Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Clovice Kankya
ID: UNCST-2020-R010154
Understanding and Improving Antimicrobial Stewardship Among Small and Medium Sized Dairy Farmers in Uganda
REFNo: HS2607ES

1. To assess the current level of knowledge, attitudes, as well as practices among target
dairy farmers and animal health service professionals
2. To understand the barriers and enablers to implement best practices in dairy production,
with a focus on behavioural barriers.
3. To develop the Food Safety AMR training curriculum by farmers and other relevant
stakeholders.
4. To ascertain the determinants of AMR among the different dairy farms.
5. To identify behaviourally informed interventions to mitigate the barriers using enabler
analysis.
Uganda 2022-12-23 18:11:07 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Monica Swahn H
ID: UNCST-2021-R012004
The Onward Project On Well-being and Adversity (“TOPOWA”): Pilot Study of Wearables
REFNo: SS1560ES

The objective of this study is to assess the feasibility and acceptability of using consumer-grade wearable wrist devices to assess sleep and activity space of adolescent girls and young women in slum communities in Kampala, Uganda. This objective will be answered through wearables wrist devices, daily diaries, focus groups discussions and a survey to collect the experiences of AGYW who are 18-24 years of age.
USA 2022-12-23 18:08:19 2025-12-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Pontiano  Kaleebu
ID: UNCST-2020-R019901
Performance evaluation of the Determine™ HIV Early Detect 4th Generation HIV Rapid Diagnostic test
REFNo: HS2603ES

Primary Objectives:
1. To evaluate the Laboratory performance (Sensitivity and specificity) of the Determine™ HIV Early Detect
2. To assess the field performance of the Determine™ HIV Early Detect in parallel with the Determine™ HIV-1/2 test
Secondary Objective:
1. To assess the effectiveness of the Determine Early Detect to identify acute HIV infection among newly infected individuals

Uganda 2022-12-23 18:06:59 2025-12-23 Medical and Health Sciences Clinical Trial Non-degree Award
Fahad Muwanda
ID:
Childhood responses to Hepatitis B vaccine in Uganda: the role of Human Leukocyte Antigen (HLA) and T-Cell Receptor (TCR) diversity
REFNo: HS2604ES

To determine the long-term persistence of protective hepatitis B vaccine antibody titers among 15-17 years old childhood recipients who were enrolled on the UNEPI. ,Characterize the T-cell immunophenotypes and function, and compare hepatitis B vaccine responders with non-responders. ,Characterize host TCR and HLA genotypes and their association with hepatitis B vaccine responses among under 5 year-old childhood recipients in the UNEPI.,To determine the prevalence of immunological non-responsiveness to hepatitis B vaccine among under 5 year-old childhood recipients in the UNEPI recruited in Kawempe Division, Kampala.,To determine the immunogenetic factors associated with non-responsiveness in hepatitis B vaccine childhood recipients, and persistence of immuno-protection accorded by the vaccine in Uganda.,
Uganda 2022-12-23 18:04:07 2025-12-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Jonathan Kayondo
ID: UNCST-2021-R008325
Contained laboratory studies of the genetically-modified, non-gene drive, self-limiting male bias Anopheles gambiae strain Ag(PMB)1.
REFNo: HS2601ES

• Establishing and maintaining wild-type Anopheles strains Ag(WT) for use in the study.
• Importing and maintaining of the Ag(PMB)1 strain from Target Malaria partner laboratories into the insectary in accordance with ACL2 standard operating procedures for this strain.
• Further Introgression and maintaining the Ag(PMB)1 strain in a local genetic background.
• Confirmation of the genotype of the Ag(PMB)1 strain by molecular methods, including storage of samples.
• Conducting experiments on specific insect life history parameters under containment including:
o Effect of the transgenes on lifecycle parameters
o Female feeding avidity
o Fecundity
o Egg hatch
o Confirming the male bias phenotype by observing the distortion of sex ratio and proportions of transgenic vs. non transgenic individuals
o Accuracy of mosquito sorting methods
o Larval development rate and adult hatching (eclosion)
o Adult eclosion (emergence of an adult insect from a pupa) and adult longevity
• Conducting a colony augmentation exercise, to temporarily increase colony numbers.
• Assessment of mating competitiveness between Ag(WT) and strain Ag(PMB)1 males.
• Assessment of insecticide susceptibility status of the Ag(PMB)1 strain compared with the non-transgenic wild-type An. gambiae, using standard World Health Organization protocols.
• Conducting experiments to optimize mosquito rearing methods.
All studies will be performed using the imported Ag(PMB)1 strain and local wild-type Ag(WT), no genetic transformation of either of these two strains will be done in country.

Uganda 2022-12-23 18:02:42 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert Downing George
ID: UNCST-2020-R014615
Sample collection for the development of a new Abbott Rapid Diagnostics COVID- 19/ Flu A&B Rapid Panel
REFNo: HS2592ES

Influenza (Flu) and COVID-19 are both contagious respiratory illnesses - they share some similar symptoms but are caused by different viruses. Because some of the symptoms of flu and COVID-19 are similar, distinguishing infection between these viruses cannot be made based on symptoms alone. Diagnostic testing is needed to determine which of the two viruses is the cause of the illness.
Abbott Rapid Diagnostics is developing a new COVID-19 / Flu A&B rapid test device that can detect both flu and COVID-19 viruses in a patient sample and distinguish between them. The test is being developed on an improved lateral flow platform, to be conducted at the point-of-care. This study is intended to collect samples to aid in the research and development process for this new test. The study will provide standard-of-care PCR testing and potentially molecular sequencing for patient management at clinical sites in Uganda.

UK 2022-12-23 18:01:38 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
DARIUS OWACHI
ID: UNCST-2022-R009373
KNOWLEDGE, ATTITUDE AND PRACTICES OF HEALTH WORKERS TOWARDS ANTIMICROBIAL RESISTANCE AND ANTIMICROBIAL STEWARDSHIP – A CROSS-SECTIONAL SURVEY IN KAMPALA, UGANDA
REFNo: HS2598ES

To determine the knowledge, attitude and practices of antimicrobial prescribers at Kiruddu Hospital towards antimicrobial resistance ,
Uganda 2022-12-23 18:00:14 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
EUNICE Ndyareeba
ID:
Achievement Goal Orientation, Self-efficacy and Academic Engagement among Compassion and Non-compassion supported Adolescent students in Secondary Schools in Southwestern Uganda
REFNo: SS1562ES

1.Assess the relationship between achievement goal orientation and academic engagement 2.Determine the relationship between self-efficacy and academic engagement 3.Examine the mediation role of self-efficacy on the relationship between achievement goal orientations and academic engagement 4. Examine whether there is a significant difference between achievement goal orientation and academic engagement among compassion-supported and non-compassion supported adolescents
Uganda 2022-12-23 17:58:52 2025-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
Joyce  Nankumbi
ID:
Effect of the healthy baby tool kit on the maternal-infant and young child feeding practices among HIV-positive/exposed mother-baby dyads
REFNo: HS2491ES

Assess the maternal, infant, and young child feeding practices among HIV-positive/exposed mother-baby dyads
Evaluate the effectiveness of the healthy baby tool kit on the maternal-infant and young child feeding practices
assess the barriers and facilitators to implementation of the Healthy baby tool kit
Uganda 2022-12-23 17:54:26 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph Mugisha Okello
ID: UNCST-2022-R009461
Functional Needs Assessment Survey in Kalungu District, Uganda
REFNo: HS2495ES

1. To pilot test the Functional Needs Assessment Tool (FNAT) survey methodology and bespoke data collection app. 2. Across the domains of vision, hearing, mobility, cognition, communication, self-care and mental health to estimate the: a. prevalence of functional difficulties b. unmet and total need for rehabilitation services c. unmet and total need for AP
Uganda 2022-12-23 17:50:49 2025-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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