Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Simons  Ezajobo
ID: UNCST-2021-R012010
Uptake of HIV Testing Services through Assisted Partner Notification (APN) among Men in Wakiso District.
REFNo: HS2537ES

2.To understand the preferred partner notification approaches to help men feel more comfortable and confident in getting tested for HIV.,1.To assess the experience of males during the process of HIV testing services provision.,To identify barriers and facilitators to HIV testing among men in Uganda,
Uganda 2022-11-08 13:23:56 2025-11-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Catriona  Waitt John
ID: UNCST-2019-R001068
PHARMACOKINETICS OF DRUGS USED TO TREAT UNCOMPLICATED MALARIA IN BREASTFEEDING MOTHER-INFANT PAIRS
REFNo: HS2392ES

Primary Objectives;
1. To define transfer of lumefantrine and its active metabolite, desbutyl-lumefantrine from mother to breastfed infant.
2. To determine the clearance, AUC, and volume of distribution of lumefantrine and desbutyl-lumefantrine
Secondary Objectives
1. To describe covariates influencing drug exposure in maternal plasma, breast milk and infant plasma
2. To develop a population pharmacokinetic model including the breast and the infant as compartments, which will both enable optimal use of sparse data from future studies and enable simulations of different doses or combinations.
3. To assess depression and anxiety levels among breastfeeding mothers on first line antimalarial drugs.
4. Beliefs about medicines in breastfeeding mothers receiving antimalarial treatment



UK 2022-11-04 16:05:41 2025-11-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Dinah Amongin
ID: UNCST-2020-R014663
Innovations for continuity of HIV, TB and malaria services during the COVID-19 pandemic in Uganda
REFNo: HS2477ES

The goal of this research is to collate and assess the impact of innovative people-centred and community-based approaches adopted during the covid-19 pandemic to ensure continued HIV, TB and malaria services in Uganda. This will inform the ongoing and future pandemic/epidemic response actions.
Specific objectives are:
1. To identify innovations used to mitigate the impact of the covid-19 pandemic on the provision, access, and utilization of HIV, TB and Malaria services in Uganda.
2. To assess the impact of innovations to mitigate the impact of the COVID-19 pandemic on HIV, TB, and Malaria services provision, access, and utilization.
3. To document the lessons learnt in innovating to mitigate the impact of COVID-19 on HIV, TB and malaria services in Uganda during the pandemic.

Uganda 2022-11-03 12:21:51 2025-11-03 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Albert Munyeshyaka
ID:
Cosmological studies in modified Gauss-Bonnet gravity
REFNo: NS434ES

To determine evolution of overdensities and velocity perturbations in f (G) grav- ity,To analyse perturbations of a Chaplygin gas model in f (G) gravity,To analyse covariant velocity and overdensities of quasi-Newtonian cosmological model in f (G) gravity,To derive evolution of 1 + 3 covariant linear perturbation equations in f (G) gravity.,The aim of this study is to explore cosmological studies in modified Gauss-Bonnet gravity.,
Rwanda 2022-11-03 12:09:30 2025-11-03 Natural Sciences Non-Clinical Trial Degree Award
MICHAEL JACKSON WAKWABUBI
ID:
Financial distress in local governments in Uganda
REFNo: SS1429ES

To establish the relationship between local government delivery system and financial distress in local governments in Uganda To assess the relationship between revenue concentration and financial distress in local governments in Uganda To examine the relationship between revenue concentration, local governance, corruption and LG delivery system in local governments in Uganda To assess the mediating effect of LG delivery system in the relationship between revenue concentration, local governance, corruption and financial distress in local governments in Uganda To establish the relationship between local governance and financial distress in local governments in Uganda To establish the relationship between corruption and financial distress in local governments in Uganda
Uganda 2022-11-03 11:38:10 2025-11-03 Social Science and Humanities Non-Clinical Trial Degree Award
Hannah Kibuuka
ID: UNCST-2020-R014355
‘Remdesivir: Monitored Emergency Use for Filoviral Disease’
REFNo: HS2531ES

To offer patients with laboratory-confirmed filovirus disease (e.g. Ebola virus [EBOV], Bundibugyo virus [BDBV], Marburg virus [MARV] disease, and Sudan virus [SUDV]) under the clinical supervision of the protocol Principal Investigator or their designated physicians, access to treatment with Remdesivir under monitored conditions.
Uganda 2022-11-02 17:30:52 2025-11-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eugene Ruzagira
ID: UNCST-2023-R008282
Efficacy, Safety and Effectiveness of Injectable Cabotegravir/Rilpivirine in Improving HIV Control in Sub-Saharan Africa: A pragmatic Phase 3 Open-label Randomized Controlled Trial.
REFNo: HS2475ES

Primary objective:
To demonstrate the non-inferior efficacy of switching to every 2 months (Q2M) intramuscular (IM) injection of cabotegravir (CAB) long acting (LA) plus rilpivirine (RPV) LA compared with continuation of first-line oral ART over 12 months in people living with HIV (PLHIV) with a history of, or at risk of, sub-optimal HIV control.

Secondary objectives:
1) To demonstrate the antiviral activity and the impact on retention in HIV care of switching to Q2M CAB LA + RPV LA compared with continuation of oral ART over 12 and 24 months in PLHIV with a history of, or at risk of, sub-optimal ART adherence or engagement in care.

2) To demonstrate the immunological activity of switching to Q2M CAB LA + RPV LA compared with continuation of oral ART over 12 and 24 months in PLHIV with a history of, or at risk of, sub-optimal ART adherence or engagement in care. This will be measured through change in CD4+ T cell count and incidence of HIV disease progression.

3) To evaluate the safety and tolerability of switching to Q2M CAB LA + RPV LA compared to continuation of oral ART.

4) To assess genotypic viral resistance in participants experiencing protocol-defined confirmed virological failure (plasma HIV-1 RNA >200 c/ml) and its impact on future treatment options including proportion who resuppress on dolutegravir.

5) To evaluate the effect of Q2M CAB LA + RPV LA on health-related quality of live, treatment satisfaction and treatment adherence. To describe cost-effectiveness and acceptability of the regimen.

Uganda 2022-11-02 17:27:11 2025-11-02 Medical and Health Sciences Clinical Trial Non-degree Award
Clare Bangirana Ahabwe
ID: UNCST-2021-R012842
Violence Against Children and Youth Surveys (VACS) Cognitive Testing of Gender Attitude and Norm Measures Among Youths in Humanitarian Settings in Uganda
REFNo: SS1486ES

• To evaluate participants’ interpretation of the gender measures, consider and weigh relevant aspects of their lives and formulate a response based on those considerations.
• To test and refine gender measures that are understandable to 13-24-year-old study participants for inclusion in the core VACS questionnaire and future VACS administration.
• To identify context specific relevance of proposed gender measures in the administration of VACS in a humanitarian setting within Uganda.

Uganda 2022-11-02 10:14:05 2025-11-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Achilles Kiwanuka
ID:
Comparative Analysis of Health Information Systems Approaches in Use in Uganda
REFNo: HS2521ES

1. Describe the achievements, challenges, lessons learned and prospects for using the paper based HMIS, Smart Paper Technology and fully digitalized approaches for managing health information in Uganda.
2. Assess performance, usability and functionality of the fully digitalised and paper based HMIS approaches at the community level and Smart Paper Technology at the health facility level using the Performance of Routine Information System Management (PRISM) framework.
3. Analyze the cost benefit of using Smart Paper Technology and fully digitalised approaches of health information systems in Uganda.
4. Analyze the cost effectiveness of using Smart Paper Technology and fully digitalised approaches over the paper based HMIS for managing health information in Uganda.
5. Assess the impact on the budget after adopting Smart Paper Technology or fully digitalised approaches for managing health information with a focus to community health information systems in Uganda.
6. Evaluate the scalability of the Smart Paper Technology and fully digitalised approaches considering geographic scale and integration with other HMIS components

Uganda 2022-11-01 18:27:02 2025-11-01 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Okee Margaret Jill
ID:
USING INFORMATION AND COMMUNICATION TECHNOLOGY FOR LEARNING ENHANCEMENT IN HIGHER EDUCATION INSTITUTIONS: CASE OF KAMPALA METROPOLITAN AREA
REFNo: SIR144ES

1.To determine the relationship between e-learning pedagogy and learning enhancement.
2.To determine the relationship between motivation of students and learning enhancement.
3.To determine the relationship between ICT systems characteristics and learning enhancement.
4.To determine the combined effects of the relations of e-learning pedagogy and ICT systems characteristics on motivation of students.
5.To determine the combined effects of the relationships of e-learning pedagogy, motivation of students and ICT characteristics on learning enhancement.
6.To establish the intermediating role of the e-learning policy between institutional support and learning enhancement.
Uganda 2022-10-31 15:34:11 2025-10-31 Engineering and Technology Non-Clinical Trial Degree Award
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