Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Japheth Noel
ID: UNCST-2021-R013959
 The Role of Inclusive Practices on Academic Resilience and Retention among Refugee Secondary School Students: A case of Nakivale Refugee Settlement Camp, Uganda
REFNo: SS3750ES

To examine the role of inclusive practices on academic resilience and retention among refugee secondary school students in Nakivale refugee settlement camp in Uganda.,(v) To analyze the relationship between academic inclusive practices and retention among secondary school students in Nakivale refugee settlement camp.,To determine the relationship between social inclusive practices and retention among secondary school students in Nakivale refugee settlement camp.,To analyze the relationship between academic inclusive practices and academic resilience among secondary school students in Nakivale refugee settlement camp.,To examine relationship between social inclusive practices and academic resilience among secondary school students in Nakivale refugee settlement camp.,To explore social and academic inclusive practices among secondary schools in Nakivale refugee settlement camp, in Uganda.,
 Uganda 2025-04-11 14:40:49 2028-04-11 Social Science and Humanities Non-Clinical Trial Degree Award
EDWIN AKUGIZIBWE
ID: UNCST-2024-R003785
 Data-driven trauma and surgery care in remote Africa: Socioeconomic insights, outcome models and equity recommendations
REFNo: SS3606ES

Develop an innovative app to enhance tracking and prediction of follow-up-treatment of trauma/surgery cases for improved health equity in Uganda and Africa at large.,Identify patterns and trends and develop models that classify and predict trauma related cases, with a particular focus on disparities in healthcare delivery.,Assess the impact of socioeconomic factors on access to surgical care for trauma patients in remote regions of Uganda ,The key aim of this study is to develop predictive models for health equity in remote African regions. These models will integrate data on SES, healthcare infrastructure, and past healthcare outcomes to anticipate potential areas of need and vulnerability (Ranapurwala et al., 2019). By proactively identifying and addressing disparities, the study seeks to contribute to the establishment of a more equitable and resilient healthcare system capable of responding effectively to trauma incidents.,
 Uganda 2025-04-11 14:37:25 2028-04-11 Social Science and Humanities Non-Clinical Trial Non-degree Award
Daniel Ebbs
ID: UNCST-2021-R012328
 A Risk Prediction Model for Prehospital Identification of Seriously Ill Children in Resource Limited Settings
REFNo: HS5672ES

Develop a risk prediction model for the early identification of serious illness in the prehospital setting. , Determine the ability of CHWs to collect new clinical exam parameters in the prehospital setting utilizing mHealth for training. ,
 USA 2025-04-11 14:34:43 2028-04-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Tadeo Winyi
ID: UNCST-2024-R002357
 FINANCIAL RESOURCE MANAGEMENT AND THE QUALITY OF EDUCATION IN HIGHER INSTITUTIONS: A CASE OF PRIVATE UNIVERSITIES IN CENTRAL UGANDA
REFNo: SS3719ES

The study's objectives are:
i. To assess the role of revenue streams in promoting quality of education in private universities in central Uganda.
ii. To determine the extent to which financial budgeting influences the quality of education in private universities in central Uganda.
iii. To analyze the effect of financial monitoring and control in the promotion of quality of education in private universities in central Uganda.
iv. To explore the mediating role of financial management practices between financial resource management and quality of education in private universities in central Uganda.


 Uganda 2025-04-11 14:31:27 2028-04-11 Social Science and Humanities Non-Clinical Trial Non-degree Award
FRED TWINOMUGISHA
ID: UNCST-2024-R003414
 THE ROLE OF INVOLVING PATIENTS IN PROMOTING HAND HYGIENE PRACTICES AMONG HEALTHCARE WORKERS IN MUKONO AND KAGADI DISTRICTS: A MIXED METHODS STUDY
REFNo: HS5449ES

1)To determine the level of knowledge and practice on hand hygiene among patients and health workers in selected healthcare facilities in Mukono and Kagadi districts, Uganda.
2)To explore the barriers and facilitators of involving patients in promoting hand hygiene practices among healthcare workers in selected healthcare facilities in Mukono and Kagadi districts, Uganda.
3)To explore the perceptions of healthcare workers on involving of patients in promoting hand hygiene practices in selected healthcare facilities in Mukono and Kagadi districts, Uganda.
4)To design and evaluate an intervention to improve hand hygiene among health workers.

Uganda 2025-04-11 14:30:15 2028-04-11 Medical and Health Sciences Clinical Trial Degree Award
Jessica Perkins M
ID: UNCST-2021-R013564
 Perceived Norms About Alcohol Use and HIV/STI Prevention among Adolescents and Young Adults in Rural Uganda (Y-SNAPS)
REFNo: HS5650ES

1. To Use qualitative methods to explore perceived norms around alcohol, HIV/STI transmission risk behavior, and HIV prevention among adolescents and young adults (AYA) in Rwampara District, Uganda. 2. To estimate the causal effects of perceived norms around alcohol use and HIV/STI transmission risk behavior on HIV/STI prevention among AYA in Rwampara District and conduct survey experiments to assess how different data collection methods affect responses. 3. To conduct a mixed-methods, randomized controlled trial to test the preliminary efficacy and mediating mechanism of a personalized normative feedback intervention on behavioral intentions, heavy alcohol use, and HIV/STI prevention among AYA in Rwampara District.
 USA 2025-04-11 14:27:29 2028-04-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edith Namakula
ID: UNCST-2022-R006923
 Antibiotic prescription patterns among inpatients at Mulago National Referral Hospital, Uganda. Incidence, UCG compliance and associated factors
REFNo: HS5646ES

To determine the incidence of antibiotic prescription among inpatients at Mulago National Referral Hospital, Uganda.
 Uganda 2025-04-11 14:26:00 2028-04-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Lucy Aciro
ID: UNCST-2023-R007829
 Income Diversification and Climate Change Adaptation among smallholder farmer in Northern Uganda
REFNo: A567ES

1. To determine the alternative livelihood strategies among smallholder wood charcoal producers
2. To analyze the effect of income diversification options on food security and living standards of the smallholder wood charcoal producers
3. To assess the climate change adaptation strategies adopted by smallholder wood charcoal producers
4. To determine the willingness of the farmers to adopt different strategies or productions process that enhances sustainability

 Uganda 2025-04-11 14:24:32 2028-04-11 Agricultural Sciences Non-Clinical Trial Degree Award
Eleanor Namusoke Magongo
ID: UNCST-2021-R013199
 Uganda Paediatric Antiretroviral Therapy (UP-ART) -THRIVE Sub-study on diagnosis, Prevention and Treatment of Advanced HIV disease in Children and Adolescents living with HIV in Uganda
REFNo: HS5592ES

Primary Objective:

1.To assess the cascade (receipt of all components of care with in one month of being eligible for screening), of care among children and adolescents living with HIV (CALHIV) with advanced HIV disease (AHD), dissecting all steps included in the Ugandan national guidelines (including screening for AHD and opportunistic infections (OI), treatment, optimization of care and prophylaxis).

Secondary objectives:

2.Describe the number and proportion of CALHIV who were eligible for AHD screening per calendar year starting in 2023, among all those in follow-up in UP ART that year

3.Describe the prevalence and incidence of AHD and its characteristics at the time of AHD diagnosis.

(i)Prevalence is based on proportion screened for AHD who met the definition of AHD at initial screening

(ii)Incidence will be estimated in two groups:

a.among those screened and not diagnosed with AHD at initial screening who meet the definition of AHD within 12 months of initial screening.

b.among those eligible for screening but were not screened for AHD, who met the definition of AHD within 12 months of becoming eligible for screening

4.Assess the clinical progression and outcomes of children and adolescents with AHD diagnosis, including mortality, morbidity (new and recurrent WHO 3 and 4 events), retention in HIV care, treatment interruption, and growth changes by 12 months after AHD diagnosis.

5.Strengthen data quality and completeness of AHD related data captured in electronic medical records through dedicated training, data monitoring plans and regular feedback to clinic staff.
 Uganda 2025-04-11 14:20:45 2028-04-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Grace Ahimbisibwe Miriam
ID: UNCST-2021-R012129
 Establishing Surveillance for Serious Neonatal Infections in sub-Saharan Africa (SNIP-Africa) Version 2.0 dated 15 Aug 2024
REFNo: HS5614ES

General Objective
To establish capacity and methods to conduct surveillance of neonatal BSI, pathogen and antimicrobial susceptibility profiles, AMR colonisation prevalence (patient and hospital environment) and antibiotic prescribing trends among hospitalised neonates (≤28 days) in sSA neonatal units.


Specific Objectives
i. To set up a surveillance network and define methods to support continuous epidemiological evaluation of neonates with suspected sepsis in participating sSA neonatal units.
ii. To create a streamlined, translatable data capture approach for use across a range of healthcare facilities.
iii. To determine the personnel and physical resources required for ongoing surveillance in different settings.
iv. To develop a real time data dashboard driving quality improvement through surveillance at the level of participating sites.
v. To describe AMR burden and patterns and identify trends in resistant bacterial invasive and carriage isolates in participating units and participants.
vi. To pilot assessment of colonization pressure and the relationship between invasive blood culture isolates, faecal carriage, the hospital environment and antimicrobial usage.
vii. To develop tools to detect and monitor outbreaks within participating neonatal units.
 Uganda 2025-04-11 14:17:57 2028-04-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
 HIV-Associated Viral Acute Respiratory Tract Illness (HAVARTI): The burden and severity of vaccine-preventable respiratory infection in people living with HIV in rural Uganda.
REFNo: HS5676ES

Primary Objective

The overarching goal of this study is to define the incidence and relative frequency of, and severity of illness from, influenza and two other vaccine-preventable viral respiratory infections, respiratory syncytial virus (RSV) and SARS-CoV-2, among people living with HIV (PLWH) in rural Uganda.


Specific Aims

1. Determine the incidence of ARI in a cohort of individuals living with HIV in rural Uganda and the proportion and incidence of those ARI episodes caused by vaccine-preventable viral respiratory infections (influenza, RSV, and SARS-CoV-2). We will enroll adolescents and adults infected with HIV who receive care at the Antiretroviral Therapy (ART) clinic at Bugoye Health Centre (BHC), a rural peripheral health facility in western Uganda. Participants will self-collect a mid-turbinate nasal swab at the onset of every episode of ARI during the study follow-up period. Samples will be tested for RSV, influenza, and SARS-CoV-2 within 48 hours of collection using a molecular assay.

2. Estimate the morbidity and mortality from influenza, RSV, and SARS-CoV-2 in this same population of PLWH. Study staff will conduct home visits 14 days after the onset of each episode of ARI to assess outcomes. Specifically, they will record any antibiotic or other treatment taken and its source (e.g., purchased at drug shop or prescribed by a healthcare provider); missed days of work (e.g., in the field for subsistence farmers); care-seeking including outpatient visits and inpatient admissions; and vital status.

3. Explore risk factors for severe disease from influenza, RSV, and SARS-CoV-2 among PLWH. As an exploratory aim, we will collect information on demographics, household and socioeconomic factors, cooking methods, past medical history including presence of underlying lung disease, smoking status, and history of pneumonia or tuberculosis, nadir and last CD4 count, most recent HIV viral load (VL) and VL at diagnosis, and ART history.

Uganda 2025-04-11 14:15:22 2028-04-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ouma Simple
ID: UNCST-2021-R012820
 Harnessing Parental Social Networks to Increase HIV Testing Uptake Among Children of At-Risk Parents in Uganda: A Parallel-Group, Two-Arm Quasi-Experimental Implementation Science Protocol
REFNo: HS5741ES

Objectives:

Main Objective

To Adapt, implement and evaluate maternal SNS to improve access to HIV testing services among children of FSW.

Specific Objectives

1. To adapt SNS that harnesses maternal SN for HIV testing in children of female sex workers
2. To implement the adapted HASHTAG intervention targeting CARP in Gulu City
3. To evaluate the effectiveness and implementation science outcomes of the HASHTAG project
 Uganda 2025-04-11 14:13:08 2028-04-11 Medical and Health Sciences Clinical Trial Non-degree Award
Davis Hafashimana Simon
ID: UNCST-2025-R018006
 An investigation into the variability of Hemileia vastatrix on Robusta coffee in Uganda
REFNo: A591ES

Objectives 1. To assess the genetic diversity of Hemileia vastatrix on Robusta coffee in Uganda 2. To make a linkage of any observed diversity to disease distribution in Uganda
Uganda 2025-04-11 14:11:00 2028-04-11 Agricultural Sciences Non-Clinical Trial Non-degree Award
Venantius Bbaale Kirwana Bbaale
ID: UNCST-2024-R002370
 RISKY SEXUAL BEHAVIOUR AMONG YOUNG PEOPLE IN UGANDA’S ISLANDS, AN ANALYSIS OF SEXUALITY INFORMATION SOURCES AND COMPLETENESS.
REFNo: SS3785ES

4-Evaluate the level of completeness of sexuality information from various sources to young people in Uganda\'s island communities,3-Compare current and preferred sources of sexuality information sources among young people in the Uganda Island communities,2-Assess the barriers young people in island communities face in accessing sexuality information from different sources.,1-Explore young people’s perceptions of risky sexual behavior in the Uganda Island communities.,Examine young people’s perceptions of risky sexual behavior and how sexuality information sources and completeness influence sexual behavior, in Uganda Island communities.,
 Uganda 2025-04-11 14:09:55 2028-04-11 Social Science and Humanities Non-Clinical Trial Degree Award
Javan Tindyebwa
ID: UNCST-2025-R017192
 ETHICAL LEADERSHIP, LEADER ACCOUNTABILITY, STAKEHOLDER PARTICIPATION, AND EDUCATION SERVICE QUALITY AT MAKERERE UNIVERSITY IN UGANDA
REFNo: SS3802ES

To examine the extent to which Stakeholder Participation mediates the relationship between Ethical Leadership and Education Service Quality in MUK in Uganda.,To establish the effect of Ethical Leadership on Education Service Quality in MUK in Uganda. ,To establish the effect of Stakeholder Participation on Education Service Quality in MUK in Uganda., To establish the effect of Leadership Accountability on Education Service Quality in MUK in Uganda,To examine the relationship between ethical leadership and leader accountability, and service quality and how these relationships are mediated by stakeholders at Makerere University.,
 Uganda 2025-04-11 14:04:32 2028-04-11 Social Science and Humanities Non-Clinical Trial Degree Award
EDIMOND SERWANGA
ID: UNCST-2025-R017659
 ASSESSING THE SITUATION OF TEACHERS IN PRIMARY AND SECONDARY SCHOOLS IN UGANDA
REFNo: SS3797ES

General objective To assess the teaching and learning situation of primary and secondary school teachers in both refugee and non-refugee settings across Uganda's West Nile and Karamoja sub-regions. 1.2.2. Specific objectives The study aims to address the following specific objectives: (i) To explore how teachers create, promote and utilise a supportive teaching environment that enhances their professional growth and well-being. (ii) To establish school and community practices that enhance child protection, well-being, and inclusion. (iii) To assess teachers’ practices on classroom management, instruction and assessment. (iv) To establish teachers’ understanding of the curriculum and how it informs teachers’ practices. (v) To establish language support strategies used by teachers to promote learning in schools.
Uganda 2025-04-09 17:19:38 2028-04-09 Social Science and Humanities Non-Clinical Trial Non-degree Award
Lolem Lucy Chegem
ID: UNCST-2024-R004656
 Nature and Degree of Karamojong Pastoral Community Participation and Integration in Wildlife Conservation Interventions in Kidepo Valley National Park, North Eastern Uganda
REFNo: SS3755ES

1. To conduct a policy review towards the establishment of national (Uganda) wildlife conservation policies and guidelines on community participation and integration of Indigenous peoples' social and cultural practices
2. To examine the Karamojong Indigenous and traditional wildlife conservation values, practices, and livelihood needs associated with KVNP
3. To explore the nature of the Karamojong participation in wildlife conservation practices in the management of KVNP
4. To determine the degree of the Karamojong participation in wildlife conservation activities in KVNP
5. To explore the nature of the Karamojong integration in wildlife conservation practices in the management of KVNP
6. To determine the degree of the Karamojong integration in wildlife conservation activities in KVNP

 Uganda 2025-04-09 17:01:55 2028-04-09 Social Science and Humanities Non-Clinical Trial Degree Award
REBECCA NANTANDA
ID: UNCST-2019-R001533
 Optimization and testing of ALRITE, a clinical decision support tool for management of respiratory illnesses in young children in primary care health facilities in Uganda
REFNo: HS5721ES

To pilot test ALRITE in 4 Ugandan health facilities after an optimization phase of iterative testing and ALRITE improvement.

1. To optimize ALRITE for health worker use through multiple cycles of reversal single-case experiments29,30* with 6-8 health workers per cycle.
2. Pilot-test study feasibility and the effectiveness of the optimized ALRITE tool on the diagnosis and management of wheezing illness and pneumonia in young children using interrupted time series (ITS) design.
3. Assess outcomes of implementation following ALRITE deployment and determinants of successful adoption using a sequential quant-> QUAL mixed methods design.
 Uganda 2025-04-09 16:40:46 2028-04-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Peter Olds
ID: UNCST-2023-R006240
 Evaluation of NT-proBNP in outpatient heart failure care in southwestern Uganda
REFNo: HS5796ES

Main Objective 1. Create and evaluate an algorithm for nurses using a point-of-care biomarker of heart failure (N-terminal-pro hormone B-type natriuretic peptide, NT-proBNP) to support heart failure management in Uganda. Specific Objectives 1. Identify an average baseline NT-proBNP for patients with HFrEF in the MRRH outpatient cardiology clinic. 2. Develop and compare the use of an algorithm for diuresis based on the NT-proBNP with standard of care diuretic plans for patients with HFrEF in the MRRH outpatient cardiology clinic 3. Evaluate the feasibility and acceptability of implementing an NT-proBNP based algorithm for heart failure care in Uganda
 USA 2025-04-09 16:31:41 2028-04-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jennifer Serwanga
ID: UNCST-2024-R002056
 VacICoP: Chimpanzee Adenovirus Type 3-Vectored Marburg Glycoprotein (GP)-Expressing Vaccine (ChAd3-MARV)-Induced Correlates of Protection
REFNo: HS5469ES

This study aims to identify the immune correlates of protection (ICoPs) against Marburg virus disease (MVD) through comprehensive analyses of humoral and cellular responses in both vaccinated and infected individuals. ICoPs will be identified by studying human and non-human
primates (NHPs) that have either survived infection, succumbed to it, or been successfully immunised. The research aims to expedite regulatory approval and licensure by identifying the most effective and durable ICoPs against MVD.
Key objectives and deliverables include:
1. Identifying the MVD ICoPs
2. Detailed humoral and cellular immune profiles distinguishing protective from nonprotective anti-MARV immunity
3. Reference reagents and scalable high-throughput screening assays
4. Predictive statistical models for forecasting vaccination effectiveness
5. Integrated clinical, immunological, and demographic datasets
6. Regulatory guidance for new vaccines approval
7. Global collaborative data exchange framework
 Uganda 2025-04-09 16:29:46 2028-04-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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