Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Judith Mbabazi
ID: UNCST-2021-R011582
​​Spotlight Kampala, Uganda - Illuminating Energy Inequities in Urban Informal Communities
REFNo: SS1437ES

General Objective: The proposed research activities support SDG7 to ensure “access to affordable, reliable, sustainable, and modern energy for all” and SDG11 to “make cities and human settlements inclusive, safe, resilient, and sustainable.”

Specific Objectives: The overarching objectives of the project are:

To highlight the unique and complex access challenges faced by informal urban communities in SSA

To create a dialogue within the SDG 7 community of practice on urban access issues

To demonstrate how participatory approaches can support more inclusive and equitable research and infrastructure design practices


Uganda 2023-01-19 13:00:40 2026-01-19 Social Science and Humanities Non-Clinical Trial Non-degree Award
YVONNE KARAMAGI
ID:
A Qualitative Study On The Impact Of COVID 19 On Mental Health Of Adolescents Living With HIV (15-19 Yrs.) At Mildmay Uganda Hospital.
REFNo: HS2612ES

Aim 1: To explore the effects of COVID-19 and its social control measures on mental health of ALHIV aged 15-19 years Aim 2: To identify the multi-level factors of resilience (i.e., individual, family and community) with their effects on ALHIV’s mental health during the COVID-19 pandemic Aim 3: To describe the Caregivers and health providers' experiences when looking after ALHIV during the COVID-19 pandemic in context to their mental health
Uganda 2023-01-18 18:43:18 2026-01-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Winnie  Muyindike R
ID: UNCST-2021-R013558
Gabapentin to Reduce Alcohol and Improve Viral Load Suppression (GRAIL) – “Promoting Treatment as Prevention”
REFNo: HS2622ES

2. To assess the impact of gabapentin compared to placebo on: a) alcohol consumption; b) pain severity; c) ART adherence; and d) engagement in HIV care, in order to explore potential mechanisms by which gabapentin may lead to HVL suppression.,1. To test the efficacy of gabapentin versus placebo to achieve undetectable HVL (Primary Outcome at 3 months; Secondary Outcome at 6 & 12 months),
Uganda 2023-01-18 18:33:54 2026-01-18 Medical and Health Sciences Clinical Trial Non-degree Award
Margaret Mbabazi Sebbale
ID: UNCST-2022-R010449
RADIOLOGY-PATHOLOGICAL CORRELATION, VALIDATION OF LUNG RADS IN TB/ HIV ENDEMIC POPULATION AND DEVELOPMENT OF A LUNG CANCER SCREENING PROTOCOL IN UGANDA
REFNo: HS2623ES

Determine the relationship between different risk factors including HIV status and lung cancer among patients presenting to Uganda Cancer Institute and Makerere Lung Institute. ,Validate the effectiveness of Lung RADS tool in a TB endemic population. ,Describe the radiological features and determine their relationship with histopathology in cases of biopsy proven lung cancer at the Uganda Cancer Institute. ,To determine the relationship between lung radiology features and histopathology of lung cancer, validate Lung RADS and develop a lung cancer screening protocol in Uganda to aid early detection and management.,
Uganda 2023-01-18 18:30:16 2026-01-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Patricia NAHIRYA Ntege Nahirya
ID: UNCST-2019-R001117
IMPACT OF SERIOUSFUN OVERNIGHT CAMP PROGRAMS ON ADHERENCE TO ANTI-RETROVIRAL THERAPY AND VIROLOGICAL SUPPRESSION AMONG CHILDREN AND ADOLESCENTS (9 to 19 YEARS) LIVING WITH HIVRECEIVING CARE AT BAYLOR-UGANDA COE CLINIC
REFNo: HS2580ES

General objective
To determine the effect and impact of attending camp on adherence to ART and virologic suppression among children and adolescents receiving care at Baylor Uganda COE.

Specific objectives
1. To retrospectively examine potential changes in viral load of ALHIV before, and a year after first attending overnight camp.

2. To compare viral loads of ALHIV who attended overnight camp to those who have never attended overnight camp.

3. To explore experiences and perceptions about overnight camp amongst ALHIV who have attended camp.

Uganda 2023-01-18 18:27:44 2026-01-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
Evaluation of the performance of novel molecular point of care diagnostics for SARS-CoV-2
REFNo: HS2588ES

To assess the ease of use of the molecular POC devices being evaluated using a System Usability Scale (SUS) questionnaire administered to platform’s operators (minimum 3, where possible)., To evaluate the diagnostic accuracy of such platforms in detecting SARS-CoV-2 on respiratory specimens, compared with reference standard RTPCR in specific subgroups defined based on disease stage (days since symptoms onset), RTPCR Ct values (as surrogate for viral load). Participant’s vaccination status, previous COVID-19 infection(s) and SARS-CoV-2 genetic variant causing participant’s infection, determined by sequencing of the viral genome, may also be considered as subgroups. , To evaluate the diagnostic accuracy of molecular POC devices in detecting SARS-CoV-2 on respiratory specimens, compared with reference standard RT-PCR (WHO EUL or FDA EUA approved), among COVID-19 symptomatic individuals,
Uganda 2023-01-18 18:21:06 2026-01-18 Medical and Health Sciences Clinical Trial Non-degree Award
Diana  Rutebarika Antonia
ID:
Child and Adolescent Research Moving towards Alternative Interventions.
REFNo: HS2525ES

1.To characterize the functionality of viral reservoir in early treated children who have been on ART for 7 or more years and are currently virally suppressed.
2.To investigate whether the profile of past response to ART and pre-ART characteristics are associated with small or less functional viral reservoirs.
3.To investigate whether there’s persisting immune dysregulation despite viral suppression and whether host genes and immune phenotypes including markers of immunosenescence and exhaustion, are associated with smaller and less functional viral reservoirs.
4.To investigate attitudes and beliefs, perceived social norms, perceived behavioral control, and intentions to participate in future trials that test interventions to achieve remission.

Uganda 2023-01-18 18:17:30 2026-01-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Andrew Edielu
ID:
Role of Schistosoma mansoni in development of Environment Enteric Dysfunction in Pre-School aged Children (SEEP) in the Albertine Region, Western Uganda
REFNo: HS2505ES

i. To determine the effect of Schistosoma mansoni infection, as diagnosed by urine Circulating Anodic Antigen (CAA), on serum/stool EED biomarkers of PSAC in Albertine region of Uganda. ii. To determine the effect of Environmental Enteric Dysfunction on Pharmacokinetics of praziquantel as measured by Area Under the Curve (AUC) in PSAC treated for Schistosoma mansoni infection iii. To describe individual and combined effects of S. mansoni infection and EED on gut microbiota in PSAC iv. To determine the accuracy and reliability of EED stool and serum biomarkers in predicting urine Lactulose-Mannitol ratio as the gold standard for diagnosis of EED
Uganda 2023-01-18 18:15:09 2026-01-18 Medical and Health Sciences Non-Clinical Trial Degree Award
Semitala Fred
ID: UNCST-2020-R014202
PULESA-Uganda: A stepped-wedge cluster randomized trial of implementation strategies to integrate hypertension care into HIV clinics of Kampala and Wakiso District, Uganda
REFNo: HS2398ES

To determine the effectiveness of HTN-BASIC and HTN-PLUS strategies to improve hypertension cascade metrics
To determine implementation outcomes of HTN-BASIC and HTN-PLUS strategies
To evaluate the economic and financial sustainability of the HIV-HTN integrated care strategies

Uganda 2023-01-18 18:13:10 2026-01-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Enoch Asiimwe Asiimwe
ID: UNCST-2022-R010482
The significance of Social Capital and Livelihoods of Urban Refugees “A Study of Democratic Republic of Congo (DRC) Refugees in Kampala city”
REFNo: SS1311ES

1. To investigate how Congolese refugees living in urban setting build their social capital
2. To explore how urban refugees, use social capital to sustain their livelihoods
3. 1.3.1.3 To investigate the impact of Covid 19 on the urban refugees’ social networks and livelihoods.
Uganda 2023-01-18 17:59:42 2026-01-18 Social Science and Humanities Non-Clinical Trial Degree Award
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