HIRALY ASABAHEBWA
ID: UNCST-2024-R016374
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A QUALITATIVE STUDY EXPLORING THE EXPERIENCES OF UNIVERSITY STUDENTS LIVING WITH HIV AND COMPLETING A UNIVERSITY-LEVEL QUALIFICATION IN KAMPALA, UGANDA
REFNo: SS3684ES
To explore the experiences of newly HIV-diagnosed university students in Kampala, Uganda ,
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Uganda |
2025-03-04 10:29:29 |
2028-03-04 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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ISMAHIL ADENIYI ADEKUNLE
ID: UNCST-2024-R002602
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EFFECTS OF ETHYL-ACETATE FRACTION OF Bidens pilosa LEAVES ON TESTES AND PITUITARY GLAND OF MALE MICE EXPOSED TO BISPHENOL A
REFNo: HS5372ES
The purpose of this study is to evaluate the impact of B. pilosa on testicular integrity and the pituitary gland of male mice exposed to BPA.
1.3.1 Specific Objectives
i. To assess the effect of B. Pilosa on spermatogenic metrics of the testes such as sperm motility, sperm count, morphology, agglutination, and vitality using routine and extended semen analysis.
ii. To determine the impact of B. pilosa on serum concentration of follicle-stimulating hormone, testosterone, and luteinizing hormone using enzyme-linked immunosorbent assay (ELISA) following BPA exposure.
iii. To assess the changes in testicular oxidative stress biomarkers (such as CAT, SOD, and GSH) and lipid peroxidation using MDA.
iv. To assess the histology, histochemical, and immunohistochemical changes in the testes and pituitary gland following treatment with B. pilosa in BPA exposure using Masson Trichrome, Periodic Acid Schiff (PAS), Hematoxylin and Eosin (H&E), Caspase 3, antiproliferating cell nuclear antigen (PCNA), Bcl-2, alpha-smooth muscle actin (?-SMA), and Bax.
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Nigeria |
2025-03-03 11:40:21 |
2028-03-03 |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
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Agapitus Kato Babumba
ID: UNCST-2021-R013866
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Linking infectious disease front-liners control efforts with central public health authorities in the African Great Lakes region (Great-Life) project
REFNo: HS5293ES
Study Objectives: The study objectives and their specific objectives are outlined in A to D below.
OBJECTIVE A – CAPACITY BUILDING
This objective involves testing the integrated nanopore sequencing capacity (DNA and RNA—single isolates and metagenomics) in the study area.
Specific objectives:
? Set -up sampling, sequencing, and simple bioinformatic/epidemiological capacity in Bidibidi Health Centre.
? Set up advanced bioinformatics/ epidemiological capacity at UVRI and cascade it to the study area health facilities
? Build capacity in genomic data interpretation and risk communication in genomic epidemiology.
OBJECTIVE B - BIOINFORMATICS, EPIDEMIOLOGY, AND INFRASTRUCTURE
This objective involves the testing of standardized laptop analysis and compression of the data generated from nanopore runs, including base calling and standard analysis for use at the frontline health facility (Bidibidi HC III). Following analysis, the analytic data (now the size of kilobytes) can be easily and in real-time shared with stakeholders.
Specific objectives:
? Develop a common understanding of the key data analytics and infrastructure needs.
? Set up a project-specific frontline laptop-based data-entering and bioinformatic pipeline.
? Set up a central data portal for storing, aggregating, and sharing raw data and analytic output.
? Provide operational user support to the use-case scenarios and external users
? Support high-throughput computation capacity
OBJECTIVE C – TRAINING IN RESEARCH TRANSLATION SKILLS, AND EQUITABLE PARTNERSHIP
One of the key elements of this project is to generate data that should be transformed into information that will result in public health actions and social impact in the country. The project will involve key stakeholders from the health facility and local and central governments to meet this goal. The stakeholders will be trained in research data interpretation and utilization. The stakeholders will use the training obtained from this project to develop measures and policies.
Specific objectives:
? Conduct training of public health authorities and researchers in public health uptake of genomic epidemiological data
? Determine how obtained data will result in local and national guidelines for individual patient treatment
? Determine how data will influence local, national, and regional public health interventions
? Investigate how cross-border disease outbreaks can be coordinated between national and regional authorities
OBJECTIVE D - EPIDEMIOLOGICAL AND GENOMIC INVESTIGATIONS
The objectives will be fulfilled by conducting three use cases
? Real-time diagnostic and characterization of diarrheal and persistent malaria cases
? Environmental surveillance for antimicrobial resistance genes in the study area.
? Horizon scanning for pathogens of novel unknown infections of epidemic nature (Disease X identification)
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Uganda |
2025-02-28 17:30:31 |
2028-02-28 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Karim Nanyiri
ID: UNCST-2024-R002952
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Role of Mother Tongue in Learning Productive and Receptive Skills in English language: An Analysis of Perceptions of Stakeholders in Secondary Schools of Bugisu Sub-Region, Eastern Uganda
REFNo: SS3393ES
Objectives of the Study
The study will be guided by the main objective and specific objectives.
Main Objective of the Study
The main objective of the study is to investigate the role of mother tongue in learning productive and receptive skills in English language through the analysis of perceptions of stakeholders in secondary schools of Bugisu sub-region, eastern Uganda.
Specific Objectives of the Study
The study will be conducted with the following specific objectives;
1. To determine the influence of students’ productive skills in mother tongue on the learning of productive skills in English language.
2. To determine the influence of students’ receptive skills in mother tongue on the learning of receptive skills in English language.
3. To explore students’ perception of the role of mother tongue in learning productive skills in English language.
4. To explore students’ perception of the role of mother tongue in learning receptive skills in English language.
5. To explore teachers’ perception of the role of mother tongue in learning productive skills in English language.
6. To explore teachers’ perception of the role of mother tongue in learning receptive skills in English language.
7. To explore the barriers encountered by lower secondary school students in the learning of productive and receptive skills in English language.
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Uganda |
2025-02-28 16:02:44 |
2028-02-28 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Jennifer Serwanga
ID: UNCST-2024-R002056
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Molecular, Serological and Immunological Characterisation of Clade 1b Mpox to Improve Diagnostics for Local and
Regional Epidemic Response.
REFNo: NS934ES
1. Genetic and Immunological Characterisation of Mpox Clade 1b: To characterise the genetic profile and immunological responses associated with the Clade 1b Mpox virus circulating in Uganda and neighbouring high-risk regions. This objective seeks to identify the molecular adaptations and immune response profiles associated with the virus's transmission dynamics and its ability to evade immunity, a critical component in understanding the virus’s spread.
2. Establish Molecular Linkage and Epidemiologic Pathways for Targeted
Interventions: To utilise molecular linkage studies to map transmission chains and epidemiologic pathways of Mpox Clade 1b within and across Uganda, the DRC, Burundi, and South Sudan. This objective will pinpoint high-risk transmission clusters and guide targeted public health interventions, particularly in vulnerable communities such as border regions and fishing populations.
3. Correlating Viral Load with Antibody Dynamics in Clade 1b Cases and Contacts:To comprehensively analyse viral load dynamics across multiple body compartments in Mpox-infected individuals and correlate these findings with IgM, IgG and IgA antibody responses, including both binding and neutralising antibodies. This investigation aims to elucidate the predictive value of antibody kinetics in Clade 1b Mpox infections, including in cases with low or undetectable viral loads. By integrating virological and immunological parameters, this study will enhance our
understanding of host-virus interactions, inform diagnostic sensitivity thresholds, and provide critical insights into the immunopathogenesis of Clade 1b Mpox.
4. Optimisation of Diagnostic Tools for Regional Mpox Response: To optimise, and validate advanced diagnostic methods, integrating molecular and serological tools tailored to Mpox Clade 1b. By leveraging UVRI's Mpox sample repository, this objective will enhance the diagnostic accuracy and timeliness essential for immediate outbreak containment, enabling Uganda and partner nations to identify cases and reduce transmission risk rapidly.
5. Facilitate Global Access to Clade 1b Resources for Vaccine and Diagnostic Development: To enhance global Mpox preparedness, this study will share well-characterized Clade 1b specimens with trusted international collaborating research partners, including World Health Organisation (WHO) and United Kingdom Health Security Agency (UKHSA), after putting in place all necessary material transfer agreements ironing outall policicies and legal issues concerning sample sharing.
These specimens will support the development of standardized reference panels for molecular and serological diagnostics, assay comparability, and the establishment of anti-Mpox reference materials to strengthen global surveillance and response efforts.
This objective aims to support global efforts in vaccine development and diagnostic advancements by providing access to Clade 1b isolates, thereby fostering robust Mpox response capacity worldwide and contributing substantially to epidemic containment.
6. Strengthening Regional Preparedness through Strategic Collaboration: To promote a coordinated Mpox surveillance network with neighbouring countries (DRC, Burundi, and South Sudan) for improved outbreak detection, data sharing, and joint response strategies. This objective aligns with regional health security goals and strengthens collaborative frameworks to combat the Mpox epidemic more effectively across East and Central Africa.
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Uganda |
2025-02-25 18:19:08 |
2028-02-25 |
Natural Sciences |
Non-Clinical Trial |
Non-degree Award |
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