome within heterosexual couples

 Uganda 2023-04-26 11:38:48 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Andrew Ssemata
ID: UNCST-2023-R008259
 Transitioning from pediatric to HIV adult care services and its impact on mental health and wellbeing for young people in Kampala: A scoping review and qualitative study
REFNo: SS1687ES

i.) To identify facilitators and barriers to successful transition process (socio-cultural, behavioural and health system factors) and how this influence adherence and virologic suppression among patients on ART.
ii.) To understand the experiences of healthcare providers and caregivers in providing care and supporting retention of young people on treatment during transition from paediatric to adult clinics.

 Uganda 2023-04-26 11:36:57 2026-04-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Grace Ndeezi
ID: UNCST-2019-R001802
 Nutritional management of growth faltering in infants aged under six months. Study protocol for an individually randomised trial
REFNo: HS2766ES

To determine the effect of nutritional supplementation plus intensive breastfeeding support compared with intensive breastfeeding support alone on mortality, morbidity and growth in infants aged 0-6 months with growth faltering in low resource settings in South Asia and Sub-Saharan Africa.
Uganda 2023-04-26 11:15:23 2026-04-26 Medical and Health Sciences Clinical Trial Non-degree Award
Mnason Tweheyo
ID:
Baseline Study for the proposed Conservation and Rural Enterprise (CARE) Project in Bwindi Impenetrable National Park and Budongo Central Forest Reserve
REFNo: SS1703ES

The key objectives of the baseline survey include:

a) Identifying and tracking indicators that enable the assessment of a potential relationship between:
 The proposed interventions of the CARE project, namely the development and launch of a luxury eco lodge and establishment of supporting small to medium enterprises in the Bwindi and Budongo areas and;
 The status of social and economic wellbeing and environmental conservation in this region.
b) Tracking changes to social and economic wellbeing over the 18-month grant period.
c) Tracking the CARE project’s interventions in economic opportunities, such as the creation of small to medium enterprises, trainings offered, employees hired, wages and income earned.
d) Tracking the CARE project’s interventions in environmental sustainability and conservation, such as alternative fuel provision, replantings, environmental education and conservation training courses, and wildlife corridor development.
e) Comparing economic and environmental interventions to changes in social and economic wellbeing, as well as changes in the region’s environment.
f) Collecting baseline data on the identified indicators through surveys and earth observation imagery. This indicator data will be able to be collected again at the culmination of the research collaborative analysis period in 18 months, and indicators should be capable of being tracked again, in the future, in the possible eventuality of a longer-term research project.
g) Using the indicator data to develop a generalizable toolkit for the joint improvement of social and economic wellbeing and environmental conservation, which can be adapted to other rural contexts.


 Uganda 2023-04-26 11:13:44 2026-04-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
 GENDER EQUALITY AND WOMEN LEADERSHIP IN HIGHER EDUCATION IN EAST AFRICA.
REFNo: SS1672ES

General objective: To establish the prevailing landscape of gender equality in universities in East Africa. Specific objectives: (1) To assess entry and completion rates of women in selected academic programs in universities in East Africa for the period 2012-2022. (2) To establish the status of female academic staff engagement in academia and research (e.g., publishing rates) and leadership in universities in East Africa for the period 2012-2022. (3) To examine existing mechanisms for promoting gender equity and women leadership (e.g., university-wide policies, practices, services) as well as success factors, challenges and barriers to gender equality in universities in East Africa.
Uganda 2023-04-26 11:12:07 2026-04-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Abel  Kakuru
ID: UNCST-2022-R009193
 The immune response to malaria within the germinal center
REFNo: HS2717ES

Comprehensively map the germinal center immune landscape during malaria infection.

Identify key cells and processes required for and/or disrupting the induction of malaria germinal center and antibody responses.

Identify key cells and processes required for germinal center and antibody induction to vaccines that are disrupted by malaria.

Identify and test drugs that can boost germinal center responses appropriate for use in malaria exposed children.

 Uganda 2023-04-26 11:08:15 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Michael Galvin
ID:
Improving HIV Outcomes through Collaborative Mental Health Interventions
REFNo: SS1642ES

To assess the perspectives of traditional and faith healers and biomedical mental health professionals on mental health treatment for people living with HIV/AIDS who have mental illness using a qualitative approach. We will interview 5-10 traditional healers and 5-10 faith healers over 2-4 months in early 2023. They will be recruited from the local area based on their experience working with people with HIV/AIDS and mental illness. These interviews will aid in characterizing the different conceptions of mental illness etiology and treatment strategies among both traditional healers in the African tradition and faith healers/pastors in the Christian tradition, and examine if collaboration between traditional and faith healers, and biomedical service providers can be developed to best serve people living with HIV/AIDS and improve health outcomes.,Objective 1b - To determine the characteristics of people living with HIV/AIDS and mental illness using a quantitative approach. We will collect cross sectional data on this population regarding of mental illness and HIV disease severity and duration, sociodemographics, and traditional and biomedical care history.,Objective 1a – To examine the experiences of people living with HIV/AIDS with mental illness in the Psychiatric Unit at Mbarara Hospital and traditional healer clinics using a qualitative approach. We will interview 15-25 patients living with HIV/AIDS and mental illness over 2-4 months in early 2023. They will be recruited from the psychiatric unit at Mbarara hospital. By interviewing mental health patients living with HIV, we can better understand how they view their illness, how local beliefs inform mental health care utilization, as well as their pathway to care and ultimately treatment outcomes.,To develop an intervention in which biomedical professionals collaborate with local traditional and faith healers to provide mental health services which will ultimately improve viral suppression, increase longevity, and reduce preventable morbidity and mortality.
 USA 2023-04-26 11:03:04 2026-04-26 Social Science and Humanities Non-Clinical Trial Degree Award
Julian Adong
ID: UNCST-2021-R013487
 An mHealth intervention to address the burden of depression and anxiety among perinatally-infected adolescents and young adults with HIV in Uganda.
REFNo: HS2691ES

Pilot U-SMART Voices among PAYWH with symptoms of anxiety and/or depression ,Adapt the group-based psychosocial mental health intervention, Sauti Ya Vijana (SYV; voice of the youth), to create the Uganda Social Media intervention to improve ART and Treatment outcomes (U-SMART)-Voices,Characterize the symptoms of depression and anxiety among PAYWH and correlation with quality of life.
 Uganda 2023-04-26 10:51:31 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Phiona Bukirwa
ID: UNCST-2022-R009880
 Self-reported knowledge about palliative care offers and access to morphine by patients with cancer in Kyadondo County, Uganda
REFNo: HS2738ES

1. To assess patient knowledge of palliative care services. 2. To assess patient access to morphine and investigate the reasons for poor access 3. To describe the barriers to the intake of morphine,
 Uganda 2023-04-26 10:44:36 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eriab Kapuru Asinja
ID: UNCST-2022-R011430
 Title: Uptake of modern contraceptive methods and birth outcomes among women with caesarian sections in Kasese district, Uganda: leveraging innovative digital technology for empowering community health workers in delivering family planning services
REFNo: HS2639ES

4- To investigate the feasibility of using mobile phone health text messaging to women through CHWs and estimate the effect on contraception uptake among women in Kagando (sub-study IV),3- To explore women’s knowledge, attitudes and practices with various methods of contraception and evaluate the perceived benefits and satisfaction with contraception services, comparing those who had CS births and those who never had CS births (sub-study III),2- To estimate the frequency of repeat caesarian sections and factors associated with birth outcomes (sub-study –II).,1- To determine if CHWs can accurately document and follow households in defined geographical areas assigned to them (demographic surveillance area) using mobile phones and the feasibility of linking these data with hospital records (sub-study I).,The main objective of this study is to build the capacity of community health workers to accurately register households, including pregnant mothers and follow them with targeted health messages to improve birth outcomes,
 Uganda 2023-04-26 10:40:21 2026-04-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Simon Walusimbi
ID:
Impact of Tuberculosis Preventive Treatment (TPT) on Tuberculosis incidence and all-cause mortality among People Living with HIV (PLHIV) Receiving Anti-Retroviral Treatment (ART) in Uganda
REFNo: HS2772ES

To determine how long after TPT completion does TB incidence begin to rise again in patients who have completed TPT,To compare TB incidence and all-cause mortality among PLHIV who received TPT as 6-month INH versus 3HP regimen,To establish the risk factors for developing TB among PLHIV who have completed TPT,To compare TB incidence and mortality among PLHIV in Uganda who have completed TPT with PLHIV who have not completed TPT,To determine the incidence of all-cause mortality among PLHIV in Uganda who have completed TPT, at 12, 24, and 36 months of TPT completion.,To determine the incidence of newly diagnosed TB disease among PLHIV in Uganda who have completed TPT, at 12, 24, and 36 months after TPT completion,To evaluate the impact of TPT on TB incidence and all-cause mortality among PLHIV in Uganda,
 Uganda 2023-04-26 10:39:06 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Charles  Kajubi
ID: UNCST-2022-R008989
 Baseline Study for Safe and Inclusive Cities Project -Uganda.MAKSHSREC-2022-420
REFNo: SS1582ES

To measure the long-term impact of the intervetions on the project participants and formulate recommendations for Plan International Uganda to further strengthen research.,To determine the baseline values for outcome indicators from the onset of the project.,
 Uganda 2023-04-26 10:37:49 2026-04-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Patrick Muinda Emmanuel
ID:
An Information Technology Governance Framework for Improved Success of Digital Transformation Projects for Technical, Vocational Education and Training (TVET)
REFNo: SIR180ES

To test and evaluate the designed ITG Framework for Improved Success of Digital Transformation Projects in TVET institutions,To design and develop an ITG Framework for Improved Success of Digital Transformation Projects in TVET institutions,To determine the factors for improved success of Digital Transformation Projects in TVET institutions,To establish the effectiveness of Information Technology Governance applied in TVET institutions,The General Objective of this study is to develop an Information Technology Governance (ITG) framework for improved success of Digital Transformation Projects in the TVET subsector,
 Uganda 2023-04-26 10:31:45 2026-04-26 Engineering and Technology Non-Clinical Trial Degree Award
ELIZABETH ASIGE
ID:
THE IMPACT AND COST-EFFECTIVENESS OF A COMMUNITY-BASED PROGRAM FOR CHILDREN WITH CEREBRAL PALSY AND THEIR CAREGIVERS AND THE STAKEHOLDERS IN UGANDA.
REFNo: HS1979ES

1. To examine the impact of a community-based program on children with CP reported frequency of participation in the home, school, and community activities. 2. To assess the impact of a community-based training program on improving caregiver knowledge regarding CP and reducing caregiver stress. 3. To determine the impact of a communication and advocacy program in broadening stakeholders’ knowledge, attitude and practices regarding childhood disability and inclusion. 4. To determine the cost-effectiveness of a community-based program on children with CP, their caregivers, and the stakeholders in relation to costs and benefits.
Uganda 2023-04-20 21:15:22 2026-04-20 Medical and Health Sciences Clinical Trial Degree Award
Jedediah Silver
ID: UNCST-2023-R007939
 The Effects of Cassava Drying Technology on Commercialization and Consumption Smoothing
REFNo: SS1700ES

The main goals of the pilot RCT are to ascertain the technical efficiency of the machines, the viability of the model where agents operate the machines and charge a fee for drying, and to observe how harvest and sales timing, consumption and cropping decisions change when farmers gain access to drying technology. In addition, we will explore additional mechanisms including varying the contract structure, and getting a sense of which channels are most salient to focus on (e.g. how likely we would be to detect effects on intertemporal smoothing beyond addressing the barriers to adoption to a seemingly profitable technology).
 USA 2023-04-20 21:05:53 2026-04-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
Beatrice  Onyango Ekesa
ID:
Bio-efficacy of Pro-Vitamin A-rich banana to improve vitamin A status among children in Uganda living in an area with a high burden of inflammation
REFNo: HS2721ES

3. Establish the stability of retinol isotopes on DSS at room temperature in the determination of TBS of vitamin A.,2. Assess the effect of inflammation and nutritional status on vitamin A absorption and TBS assessment among school-aged Ugandan children.,1. Determine the bio-efficacy of carotenoids in Pro-Vitamin A rich bananas in improving TBS in children aged 6-14years.,This study will determine the bio-efficacy of carotenoids in Pro-Vitamin A-rich banana-based diets and their potential in improving the vitamin A body stores by the RID technique among school-going children aged 6-14years living in Tororo district, an area with a high burden of inflammation.,
 Kenya 2023-04-19 12:44:24 2026-04-19 Medical and Health Sciences Clinical Trial Non-degree Award
Bernard Muhangi Wakabi
ID:
Managerial competences and performance of Microfinance Institutions in Uganda
REFNo: SS1693ES

iii. To establish the moderating effect of stakeholder management on the relationship between managerial competencies and financial performance of MFIs in Uganda.,ii. To examine the mediating effect of competitive advantage in the relationship between managerial competencies and financial performance of MFIs in Uganda.,i. To examine the relationship between managerial competencies and financial performance of MFIs in Uganda.,The study will examine the relationship between managerial competencies and financial performance while examining the mediating effect of competitive advantage and stakeholder management's moderating effect in the relationship between managerial competencies and financial performance of MFIs in Uganda.,
 Uganda 2023-04-19 12:41:29 2026-04-19 Social Science and Humanities Non-Clinical Trial Degree Award
Violet  Gwokyalya
ID: UNCST-2022-R010490
 An Evaluation Study of Oral PrEP Delivery Models in Uganda
REFNo: HS2734ES

Primary Objectives 1. To document Oral PrEP delivery models currently in use in Uganda. 2. To establish the contribution of the various Oral PrEP delivery models to uptake of PrEP. 3. To establish the contribution of the various Oral PrEP delivery models to continuity of PrEP. 4. To establish the costs involved in implementing different PrEP delivery models in Uganda. 5. To document the best practices from the different PrEP Delivery models and the recommendations for promoting efficient and sustainable PrEP services. Secondary objective. To establish the feasibility of injectable PrEP delivery in Uganda
Uganda 2023-04-19 12:27:39 2026-04-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rosalind  Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
 A pilot etiological study of genital ulcer disease in Uganda, including the burden of macrolide resistant T pallidum
REFNo: HS2728ES

-To determine the proportion of genital ulcers caused by syphilis compared with other causes of genital ulcer disease in a contemporary Ugandan setting.
-To determine the proportion of T pal isolates with evidence of macrolide resistance markers.
-To determine agreement between clinical diagnosis and treatment compared with laboratory diagnosis of GUD.
-To determine agreement between GUD PCR result and serological markers of infection including POCT and lab-based assays.
-To develop a library of GUD pictures stratified by microbiological diagnosis.


 UK 2023-04-19 12:17:44 2026-04-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
GODFREY TUMUHAISE
ID:
Rapid Assessment of Avoidable blindness /Disability in the Northern, Eastern and Western Regions of Uganda in people aged 50 Years and above
REFNo: SS1695ES

• To determine the causes of blindness and VI.,• To explore the relationship between disability and socio-economic status and eye health,To determine the prevalence of disability among the study population. ,• To assess factors affecting access to cataract surgical services by determining cataract surgical coverage.,• To determine the prevalence and distribution of blindness and VI in the study population.,To estimate the prevalence and causes of blindness and visual impairment among people aged ≥50 years in Uganda.,
 Uganda 2023-04-19 12:14:06 2026-04-19 Social Science and Humanities Non-degree Award
Carolyne Akello Agwau
ID: UNCST-2021-R013375
 The CATALYST Study: Catalyzing access to new prevention products to stop HIV
REFNo: HS2801ES

The overall goal of the study is to characterize and assess the implementation of an enhanced service delivery package providing choice of PrEP products among women at PEPFAR/USAID delivery sites in Kenya, Lesotho, South Africa, Uganda, and Zimbabwe. The study has three primary objectives: Objective 1: Characterize the implementation of the enhanced service delivery package for informed PrEP choice for women in PEPFAR/USAID public health service delivery sites and assess individual-, provider-, facility-, community-, and health system-level facilitators of and barriers to the implementation process. (Achieved through process evaluation, and nested costing and community acceptance studies) Objective 2: Describe patterns of PrEP use and use effectiveness in the context of informed PrEP choice and assess sociodemographic and contraceptive use correlates of PrEP use patterns. (Achieved through cohort and nested PEU study) Objective 3: Describe clinically relevant indicators among PrEP users, including rates of HIV infection and drug resistance among PrEP users who acquire HIV following PrEP initiation or had undetected HIV prior to PrEP initiation. (Achieved through cohort, including CAB HIV testing algorithm nested study)
Uganda 2023-04-13 16:51:59 2026-04-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Pontiano  Kaleebu
ID: UNCST-2020-R019901
 Field Evaluation of National HIV Testing Services Algorithm
REFNo: HS2701ES

Main Objective
To determine the appropriate HIV rapid test algorithm to be used in Uganda considering the new kits on the market.

Specific objectives
1. To assess specificity, sensitivity, negative predictive value (NPV), positive predictive value (PPV) of the rapid HIV tests on the market in Uganda and come up with best RDT algorithm.
2. To identify an algorithm that will best identify acute HIV infections
3. To determine the inter-observer and inter-lab agreement in HIV diagnosis using evaluated RDTs.

 Uganda 2023-04-12 15:44:58 2026-04-12 Medical and Health Sciences Clinical Trial Non-degree Award
STUART TURANZOMWE
ID:
PREVALENCE, SEVERITY AND FACTORS ASSOCIATED WITH ANAEMIA AMONG WOMEN WITH CERVICAL CANCER AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS2749ES

To determine the factors associated with anaemia among women with cervical cancer at Mbarara Regional Referral Hospital,To describe the severity of anaemia among women with cervical cancer at Mbarara Regional Referral Hospital,To determine the prevalence of anaemia among women with cervical cancer at Mbarara Regional Referral Hospital,To determine the prevalence, severity and factors associated with anaemia among women with cervical cancer at Mbarara Regional Referral Hospital,
 Uganda 2023-04-12 14:46:12 2026-04-12 Medical and Health Sciences Non-Clinical Trial Degree Award
Samuel Kawuma
ID:
Facilitators and barriers to retention on Pre-exposure prophylaxis (PrEP) among Female Sex Workers attending Kiruddu National Referral Hospital.
REFNo: HS2771ES

1. To identify the implementation gaps along the Pre-Exposure Prophylaxis continuum of care and assess the factors associated factors with retention on PrEP among FSWs at Kiruddu National referral Hospital.,To design a stakeholder informed evidence-based intervention to improve retention on PrEP among FSWs at Kiruddu National Referral Hospital ,2. To determine the facilitators and barriers of retention on PrEP among FSWs in care at Kiruddu National referral Hospital.,
 Uganda 2023-04-12 14:43:04 2026-04-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Francis Ssali
ID: UNCST-2021-R012134
 Protocol A5394: “Safety, Tolerability, and Impact of Oral TLR8 Agonist Selgantolimod on HBsAg in Participants with both Chronic Hepatitis B and HIV” Version 1.0, May 27, 2022
REFNo: HS2647ES

1.2 Primary Objectives

1.2.1 To assess the safety and tolerability of treatment with SLGN administered once weekly by mouth for 24 weeks.

1.2.2 To determine the proportion of participants with ≥1 log10 IU/mL decline in quantitative HBsAg (qHBsAg) after SLGN treatment at Week 24.

1.3 Secondary Objectives

1.3.1 To determine the proportion of participants with ≥1 log10 IU/mL decline in qHBsAg at any time during the study after SLGN treatment initiation.

1.3.2 To determine the proportion of participants with ≥0.5 log10 IU/mL decline in qHBsAg after SLGN treatment at Week 24.

1.3.3 To determine the proportion of participants with ≥0.5 log10 IU/mL decline in qHBsAg at any time during the study after SLGN treatment initiation.

1.3.4 To evaluate the proportion of participants who achieve HBsAg loss after SLGN initiation and who sustain HBsAg loss during follow-up.

1.3.5 To evaluate changes in qHBsAg levels at Weeks 4, 12, 24, 36, and 48 after SLGN initiation and, separately, among the placebo recipients.

1.3.6 To determine the proportion of HBeAg positive participants at baseline who lose HBeAg at any time during the study, by study arm.

1.3.7 To determine the proportion of anti-HBe negative participants at baseline who develop anti-HBe at any time during the study, by study arm.

1.3.8 To determine the proportion of hepatitis B surface antibody (anti-HBs) negative participants at baseline who develop anti-HBs at any time during the study, by study arm.
1.3.9 To evaluate levels of circulating cytokines, including IFN-gamma, IL-12p40, IL-1RA, and CD163 at entry, 24 hours post-first study drug dose, Weeks 4, 12, 24, 36, and 48, by study arm.

1.3.10 To determine whether administration of SLGN will perturb HIV latency as measured by an increase in HIV transcription.

1.3.11 To determine whether administration of SLGN will decrease the size of the latent reservoir, as measured by the change in amount of cell-associated unspliced HIV RNA, HIV DNA, replication-competent and/or intact virus at Weeks 2, 4, 24, and 48.

1.4 Exploratory Objectives

1.4.1 To define the pharmacokinetic (PK) profile and PK-pharmacodynamic (PD) associations of SLGN in people with both HIV and CHB taking suppressive antiviral therapy for both viruses.

1.4.2 To explore if SLGN and antiretroviral (ARV) PK are altered when administered together.

1.4.3 To evaluate participants’ adherence by using several tools, including self-report, directly observed therapy (DOT), and drug concentrations.

1.4.4 To compare quantitative changes in experimental measures of HBV antiviral efficacy (including HBV RNA, hepatitis B core related antigen [HBcrAg], qHBeAg, and low positive HBsAg measured with a high sensitivity qHBsAg assay [LLOQ of 0.05 IU/mL]) and measure changes in large, medium, and small HBsAg isoforms from baseline during and after treatment.

1.4.5 To determine the immunological effects of SLGN on circulating immune signaling by performing single cell RNA sequencing using peripheral blood mononuclear cells (PBMCs) and evaluating HIV-specific T-cell responses.

1.4.6 To determine the effects on circulating immune cells, including cellular phenotypes and T and B-cell responses.

1.4.7 To determine whether administration of SLGN will affect levels of circulating cytokines, including TNF-alpha, IL-12, IL18, IP-10, ISG15, IL-21, Fas Ligand, and TRAIL.

 Uganda 2023-04-12 14:38:49 2026-04-12 Medical and Health Sciences Clinical Trial Non-degree Award
Alex Mwesigwa
ID:
P. falciparum genetic diversity, multiplicity of infection, gametocytaemia and recrudescence in areas of varied malaria transmission intensity in Uganda.
REFNo: HS2744ES

1. To compare the genetic diversity and multiplicity of P. falciparum infections in areas of varied malaria transmission intensity in Uganda.
2. To evaluate the relationship between malaria severity and P. falciparum genetic diversity, multiplicity of infection among patients living in areas of varied malaria transmission intensity in Uganda.
3. To investigate the temporal and seasonality changes in P. falciparum genetic diversity and multiplicity of infection among patients with malaria infection living in areas of varied malaria transmission intensity in Uganda.
4. To evaluate the performance of microsatellites in differentiating P. falciparum recrudescence from new infections.

 Uganda 2023-04-12 14:27:32 2026-04-12 Medical and Health Sciences Non-Clinical Trial Degree Award
Jane Frances Zalwango
ID:
Etiopathogenesis of Blackwater Fever in Budaka District, Uganda: a pilot study
REFNo: HS2752ES

a)To explore the aetiology of BWF in Budaka District b)To identify therapeutic interventions for the treatment of BWF
Uganda 2023-04-12 14:23:40 2026-04-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Elizeus Rutebemberwa
ID: UNCST-2022-R009070
 Evaluation of a Community Health Entrepreneur model in rural Uganda
REFNo: HS2196ES

4.3 General objective
To explore the role, reach, and scalability of CHE programme as a social franchise approach to address the issue of access to healthcare and potential embedment of the programme in the larger health system.

4.4 Specific objectives
1. To investigate health care seeking behaviour of residents in rural communities in Uganda, in order to assess community access, choice and use of health (care) services, service availability and quality, and experience of health care of households in villages in Uganda
2. To investigate the strengths and weaknesses of a CHE programme in communities which already have adopted this programme and the potential added value of a strengthened community health system by a CHE programme in communities without this programme
3. To investigate multi-stakeholder perceptions on the functioning, potential scale-up, and the possibility of integration of a social franchise approach in the larger health system in Uganda


 Uganda 2023-04-12 14:20:54 2026-04-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 Protocol for the establishment of clinical specimen panel for WHO Prequalification performance evaluation of HIV serology assays
REFNo: HS2786ES

To establish an HIV specimen repository at ITM.,To register the specimens into a Biobank at ITM; ,To characterize the specimens for HIV and syphilis serostatus using standardized reference assays and algorithms at ITM;,To collect biological specimens from patients with known HIV serostatus or blood donors from different regions of the world to establish a WHO HIV specimen evaluation panel that will be used for the laboratory performance evaluation of HIV serology assays undergoing WHO prequalification assessment; ,The overall objective is to assemble a new WHO HIV specimen evaluation panel in collaboration with PELs and collaborating centers, which will be made accessible on demand to all the PELs conducting HIV or dual HIV-syphilis serology test evaluations for WHO prequalification.,
 Uganda 2023-04-12 12:56:08 2026-04-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
 Environmental Drivers of Pediatric Postinfectious Hydrocephalus in Western Uganda: Case-Control Study
REFNo: HS2699ES

The overarching objective of the study is to elucidate potential factors that underlie the ecological correlation between precipitation and PIH. Identification of these environmental intermediaries may elucidate potential targets for intervention to reduce the incidence of PIH.,
 Uganda 2023-04-11 15:42:30 2026-04-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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