Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Sabiti Makara
ID: UNCST-2024-R003444
Crisis Emergencies, State Responses and ‘Windows’ of Corruption in Uganda
REFNo: SS3621ES

To implement bottom-up strategies for fighting corruption in emergency responses ,To examine the possibilities of grassroots actions and pressures that could have significant impacts on the fight against corruption,To establish the extent to which political considerations abate corruption with a focus on procurement and contracting during emergency crisis responses,To establish the gaps in regulatory frameworks that are opportunistically exploited by corrupt officials and their cronies to undermine anti-corruption efforts during emergency responses,Establish the actual costs of corruption and find out if the population is aware of its effects on public service delivery for the ordinary citizens,To examine the forms, practices, and patterns of corruption in emergency crisis responses in Uganda,Our main objective is to highlight and deepen our understanding of the extent which the risk of corruption intensifies during emergencies and to develop grassroots-based strategies to fight the vice.,
Uganda 2025-01-31 7:50:39 2028-01-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
Vincent Ferrer Bukenya
ID: UNCST-2024-R004868
Examination of the relationships between refugee settlements and wood energy consumption: A case study of Bidibidi refugee settlement in northwest Uganda
REFNo: A527ES

This research will examine the relationships between refugee settlements and household access to sustainable wood energy. 1. To establish what forms the bulk of wood energy used by refugees and host communities in Bidibidi Refugee Settlement in North-Western Uganda. 2. To assess wood energy consumption patterns in refugee and host communities in relation to the right to energy in Bidibidi Refugee Settlement in North-Western Uganda. 3. To examine how the refugee response framework provides for household access to wood energy by refugees and host communities in Bidibidi Refugee Settlement in North-Western Uganda. 4. To determine the contribution of the refuge-host community relationships to households’ ability to sustainably access wood energy.
Uganda 2025-01-31 7:43:24 2028-01-31 Agricultural Sciences Non-Clinical Trial Degree Award
Ikuomola  Orire Emmanuel
ID: UNCST-2024-R003700
EFFECT OF DIFFERENT FRACTIONS OF BRASSICA OLERACEA (COLLARD GREENS) ETHANOL EXTRACT ON CIMETIDINE INDUCED REPRODUCTIVE TOXICITY IN MALE WISTAR RATS.
REFNo: HS5192ES

i. Identify and quantify the constituents of crude aqueous leaf extract and fractions of Uganda collard green plant using gas chromatography mass spectrometry (GCMS);
ii. Evaluate the impact of crude aqueous leaf extract and fractions of Uganda collard greens on the relative weights of the testes, epididymis and anterior pituitary gland compared to body weight in male Wistar rats with cimetidine-induced reproductive toxicity by [specific date] male Wistar rats;
iii. Assess the effects of crude aqueous leaf extract and fractions of Uganda collard greens on sperm parameters, including motility, morphology, viability, agglutination, and total sperm count in Wistar rats with cimetidine-induced reproductive toxicity;
iv. Analyze the effect of crude aqueous leaf extract and fractions of Uganda collard greens on serum levels of steroid androgens (LH, FSH, Testosterone and antioxidant enzyme activities (catalase, Malondialdehyde, superoxide dismutase) in male Wistar rats with cimetidine-induced reproductive toxicity in male Wistar rats;
v. Examine the histological changes in the testes, epididymis, and anterior pituitary gland in male Wistar rats with cimetidine-induced reproductive toxicity following treatment with crude aqueous leaf extract and fractions of Uganda collard greens in male Wistar rats.

Nigeria 2025-01-31 7:40:27 2028-01-31 Medical and Health Sciences Non-Clinical Trial Degree Award
Miriam  Amutuheire
ID: UNCST-2024-R001859
Home-based tourism businesses and destinaion sustainability in Kabale Municiplaity, Kabale District, Uganda.
REFNo: SS3399ES

i.To assess the effect of the home-based tourism business operations on destination sustainability in Kabale municipality, Kabale District, Uganda.    
ii. To determine the influence of home-based tourism businesses competitiveness on destination sustainability in Kabale municipality, Kabale District, Uganda.  
iii. To establish the influence of government policies, impart on home-based tourism businesses that affect destination sustainability in Kabale municipality, Kabale District, Uganda.  
Uganda 2025-01-31 7:38:46 2028-01-31 Social Science and Humanities Non-Clinical Trial Degree Award
Karugahe Wilber
ID: UNCST-2023-R005686
Effectiveness of Cognitive behaviour therapy for mental health problems among adult patients with type-II diabetes mellitus: a controlled study
REFNo: SS3413ES

a. To assess the effectiveness of CBT in treating mental health problems (psychological distress, depression, anxiety, quality of life, treatment adherence, hopelessness, pessimism) among adult patients with T2DM
b. To assess whether CBT affords a better control of glycaemia and the metabolic disturbances associated with T2DM.

Uganda 2025-01-31 7:37:29 2028-01-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
ANNETTEE NAKIMULI OLIVIA
ID: UNCST-2022-R011194
Maternal immunization readiness network for the introduction of potential new maternal vaccines to prevent early childhood infectious diseases in Uganda
REFNo: HS5271ES

General objective:

To identify, characterize and support the platform, policy, and preparedness requirements for the introduction of potential new maternal vaccines to prevent infectious diseases in Uganda


Specific objectives:

1. To identify and implement approaches to assess health systems, facilities, and community readiness to introduce new maternal vaccines in Uganda
a. Identify and implement approaches to assess MI readiness for respiratory syncytial virus / Group B streptococcus vaccinations across the health system, including mapping key regulatory and financing requirements.
b. Map professional societies within the country and initiate country-based communities of practice for MI.
2. Generate and synthesize health economic evidence, in the Ugandan context, to support decision-making of respiratory syncytial virus / Group B streptococcus vaccination program adoption in low- and middle-income countries (LMICs).
3. Prospectively develop nationally tailored maternal vaccine demand strategies to support the uptake and sustained demand for existing and new maternal vaccines in Uganda.
4. Identify and effectively engage with diverse stakeholders, in a harmonized manner, to incorporate their views and expertise in the study’s outputs, to advance the maternal immunization readiness agenda in Uganda.

Uganda 2025-01-31 7:35:56 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel Rukundo NSHAKIRA
ID: UNCST-2021-R012277
Improving School Management in a Low-Income Country: Experimental Evidence from Uganda
REFNo: SS3462ES

To evaluate the impact of the Inspect and Improve (I&I) program on student outcomes (learning, safeguarding, and inclusion) and school quality, focusing on both short-term and long-term effects.
Uganda 2025-01-31 7:32:19 2028-01-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
Moses Ochora
ID: UNCST-2021-R012659
RUNYA-PHIV: Rural Uganda Neurocognitive Youth Assessment with Perinatally acquired HIV
REFNo: HS5534ES

To explore the differences in NeuroScreen performance among adolescents aged 12-19 years with Perinatally acquired HIV in urban (Kampala) vs rural areas (Mbarara).,To adapt NeuroScreen to assess neurocognition among Runyankole-speaking adolescents aged 12-19 years with Perinatally Acquired HIV ,
Uganda 2025-01-31 7:31:16 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Samuel Kyobe
ID: UNCST-2019-R000108
DSpace – Ethical Implications of Pediatric EHR Use in Medical Research in Uganda and Botswana
REFNo: HS5301ES

1. Analyze the ELP issues raised by the use of pediatric EHR in medical research in Uganda and Botswana
2. Determine/analyze the implications of data linkage on participant consent and privacy
Uganda 2025-01-31 7:27:19 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel Maleka
ID: UNCST-2024-R015301
Sex differences in alcohol consumption and its impact on vulnerability and susceptibility to develop dementia in rural Uganda.
REFNo: SS3477ES

1. To determine the patterns of alcohol consumption among men and women aged 60 years and above in Ibanda and Lira districts.
2. To assess the association between alcohol consumption and cognitive impairment among men and women in rural Uganda
3. To determine the socio-cultural factors that contribute to gender differences in the vulnerability to alcohol-related cognitive impairment in Ibanda and Lira districts.

Uganda 2025-01-31 7:24:38 2028-01-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
john semuwemba
ID: UNCST-2022-R015225
Association between prenatal alcohol exposure and Cognitive and Behavioral impairments among primary school children aged 6 to 10 years in rural Rwampara and Lira districts.
REFNo: HS5331ES

General Objective.
To determine the prevalence of prenatal alcohol exposure and the association between prenatal alcohol exposure and cognitive and behavioral impairments among primary school children aged 6 to 10 years in rural Rwampara and Lira districts.
Specific Objectives.
1 To determine the prevalence of prenatal alcohol exposure in rural Rwampara and Lira districts.
2 To determine the prevalence of cognitive and behavioral impairments among primary school children aged 6 to 10 years in rural Rwampara and Lira districts.
3 To determine the association between prenatal alcohol exposure and cognitive and behavioral impairments among primary school children aged 6 to 10 years in rural Rwampara and Lira districts.

Uganda 2025-01-31 7:22:50 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
David Mukunya
ID: UNCST-2022-R010707
A phase III, randomized, open-label, clinical trial to evaluate the safety and efficacy of emollient therapy for very low birthweight infants (<1500g) in Uganda in promoting survival, health, growth and development compared to no emollient treatment
REFNo: HS5338ES

To evaluate the efficacy of emollient therapy with SSO – compared to standard care without use of emollients – among hospitalised very low birth weight (VLBW, <1500g) infants in Uganda on: the rate of in-hospital mortality, serious infections, hypothermia, growth, intraventricular haemorrhage, and skin condition; maternal depression and anxiety; maternal and neonatal interaction; infant growth and neurodevelopment at 12 month corrected age (chronological age reduced by the number of weeks born before 40 weeks of gestation); and infant mortality.
Uganda 2025-01-31 7:21:53 2028-01-31 Medical and Health Sciences Clinical Trial Non-degree Award
Adam Hewitt Smith
ID: UNCST-2019-R001658
Evidence based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU): protocol for type III hybrid implementation-effectiveness study.
REFNo: HS5389ES

To evaluate the impact of a structured antimicrobial review on rates of antimicrobial density, redundancy and associated indicators of antimicrobial utilisation.,To determine whether a structured antimicrobial review can be implemented in LMIC ICUs,
UK 2025-01-31 7:20:18 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
WAYENGERA Misaki
ID: UNCST-2024-R002503
DECIPHERING HOST GENETICS AND VIRAL DETERMINANTS OF MPOX PATHOGENESIS IN THE DEMOCRATIC REPUBLIC OF CONGO AND THE NEIGHBORING COUNTRIES (DECIPHER-MPOX)
REFNo: HS5409ES

The goal of the DECIPHER-MPOX project is to determine the host genetic and viral determinants of mpox in Uganda and in the Democratic Republic of Congo (DRC) among survivors of mpox and their house hold contacts ,
Uganda 2025-01-31 7:18:46 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jackson Tumwine Bwagiro
ID: UNCST-2024-R004504
Promotion of integrated and sustainable community interventions to prevent GBV and strengthen Adolescent Sexual Reproductive health and rights. A realistic evaluation protocal from Uganda
REFNo: SS3540ES

The overall objective is to promote integrated and sustainable community interventions to prevent GBV and Strengthen SRHR,
Uganda 2025-01-31 7:17:15 2028-01-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
Andrew Kanyike Marvin
ID: UNCST-2020-R014554
Optimizing Hypertension and Type 2 Diabetes Mellitus Management among People Living with HIV using a HEARTS-Based Strategy in Eastern Uganda: A Feasibility and Preliminary Effectiveness Study.
REFNo: HS5399ES

To identify the barriers and facilitators to the optimal management of HTN and T2DM among PLHIV at Mbale Regional Referral Hospital in Eastern Uganda.

To develop and implement a HEARTS-based strategy for optimized management of HTN and T2DM among PLHIV at Mbale Regional Referral Hospital in Eastern Uganda.

To determine the feasibility, acceptability, and preliminary effectiveness of the HEARTS-based strategy in optimizing the management of HTN and DM among PLHIV at the Mbale Regional Referral Hospital in Eastern Uganda.

To evaluate the reach, adoption, implementation, and maintenance of the HEARTS-based strategy for optimizing hypertension and diabetes mellitus management among PLHIV at Mbale Regional Referral Hospital.

Uganda 2025-01-31 7:16:22 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mordecai Tayebwa
ID: UNCST-2024-R002437
Expanded Strengthening of Makerere University's Research Administration Capacity Program (E-SMAC)
REFNo: HS5531ES

Test knowledge and skills change over time of faculty prior to and following the SOP trainings and implementation activities ,Test knowledge and skills change over time of participating RA staff prior to and following the SOP trainings and implementation activities ,Test knowledge and skills change over time of participating RA staff and faculty prior to and following the SOP trainings and implementation activities ,
Uganda 2025-01-30 18:30:42 2028-01-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Freddy Kitutu Eric
ID: UNCST-2020-R014751
Evidence Synthesis To Inform Strengthening Medical Oxygen Systems in low- and middle-income countries”. (ESTISMOS)
REFNo: HS5437ES

10. To assess the implementation outcomes and impact of the Oxygen-as-a- service intervention in Uganda, Kenya, Tanzania, and Nigeria,9. To determine the health facility readiness, also known as “change valence”, to implement the Oxygen-as-a- service intervention in Uganda, Kenya, Tanzania, and Nigeria.,8. To assess the capability (real and perceived) of the selected health facilities, also known as, “change efficacy” to implement the Oxygen-as-a- service intervention in Uganda. ,7. To examine the coordination mechanisms at national, district, health facility levels that facilitate availability of medical oxygen at health facilities.,6. To examine the stakeholder positions, interests, and influences along the medical oxygen supply chain on access to medical oxygen at health facilities.,5. To characterize processes and tools for information flow and management for medical oxygen and oxygen related equipment.,4. To map the medical oxygen supply chain system and explore the nodes and links from the medical oxygen sources to health facilities where it is needed.,3. To synthesize the extent to which healthcare packages have incorporated oxygen therapy solutions to promote their adoption, scale up and sustainability. ,2. To summarize the implementation outcomes of oxygen therapy solutions from published intervention studies in LMICs. ,1. To synthesize determinants of implementation outcomes of oxygen therapy solutions in low- and middle-income countries.,
Uganda 2025-01-30 18:27:31 2028-01-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adityavarman Mehta Umesh
ID: UNCST-2024-R002841
The Role of Global Health Diplomacy in Achieving Peacebuilding in Post-Conflict Northern Uganda
REFNo: SS3590ES

In this context, the thesis will examine the use of global health diplomacy, which aims to bridge the disciplines of public health, international relations, and public policy, as a peacebuilding instrument in northern Uganda. With numerous health initiatives such as those that addressed the increasing incidence of HIV/AIDS and Ebola during the civil war between 1986 and 2006, and psychosocial programs following the conclusion of the war, there is scope to determine whether these health initiatives contributed to the cessation of violence and ultimately, peacebuilding. This thesis will arrive at this determination by assessing if health initiatives implemented in northern Uganda during and after the conflict fostered social cohesion and afforded Ugandans, particularly women, agency or the opportunities to follow through on their choices. The twenty-year conflict in northern Uganda provides an effective context for this thesis because the violence was largely a product of its political and social history (Kustenbauder, 2010). The violence had ethnic and religious dimensions as well, with academic literature on the subject suggesting that the largest rebel group fighting the national army, the Lord’s Resistance Army, viewed its struggle against the government of Uganda as a divine cause, which was guided by God through its leader, Joseph Kony (Van Acker, 2004). Against this political and historical backdrop, this thesis will aim to determine if global health diplomacy was able to, in whole or in parts, achieve peacebuilding objectives in northern Uganda.
Uganda 2025-01-30 18:24:54 2028-01-30 Social Science and Humanities Non-Clinical Trial Degree Award
Hilary Muheezangango
ID: UNCST-2024-R002492
GOVERNANCE PRACTICES AND ECONOMIC SECURITY IN PINEAPPLE VALUE CHAIN COMMUNITIES IN SELECTED DISTRICTS; CENTRAL UGANDA.
REFNo: SS3466ES

Main Objective: To examine the relationship between governance practices, and economic security of Pineapple Value Chain Communities in Central Uganda.

Specific objectives
i. To examine the contribution of shared goals among stakeholders on the economic security of Pineapple Value Chain Communities in the Districts of Luweero, Kayunga and Mukono; Central Uganda.
ii. To examine the relationship between shared roles and economic security of Pineapple Value Chain Communities of Luweero, Kayunga and Mukono Districts; Central Uganda.
iii. To analyze the relationship between shared knowledge and economic security of Pineapple Value Chain Communities of Luweero, Kayunga and Mukono Districts; Central Uganda.
iv. To assess the mediating effect of work environment on the relationship between governance practices and economic security in Pineapple Value Chain Communities of Luweero, Kayunga and Mukono Districts; Central Uganda.

Uganda 2025-01-24 14:40:20 2028-01-24 Social Science and Humanities Non-Clinical Trial Degree Award
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