Erisa Mwaka Sabakaki
ID: UNCST-2019-R001625
|
Stakeholder perceptions and ethical considerations in gene therapy clinical trials for sickle cell disease in Uganda
REFNo: SS3570ES
Aim 1: To determine stakeholder perceptions of somatic gene therapy for SCD. We shall engage patient support and advocacy groups to ascertain knowledge gaps, expectations, and preferences regarding gene therapy. This will facilitate patient education and smooth implementation of research and development of affordable and accessible gene therapy in LMICs.
Aim 2: To examine the ethical, legal, and social considerations in somatic gene therapy clinical trials for SCD in a resource-limited setting. We shall use deliberative focus group discussions and key informant interviews to explore the ethical and social considerations in somatic gene therapy research in low-resource settings.
|
Uganda |
2025-04-09 16:28:31 |
2028-04-09 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Willbroad Byamukama
ID: UNCST-2022-R010646
|
RURAL LANDLESSNESS AND FOOD INSECURITY IN UGANDA; A CASE OF KIGEZI SUB-REGION (KABALE, RUBANDA, RUKIGA, AND KISORO DISTRICTS)
REFNo: A561ES
iii. To establish workable strategies to address food insecurity in Kigezi sub-region (Kabale, Rubanda, Rukiga, and Kisoro).,ii. To examine the effect of rural landlessness on food insecurity in Kigezi region (Kabale, Rubanda, Rukiga, and Kisoro).,i. To examine the causes of rural landlessness in Kigezi sub-region (Kabale, Rubanda, Rukiga, and Kisoro).,The purpose of the study is to examine the effect of rural landlessness and food insecurity in, Uganda case of Kigezi region and come up with strategies to increase food security in Kigezi sub region with the rural landlessness.,
|
Uganda |
2025-04-09 16:09:36 |
2028-04-09 |
Agricultural Sciences |
Non-Clinical Trial |
Non-degree Award |
|
DICKSON NIWASASIRA
ID: UNCST-2024-R003949
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The Effectiveness of Electronic Media on Utilization of Health Services in a Rural Setting
REFNo: SS3705ES
I. Establish the electronic media channels used by different demographic segments of the rural population to access health information.
II. Determine the impact of electronic media on overall utilization of facility- based Health services in a rural setting.
III. Establish the effectiveness of different electronic media channels on utilization of facility-based health services among different demographic segments of the rural population.
|
Uganda |
2025-04-08 7:35:22 |
2028-04-08 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
Glenn Ogolah
ID: UNCST-2025-R017145
|
Asset Financing and Micro Leasing in Agriculture
REFNo: SS3726ES
1. Examining barriers and opportunities in asset financing and micro-leasing
adoption for smallholder farmers and microenterprises:
a. Identifying and analyzing the barriers and opportunities affecting the access of
asset financing solution amongst smallholder farmers
b. Examine gender differences in barriers to accessing asset financing for
smallholder farmers
c. Explore interactions among key stakeholders, including farmers,
microenterprises, SACCOs, and MFIs, to assess their roles and influences in
the asset financing landscape
2. Examining the role of clean energy assets in meeting farmers most urgent needs:
a. Identifying and analyzing the barriers and opportunities affecting the adoption
of clean energy assets by farmers
b. Exploring available productive assets in the market and their distribution
channels for rural farmers
|
Kenya |
2025-04-07 7:58:51 |
2028-04-07 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Josephine BIRUNGI
ID: UNCST-2024-R003480
|
A Roadmap towards the successful deployment of a fixed dose combination of Artemether-Lumefantrine+Amodiaquine (FDC ALAQ) in Uganda (DeTACT Study)
REFNo: SS3706ES
Main Objective: to identify and address obstacles in implementation and deployment of FDC ALAQ at an early stage, and contribute to the smooth introduction of FDC ALAQ in Uganda.
Specific Objectives:
To identify and engage with key national stakeholders involved in Malaria control and introducing new antimalarials in Uganda;
ii. To obtain understanding into relevant policy, regulatory and implementation procedures of new antimalarials and to identify areas that require strategic attention before any new antimalarials are introduced in Uganda;
iii. To develop a practical roadmap that can be used for the effective introduction and deployment of FDC ALAQ in Uganda aiming to control and contain artemisinin resistance in Uganda.
|
Uganda |
2025-04-03 16:55:55 |
2028-04-03 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Robinson Amanyiraho
ID: UNCST-2024-R016357
|
Impact of the Growing Expertise in E-health Knowledge and Skills (GEEKS) Program in Reducing Immunization Defaulters and Enhancing Timely Reporting of Vaccine-Preventable Disease Cases in Uganda
REFNo: HS5737ES
Goal:
The goal of this study is to evaluate the contributions and sustainability of GEEKS Cohort 1 projects, while also providing actionable recommendations to enhance the effectiveness of current and future implementations of the GEEKS program.
Specific Objectives
1.
To document and analyze the contributions of GEEKS Cohort 1 projects in strengthening Vaccine Preventable Disease Surveillance (VPDS) and routine immunization coverage.
2.
To assess the sustainability of GEEKS Cohort 1 projects and identify factors influencing their long-term impact.
3.
To provide evidence-based recommendations for strengthening the design and implementation of current and future GEEKS program initiatives.
|
Uganda |
2025-04-02 9:37:17 |
2028-04-02 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Geofrey Musinguzi
ID: UNCST-2024-R015961
|
HIV Prevention Program Outcomes: Measurement of accessibility, and utilization of key HIV prevention services and linkage to care among adolescent girls and young women, female sex workers, and people who inject drugs in Uganda – A Rapid Coverage Survey
REFNo: HS5730ES
Main objective
The survey’s main objective is to measure the HIV prevention program outcomes among key and priority populations, particularly the AGYW, FSWs, and PWIDs, to inform ongoing and future HIV prevention programs (among such populations) in Uganda.
Specific objectives
1. To assess access to key HIV prevention services and products among AGYW, FSWs, and PWIDs in Uganda.
2. To assess the utilization of key HIV prevention products and services among AGYW, FSWs, and PWIDs in Uganda.
3. To measure the proportion of HIV-positive AGYW, FSWs, and PWIDs linked to HIV/AIDS, STD care and desired health services.
|
Uganda |
2025-04-02 9:35:25 |
2028-04-02 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Stella Achen
ID: UNCST-2025-R016855
|
PARTICIPATORY INTERVENTION RESEARCH TO ADDRESS CHILD EXPLOITATION IN KARAMOJA, UGANDA
REFNo: SS3733ES
i. Explore the main forms of exploitation and modern slavery in Napak and Moroto Districts;
ii. Assess interventions and program components that should be prioritized concerning child exploitation, bearing in mind the major intersecting issues such as gender discrimination, food security, and climate change;
iii. Explore the traditions, narratives, and cultural beliefs that could be mobilized as assets to the program; and lastly,
iv. Map out the key actors and influencers in the child exploitation debate.
|
Uganda |
2025-04-02 9:26:44 |
2028-04-02 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Sebastian Linnemayr
ID: UNCST-2021-R012696
|
R01 Study “INcentives and ReMINDers to Improve Long-term Medication Adherence” (INMIND)
REFNo: SS3732ES
Main Objective
1. We propose to optimize an adaptive intervention using the INMIND approach in a Stage III efficacy randomized trial using a two-stage SMART design in Uganda. All clients (including the control group) will receive information about the importance of behavioral routines, as is part of the standard adherence counseling for treatment initiators and create personalized ART adherence anchoring strategies. We will first enroll patients into an Wisepill use only phase for one month. We will then randomize them to receive either usual care / information only or low-cost daily text messages. All clients will have the opportunity to select a new anchoring plan in the first two months, so that they then have another 4-month period during which to establish a routine. Those who if fail to take their ART pills very regularly, meaning at the same time for at least 80% of the days at the end of month three will be re-randomized to one of two more intensive interventions for the subsequent three months: monthly or monthly escalating prizes.
The Specific Aims are to:
SA1 (Primary): Test the first-stage main effect of Messages vs. Control on the maintenance of ART adherence (primary outcome) and viral suppression (secondary outcome).
SA2 (Secondary): Examine (a) the second-stage main effect of receiving monthly vs. monthly escalating incentives on the primary and secondary outcomes among first-stage non-responders, and (b) whether changing one’s anchoring plan at month two moderates the effect of monthly and monthly escalating incentives.
SA3. Synthesis Phase: Perform a cost-effectiveness analysis including a comparative analysis of the INMIND components among first-stage responders and non-responders and conduct information dissemination activities in Uganda after completion of the trial.
|
USA |
2025-04-02 9:23:18 |
2028-04-02 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Henry Kyobe Bosa
ID: UNCST-2021-R013941
|
UNDERSTANDING THE SOCIO-ECOLOGICAL AND BEHAVIORAL DRIVERS OF MPOX DISEASE IN AFRICA
REFNo: HS5719ES
General Objective
To assess the state of knowledge, attitudes, and practices, including socio-ecological and behavioral determinants of health considerations, regarding MPXV acquisition and vaccine uptake in Uganda.
Specific Objectives
1. To assess the determinants of the Mpox disease spread and modes of transmission
2. To determine the community’s knowledge, attitude, practices, and perception on Mpox disease
3. To evaluate health-seeking behavior for Mpox disease
4. To identify the barriers and facilitators to Mpox vaccine uptake
|
Uganda |
2025-04-02 9:21:50 |
2028-04-02 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Walter Akwat
ID: UNCST-2024-R003452
|
Uganda Multi-Sectoral Needs Assessment (MSNA) 2024
REFNo: SS3727ES
• Conduct a thorough inter-sectoral analysis to assess the magnitude and
severity of humanitarian needs and conditions among refugee and host
community households across all 13 formal refugee settlements across
the country and refugee concentrations in Kampala.
• Identify variations in humanitarian needs across different areas of study,
population groups, and household vulnerability profiles.
• Compare key findings of the 2024 MSNA with the Vulnerability and
Essential Needs Assessment (VENA) (2019) and 2018 MSNA.
• Offer insights into inter-sectoral needs to inform prioritization of refugee
response efforts and strategic planning.
|
Uganda |
2025-04-02 9:20:09 |
2028-04-02 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Agrace Atwikirize
ID: UNCST-2024-R002716
|
Stressors, Coping Strategies, Hope and Academic Perfomance of Teacher-Trainees in Universities in Central Region, Uganda
REFNo: SS3485ES
i. To find out the variations of stressors with biodata among teacher-trainees in universities in Central Region, Uganda.
ii. To investigate the relationship between stressors and coping strategies among teacher-trainees in universities in Central Region, Uganda.
iii. To establish the relationship between coping strategies and academic performance among teacher-trainees in universities in Central Region, Uganda.
iv. To assess if the relationship between stress and academic performance is mediated by coping strategies among teacher-trainees in universities in Central Region, Uganda.
v. To determine the mediating effect of coping strategies and hope on the relationship between stressors and academic performance among teacher-trainees in universities in Central Region, Uganda.
|
Uganda |
2025-04-02 9:18:20 |
2028-04-02 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
Mohamed Ali Bashir
ID: UNCST-2024-R002641
|
PREVALANCE AND FACTORS ASSOCIATED WITH IMMEDIATE ADVERSE PERINATAL OUTCOMES AMONG WOMEN WITH UNINTENDED PREGNANCIES DELIVERING AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS5383ES
General Objectives
To determine prevalence and factors associated with immediate adverse perinatal outcome among women with unintended pregnancies delivering at Mbarara Regional Referral Hospital.
Specific Objectives
1. To determine prevalence of immediate adverse perinatal outcomes among women with unintended pregnancies delivering at Mbarara Regional Referral Hospital.
2. To determine factors associated with immediate adverse perinatal outcome among women with unintended pregnancies delivering at Mbarara Regional Referral Hospital.
|
Somalia |
2025-04-02 9:16:24 |
2028-04-02 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
|
Cecilia Akatukwasa
ID: UNCST-2024-R002112
|
Feasibility and acceptability of the Vxnaid-Immunization Information System (Vxnaid-IIS) for improved Immunization Monitoring and Data Management through Digitization in Wakiso district.
REFNo: SS3734ES
4. To explore stakeholder’s insights and perspectives into future use of Vxnaid-Immunization Information System including sustainability,3. To assess the barriers and enablers to implementation of the Vxnaid-Immunization Information System across four HSDs and four Municipal councils in Wakiso district.,2. To explore key stakeholders’ perceptions, attitudes and acceptance of the Vxnaid-Immunization Information System,1. Explore key stakeholders’ perspectives on practicality, ease of use and overall experience with integrating Vxnaid into current Immunization Information systems across four HSDs and four Municipal councils in Wakiso district.,
|
Uganda |
2025-04-02 9:08:21 |
2028-04-02 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
William Blackmon
ID: UNCST-2025-R017006
|
Consumer Protection Surveys - Uganda
REFNo: SS3650ES
The project aims to:
• Measure consumer protection risks associated with digital financial services (DFS) usage in Uganda
• Track consumer protection risks across two survey rounds
• Create a comparable cross-country analysis (the survey is also carried out in 10 other countries)
|
USA |
2025-04-02 9:06:12 |
2028-04-02 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Maxensia owor
ID: UNCST-2021-R014003
|
An open-label randomised controlled trial comparing novel combination and currently used antibiotic regimens for the empiric treatment of neonatal sepsis with a run-in confirmatory pharmacokinetic phase: NeoSep1
REFNo: HS5639ES
In Part 2, a secondary objective is to provide a ranking of clinically relevant antibiotic regimens based on other efficacy and safety secondary outcomes, as well as on health economic measures and the potential selection of resistance. The trial data will provide data to inform the balance between efficacy, safety, costs (and cost-effectiveness and equity, using health economic analysis) and propensity for resistance selection (based on microbiology tests) that will influence facility-level and national decision-making about adoption of studied regimens, and potential future inclusion in WHO guidelines.,In Part 2, the primary objective is to provide a ranking of eight different clinically relevant antibiotic regimens for first-line empiric and second-line (after lack of response/deterioration) treatment in terms of 28-day mortality as the primary outcome measure. It will flexibly compare these multiple different relevant treatment regimens to enable the trial to be run in sites worldwide with very different background rates of different pathogens, of resistance and patterns of routine clinical care by randomising each participant to locally relevant antibiotic regimens agreed prior to site initiation. The trial will ensure generalisability by focusing inclusion based on clinical symptoms associated with high mortality risk in the NeoOBS study, which have been developed into a novel neonatal sepsis severity score – the NeoSep Severity Score.,
|
Uganda |
2025-04-02 9:04:16 |
2028-04-02 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Gloria Lubega
ID: UNCST-2025-R017180
|
A retrospective review of patients admitted with SARS-COV-2 at Entebbe regional referral hospital in Uganda across multiple waves.
REFNo: HS5695ES
I. To evaluate the mortality rate, risk factors associated with mortality and prolonged hospital admission among patients admitted with severe COVID-19 disease at ERRH.
II. To determine the time to discharge of patients admitted with severe COVID-19 disease at ERRH.
III. To describe the characteristics of patients across different age groups admitted with severe COVID-19 at Entebbe Regional Referral Hospital
IV. To describe treatment options offered to patients admitted with severe COVID-19 disease with reference to Uganda MoH and WHO recommended treatment options.
V. To compare characteristics of patients who were vaccinated against COVID-19 admitted with severe disease and unvaccinated patients admitted with severe COVID-19 disease.
|
Uganda |
2025-04-02 9:01:54 |
2028-04-02 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Mark Kaddumukasa
ID: UNCST-2020-R001798
|
Building a Collaborative Research and Training Platform for HIV and Rheumatic and Musculoskeletal Diseases in Uganda
REFNo: HS5606ES
Objective 1. Establish the Ugandan Registry of RMDs in HIV (GEMINI), to create a foundation for future prospective studies on HIV and RMDs.
Objective 2. In a pilot study, among a subset of participants from GEMINI with both RA and HIV, compared to participants with HIV only and RA only, explore the impact of co-morbid disease status on markers of bone metabolism, bone mineral density, as well as quality of life and functional disability.
|
Uganda |
2025-04-02 9:00:14 |
2028-04-02 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Sylvia Kusemererwa
ID: UNCST-2019-R001717
|
A phase III, multi-center, randomized, placebo-controlled, double-blind
study to assess efficacy and safety of crizanlizumab (5 mg/kg) versus placebo, with or without hydroxyurea/hydroxycarbamide therapy, in adolescent and adult Sickle Cell Disease patients with frequent vaso-occlusive crises
REFNo: HS5607ES
To assess the efficacy and safety of crizanlizumab (5 mg/kg) versus placebo, with or without
hydroxyurea (HU)/hydroxycarbamide (HC) , on VOC rate in Sickle Cell Disease (SCD) patients aged 12 years and older who experience frequent vaso-occlusive crises (VOCs)
Primary Objective
1. To compare the efficacy of 5 mg/kg of crizanlizumab versus placebo, with or without hydroxyurea/hydroxycarbamide, on the annualized rate of VOCs* that are HCP managed (including VOCs leading to management at a health care facility or those via remote consultation) over the planned 52-week treatment period in SCD patients aged 12 years and older with a history of frequent VOCs (4-12 events in 12 months prior to the screening visit).
Secondary Objectives
1. To compare the efficacy of 5 mg/kg of crizanlizumab versus placebo, with or without
hydroxyurea/hydroxycarbamide, on the annualized rate of all VOCs including VOCs that are HCP-managed (including VOCs leading to management at a health care facility or those managed via remote consultation) and VOCs that are self-managed without recommendations from HCP during the event over the planned 52-week treatment period in SCD patients aged 12 years and older with a history of frequent VOCs (4-12 events in the 12 months prior to the screening visit).
2. To evaluate the annualized rate of VOCs by type of management between treatment arms over the planned 52-week treatment period:
VOCs that are HCP-managed at a health care facility
VOCs that are HCP-managed via remote consultation
Page 4 of 18
VOCs that are self-managed without recommendations from HCP during the event
VOCs that are HCP-managed via remote consultation or self-managed without recommendations from HCP during the event
|
Uganda |
2025-04-02 8:58:47 |
2028-04-02 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Aloysious Ssemaganda
ID: UNCST-2023-R008046
|
Clinical Performance of i.Mune CD4 diagnostic assay amongst people living with Human immunodeficiency virus (HIV) in Uganda (CPHL-CPSP_001)
REFNo: HS5680ES
The primary objective of this study is to evaluate the clinical performance and validity of the i.Mune CD4 diagnostic assay compared to WHO pre-qualified and CE-marked Abbott PIMA CD4 test using matched liquid and dried venous blood as well as capillary dried blood specimen
collected from people living with HIV in Uganda.
Secondary objectives of this study are:
-To validate the i.Mune CD4 diagnostic assay using the Applied Biosystems™ QuantStudio 5 PCR System in Uganda to support WHO pre-qualification.
-To establish trueness of measurement of the i.Mune CD4 diagnostic assay using the LightCycler 480 Instrument II and the LightCycler PRO in comparison to the reference method (Abbott CD4 PIMA) to support CE-marking of the assay.
|
Uganda |
2025-04-02 8:53:21 |
2028-04-02 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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