Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
DANIEL KIIZA
ID: UNCST-2024-R004044
Retrospective chart review of patients with Laboratory-Confirmed Sudan Virus Disease Hospitalized in Two Ebola Disease Treatment Units in Uganda (September 2022 to January 2023)
REFNo: HS5541ES

To evaluate the safety and clinical course of patients receiving investigational treatments for SVD,To identify host and disease factors associated with outcomes from SVD,To characterize the natural history and outcomes of Sudan virus disease (SVD) among hospitalized patients with RT-PCR detected Orthoebolavirus sudanense (SUDV) RNA,
Uganda 2025-02-07 18:10:59 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Clare Bangirana Ahabwe
ID: UNCST-2021-R012842
AN OUTCOME RESEARCH ON THE WESTERN UGANDA BANTWANA PROGRAM ON VIOLENCE AGAINST CHILDREN IN SCHOOLS AND SURROUNDING COMMUNITIES (VACiSC) IN THE THREE DISTRICTS OF KABAROLE, KYENJOJO and BUNYANGABU
REFNo: SS3625ES

The study aims to assess the effectiveness of the Western Uganda Bantwana Program (WUBP) in preventing and responding to Violence Against Children (VAC), including child sexual abuse (CSA), in schools and surrounding communities in the three Districts of Kabarole, Kyenjojo, and Bunyangabu

Specific Objectives
1. To measure the change in knowledge, attitude and practices on risks exposures to VACiSC including CSA with focus on prevention and response among children, young adults, caregivers and teachers.
2. To assess how the WUBP aligned to the needs of communities and existing practices (structures and approaches) on prevention and response to VACiSC including CSA.
3. To evaluate the role of caregivers, teachers, para-social workers, and community leaders in creating and maintaining safe environments for children.

Uganda 2025-02-07 18:09:14 2028-02-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Eva Smallegange Sophia
ID: UNCST-2023-R005788
Effectiveness of PlayMatters in Uganda: a teacher professional development programme aiming to integrate Learning through Play as pedagogical approach in the classroom
REFNo: SS3617ES

1. To study the effectiveness of PlayMatters Teacher professional Development program on teacher practices and teacher wellbeing.
2. To study how do the effects of the intervention vary by teachers’ age, gender, displacement status, level of education and professional experience?
3. To study how do effects of the intervention vary by differences in adherence to implementation of the Teacher Continuous Professional Development (TCPD) component of the intervention?
4. To study the effectiveness of the PlayMatters Teacher professional Development program at child outcome level (cognitive, social, emotional, physical and creative skills and on their mental health and wellbeing).
5.To study the cost-effectiveness of the PlayMatters intervention.
Netherlands 2025-02-07 18:07:38 2028-02-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Damari Atusasiire
ID: UNCST-2024-R002645
Evaluation of the One Acre Fund project - making 34,000 coffee farmers more resilient by 2027
REFNo: A560ES

To establish whether all household members are equally benefiting from the impacts of the project and how? ,To determine which pursued pathways of change are the main drivers in delivering outcome and impact? ,To establish the causal effects of the project for direct project participants? ,
Uganda 2025-02-07 18:04:15 2028-02-07 Agricultural Sciences Non-Clinical Trial Non-degree Award
Michelle Brown
ID: UNCST-2022-R009670
Describing the vocal repertoire of L’Hoest’s monkeys
REFNo: NS410ES

To test whether L’Hoest’s monkeys (Allochrocebus lhoesti) contradict the ‘social complexity hypothesis’ by determining whether they communicate in frequencies too low for human hearing.
USA 2025-02-07 18:02:59 2028-02-07 Natural Sciences Non-Clinical Trial Non-degree Award
Damari Atusasiire
ID: UNCST-2024-R002645
Incidence and economic impacts of bovine mastitis in smallholder dairy farms in Kenya and Uganda
REFNo: A564ES

To assess knowledge of bovine mastitis, its control and treatment among smallholder dairy farmers.
To assess the effectiveness of using cell phone technology as a method of disseminating information on udder health to farmers.
To estimate the incidence rate of clinical and subclinical mastitis among recently-calved dairy cows (≤4 weeks prior to baseline data collection).
To determine the drivers of bovine mastitis among sampled dairy cows.
To estimate the monthly and annual financial losses attributed to clinical and subclinical mastitis.
Uganda 2025-02-07 18:01:56 2028-02-07 Agricultural Sciences Non-Clinical Trial Non-degree Award
Benard Nsubuga
ID: UNCST-2024-R002324
Assessment of the functionality of health unit management committees in primary healthcare health facilities in Uganda: a case of health center IIIs
REFNo: HS5407ES

a) To determine the presence and functionality of HUMCs in HCIIIs
b) To determine the factors influencing the functionality status of HUMCs in HCIIIs
c) To identify any interventions needed to strengthen the performance of HUMCs in HCIIIs.

Uganda 2025-02-07 17:59:08 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Benard Nsubuga
ID: UNCST-2024-R002324
Factors influencing the Functionality of Medicines and Therapeutic Committees in Public Health Facilities in Uganda: A Longitudinal Assessment
REFNo: HS5391ES

a) Provide the current functionality of MTCs in public HFs
b) Determine the factors associated with the functionality of MTCs in public HFs

Uganda 2025-02-07 17:56:57 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eve Nakabembe
ID: UNCST-2024-R015226
PReparing for OptimalPhase III/IV maTErnal Group B StreptococCal vaccine Trials in Africa
REFNo: HS5463ES

1. To generate longitudinal cohort data on pregnancies, deliveries and infant outcomes for maternal Group B Streptococcus vaccine safety assessment
2. To develop and strengthen capacities for Group B Streptococcus disease surveillance in infants less than 90 days old at Kawempe National Referral Hospital, using microbiological and molecular detection methods.
3. To explore the perceptions of pregnant women, health care providers, community members and other relevant stakeholders about the barriers and drivers for pregnant women to participate in Group B Streptococcus vaccine trials.
4. To co-create a communication/education toolkit to enhance understanding of the importance of maternal Group B Streptococcus vaccine trials and improve enrolment of pregnant women in vaccine trials in Uganda.

Uganda 2025-02-07 17:52:29 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Tonny Okecha
ID: UNCST-2022-R011105
CLINICOPATHOLOGICAL AND MOLECULAR PROFILE OF MALE BREAST CANCER AT THE UGANDA CANCER INSTITUTE
REFNo: HS5435ES

2. To describe the mutational profile of male breast cancer at the Uganda Cancer Institute.,1. To describe the clinico-pathological features of male breast cancer at the Uganda Cancer Institute,To describe the clinicopathological and molecular profile of male breast cancer at the Uganda Cancer Institute.,
Uganda 2025-02-07 17:49:22 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Andrea Spray Lynn
ID: UNCST-2023-R007304
Maternal mental health and early childhood development in Kawempe
REFNo: HS5448ES

PRIMARY: To assess the associations between symptoms of common MMH conditions (depression and anxiety) and child care practices and outcomes (physical growth and ECD) in the Kawempe Division of Kampala, Uganda.
SECONDARY: To assess the associations between symptoms of common MMH conditions (depression and anxiety) and underlying individual, interpersonal, and household factors.
SECONDARY: To explore what "mental health" means to mothers of children under two years of age currently living in Kawempe, how their mental health effects their daily life; the activities they do that contribute to "good" and "bad" mental health.
TERTIARY / EXPLORATORY: To determine the prevalence of common MMH conditions (depression and anxiety) in the KYC catchment area.
TERTIARY / EXPLORATORY: To create Luganda versions of the CREDI, GSED, RSES, PSS, and CFAT.
TERTIARY / EXPLORATORY: To compare the CREDI and GSED tools for measuring ECD in this context.
USA 2025-02-07 17:47:50 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
MIRIAH KEMIGISHA
ID: UNCST-2022-R009927
Evaluating Ventricle Size and Shunt Failure Rates in Ugandan Children Shunted Early in Life
REFNo: HS5382ES

General objective
To study proximal shunt obstruction and its predictors among patients with hydrocephalus secondary to myelomeningocele or encephalocele at CCHU from 2010 to 2023.

Specific Objectives.

1.To determine the rate of proximal obstruction among shunted patients with hydrocephalus secondary to myelomeningocele or encephalocele.
2.To determine the incidence of small ventricles among shunted patients with hydrocephalus following myelomeningocele or encephalocele closure.
3.To assess if ventricle size and catheter environment can predict proximal shunt failure in shunted patients with hydrocephalus secondary to myelomeningocele or encephalocele.

Uganda 2025-02-07 17:46:28 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JOYCE NAMWASE
ID: UNCST-2024-R005002
ACCEPTABILITY, FEASIBILITY AND EFFECTIVENESS OF INVOLVING LAY HEALTH WORKERS IN RECOGNIZING AND LINKING PEOPLE WITH ALCOHOL USE DISORDER TO PRIMARY HEALTH CARE PROVIDERS
REFNo: HS5364ES

1.
To explore the perceived capability, opportunities, and motivation of LHWs to identify AUD in Ibanda district, southwestern Uganda.
2.
To implement a strategy of training lay health workers in the use of CAGE screening tool to identify AUD in Ibanda district, southwestern Uganda.
3.
To evaluate the acceptability, appropriateness, and feasibility of involving LHWs in screening for AUD in the community of Ibanda district, southwestern Uganda
Uganda 2025-02-07 17:44:48 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Clare Bangirana Ahabwe
ID: UNCST-2021-R012842
UBUMWE 2.0 Integrating Arts for Education and Psychosocial Support with Children & Youth affected by Displacement in Uganda
REFNo: SS3567ES

1. To document how the Ubumwe curriculum influenced the roles and responsibilities of the teachers;
2. To identify additional teacher professional development opportunities that teachers feel are needed to be successful in teaching the Arts;
3. To explore the ways in which the art curriculum impacted Learners’ academic and psychosocial development;
4. To assess overall feasibility, acceptability, strengths and limitations of the Ubumwe curriculum for teachers.

Uganda 2025-02-07 17:43:07 2028-02-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Benard Nsubuga
ID: UNCST-2024-R002324
Factors influencing the availability and use of Electronic Medical Records Systems in Public Health Facilities in Uganda: A landscape assessment
REFNo: HS5379ES

i. Assess the extent of EMR adoption in public health facilities.
ii. Identify the types of EMR systems currently in use.
iii. Evaluate the functionality and integration of existing EMR systems.
iv. Understand the challenges and barriers to effective implementation of EMR integration.
v. Identify the factors influencing the use and adoption of EMR systems in public health facilities.
vi. Provide recommendations for enhancing EMR adoption and utilization.

Uganda 2025-02-07 17:42:08 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Prossy Bibangambah Kyasimire
ID: UNCST-2024-R002215
Pericoronary Adipose Tissue, Inflammation, and Subclinical Coronary Artery Disease in People with HIV in Uganda
REFNo: HS5418ES

Aim 1: Perform CCTA -based segmentation of PCAT (1a) and compare the density between PWH and PWOH (1b) in Uganda.
Aim 2: Extract PCAT radiomics features (2a) and compare differences in PCAT radiomics signatures between PWH and PWOH (2b) in Uganda.
Aim 3: Determine whether the PCAT density (from Aim 1) or radiomics signatures (from Aim 2) improve the performance of cardiovascular risk prediction in Uganda.
Uganda 2025-02-07 17:38:35 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Flavia Matovu Kiweewa
ID: UNCST-2021-R013337
Bone Health in Older Ugandan Women with and without HIV
REFNo: HS5455ES

To examine bone mineral density (BMD) and body composition in older (peri-menopausal and postmenopausal) African women who are living with HIV and taking antiretroviral therapy (ART) drugs compared to women representing similar age and background characteristics who are HIV-negative.
Uganda 2025-02-07 17:30:13 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jennifer Serwanga
ID: UNCST-2024-R002056
Universal Protocol for Standardizing emerging Assays and Advancing vaccine Immunogenicity Assessments for Emerging and Re-emerging viral Threats through UVRI’S Partnership with the coalition for Epidemic Preparedness Innovations (CEPI)’s Centralized Clinical Laboratory Network (CLN).
REFNo: HS5330ES

To standardize and accelerate the evaluation of vaccine candidates against CEPI priority diseases, including Ebola, Marburg, Lassa, Nipah, Rift Valley Fever, SARS-CoV-2, MPOX and unidentified emerging threats, by leveraging UVRI's infrastructure and expertise.

To contribute to accelerated global vaccine development and licensure by ensuring rapid, accurate, and consistent data generation, while enhancing regional outbreak preparedness through technology transfer and capacity building.
Uganda 2025-02-04 8:15:09 2028-02-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ronald  Bahati
ID: UNCST-2023-R007024
NAVIGATING MENTAL HEALTH IN SCHOOLS PROJECT: EDUCATORS’ MENTAL HEALTH LITERACY CONCERNING ANXIETY, DEPRESSION AND NON-SUICIDAL SELF INJURY
REFNo: HS5381ES

To ascertain the educators’ confidence in providing help to affected school aged adolescents in selected schools in southwestern Uganda.,3. To assess educators’ level of mental health literacy about non-suicidal self-injury among school aged adolescents in selected schools in southwestern Uganda.,2. To assess educators’ level of mental health literacy about depression among school aged adolescents in selected schools in southwestern Uganda,1. To assess educators’ level of mental health literacy about anxiety among school aged adolescents in selected schools in southwestern Uganda,To assess educator’s mental health literacy about anxiety, depression and non-suicidal self-injury and their confidence in providing help to affected school aged adolescents in selected schools in southwestern Uganda.,
Uganda 2025-01-31 8:00:54 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Shevin  Jacob Thomas
ID: UNCST-2022-R010715
The Sub-Saharan Africa ConsorTium for the Advancement of Innovative Research and Care in Sepsis (STAIRS) Cohort Study: A prospective multi-country network cohort of hospitalized sepsis patients
REFNo: HS5205ES

1. Describe the cohort’s epidemiologic, sociodemographic, clinical and management characteristics and to identify risk factors for disease severity and outcomes. 2. Characterize etiologic (and antimicrobial resistance patterns when relevant) and host response profiles and to evaluate their potential associations with clinical presentation, disease severity and outcome. 3. Determine the performance characteristics of innovative sepsis diagnostic platforms for pathogen identification, host response profiling and risk stratification in comparison with diagnostic testing available for usual care (including blood culture and existing sepsis scores).
USA 2025-01-31 7:59:00 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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