Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Anna  Vitari
ID: UNCST-2024-R002485
 The nature of the firm revisited: Documenting Relational Contracts within and between firms in Uganda
REFNo: SS3360ES

Our end objective is to shed light on the constraints that prevent a myriad of micro-entrepreneurs from turning into salaried workers hired by firms. This would contribute to our understanding of structural change and how it fundamentally hinges on a transformation in the organization of labor (Bandiera et al. 2022). Moreover, we aim to investigate whether the evidence points to the existence of multiple equilibria and, if so, what the transition phase of moving from one equilibrium to another involves. In doing this, we will also shed light on the role that policymakers can play in creating coordination devices to select the “good equilibrium,In this proposal, we seek to deepen our understanding of the dynamics and payoffs that govern relational contracts in different industries operating in Kampala, Uganda. This will enhance our knowledge of the barriers to firm growth and specialization in developing countries, a well-known puzzle in the literature on structural transformation and growth (Hsieh and Olken 2014). In particular, by documenting the nature of the relationships between and within firms, we aim to understand the organizational frictions that prevent firms from merging, a necessary condition for countries’ structural transformation. ,
 Italy 2025-05-14 9:36:07 2028-05-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Brenda Nakirya Doreen
ID: UNCST-2023-R006312
 Impacts of extreme rainfalls on access to SRHR services for adolescent girls and young women in Mayuge district Uganda: a Case Study
REFNo: HS5852ES

1. To assess the differences in the prevalence of adolescent girls accessing SRHR services in remote areas of Mayuge District during periods of extreme rainfalls compared to times of moderate rainfall or the dry seasons over the past two years. 2. To explore the effects of extreme rainfalls on AGYW access to SRHR services in remote areas of Mayuge District. 3. To identify existing and recommend strategies to ensure sustainable systems for continued provision of SRHR services for AGYW during periods of extreme rainfalls in Mayuge District.
Uganda 2025-05-14 9:34:07 2028-05-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Fred  Bulamba
ID: UNCST-2020-R014888
 Rule of THUMB: A multi-centre cluster trial evaluating the implementation of a perioperative care complex intervention to improve outcomes from haemorrhage during and after caesarean section in African hospitals
REFNo: HS5855ES

To evaluate the effect of the trial intervention on patient outcomes relevant to future trials.,To evaluate whether implementation of the ‘Rule of THUMB’ perioperative complex intervention increases risk assessment and improves diagnosis and compliance with proven interventions for haemorrhage during and after caesarean section.,
 Uganda 2025-05-14 9:24:07 2028-05-14 Medical and Health Sciences Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 EVALUATING THE FEASIBILITY OF PLASMA SEPARATION CARDS (PSC) AS AN ADDITIONAL SPECIMEN TYPE FOR THE ALINITY M HIV-1 ASSAY
REFNo: HS5963ES

The primary objectives of this protocol are to:
1) prospectively enrol and collect capillary PSC and venous PSC from subjects undergoing routine viral load monitoring at ART clinics, from subjects undergoing HIV-1 screening, and from subjects undergoing testing for CD4 counts. Note that plasma will also be collected and tested from each individual as part of routine test of record HIV-1 testing at CPHL.
2) perform testing of the PSC and plasma specimens using the Alinity m HIV-1 assay.
3) assess the following key performance attributes of the Alinity m HIV-1 assay testing PSC as a specimen type:
o correlation between Alinity m HIV-1 viral load from PSC and Alinity m HIV-1 viral load plasma
o clinical sensitivity and specificity for Alinity m HIV-1 viral load from PSC based on the agreement between Alinity m HIV-1 PSC results and Alinity m HIV-1 plasma results
o misclassification rates by Alinity m HIV-1 PSC results above and below the clinical threshold based on Alinity m HIV-1 plasma results
o suppression rates in participants based on Alinity m HIV-1 plasma and PSC results
The secondary objectives of the protocol are to:
1) Following Alinity m HIV-1 PSC testing, if the data analysis described above indicates promising performance and if sufficient left-over PSC spots are available, remaining PSC may be tested with another HIV-1 viral load test for which PSC is a claimed sample type (e.g., cobas HIV-1 Quantitative nucleic acid test for use on the cobas 6800/8800 Systems).
2) PSC results for the additional testing (if performed) will be analyzed for correlation to plasma results, clinical sensitivity and specificity, misclassification rates, and suppression rates to further determine if Alinity m PSC performance is equivalent to other HIV-1 testing technology.

Uganda 2025-05-14 10:16:37 2028-05-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mulemangabo Bisimwa
ID: UNCST-2025-R016823
 The Politics of Sustainable Energy Transition in Refugee Settlements: The case of Uganda
REFNo: SS3865ES

The research aims to examine the interactions between the top-down humanitarian energy system and the bottom-up community led-energy action, and how they shape sustainable energy access for displaced households in camp settings. Specifically, the research will address the following objectives: 1. To explore how the humanitarian system supports renewable energy access for displaced communities. 2. To examine the interrelationships between refugee-led energy initiatives and the international humanitarian agencies. 3. To examine how social interactions between refugee households and other energy stakeholders shape and influence the uptake of energy technologies and services in refugee camps.
Democratic Republic of Congo 2025-05-14 10:12:48 2028-05-14 Social Science and Humanities Non-Clinical Trial Degree Award
Richard Katuramu
ID: UNCST-2022-R011266
 OPTIMIZING LINKAGE OF PATIENTS WITH ADVANCED HIV DISEASE TO PRIMARY HIV CARE FACILITIES AFTER HOSPITAL DISCHARGE (LINK STUDY)
REFNo: HS5890ES

1. To systematically review and describe the different interventions that have been tried to improve timely linkage among PLHIV after discharge from hospital in LMIC.
2. To explore the barriers and facilitators influencing the timely linkage of PLHIV with AHD to primary HIV care facilities after hospital discharge in Mbale regional Referral hospital.
3. To determine the proportion of PLHIV with AHD linked to HIV care facilities within 14 days post-hospitalization in Mbale regional referral hospital.
4. To design and evaluate the acceptability, feasibility, and preliminary effectiveness of implementing a theory-informed intervention to improve timely linkage among post-hospital discharge PLHIV with AHD in Mbale regional referral hospital.
5. To evaluate the implementation process of the LINK intervention using REAIM framework among PLHIV with AHD in Mbale regional referral hospital

 Uganda 2025-05-14 10:06:38 2028-05-14 Medical and Health Sciences Non-Clinical Trial Degree Award
Martin Kasenge
ID: UNCST-2024-R001999
 Credit Risk Management Practices and Loan Portfolio Quality in Uganda's Commercial Banking Sector: A Survey of Selected Banks
REFNo: SS3740ES

1. To examine the effect of Risk identification and profiling on loan portfolio Quality
2. To examine the effect of Risk assessment on loan portfolio Quality
3. To assess the effect of Risk Monitoring and control on portfolio Quality
4. To examine the moderating effect of adverse selection on both credit risk management practices and loan portfolio quality

 Uganda 2025-05-12 10:29:57 2028-05-12 Social Science and Humanities Non-Clinical Trial Degree Award
Christine Mulowoza
ID: UNCST-2025-R017337
 Evaluating the Effect of Multi Month Dispensing in Community Differentiated Service Delivery models (EEMCD) on viral load coverage and suppression among Children (0-9) and Adolescents (10-19) living with HIV (CALHIV) in Uganda
REFNo: HS5907ES

PRIMARY OBJECTIVE:
1.Among CALHIV, enrolled on MMD in community DSD models, determine the extent of viral load coverage and suppression as per the Uganda national guidelines.
SECONDARY OBJECTIVES:
2.To describe the demographic and clinical characteristics of CALHIV on MMD in community DSD model program
3.To determine the extent of viral load coverage for the CALHIV since being enrolled on the program
4.To assess the prevalence of viral load suppression CALHIV on MMD in community DSD models
5.To explore the barriers and facilitators influencing viral load testing uptake.
6.Explore the barriers and facilitators to effective implementation of MMD in the community DSD model

Uganda 2025-05-07 18:39:14 2028-05-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Damari Atusasiire
ID: UNCST-2024-R002645
 A cluster- randomised controlled trial to assess the effectiveness and impact of the Tiko platform on increasing access to sexual and reproductive health (SRH) services among Adolescents and Young People (AYP) in Uganda
REFNo: SS3858ES

To assess whether the Tiko Model increases the modern Contraceptive Prevalence Rate (mCPR) among adolescents and young people in treatment areas relative to control areas.
To determine if there is a reduction in unintended pregnancies.
To evaluate improvements in knowledge, perceived norms, and attitudes towards contraception and HIV services (testing, ART, and PrEP).
To assess whether there is an increase in the uptake of HIV testing, ART, and PrEP.
To determine if there is an increase in access to high-quality, youth-friendly health services.
To examine whether there is a reduction in the HIV test positivity rate.
To assess improvements in the continued use of short-acting contraception and retention in ART and PrEP.
To evaluate whether there is an improvement in the number of Couple Years of Protection (CYP) offered.
 Uganda 2025-05-07 18:25:50 2028-05-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Victoria Isika Kiasyo
ID: UNCST-2025-R017083
 WOMEN'S DIGITAL SAFETY: Measurement for bolstering policy response
REFNo: SS3824ES

1. Conduct formative, human-centered research. We plan to co-create an instrument and contextualize our understanding of TFGBV, we will hold co-creation workshops with women and institutional stakeholders. 2. Translate formative human-centered findings to measurement. We will use qualitative insights from Aim 1 to compare local findings with existing TFGBV measures (developed mostly in high-income settings). 3. Pilot novel measure of TF-GBV exposure. We will pilot a quantitative instrument and submit this in an amendment to this ethics proposal. This amendment will specify the instrument, sampling, data collection procedures, analytical plan, community engagement and dissemination plan. Briefly, a long-list of items will be tested through quantitative surveys delivered both in person and digitally. Output from these surveys will enable us to validate and refine the instrument before dissemination.
 Kenya 2025-05-07 18:23:51 2028-05-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Winnie Kibone
ID: UNCST-2023-R008421
 Navigating Dual Diagnoses: Experiences of Individuals Living with Sickle Cell Disease and HIV in Uganda
REFNo: HS5859ES

1. To explore the experiences of people living with SCD and HIV in Northern and Central
Uganda
2. To determine indications for hospitalization, co-morbidities and clinical outcomes of
patients with SCD in Northern and Central Uganda
 Uganda 2025-05-07 18:22:49 2028-05-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eleanor Namusoke Magongo
ID: UNCST-2021-R013199
 Uganda Paediatric Antiretroviral Treatment study on uptake and long term outcomes on dolutegravir in Children and Adolescents living with HIV in Uganda (UP-ART DTG study).
REFNo: HS5830ES

Primary objectives: 1.To describe the uptake of DTG in the UP ART cohort and characteristics at start of dolutegravir (DTG)- based regimens (DBRs) 2.To describe mortality and loss to follow-up among CALHIV after start of DBRs 3.To assess the effectiveness of DBRs by assessing viral load (VL) response over time on DBR (viral suppression and viral failure) Secondary objectives: 4.To identify factors associated with viral failure 5.To assess the number/proportion of CALHIV discontinuing DTG and reasons for discontinuation 6.To assess changes in weight, height and body mass index (BMI) over time on DBR In analyses for Objectives 1-6, the key results will be presented overall and stratified by the following characteristics at start of DBR (where sufficient numbers n>20): a)Age at start of DBR: <2, 2 to <6, 6 to <12 and 12 to <20 years b)ART history and VL status at start of DBR: Naive, ART-experienced and suppressed (VL<1000 copies/mL), ART experienced and viremic (VL≥1000 copies/mL) and ART- experienced and unknown VL. The VL status is based on most recent measurement within 6 months of start of DBR. c)DTG regimen: DTG/ABC/3TC, DTG/TDF/3TC, other DTG-based regimen
Uganda 2025-05-07 18:21:47 2028-05-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
AGNES SANSA
ID: UNCST-2025-R017934
 MULTI-GENERATIONAL WORK ETHICS, INCLUSIVITY, DIVERSITY MANAGEMENT PRACTICES AND THE PERFORMANCE OF PUBLIC AGENCIES IN UGANDA
REFNo: SS3782ES

i. To establish the relationship between multigenerational work ethics and the performance of public agencies in Uganda. ii. To assess the influence of inclusivity in the relationship between multigenerational work ethics and the performance of public agencies in Uganda. iii. iii. To examine the effect of diversity management practices in the relationship between multigenerational work ethics and the performance of public agencies in Uganda. iv. iv. To determine the joint effect of multigenerational work ethics, inclusivity and diversity management practices on the performance of public agencies in Uganda.
Uganda 2025-05-07 18:19:31 2028-05-07 Social Science and Humanities Non-Clinical Trial Degree Award
Joel Ongom
ID: UNCST-2024-R015752
 Impact of Dichrostachys cinerea management interventions on Soil Properties and subsurface Macrofauna in Queen Elizabeth National Park, Uganda
REFNo: NS902ES

1. To determine the effect of management intervention on D.cinerea by excavation and burning on the physico chemical properties of soil.
2. To assess the effect D.cinerea management intervention in QENP on the abundance and diversity of above ground soil macrofauna
3. To assess the effect D.cinerea magement interventions in QENP on the abundance and divesity of below ground soil macrofauna

 Uganda 2025-05-07 18:17:57 2028-05-07 Natural Sciences Non-Clinical Trial Non-degree Award
Mohamed Farah Mohamud
ID: UNCST-2025-R016841
 EFFECTIVENESS OF INTRAVENOUS PETHIDINE VERSUS INTRAVENOUS TRAMADOL FOR PERIOPERATIVE ANALGESIA IN UTERINE EVACUATION PROCEDURES AT JINJA REGIONAL REFERRAL HOSPITAL
REFNo: HS5960ES

1. To assess the effectiveness of intravenous pethidine versus intravenous tramadol for perioperative analgesia in uterine evacuation procedure at Jinja Regional Referral Hospital
2. To compare the secondary outcomes encountered among women administered with intravenous pethidine versus those with Intravenous Tramadol for perioperative analgesia in uterine evacuation procedures at Jinja Regional Referral Hospital
3. To compare the level of patient satisfaction with intravenous pethidine versus Intravenous tramadol in uterine evacuation procedures at Jinja Regional Referral Hospital

 Somalia 2025-04-30 7:27:21 2028-04-30 Medical and Health Sciences Clinical Trial Degree Award
Lillian Wambuzi Ogwang
ID: UNCST-2021-R013189
 Evaluation of eye-tracking tests of affection and executive function among adolescents living with HIV in Kampala, Uganda version 3.0 dated 13 Mar 2025
REFNo: HS5920ES

1) to assess executive functioning and affect with three tests adapted to eye-tracking instrumentation
2) to correlate measures of eye-tracking with standardized mental health assessments

 Uganda 2025-04-30 17:55:08 2028-04-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Muriel Mac-Seing
ID: UNCST-2024-R005208
 The Together Project 2.0: Co-creation and co-evaluation of accessible and gender-sensitive sexual and reproductive health and rights education video series for and with youth in situations of vulnerability in Uganda and Bangladesh
REFNo: SS3812ES

1. To identify SRHR education gaps and needs for youth in situations of vulnerability with limited to no access to SRHR education programs, in Gulu, Uganda, and Dhaka, Bangladesh (Phase 1) 2. To co-develop with youth in situations of vulnerability inclusive SRHR education programs that are contextually adapted to their needs and realities, while considering accessibility, social acceptability, and available SRHR resources (Phase 2). 3. To co-evaluate the relevance of the co-developed SRHR education content and co-learn for improved adaptation through community feedback-seeking and to inform further dissemination strategies tailored to the specific needs and preferences of youth in Gulu, Uganda, and Dhaka, Bangladesh (Phase 3).
Canada 2025-04-30 17:51:45 2028-04-30 Social Science and Humanities Non-Clinical Trial Non-degree Award
SSENYONJO  TADDEO BIRUNGI
ID: UNCST-2024-R002326
 EFFECT OF CLIMATE CHANGE ON THE SOCIO-ECONOMIC CONDITION OF SUBSISTENCE CATTLE FARMERS IN NAKASONGOLA DISTRICT,UGANDA.
REFNo: A593ES

1.3 Objectives of the Study 1.3.1 Major objective To examine the effects of climate change on the socio- economic condition of subsistence cattle farmers in Nakasongola district and propose an appropriate farmer adaptation strategy. 1.3.2 Specific objectives 1.To describe negative effects of climate change faced by subsistence cattle farmers in Nakasongola District. 2.To explore impact of climate change on the socio-economic conditions of subsistence cattle farmers in Nakasongola District. 3. To evaluate adaptation and coping practices of subsistence cattle farmers in Nakasongola District with the effects of climate change. 4.To develop an adaptation strategy to the effects of climate change relevant to subsistence cattle farmers in Nakasongola District.
Uganda 2025-04-30 17:47:19 2028-04-30 Agricultural Sciences Non-Clinical Trial Degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 KHB HIV I/II Ab RAPID TEST (REF: R-429-1-C-1 and REF: R-429-50-C-1 ): Part of the Diagnostic Sensitivity and Diagnostic Specificity
REFNo: HS5945ES

The objective of this evaluation is twofold. By collecting capillary whole blood (i.e. fingerprick) samples and corresponding venous whole blood (EDTA-K2) and plasma (EDTA-K2) samples the following objectives are assessed:
1) To establish the performance of the KHB HIV I/II Ab RAPID TEST using capillary whole blood or fingerprick samples when performed by lab technicians at an African hospital lab and by lay providers/healthcare workers (Nurses, Counsellors, clinical officers) at an African rural hospital lab.
2) To demonstrate specimen equivalence between capillary whole blood, venous whole blood and plasma.
This study will be conducted according to WHO TSS-1; Part 1 and part 2: Establishing clinical performance characteristics (professional use and/or self-testing.

 Uganda 2025-04-28 12:28:00 2028-04-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Justine  Komunyena Tumusiime
ID: UNCST-2023-R008465
 Assessment of the Country-Level Implementation and Use of Vaccine-Preventable Disease Surveillance Information Systems in the WHO African Region
REFNo: HS5798ES

To assess the current landscape of VPD surveillance systems across the 47 WHO AFRO member states, with a focus on system type, dreadiness, integration with broader health information systems, and identification of key gaps, needs, and opportunitiesigital ,
 Uganda 2025-04-28 12:19:35 2028-04-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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