Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Martin Hasselmann
ID:
The molecular mechanisms underlying local adaptation to high elevation habitats in the honey bee Apis mellifera
REFNo: NS350ES

The overall objective is to obtain a better understanding of the molecular mechanisms that have driven the local adaption of mountain honey bees.

The research plan is divided into a sequence of different complementary approaches that will
1.) Unravel the evolutionary history of chromosomal rearranged regions contributing to the genetic differentiation of mountain honeybees,
2.) Gain insight into key regulators and gene networks underlying the local adaption of honeybees,
3.) Specifically analyze the role of octopamine ? receptors and further candidate genes as key players for local adaptation to elevation (mainly temperature) in honey bees.

Germany 2022-07-14 12:35:17 2025-07-14 Natural Sciences Non-Clinical Trial Degree Award
Katungi Ninsiima Remmy Brian
ID:
Assessment of Alternative Rites of Passage Interventions implemented by UNFPA/UNICEF Joint Programme on the Elimination of Female Genital Mutilation in Uganda
REFNo: SS1352ES

Specific objective 4: Assess the impact and sustainability of ARPs in fostering FGM abandonment and promoting egalitarian gender norms, attitudes, and behaviours among community members, by: a) assessing whether previous ARP cohorts have sustained any changes b) assessing whether communities who have undergone or are undergoing ARPs have the commitment and capacity to continue ARPs (rather than FGM) c)identifying lessons for replication/scaling up of ARP interventions (including, for example, what needs to be in place for particular ARPs to be implemented in future or in other contexts),Specific objective 3: Assess the effectiveness of ARPs in achieving positive outcomes, including: a) increasing girls’ knowledge of FGM-related issues including sexual and reproductive health, prevention of gender-based violence, and child marriage b) Promoting positive attitudes and behaviours among girls in relation to FGM and sexual and reproductive health, gender-based violence and child marriage. c) promoting social norm change within communities, including promoting egalitarian gender norms among girls, boys, parents, elders and community leaders,Specific objective 2: Assess the coherence (in terms of compatibility) of ARPs with other interventions to end FGM by implementing partners or other stakeholders in the geographical region, including by: a) identifying synergies and interlinkages between ARPs and other interventions to end FGM that are either carried out within or are expected to affect the same communities b) analysing the extent to which other interventions (including, for example, policy advocacy) support or undermine ARPs, and vice versa c )assess the consistency of the intervention with other interventions in/affecting the same contexts, including coordination with others, and the extent to which the intervention is adding value while avoiding duplication of effort,Specific objective 1: Assess the relevance of ARPs to the aim of eliminating FGM, by: a) describing the context of ARP interventions, with specific attention paid to the significance and symbolic meaning within communities of girls’ initiation rites or coming of age ceremonies b) identifying the intervention models (operating structure and procedures) of ARPs, and the roles of various community institutions and actors (such as parents, and religious and community leaders) engaged in ARPs c) analyzing if (and why/why not) specific ARPs meet community needs and are a relevant approach to include in programming to eliminate FGM d) analyzing the extent to which framing interventions as an ARP bring added value, over and above delivering the intervention under non-ARP rubric (including, for example, exploring whether framing life skills courses with graduation ceremonies as ARPs brings added value, or whether it introduces extra risk of the intervention being rejected),The primary objective of this evaluation is to provide an assessment of whether ARPs ‘work’ has been successful in promoting FGM abandonment, based on evidence of their relevance, coherence, effectiveness, impact and sustainability.,
Uganda 2022-07-13 17:13:28 2025-07-13 Social Science and Humanities Non-Clinical Trial Non-degree Award
Moffat  Nyirenda Joha
ID: UNCST-2020-R019333
Development and Evaluation of an Integrated Community-based Management Model for HIV, Diabetes, and Hypertension in Tanzania and Uganda (The INTE-COMM study)
REFNo: HS2278ES

To determine the effectiveness of community-based integrated management of HIV, diabetes, and hypertension in comparison to clinic-based integrated management of these conditions in terms of patient outcomes, acceptability, and potential cost-effectiveness.
Malawi 2022-07-13 16:33:33 2025-07-13 Medical and Health Sciences Clinical Trial Non-degree Award
Jackson Mukonzo
ID: UNCST-2021-R013916
Ivermectin-artemisinin Combination Therapy for Eradication of Malaria
REFNo: HS2081ES

Main Objective: 1. To investigate the effect of ivermectin adjunct therapy on household transmissibility of malaria from malaria-infected patients receiving artemether /lumefantrine Specific objectives 1. To determine the household malaria transmissibility within one month of IVN and artemether / lumefantrine therapy. 2. To determine the structural similarity of the nanopore plasmodium sequences between infecting plasmodium species isolated from the index patient and other household malaria positive patients. 3. To assess the safety of ivermectin-artemether/lumefantrine in malaria-infected patients.
Uganda 2022-07-13 16:29:55 2025-07-13 Medical and Health Sciences Clinical Trial Non-degree Award
Eleanor  Brown Lucy
ID:
A sex and gender-based analysis of access to Vitamin A programmes in four sites in Uganda
REFNo: HS2320ES

The overall objective of the SGBA is to identify gender inequalities and inequities, as well as associated barriers and needs, which affect access and uptake of Vitamin A supplementation programmes. The SGBA will also identify strengths and opportunities and provide recommendations to make VAS programmes more gender responsive.

1. To identify the gender equality issues that influence access to preventative health and nutrition services for child survival, and the quality of services provided.
2. To assess the level of gender mainstreaming in the design of preventative health nutrition services for child survival such as VAS, their implementation and MEAL system and indicators.
3. To identify potential opportunities and enablers and provide recommendations to increase the level of gender responsiveness in preventative health and nutrition services for child survival programming models such as the VAS programme.
4. To explore how COVID-19 affected access to and use of preventative health and nutrition services for child survival programme areas, including VAS programmes, and to provide recommendations for gender-sensitive support to both programme beneficiaries and key services providers and promoters at health facility and community levels.

UK 2022-07-13 10:48:27 2025-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Elizabeth Ayebare Ombeva
ID: UNCST-2020-R003666
Translation and validation of the Perinatal Grief Intensity Scale in Kenya and Uganda
REFNo: HS2296ES

1. To perform a culturally sensitive translation and adaptation of the Perinatal Grief Intensity Scale in Kiswahili and Luganda 2. To assess validity and reliability via face, content and construct validity and internal consistency 3. To obtain statistical estimates pertaining to the use of the tool
Uganda 2022-07-13 10:47:29 2025-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
Sentinel Surveillance of Acute Febrile Illness (AFI) in Regional Referral and District Hospitals in Uganda
REFNo: HS2277ES

Identify etiologies and define the epidemiology of AFI among children, adolescents and adults attending referral hospitals in Uganda.
Build and strengthen sustainable surveillance, laboratory, and information systems to improve epidemic intelligence across multiple priority outbreak-prone febrile illness in Uganda.

Nigeria 2022-07-13 10:45:57 2025-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Maureen Sylvia Kusiima
ID:
Multisectoral maternal and child healthcare financing in Uganda
REFNo: SS1355ES

To develop a multisectoral MCH financing policy framework that can enable adequate funding for MCH programmes and interventions aimed at improving the MCH services and reducing maternal and child mortality by 2030.,To analyse the major determinants of enrolment of women and children for CBHIs to enable policymakers to adopt the best strategies for increasing enrolment and raise adequate MCH funds. ,To examine the relationship between Uganda’s healthcare financing strategy and access to MCH services that will inform decision making in MCH financing in Uganda.,To explore international best practices regarding multisectoral MCH financing strategies to gain knowledge and inform the development of a multisectoral MCH financing policy framework for Uganda.,
Uganda 2022-07-13 10:42:17 2025-07-13 Social Science and Humanities Non-Clinical Trial Degree Award
Moses Joloba
ID:
Improving the TB/HIV Clinic-Laboratory Interface in Uganda
REFNo: HS2162ES

The overall goals of this project include: (1) Improve TB case finding and TB treatment among eligible persons in Uganda (2) Improve time-to-TB diagnosis and time-to-TB therapy or treatment initiation among HIV-positive and HIV-negative persons with presumptive or confirmed TB in Uganda.

To achieve the above goals, CLICQ! – ECHO implementation has four major objectives:
1. LAB TESTING SERVICES
Increase the number and proportion of HIV-positive and HIV-negative persons with presumptive TB that receive TB laboratory testing services and/or accurate test results in a timely manner.

2. INITIATE APPROPRIATE TREATMENT
Increase the number and proportion of HIV-positive and HIV-negative TB patients that initiate appropriate (drug-sensitive or drug-resistant) TB treatment.

3. TURNAROUND TIMES
Reduce turnaround times associated with TB laboratory receipt of specimens for testing, lab-confirmation of TB disease, and return of TB laboratory test results and/ or initiation of appropriate TB therapy.

4. DiCE ASSESSMENTS ALONE VERSUS DiCE ASSESSMENTS WITH CQI TRAINING
Quantify the value of providing sites DiCE assessments alone versus providing sites DiCE assessments plus 2 learning sessions that are strengthened with weekly, ECHO-based, mentorship as well as ad hoc consultations via WhatsApp.

Uganda 2022-07-13 10:41:00 2025-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Judith Owokuhaisa
ID: UNCST-2022-R011528
Transfer of care from hospital to outpatient and community settings for older people with diabetes mellitus/hypertension( DM/HTN) in south western Uganda
REFNo: HS2304ES

To explore experiences of older people with DM/HTN and their caregivers about transition of care to the community and self-management of health problems after discharge.,To explore the barriers and facilitators to discharge planning and transition of care for older people with DM/HTN.,General objective To describe the transfer of care from hospital to outpatient and community settings for older people with diabetes mellitus/ hypertension( DM/HTN) in south western Uganda.,
Uganda 2022-07-12 12:37:00 2025-07-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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