Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Betty Akwongo
ID: UNCST-2021-R003759
BIOACTIVITY AND SAFETY OF MEDICINAL PLANTS USED IN THE MANAGEMENT OF CANDIDIASIS IN PADER DISTRICT, NORTHERN UGANDA
REFNo: NS929ES

Main objective: To document and investigate the efficacy and safety of medicinal plants used for treatment of candidiasis in Pader district.

Specific objectives:
1.Document medicinal plant species used to treat candidiasis in Pader District
2.Determine the antifungal activity of priority plants against Candida albicans, Candida glabrata and Candida tropicalis.
3.Evaluate the acute and subacute toxicity of the most active plant species used for treatment of candidiasis.

Uganda 2025-03-10 16:12:24 2028-03-10 Natural Sciences Non-Clinical Trial Degree Award
Betty Akwongo
ID: UNCST-2021-R003759
Inventory of Medicinal and Nutraceutical Plants of West Nile Region for Establishment of Botanical Garden in Muni University, Northern Uganda
REFNo: NS931ES

1. To carry out ethno-botanical survey of medicinal and nutraceutical plants used for management/ treatment of various diseases in West Nile region, Northern Uganda.
2. To document usage of medicinal and nutraceutical plants of West Nile region so as to conserve and preserve the traditional indigenous knowledge
3. To find out the ecology of the medicinal and nutraceutical plants of West Nile region to guide future creation of botanical garden

Uganda 2025-03-10 13:46:41 2028-03-10 Natural Sciences Non-Clinical Trial Non-degree Award
Okello Ronald
ID: UNCST-2024-R002778
Board of Governors Outlook and the Educational Performance of Catholic-Founded Schools in Uganda
REFNo: SS3659ES

i) To establish the influence of board independence on the educational performance of Catholic founded Grant Aided Secondary Schools in Uganda.
ii) To determine the influence of board composition on the educational performance of Catholic founded Grant Aided Secondary Schools in Uganda.
iii) To examine the head teacher’s role duality and its influence on the educational performance of Catholic founded Government Aided Secondary Schools in Uganda.

Uganda 2025-03-10 13:44:32 2028-03-10 Social Science and Humanities Non-Clinical Trial Degree Award
Kishaija Noel
ID: UNCST-2024-R004309
Assessing the impact of climate change on farming systems and livelihoods of smallholder coffee farmers in Southwestern Uganda
REFNo: A551ES

i. To document production systems, livelihood sources, and climate change adaptation practices among smallholder coffee farmers in Southwestern Uganda
ii. To determine how climate change has changed coffee farming systems among smallholder coffee farmers in Southwestern Uganda
iii. To determine the relationship between livelihood components and climate change adaptation strategies among smallholder coffee farmers in Southwestern Uganda
iv. To determine the relationship between gender and climate change adaptation strategies among smallholder coffee farmers in Southwestern Uganda
v. To recommend policy interventions that will enhance the sustainability of smallholder coffee production

Uganda 2025-03-10 13:29:02 2028-03-10 Agricultural Sciences Non-Clinical Trial Degree Award
Josephine Akellot
ID: UNCST-2024-R016329
Applying findings from prior mental health training and supervision research in rural Ugandan settings: a transdisciplinary research proposal
REFNo: SS3626ES

1. To explore retrospective and future-looking stakeholders’ perspectives on the scope and complexity of task-shifting training and supervision in mental health care
2. To explore retrospective and future-looking policy voice-over the strategy to follow before, during and after task-shifting training and supervision in mental health care

Uganda 2025-03-10 13:24:40 2028-03-10 Social Science and Humanities Non-Clinical Trial Degree Award
Elizabeth Ekirapa
ID: UNCST-2020-R014390
Opt-AMR: Optimizing Antibiotic Usage to Mitigate AMR
REFNo: HS5547ES

Aim: To develop a metric and evidence use process for improving the management of childhood febrile illness in community settings.

Objectives
1) Investigate associations of QoC in a sample of healthcare facilities (HCFs) with AMR to key antibiotics used for febrile illnesses in children.
2) Assess the risk of AMR development through analysis of genomic traits from samples collected in study sites; determine future risk of resistance development.
3) Use mixed methods to investigate community level health system drivers of ABU and AMR at the district level with particular focus on febrile illnesses.
4) Develop a rapid and recurrent surveillance system of ABU and AMR prevalence and of community voices in districts for evidence-based improvement of health system strategies and policies.
Uganda 2025-03-10 13:18:54 2028-03-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jamil Wesigomwe Mohammed
ID: UNCST-2024-R015957
Understanding Conflicts in the Management of Construction of Public Water Works Projects in Uganda
REFNo: SS3725ES

vi. To develop a robust model for efficient and effective conflict management in construction of public water works projects in Uganda,v. To assess the effectiveness of the existing conflict management approaches in the management of construction of public water works projects in Uganda.,iv. To examine the consequences of administrative conflict in the management of construction of public water works projects in Uganda.,iii. To assess the effect of technical conflict in the management of construction of public water works projects in Uganda.,ii. To evaluate the influence of contractual conflict in the management of construction of public water works projects in Uganda.,i. To determine the effect of behavioural conflict in the management of construction of public water works projects in Uganda.,The main objective is to investigate the sources of conflicts in the management of construction of public water works projects in Uganda and devise effective conflict management strategies. ,
Uganda 2025-03-10 13:13:56 2028-03-10 Social Science and Humanities Non-Clinical Trial Degree Award
Godfrey  Siu
ID: UNCST-2021-R005439
Reducing violence against children and intimate partner violence in Uganda: Feasibility Study of Digital Delivery of the Parenting for Respectability Programme
REFNo: HS5488ES

Overall research objective
The overarching objective of the study is to test the readiness, feasibility, and initial effectiveness of the PfR-App in reducing VAC, IPV, and optimising male engagement in order to lay grounds for a Randomised Controlled Trial (RCT) and eventual wider scale-up of the programme.
The specific objectives are to:
1. Assess users’ and facilitators’ perspectives and experiences, acceptability and satisfaction with the PfR-App functionality across contexts and sub-populations.
2. Use the in-app data collection tool to measure evidence of the initial effectiveness of the app by evaluating at the immediate post-test the effect of the digital intervention on knowledge, attitude and practices in parenting.
3. Compare different population characteristics and different delivery options on parents’ engagement with the App and evidence of initial effectiveness, acceptability, attrition, relevance, engagement, usability, and satisfaction.
4. Test the impact of the design features and content of the PfR-App on initial parental engagement and retention in order to achieve the highest possible fidelity/participation rates in the one month after enrolment and use it to improve the App experience for target users.
5. Test the impact of various factors including the timing, frequency, length and order of sessions, push notifications and in-App survey questions on engagement and response rates in order to implement the most effective strategies to achieve the highest possible engagement and retention rates, including optimising male engagement.


Uganda 2025-03-10 13:12:40 2028-03-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
KEVIN ABER
ID: UNCST-2024-R002518
Microservice Framework for Research Data Management: A Case of Interdisciplinary Research Project-UPCHAIN
REFNo: SIR465ES

To validate MF-RDM using the RDMS,To implement the Research Data Management System (RDMS) based on the developed MF-RDM framework.,To design a Microservice Framework for Research Data Management (MF-RDM).,To determine data requirements for RDM based on the work package in the UPCHAIN interdisciplinary research project.,To develop a scalable Microservice Framework for Research Data Management (MF-RDM).,
Uganda 2025-03-10 13:02:30 2028-03-10 Engineering and Technology Non-Clinical Trial Degree Award
Robert Odendi Gideon
ID: UNCST-2024-R002130
ALCOHOL USE, COGNITIVE FUNCTIONS, AND DEMENTIA SUSCEPTIBILITY AMONG ADOLESCENTS IN IBANDA AND LIRA DISTRICTS, UGANDA
REFNo: HS5517ES

4. To explore the proposed approaches to address adolescent alcohol use in Uganda.,3. To explore the perceptions regarding alcohol use among adolescents in Uganda. ,2. To assess the factors associated with cognitive impairment and risky behavioural patterns among adolescents with alcohol use in selected regions of Uganda,1. To determine the prevalence of cognitive impairment and risky behavioural patterns among adolescents who use alcohol in selected regions of Uganda.,To determine the prevalences and factors associated with cognitive impairment and risky behavioral patterns among adolescents who use alcohol, and explore the perceptions of alcohol use among adolescents, and proposed interventions to address adolescent alcohol use in Uganda,
Uganda 2025-03-10 12:54:08 2028-03-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ronald Nkangi
ID: UNCST-2021-R012153
ASSESSMENT OF VACCINE RESPONSES IN 3D TONSIL CULTURES
REFNo: HS5501ES

1. Assess humoral and cellular responses to vaccines and evaluate the vaccine induced metabolic profiles.
2. Modulate vaccine responsiveness using metabolic and immunologic modulatory compounds.
Uganda 2025-03-10 12:47:51 2028-03-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jafesi Pulle
ID: UNCST-2020-R014213
Defining the Risk Factor Cascade in Rheumatic Heart Disease
REFNo: HS5503ES

Aim 1: Identify modifiable risk factors for developing RHD using prospective population case-control methodologies. Aim 2: Determine the independent and joint contributions of multi-level risk factors for RHD among children and adults in Uganda. Aim 3: Establish a biobank of RHD patients' tissue samples for future RHD research studies.
Uganda 2025-03-10 12:29:08 2028-03-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Schola  Matovu Nakachwa
ID: UNCST-2022-R011040
Development and Testing of BAJJAJJA: An Intervention to Promote Economic Empowerment and Health of Grandmothers who Provide Primary Care for Grandchildren in Uganda
REFNo: SS3611ES

Main Objective
The study’s objective is to refine and test the feasibility and acceptability of my innovative intervention, BAJJAJJA: Building A Joint Action for JaJJAs which couples an income- generating activity (IGA) with nurse-facilitated group health coaching. This objective is informed by the NIH Stage Model of behavioral intervention development.

Specific Objectives
Aim 1: To refine and adapt the BAJJAJJA intervention through a collaborative and iterative feedback process with a diverse community group of 18 members. In a series of sessions, I will iteratively engage diverse community groups (nurses, local officials, IGA experts, and GMCs) and use cognitive interviewing to gain feedback on the appropriateness of study measures, content, delivery, and intervention format.
Aim 2: To test the feasibility, acceptability, and preliminary efficacy of the BAJJAJJA intervention in improving economic and health outcomes among 24 Ugandan GMCs. Over a 12-month period and at three time points of assessment, I will use a mixed methodology with a quasi-experimental design to collect data that will be examined to assess the feasibility, acceptability, and preliminary efficacy of the intervention on participants’ household income and health outcomes.
Aim 3: To explore the barriers and facilitators to (3a) maintenance of the BAJJAJJA individual intervention benefits (e.g., physical activity level and frequency) and (3b) sustainability of the IGA activities (e.g., grandmothers’ accessing external supports such as community resources) at 6 months post-intervention. Following a mixed methods approach, the 24 GMCs from Aim 2 will be interviewed to further evaluate the long-term maintenance and sustainability of the intervention. Health assessments, interviews, and IGA site visits will be used to explore the intervention outcomes and benefits at 6 months post-intervention.

USA 2025-03-10 12:23:29 2028-03-10 Social Science and Humanities Clinical Trial Non-degree Award
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
Randomized trial to evaluate the efficacy and safety of select therapeutic agents in the treatment of Ebola Disease (TOKOMEZA - Ebola Disease Therapeutics)
REFNo: HS5686ES

This is an open-label, adaptive, randomised platform clinical trial to evaluate the impact of 278 potential treatments on mortality in patients with Ebola Disease
Uganda 2025-03-07 18:39:19 2028-03-07 Medical and Health Sciences Clinical Trial Non-degree Award
Shillah  Kwikiiriza
ID: UNCST-2021-R012682
Entrepreneurship among rural youth in the Kamuli district, Uganda,
REFNo: A575ES

I. Identify the specific entrepreneurship opportunities available for youth in the Kamuli district
II. Inform YEP of the potential entrepreneurship opportunities for improved and sustained youth livelihoods in Kamuli district.
Uganda 2025-03-07 18:36:02 2028-03-07 Agricultural Sciences Non-Clinical Trial Non-degree Award
Andrew Kanyike Marvin
ID: UNCST-2020-R014554
Exploring Fund-Pooling Peer-led Patient Support Groups among Hypertension and Diabetes Mellitus Patients in Public Health Facilities in Uganda.
REFNo: HS5668ES

1. To map out fund-pooling peer-led patient support groups for hypertension and diabetes patients at public health facilities in Uganda.

2. To explore the operational mechanisms faced by fund-pooling peer-led patient support groups for hypertension and diabetes patients at public health facilities in Uganda.

3. To explore the barriers and facilitators to hypertension and diabetes patient involvement in fund-pooling peer-led patient support groups at public health facilities in Uganda.
Uganda 2025-03-07 18:34:54 2028-03-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Shillah  Kwikiiriza
ID: UNCST-2021-R012682
Assessment of Vegetable Seed Production and Management Practices in Uganda
REFNo: A566ES

1. Determine and assess the existing seed production and management practices by local seed business owners and small-holder individual seed producers in Uganda.
2. evaluate opportunities and limitations associated with vegetable seed production, management, and marketing within seed sources that are readily available to smallholder vegetable growers in Uganda.

Uganda 2025-03-07 18:30:46 2028-03-07 Agricultural Sciences Non-Clinical Trial Degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY EVALUATING THE EFFICACY AND SAFETY OF INAVOLISIB IN COMBINATION WITH PHESGO→ VERSUS PLACEBO IN COMBINATION WITH PHESGO→ AS MAINTENANCE THERAPY AFTER FIRST LINE INDUCTION THERAPY IN PARTICIPANTS WITH PIK3CA‑MUTATED HER2‑POSITIVE LOCALLY ADVANCED OR METASTATIC BREAST CANCER (INAVO122)
REFNo: HS5649ES

This study will enrol particpants
Uganda 2025-03-07 18:26:49 2028-03-07 Medical and Health Sciences Clinical Trial Non-degree Award
ADENGO EMMANUEL
ID: UNCST-2024-R016315
EXPLORING THE FOSTERING OF GENERIC SKILLS AMONGST LEARNERS USING THE COMPETENCE-BASED CURRICULUM IN UGANDA: A CASE STUDY OF IGANGA DISTRICT
REFNo: SS3675ES

This study will be guided by the following research questions
i. How do lower secondary teachers perceive generic skills in the competence-based curriculum in Uganda?
ii. What pedagogical strategies are teachers employing in fostering generic skills using the competence-based curriculum in Uganda?
iii. What are the learners’ experiences in learning generic skills using the competence-based curriculum in Uganda?
Uganda 2025-03-06 15:52:22 2028-03-06 Social Science and Humanities Non-Clinical Trial Degree Award
DOROTHY ATUHURA
ID: UNCST-2024-R002023
A Study of the Lived Experiences of African Intersex Lives
REFNo: SS3670ES

1. Generate Indigenous Epistemologies: To cultivate and document local and indigenous knowledge and cultural perspectives surrounding biological variations in sex development.
2. Analyze Sociocultural Lived Experiences: To understand the lived experiences and sociocultural ramifications for individuals born with differences in sex development, highlighting their interactions within societal structures
3. Produce Knowledge and Create Awareness about Harmful Cultural Practices and Traditions: The study aims to document the harmful cultural practices surrounding variations in sex development and to contribute to the deconstruction of harmful stereotypes, stigmas, and cultural practices (including infanticide, exploratory rape and “breast ironing”) that adversely affect the quality of life for individuals with sex development differences
Uganda 2025-03-06 10:58:58 2028-03-06 Social Science and Humanities Non-Clinical Trial Non-degree Award
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