Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Victoria Ndyanabangi
ID: UNCST-2021-R012645
 IMPAACT 2036: Phase I/II Study of the Safety, Tolerability,Acceptability, and Pharmacokinetics of Oral and Long-ActingInjectable Cabotegravir and Rilpivirine in Virologically SuppressedChildren Living with HIV-1, Two to Less Than 12 Years of Age, DAIDSStudy ID #38932 IND # 138754
REFNo: HS2688ES

To propose the weight band dosing of oral cabotegravir (CAB) + oral rilpivirine (RPV)followed by long-acting injectable CAB (CAB LA) + long-acting injectable RPV (RPV LA)in children living with HIV-1, and to describe participant choice and experience with theregimen with or without an oral lead-in period.
To describe the repeat-dose pharmacokinetics of CAB + RPV (oral and injectable)through Week 24
To assess the safety of the oral lead-in of CAB + RPV, and the safety of CAB + RPV (oraland injectable) through Week 24
To assess the safety of CAB + RPV (oral and injectable) through Weeks 48 and 72
To describe the repeat-dose pharmacokinetics of injectable CAB LA + RPV LA throughWeeks 48 and 72
To assess the maintenance of viral suppression of CAB + RPV (oral and injectable)through Weeks 24, 48, and 72
To evaluate the tolerability and acceptability of injectable CAB LA + RPV LA throughWeeks 24, 48, and 72
To describe HIV-1 genotypes and phenotypes for children who experience virologicfailure during study treatment
To assess immunologic activity of CAB + RPV (oral and injectable) through Weeks 24,48, and 72
To describe tolerability and acceptability of 48 weeks of CAB + RPV (oral and injectable)and 44 weeks of CAB LA + RPV LA (injectable only)
To describe the safety and repeat-dose pharmacokinetics of 48 weeks of CAB + RPV(oral and injectable) or 44 weeks of CAB LA + RPV LA (injectable only)
To describe the maintenance of viral suppression and immunologic activity of 48 weeks ofCAB + RPV (oral and injectable) or 44 weeks of CAB LA + RPV LA (injectable only)
To describe HIV-1 genotypes and phenotypes for children who experience virologicfailure during 48 weeks of CAB + RPV (oral and injectable) or during 44 weeks of CABLA + RPV LA (injectable only)
To characterize long-term safety and washout PK through 48 weeks after permanentdiscontinuation of injectable CAB LA + RPV LAV LA
To characterize PK of CAB + RPV oral formulations when dispersed in liquid vs. directly ingested (Weight Bands 3, 4 and 5)
 Uganda 2023-03-16 12:55:20 2026-03-16 Medical and Health Sciences Clinical Trial Non-degree Award
Charles Batte
ID: UNCST-2021-R013587
 The impact of COVID-19 on school enrolment and mental health of children in the Manafwa Watershed area in Uganda.
REFNo: HS2725ES

To assess the coping strategies of school-going children in the Manafwa Watershed area during the COVID-19 pandemic.,To assess the post-lockdown mental health status of school-going children in the Manafwa Watershed area. ,To evaluate the effects of COVID-19 lockdown on school enrolment of children in the Manafwa Watershed area.,To assess the impact of COVID-19 and its associated restrictive measures on school enrolment and mental health of children in a disaster-prone area, Manafwa Watershed area, in Eastern Uganda.,
 Uganda 2023-03-16 12:51:27 2026-03-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jack Richardson Lloyd
ID:
The role of social play in the development of wild mountain gorillas in Bwindi Impenetrable National Park, Uganda
REFNo: NS490ES

(1) determine how biological, ecological, and social factors influence amount of time spent in social play.
(2) examine how structural components of play (asymmetry, dominance, play
partnerships, play type) can differentiate between functions.
(3) investigate proposed trade-offs and developmental outcomes of social play.
UK 2023-03-16 12:48:10 2026-03-16 Natural Sciences Non-Clinical Trial Degree Award
Peter Elyanu James
ID: UNCST-2021-R013210
 GS-US-380-1474: A Phase 2/3, Open-Label Study of the Pharmacokinetics, Safety, and Antiviral Activity of the GS-9883/Emtricitabine/Tenofovir Alafenamide (GS-9883/F/TAF) Fixed Dose Combination (FDC) in HIV-1 Infected Adolescents and Children
REFNo: HS2708ES

This is a multisite, multi-cohort study that aims to recruit subjects in four weight-based cohorts (i.e. Cohort 1, 2, 3 and 4), with each cohort having specific objectives aligned with it. Baylor Uganda site will recruit subjects in cohort 4 with is further subdivided in 4 weight-based sub-groups. The study objectives in relation to the Cohort 4 are as follows;
Cohort 4
Group 1:
The primary objective of this study is:
• To evaluate the safety and tolerability of B/F/TAF 30/120/15 mg (administration of 2 B/F/TAF 15/60/7.5 mg FDC TOS) once daily through Week 24 in HIV-1 infected, virologically suppressed children ≥ 2 years of age weighing ≥ 14 to < 25 kg who are unable to swallow tablets
The secondary objectives of this study are:
• To evaluate the safety and tolerability of B/F/TAF 30/120/15 mg (administration of 2 B/F/TAF 15/60/7.5 mg FDC TOS) once daily through Week 48 in HIV-1 infected, virologically suppressed children ≥ 2 years of age weighing ≥ 14 to < 25 kg who are unable to swallow tablets

• To evaluate the antiviral activity of B/F/TAF 30/120/15 mg (administration of 2 B/F/TAF 15/60/7.5 mg FDC TOS) once daily through Weeks 24 and 48 in HIV-1 infected, virologically suppressed children ≥ 2 years of age weighing ≥ 14 to < 25 kg who are unable to swallow tablets
Group 2:
The primary objectives of this study are:
• To evaluate the steady state PK of BIC and TAF and confirm the dose of B/F/TAF 7.5/30/3.75 mg (administration of 2 B/F/TAF 3.75/15/1.88 mg FDC TOS) twice daily in HIV-1 infected children ≥ 1 month of age, on ARV treatment or treatment naive, weighing ≥ 10 to < 14 kg

• To evaluate the safety and tolerability of B/F/TAF 7.5/30/3.75 mg (administration of 2 B/F/TAF 3.75/15/1.88 mg FDC TOS) twice daily through Week 24 in HIV-1 infected children ≥ 1 month of age, on ARV treatment or treatment naive, weighing ≥ 10 to < 14 kg
The secondary objectives of this study are:
• To evaluate the safety and tolerability of B/F/TAF 7.5/30/3.75 mg (administration of 2 B/F/TAF 3.75/15/1.88 mg FDC TOS) twice daily through Week 48 in HIV-1 infected children ≥ 1 month of age, on ARV treatment or treatment naive, weighing ≥ 10 to < 14 kg

• To evaluate the antiviral activity of B/F/TAF 7.5/30/3.75 mg (administration of 2 B/F/TAF 3.75/15/1.88 mg FDC TOS) twice daily through Weeks 24 and 48 in HIV-1 infected children ≥ 1 month of age, on ARV treatment or treatment naive, weighing ≥ 10 to < 14 kg.
Group 3:
The primary objectives of this study are:
• To evaluate the steady state PK of BIC and TAF and confirm the dose of B/F/TAF 3.75/15/1.88 mg (administration of 1 B/F/TAF 3.75/15/1.88 mg FDC TOS) twice daily in HIV-1 infected children ≥ 1 month of age, on ARV treatment or treatment naive, weighing ≥ 6 to < 10 kg

• To evaluate the safety and tolerability of B/F/TAF 3.75/15/1.88 mg (administration of 1 B/F/TAF 3.75/15/1.88 mg FDC TOS) twice daily through Week 24 in HIV-1 infected children ≥ 1 month of age, on ARV treatment or treatment naive, weighing ≥ 6 to < 10 kg.
The secondary objectives of this study are:
• To evaluate the safety and tolerability of B/F/TAF 3.75/15/1.88 mg (administration of 1 B/F/TAF 3.75/15/1.88 mg FDC TOS) twice daily through Week 48 in HIV-1 infected children ≥ 1 month of age, on ARV treatment or treatment naive, weighing ≥ 6 to < 10 kg

• To evaluate the antiviral activity of B/F/TAF 3.75/15/1.88 mg (administration of 1 × B/F/TAF 3.75/15/1.88 mg FDC TOS) twice daily through Weeks 24 and 48 in HIV-1 infected children ≥ 1 month of age, on ARV treatment or treatment naive, weighing ≥ 6 to < 10 kg.
Group 4:
The primary objectives of this study are:
• To evaluate the steady state PK of BIC and TAF and confirm the dose of B/F/TAF 1.88/7.5/0.94 mg (administration of 1 B/F/TAF 1.88/7.5/0.94 mg FDC TOS) twice daily in HIV-1 infected children ≥ 1 month of age, on ARV treatment or treatment naive, weighing ≥ 3 to < 6 kg.

• To evaluate the safety and tolerability of B/F/TAF 1.88/7.5/0.94 mg (administration of 1 B/F/TAF 1.88/7.5/0.94 mg FDC TOS) twice daily through Week 24 in HIV-1 infected children ≥ 1 month of age, on ARV treatment or treatment naive, weighing ≥ 3 to < 6 kg
The secondary objectives of this study are:
• To evaluate the safety and tolerability of B/F/TAF 1.88/7.5/0.94 mg (administration of 1 B/F/TAF 1.88/7.5/0.94 mg FDC TOS) twice daily through Week 48 in HIV-1 infected children ≥ 1 month of age, on ARV treatment or treatment naive, weighing ≥ 3 to < 6 kg

• To evaluate the antiviral activity of B/F/TAF 1.88/7.5/0.94 mg (administration of 1 B/F/TAF 1.88/7.5/0.94 mg FDC TOS) twice daily through Weeks 24 and 48 in HIV-1 infected children ≥ 1 month of age, on ARV treatment or treatment naive, weighing ≥ 3 to < 6 kg

 Uganda 2023-03-16 12:47:17 2026-03-16 Medical and Health Sciences Clinical Trial Non-degree Award
Bjorn Van Campenhout -
ID: UNCST-2020-R014080
 Increasing Adoption and Varietal Turnover of Seed: Consumer and Producer Side Interventions
REFNo: SS1657ES

The study will be implemented through a cluster randomize control trial, where a sample of treatment villages (clusters) will receive producer side treatments (free seed trial packs or discounted seed trial packs of a poorly adopted improved maize variety, Bazooka) while other treatment villages will receive a consumer side intervention involving cooking and tasting demonstration of maize from the improved variety. However, in both treatment and control groups, we will inform farmers about the existence of the improved seed variety and the benefits of using them, to be able to isolate the effect of the trail pack from merely knowledge effects.
 Belgium 2023-03-16 12:43:52 2026-03-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jennifer  Kealy
ID:
Community Engagement in Paediatric Biobanking Governance in Uganda.
REFNo: SS1651ES

The aim of this study is to provide IARC and the Ugandan Government with actionable recommendations concerning the development of paediatric biobanking guidelines. The primary objective is to identify the key ethical issues/concerns for researchers, laboratory staff, and health authorities in Uganda, specifically related to public trust in biobanking, and how trust/ trustworthiness could be addressed in paediatric biobanking governance as well as how the community might be engaged.
• Does it hold true that trust/ trustworthiness is contextual and that effectively would preclude any harmonisation of guidelines for biobanking? Or is there any common ground on which to build global /international guidelines,
• What are the gaps in biobanking in Uganda, particularly with respect to paediatric biobanking and,
• How can Uganda create paediatric biobanking guidelines that reflect the needs identified by communities and what would this look like, and,
• How can biobanks show they are trustworthy through their governance and what does that look like to Uganda? Is it sufficient to be transparent and accountable or are other cultural/economic/religious/aspects that parents consider in their assessment of trust in a biobank?
• How can ethical considerations related to biobank governance be addressed in an inclusive, collaborative and deliberative manner

 USA 2023-03-16 12:41:09 2026-03-16 Social Science and Humanities Non-Clinical Trial Degree Award
Jennifer Verdolin
ID:
Establishing a Long-Term Behavioral and Ecological Monitoring Research Program in Bwindi Impenetrable Forest National Park and Mgahinga Gorilla National Park
REFNo: NS500ES

1) Understand the factors contributing to within and between group variability in parasite infection and transmission; 2) Characterize the diet of mountain gorillas across different habitats in Bwindi Impenetrable Forest National Park and Mgahinga Gorilla National Park; 3) Explore habitat use and spatial dynamics of mountain gorillas in Bwindi Impenetrable Forest National Park and Mgahinga Gorilla National Park; 4) Collaborate with UWA to yield insights critical for the protection and management of mountain gorillas and other species in Bwindi Impenetrable Forest National Park and Mgahinga Gorilla National Park; 5) Characterize the biodiversity of Bwindi Impenetrable Forest National Park and Mgahinga Gorilla National Park, including genomics of multiple species using opportunistically collected fecal samples. These species include but would not be limited to forest elephants and pangolins.
USA 2023-03-16 12:39:44 2026-03-16 Natural Sciences Non-Clinical Trial Non-degree Award
Florence Kyoheirwe Muhanguzi
ID: UNCST-2021-R002777
 Building women smallholder farmers’ empowerment and adaptive capacities: A pathway to enhancing women’s resilience to climate change in Uganda
REFNo: SS1660ES

General objective
● To strengthen the empowerment and adaptive capacity of women smallholder farmers in the cattle corridor of Uganda using gender transformative approaches.

Specific objectives
1. Establish women smallholder farmers’ levels of empowerment and adaptive capacities to the effects of climate change;
2. Assess the social cultural gender norms, economic and political trade-offs and barriers to empowerment and climate adaptation by women smallholder farmers;
3. Design and test a mix of gender transformative climate change adaptation innovations that are effective in enhancing women smallholder farmers’ empowerment and resilience to the effects of climate change.
4. Advocate for policies and practices that enhance women smallholder empowerment and adaptive capacities to climate change shocks.

 Uganda 2023-03-16 12:37:54 2026-03-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Adoke Yeka
ID: UNCST-2021-R004300
 Phase IIa Proof of Concept, Multicenter, Randomized, Open-label Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of the Combination M5717 plus Pyronaridine Administered once Daily for 1 or 2 Days to Adults and Adolescents with Acute Uncomplicated Plasmodium falciparum Malaria
REFNo: HS2736ES

To evaluate the safety and
tolerability of the M5717-
pyronaridine combination in
adult participants with acute
uncomplicated malaria due to
P. falciparum.
Secondary.
o describe the clinical efficacy
of the M5717-pyronaridine
combination in adult participants
with acute uncomplicated
malaria due to P. falciparum
 Uganda 2023-03-16 12:35:56 2026-03-16 Medical and Health Sciences Clinical Trial Non-degree Award
Charles Masembe Kikubo
ID: UNCST-2019-R001092
 The Dispersal of Antibiotic Resistance and Antibiotics in Water Ecosystems and Influence on livestock and Aquatic wildlife (PAIRWISE)
REFNo: A240ES

i) To investigate the dispersal of Antibiotic Resistant Bacteria (ARB), Antibiotic Resistant Genes (ARG) and Antibiotics (ATB) in surface waters downstream of WWTPs ii) To investigate the carriage of ARB and ARG in livestock linked to surface waters influenced by WWTPs iii) To ascertain the role of aquatic birds in dispersal of ARB and ARG
Uganda 2023-03-09 23:54:51 2026-03-09 Agricultural Sciences Non-Clinical Trial Non-degree Award
Francis Garuzooka John
ID:
Investment practices of persons with a disability in informal microfinance groups in Uganda
REFNo: SS1617ES

1. Examine the attitudes of persons with a disability regarding investment, saving and borrowing from VSLAs and ROSCAs in selected districts in Uganda. 2. Analyse what influences the persons with a disability’ investment choices as individuals and members of groups (Revised as: Analyse what influences persons with disabilities’ investment choices as individuals and as members of groups.) 3. Explain how persons with a disability acquire the knowledge and skills they use while investing resources obtained from VSLAs and ROSCAs. 4. Describe the experiences that persons with a disability have regarding investment of loans obtained from VSLAs and ROSCAs in selected districts in Uganda.
Uganda 2023-03-09 23:52:14 2026-03-09 Social Science and Humanities Non-Clinical Trial Non-degree Award
Bonniface Oryokot
ID:
Adaptation and Evaluation of the Operation Triple Zero (OTZ) model to improve Retention and HIV viral suppression among the Adolescents Living with HIV in TASO Uganda using the RE-AIM framework.
REFNo: SS1610ES

• To implement and test the adapted OTZ intervention from January 2023 to end of August 2023.,• To adapt and design the OTZ model to the TASO Uganda context,• To determine the barriers and facilitators to Retention and VLS,• To improve health outcomes among CALHIV in selected TASO Uganda COEs.,
 Uganda 2023-03-09 23:48:16 2026-03-09 Social Science and Humanities Non-Clinical Trial Non-degree Award
JOSAPHAT KAYOGOZA BYAMUGISHA
ID: UNCST-2019-R001680
 Observational study on management of post-partum haemorrhage at Kawempe National Referral Hospital (REBOA-PPH baseline study)
REFNo: HS2730ES

To suggest a customized training to improve PPH management in a large referral hospital in Uganda,To identify specific areas of potential improvements in PPH management,To describe the actions taken in the process of managing PPH among mothers admitted to KNRH,To describe the current management of severe PPH with timelines from identification until bleeding is controlled,To map the occurrence of severe PPH among birthing mothers admitted at Kawempe National Referral Hospital (KNRH),The aim of this study is to map the occurrence of severe post-partum haemorrhage (PPH) and its current management and to identify potential improvements in the management of severe PPH in a large referral hospital in Uganda. ,
 Uganda 2023-03-09 23:43:20 2026-03-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
EZRA BYAKORA
ID: UNCST-2022-R009194
 Investigating the enhancement of Nile tilapia breeding in Uganda through integration of modern aquaculture breeding and genetics tools
REFNo: A269ES

1)Support NAGRC&DB to improve its Nile tilapia breeding program via establishing individual fish identification and phenotyping system.
2)Investigate genetic health and diversity of Uganda’s farmed Nile tilapia breeding population in comparison to their wild relatives in the three major lakes (L. Victoria, L. Kyoga and L. Albert) in Uganda.
3)Estimate genetic parameters of key production traits (including growth rate, body length and harvest weight).
4)Identify genomic regions associated with production traits.
5)Investigate potentials of integrating genomic tools into selective breeding for improving Nile tilapia in Uganda.

 Uganda 2023-03-09 23:41:58 2026-03-09 Agricultural Sciences Non-Clinical Trial Non-degree Award
Carolyn Pelnik
ID:
School Management and Re-Enrolling Dropouts: Experimental Evidence from Schools in Rural Uganda
REFNo: SS1656ES

Which version of the program is more cost-effective in terms of gains to student learning: an intervention that assigns highly qualified university graduates to partner with community members to implement enrollment and remedial education activities, or an intervention where enrollment and remedial education activities are executed by community members alone? ,What is the effect of a school management intervention targeted towards the head teacher on school inputs (administrator time use and other measures of school functionality such as teacher attendance) and outputs (enrollment and learning, as measured by literacy and numeracy test scores)?,
 USA 2023-03-09 23:39:42 2026-03-09 Social Science and Humanities Non-Clinical Trial Degree Award
Flavia Matovu Kiweewa
ID: UNCST-2021-R013337
 A Phase 2/3, Multicenter, Open-label, Multicohort Study Evaluating Pharmacokinetics (PK), Safety, and Efficacy of Cobicistat-boosted Atazanavir (ATV/co) or Cobicistat-boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in HIV-1 Infected, Virologically Suppressed Pediatric Participants.
REFNo: HS2646ES

The primary objective of this study is to confirm the dose of ATV/co or DRV/co in HIV-1 infected pediatric participants, to confirm the dose of F/TAF in HIV-1 infected pediatric participants and to evaluate the safety and tolerability these medications.
 Uganda 2023-03-09 23:33:04 2026-03-09 Medical and Health Sciences Clinical Trial Non-degree Award
Pooja Chitneni
ID: UNCST-2021-R012955
 Developing an STI partner notification services delivery intervention in southwestern, rural Uganda.
REFNo: HS2720ES

Explore facilitators and barriers to task-shifting delivery models for STI partner notification among healthcare workers, administrators, and potential patients. Also to develop a novel STI partner notification services delivery intervention for Uganda and similar settings.
USA 2023-03-09 22:41:48 2026-03-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph  Kampumure
ID:
FINANCIAL LITERACY, SELF-EFFICACY AND FINANCIAL INCLUSION AMONG WORKING WOMEN IN UGANDA
REFNo: SS1474ES

i) Establish the effect of financial literacy on financial inclusion among working women in Uganda. ii) Establish the effect of financial literacy on self-efficacy among working women in Uganda. iii) Determine the effect of self-efficacy on financial inclusion among working women in Uganda. iv) Determine the effect of self-efficacy on the connexion between financial literacy and financial inclusion among working women in Uganda.
Uganda 2023-03-07 11:05:55 2026-03-07 Social Science and Humanities Non-Clinical Trial Degree Award
Jiseon Chang
ID:
Empowering Developing Countries: Combating Misinformation and Correcting (Mis)perceptions of Foreign Aid
REFNo: SS1545ES

Understand how and when are perceptions of aid created
 South Korea 2023-03-07 11:04:27 2026-03-07 Social Science and Humanities Non-Clinical Trial Degree Award
Patricia Ndugga
ID: UNCST-2022-R009605
 Parent-adolescent communication on sexual and reproductive health in Kyotera border district, Central Uganda
REFNo: HS2702ES

The main objective of this study is to investigate the practice of SRH communication between parents and adolescents in Kyotera district, Central Uganda., 1. To determine the prevalence and factors associated with parent adolescent communication about SRH in Kyotera district. A cross-sectional survey for both parents and children will be conducted to establish the proportion of parents / children who discuss SRH issues, 2. Explore the approaches to, content and frequency of SRH communication between parents and adolescents in Kyotera., 3. To assess the community and district level stakeholders’ recommended strategies for improving communication of SRH between parents and adolescents.,
Uganda 2023-03-07 10:57:19 2026-03-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eugene Ruzagira
ID: UNCST-2023-R008282
 COVID-19 vaccine effectiveness and variants in Uganda: a test-negative case-control study with genetic sequencing (COVVAR)
REFNo: HS2672ES

Primary Objective To estimate vaccine effectiveness of licensed COVID-19 vaccines against laboratory-confirmed COVID-19 disease. Secondary Objectives 1. To identify circulating SARS-CoV-2 variants in Uganda. 2. To estimate vaccine effectiveness against specific SARS-CoV-2 variants identified by genetic sequencing. 3. To estimate vaccine effectiveness against severe COVID-19 disease. 4. To estimate effectiveness of COVID-19 vaccines against different SARS CoV-2 variants and different COVID-19 disease severities. Exploratory objective 1. To evaluate disease severity due to different circulating SARS CoV-2 variants
 Uganda 2023-03-07 10:53:48 2026-03-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
DENIS MUGIZI RWABIITA
ID:
Assessment of meat handler training interventions on hygiene and disease detection in Ugandan slaughterhouses and meat retail outlets
REFNo: A266ES

Use syndromic surveillance to understand the incidence and distribution of important animal and zoonotic disease in Uganda,Assess the impact of mobile training tool on meat inspector knowledge,Assess the impact of nudges on knowledge and practices and food contamination at pork retail,Assess the impact of a targeted meat handler training on the knowledge, attitudes, and practices of meat handlers in Uganda.,
 Uganda 2023-03-07 10:50:39 2026-03-07 Agricultural Sciences Non-Clinical Trial Non-degree Award
Raymond Tweheyo
ID: UNCST-2020-R014507
 Understanding the effect of varied financial compensation structure for improving the performance, motivation and retention of Community Health Workers in Uganda - a quasi experiment
REFNo: HS2689ES

General objective: To understand the effect of varied financial compensation structure for improving the performance, motivation and retention of Community Health Workers in Uganda.

Specific objectives:
1. To determine the optimal performance based financial incentive incentive's structure required for improving the performance, motivation and retention of CHWs.

2. To explore the acceptability and perceptions of potential sustainability of CHWs financial compensation structure to various stakeholders, including the CHWs, and the CHW supervisors at the district and Ministry of Health.

3. To explore the perceived value and impact of financial incentives on CHW's job satisfaction, personal income and livelihood.
 UK 2023-03-07 10:40:31 2026-03-07 Medical and Health Sciences Clinical Trial Non-degree Award
Stephen  Ojiambo Wandera
ID: UNCST-2021-R012147
 Assessing Dementia and Frailty among Older Persons in selected rural districts in Eastern Uganda
REFNo: HS2693ES

Therefore, the aim this study is to determine the prevalence of frailty and dementia among older persons in rural Uganda. Specific aims of the study include:
Aim 1: To estimate the prevalence and factors associated with dementia among older persons in Uganda.
Aim 2: To estimate the prevalence and factors associated with frailty among older persons in Uganda.
Aim 3: To explore the experiences and perceptions of caregivers of older persons with dementia in Uganda.
In this study, we refer to point prevalence only.

Uganda 2023-03-07 10:36:00 2026-03-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
SONNY ASIMO
ID:
RISK FACTORS FOR FLUOROQUINOLONE RESISTANCE AMONG PATIENTS WITH SECOND LINE-DRUG RESISTANT TUBERCULOSIS EVALUATED AT THE UGANDA NATIONAL TUBERCULOSIS LABORATORY RefNo: CLARKE-2022-546
REFNo: HS2709ES

iii. To determine clinical factors associated with fluoroquinolone resistance in patients with second-line drug resistant TB evaluated at the Uganda National Tuberculosis Reference Laboratory. ,ii. To characterize fluoroquinolone-resistance among patients with second-line drug resistant TB evaluated at the Uganda National Tuberculosis Reference Laboratory. ,i. To determine the individual characteristics associated with fluoroquinolone resistance among patients with second-line drug resistant TB evaluated at the Uganda National Tuberculosis Reference Laboratory. ,The study will determine the risk factors for fluoroquinolone resistance among patients with second-line drug resistant tuberculosis among previously evaluated samples in Uganda. ,
 Uganda 2023-03-07 10:25:46 2026-03-07 Medical and Health Sciences Non-Clinical Trial Degree Award
Perpetra Akite
ID: UNCST-2023-R008264
 Systematic study of insect fauna in selected sites in Uganda (Insect Systematic Project)
REFNo: NS494ES

To sample a broad geographic area, including some of the never-collected or poorly-collected sites to yield new species that will be valuable to the insect systematic community and inform their conservation management
 Uganda 2023-03-07 10:24:40 2026-03-07 Natural Sciences Non-Clinical Trial Non-degree Award
JOAN TUSABE
ID: UNCST-2021-R013942
 FACTORS INFLUENCING UPTAKE AND ADHERENCE TO PREVENTION OF MOTHER TO CHILD TRANSMISSION (PMTCT) CARE AMONG REFUGEE HIV POSITIVE PREGNANT MOTHERS AGED 18 YEAS AND ABOVE IN KYANGWALI REFUGEE CAMP
REFNo: HS2711ES

1. To determine the level of uptake and adherence to prevention of mother to child transmission (PMTCT) services among refugee pregnant mothers aged 18 years and above in Kyangwali refugee camp

2. To determine factors associated with uptake and adherence to prevention of mother to child transmission (PMTCT) services among refugee pregnant mothers aged 18 years and above in Kyangwali refugee camp

3. To explore barriers and facilitators for uptake and adherence to prevention of mother to child transmission (PMTCT) services among HIV positive pregnant mothers aged 18 years and above in Kyangwali refugee camp


4. To determine strategies that can be put in place to improve uptake and adherence to prevention of mother to child transmission (PMTCT) among refugee HIV positive pregnant mothers in Kyangwali refugee camp?

 Uganda 2023-03-07 10:23:51 2026-03-07 Medical and Health Sciences Non-Clinical Trial Degree Award
Samson Udho
ID: UNCST-2021-R013728
 Respectful maternity care in childbirth among adolescents aged 14 to 19 years in rural northern Uganda: a mixed-method study
REFNo: HS2727ES

The objectives are to: 1. Determine the prevalence of D&A of adolescents by SBA during childbirth in public health facilities in rural northern Uganda. 2. Determine the predictors of D&A of adolescents by SBA during childbirth in public health facilities in rural northern Uganda. 3. Explore the experiences of D&A of adolescents by SBA during childbirth in public health facilities in rural northern Uganda. 4. Explore the drivers of D&A of adolescents aged by SBA during childbirth in public health facilities in rural northern Uganda.
 Uganda 2023-03-02 16:34:50 2026-03-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Fred Kaggwa
ID: UNCST-2022-R008842
 Evaluating Mbarara University of Science and Technology (MUST) Internal Quality Assurance Mechanisms (IQAMs) on her Quality
REFNo: SS1629ES

General Objective
To evaluate MUST’s IQAMs on her quality using the IUCEA Model
Specific Objectives
1.To evaluate MUST’s IQAMs on the quality of Teaching and Learning
2.To examine MUST’s IQAMs on the quality of Research and Innovations
3.To assess MUST’s IQAMs on the quality of Community outreach

Uganda 2023-03-02 16:23:10 2026-03-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Francis Ssali
ID: UNCST-2021-R012134
 ESTABLISHMENT AND EVALUATION OF CAPRI CELLS IN UGANDA FOR ADOPTIVE CELL THERAPY
REFNo: HS2684ES

1. Evaluate the reproducibility of Cascade Primed Cells with Apheretic collected Autologous PBMCs in Uganda
2. Test the effect of the reproduced CAPRI cells on Lung and Cervical cancer cells in vitro

 Uganda 2023-03-02 15:39:34 2026-03-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rachel Brathwaite
ID:
Assessing the Feasibility of Economic Approaches to Prevention of Substance Abuse among Adolescents
REFNo: HS2683ES

Aim 1. Examine the prevalence and consequences of ADU in a cohort of 200 AYLHIV (ages 18-24) seen at six (6) HIV clinics in southwestern Uganda.
Aim 2. Using a mixed methods approach, identify the multi-level (individual, interpersonal, community and structural) factors associated with ADU among AYLHIV.
Aim 3. Using a subset of the sample, explore the feasibility and short-term effects of a family-based economic empowerment intervention on ADU among AYLHIV.

 Trinidad and Tobago 2023-03-02 15:32:31 2026-03-02 Medical and Health Sciences Clinical Trial Non-degree Award
NALWANGA ROSEMARY
ID:
Towards reconstructing latitudinal and altitudinal temperature gradients from the Last Glacial Maximum to the Present – Development of a globally applicable palaeothermometry method based on luminescence
REFNo: NS487ES

Reconstruction of surface air temperatures over the past 20,000-30,000 years along an
Achieve a better understanding of atmospheric dynamics in the tropics during the transition
from the Pleistocene to the Holocene
altitudinal gradient (lapse rate) and comparison to currently measured temperatures
 Uganda 2023-03-02 15:14:46 2026-03-02 Natural Sciences Non-Clinical Trial Non-degree Award
Victoria Nambasa Prudence
ID: UNCST-2022-R008757
 Landscape Assessment To Understand Maternal Vaccine Pharmacovigilance In Uganda
REFNo: HS2680ES

Main objective
The aim is to conduct a rapid assessment gap analysis and stakeholder mapping for safety monitoring of vaccines used in pregnancy and potential for use of Electronic Medical Record (EMR) for sentinel site surveillance in Uganda for post licensure studies as well as current tetanus and COVID-19 vaccination. The results of the assessment will inform areas of focus for establishment of robust safety surveillance of novel maternal vaccination and vaccines that maybe administered during pregnancy in pandemic situations in the country.
Specific objectives
1. Map stakeholders involved in regulation, policy setting, collection and reporting of adverse events following maternal vaccination and their linkages
2. Understand the existing methods, tools, and information flow for collecting and flow of adverse event following maternal vaccination
3. Mapping of current Electronic Health Record and registries roll-out and how they interface with national drug safety reporting system especially in relation to maternal vaccination
4. To understand the Community views, and perceptions on vaccination and reporting of AE during maternal immunization

Uganda 2023-03-02 15:08:39 2026-03-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edmund  Mugayehwenkyi Kenneth
ID:
Women Rise Together across the Lifecourse (Write-Life)
REFNo: SS1633ES

3. What do women need to address their health and wellbeing issues and to feel more empowered? ,2. How empowered are women feeling? Document levels of perceived empowerment among women across the lifecourse, from young women through middle aged, to older women as well and capture the varied experiences of women in varied socioeconomic, cultural and community situations.,1. How are women doing? Examine associations between work (both paid and unpaid) and health throughout the COVID-19 pandemic among women across the lifecourse.,
 Uganda 2023-03-02 14:46:12 2026-03-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Irumba Eleazar Paddy
ID:
The environmental stewardship by the church of Uganda in Albertine region- a case of Bunyoro-Kitara diocese.
REFNo: HS2675ES

4. To Explore the Theological Practices that the Church can use to enhance Environmental Stewardship in the Albertine Region.,3. To Establish the Relationship of Religious Teachings and Ethical Practices regarding Environmental Stewardship in the Albertine Region.,2. To Examine the role played by Church of Uganda in Environmental Stewardship in the Albertine Region,1. To investigate the current factors responsible for Environmental Degradation in the Albertine Region,
 Uganda 2023-03-02 14:04:06 2026-03-02 Medical and Health Sciences Non-Clinical Trial Degree Award
John Bosco Ddamulira Mayanja
ID: UNCST-2022-R010819
 ASSESSMENT OF THE MAGNITUDE AND CORRELATES OF HIV STIGMA AND DISCRIMINATION AND ITS EFFECTS ON THE COUNTRY’S HIV RESPONSE
REFNo: HS2690ES

To describe how different groups are affected by HIV related stigma and discrimination especially the key populations. ,To identify factors that perpetuate or mitigate stigma as well as the actions (resilience) taken by PLHIV to mitigate the impact of stigma and discrimination,To assess the effect of stigma and discrimination on the country’s HIV response.,To describe trends in experience of stigma and discrimination among PLHIV over time (comparing 2013, 2019 and 2022).,To determine the prevalence and distribution of the modes (internal and external) of HIV related stigma and discrimination manifestations among PLHIV ,To assess the magnitude and correlates of HIV stigma and discrimination and its effects on the country’s HIV response ,
 Uganda 2023-03-02 14:02:36 2026-03-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Harriet Mpairwe
ID: UNCST-2025-R017439
 Causes And MEchanisms foR non-atopic Asthma in children (CAMERA) Study
REFNo: HS2510ES

There is an urgent need for new and innovative research into the causes of non-atopic asthma (NAA), and the likely mechanisms involved. The objectives of this study are therefore to: I. investigate the causes of NAA in a variety of settings: high and low asthma prevalence, HICs and LMICs (Work Package 1 (WP1) II. investigate three possible mechanisms of NAA in these different settings, including the relative importance of neural mechanisms (Work Package 2 (WP2)) This intended scientific value of study is to provide key ground-breaking insights into the causes and mechanisms of the poorly-studied yet predominant non-atopic asthma phenotype because: (i) non-atopic asthma likely has different causes from atopic asthma, and these have been little studied to date in both high-income countries and low- and middle-income countries; (ii) non-atopic asthma likely involves different mechanisms, which require different treatments. This study is likely to show, in a variety of settings, that a substantial proportion of non-atopic asthma may involve different mechanisms, and will identify new directions and priorities for prevention, mechanistic research, and the development of new therapies
Uganda 2023-03-02 13:54:33 2026-03-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Iddi  Matovu
ID:
HIV RISKS AND INFECTION AMONG ADOLESCENT GIRLS AND YOUNG WOMEN AGED 15-24 YEARS IN UGANDA: DEVELOPMENT OF AN HIV-RISK REDUCTION MODEL FOR CENTRAL REGION
REFNo: HS2554ES

1) To determine the influence of behavioral and biological practices on the HIV Infection among AGYW in the Central region, Uganda.2) To assess the influence of socioeconomic factors on behavioral and biological practices associated with HIV Infection among AGYW in Central region, Uganda.3) To analyze the influence of structural factors on behavioral and biological practices associated with HIV Infection among AGYW in Central region, Uganda.4) To develop a multilevel HIV-Risk reduction model to facilitate the delivery of appropriate HIV prevention services responsive to the particular needs of the AGYW aged 15–24 years in the Central region, Uganda.
 Uganda 2023-03-02 12:56:09 2026-03-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Ritwika Sen
ID:
Supervision and Productivity Dynamics: Evidence from a Field (Work) Experiment
REFNo: SS1612ES

To examine the direct effects of the supervision of survey enumerators on their learning and individual performance., Examine the impact of supervision on the performance of employees through two distinct channels: monitoring and feedback.,
 India 2023-03-02 12:53:15 2026-03-02 Social Science and Humanities Non-Clinical Trial Degree Award
Diana  Ntamu Nandagire
ID:
Baseline survey for diverse and resilient livelihoods for youth and women from refugee and host communities in Isingiro and Lamwo districts
REFNo: SS1547ES

Main objective
To establish baseline status of the selected indicators for the Uthabiti project impact, outcome and outputs.


a)To provide initial values for the impact and outcome indicators disaggregated by gendered households as appropriate in the Uthabiti intervention areas, establishing target levels for improvements in these indicators over the three-year implementation period.

b)To provide more evidence to describe the prevailing conditions of the target communities or populations in terms of their socio-economic wellbeing and self-reliance and refine intervention. This will provide the consortium team a deeper understanding of the context to tailor the interventions as well understanding how well or not, the proposed theory of change aligns with the demonstrated need of the target population survey.


c)To provide Uthabiti baseline indicator values that can be compared with the endline indicator values to measure the level of changes and inform future programing,, and


d)To integrate gender and social inclusion throughout the review.

Uganda 2023-03-02 12:52:03 2026-03-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Raymond Atwine
ID: UNCST-2022-R011223
 A clinicopathologic digital image platform to aid the diagnosis of breast cancer amongst patients at Mbarara Regional Referral Hospital.
REFNo: HS2606ES

i. To develop a digital platform that will be used to process and store breast lesion images, symptoms, and risk factors among women presenting at Mbarara regional referral hospital with breast lesions.
ii. To digitize gross and histology annotated images of breast lesions from patients presenting at Mbarara regional referral hospital
iii. To develop a machine learning model for diagnosis of breast cancer in patients presenting with breast lesions at Mbarara Regional Referral Hospital

 Uganda 2023-03-02 12:50:32 2026-03-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Fred Kayemba Jonah
ID:
CLIMATE CHANGE ADAPTATION AND SUSTAINABLE LIVELIHOOD OF WOMEN IN AGRICULTURE IN BUSOGA SUBREGION, EASTERN UGANDA: THE MODERATING EFFECT OF POLICY IMPLEMENTATION
REFNo: SS1620ES

1. To examine Structural Climate Change Adaptation factors associated with sustainable livelihood of women in agriculture in the Busoga sub region, Eastern Uganda. 2. To assess Social Climate Change Adaptation factors associated sustainable livelihood of women in agriculture in the Busoga sub region, Eastern Uganda. 3. To determine Institutional Climate Change Adaptation factors associated with sustainable livelihood of women in agriculture in the Busoga sub region, Eastern Uganda. 4. To assess climate change policy implementation factors moderating in the relationship between climate change adaptation and the sustainable livelihood of women in agriculture in the Busoga subregion, Eastern Uganda.
Uganda 2023-03-02 12:49:17 2026-03-02 Social Science and Humanities Non-Clinical Trial Degree Award
Henry Twinomujuni Kafunjo
ID:
INDIGENOUS KNOWLEDGE AND INTELLECTUAL PROPERTY OF TRADITIONAL MEDICINE IN UGANDA
REFNo: SS1539ES

1) To assess the perceptions of traditional healers in Uganda on the use of an intellectual property system in the protection of traditional medicine knowledge.
2) To examine the suitability of an intellectual property system in protecting traditional medicine knowledge and practice.
3) To evaluate the factors that facilitate proper functioning of the intellectual property system in protecting traditional medicine knowledge and practice.

 Uganda 2023-02-27 10:10:15 2026-02-27 Social Science and Humanities Non-Clinical Trial Degree Award
Monil Khera
ID:
Investigate the effect of climate on the behaviour and demography of banded mongooses (Mungos mungo).
REFNo: NS443ES

Understand how body temperatures change in relation to the surrounding climate and what behaviours they are performing.
 UK 2023-02-27 10:06:38 2026-02-27 Natural Sciences Non-Clinical Trial Degree Award
Josephine Bwogi
ID:
IDENTIFICATION OF PATHOGENS ASSOCIATED WITH MEASLES-LIKE ILLNESSES (MLI) IN UGANDA
REFNo: HS2678ES


To identify aetiological pathogens associated with measles-like rash illnesses in Uganda
Uganda 2023-02-24 17:00:31 2026-02-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Job Morukileng
ID:
Estimating the impact of COVID-19 on all-cause mortality in Uganda, during March 2021 to March 2022
REFNo: HS2687ES

To describe the distribution of excess mortality rate by key factors including cause, age, sex, ethnicity, location and socioeconomic status,To estimate excess mortality rate in Uganda during the COVID-19 pandemic (April 2020-March 2022),To estimate the impact of COVID-19 on all-cause mortality in Uganda, during April 2020 to March 2022 for planning, evaluating public health interventions and policy making.,
 Uganda 2023-02-24 16:58:26 2026-02-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan  Nabadda
ID: UNCST-2020-R014331
 Establishing capacity for wastewater-based COVID-19 epidemiology and supporting implementation of pilot surveys in Uganda
REFNo: NS480ES

To strengthen laboratory capacity to implement wastewater-based COVID-19 Surveillance and support the use of data from the surveys to complement disease surveillance and monitor trends in Uganda.
Uganda 2023-02-24 16:51:42 2026-02-24 Natural Sciences Non-Clinical Trial Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
 Active Prevention and Treatment of Maternal Sepsis
REFNo: HS2613ES

To examine if the APT-Sepsis programme is effective at reducing infection related maternal mortality and severe morbidity.
To evaluate if the APT-Sepsis programme is effective at reducing secondary clinical outcomes of: Stillbirth, early neonatal death (infection related and total), maternal mortality (any cause), maternal near miss (any cause)
To explore differential or subgroup effects of the APT-Sepsis programme.
To understand the implementation of the APT-sepsis programme in Malawi and Uganda, to facilitate interpretation of trial outcomes and development of a longer-term implementation strategy.
To determine if the APT-Sepsis programme is cost effective.
 Nigeria 2023-02-24 16:50:45 2026-02-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Moses Ocan
ID: UNCST-2020-R014731
 COVID-19 Vaccine Effectiveness, Vaccine Uptake Determinants, and Impact of Pandemic on Health Programs in Uganda
REFNo: HS2664ES

Objective 1: To evaluate the real-world COVID-19 vaccine effectiveness in Uganda using a retrospective study design

Objective 2: To identify the barriers and enhancers to COVID-19 vaccination among healthcare workers in Uganda

Objective 3: To assess the impact of COVID-19 on healthcare programs in Uganda

Objective 4: To evaluate the real-world COVID-19 vaccine effectiveness and safety in Uganda using a prospective study design

Objective 5: To develop a national biorepository for COVID-19 samples at H3Africa Biorepository at Makerere University Biomedical Research Center (MaKBRC), College of Health Sciences, Uganda

 Uganda 2023-02-23 8:26:55 2026-02-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert Ssekitoleko
ID: UNCST-2019-R001716
 Promoting Universal Health Coverage for Amputees in Uganda through Social Enterprise and Engineering Innovation
REFNo: SIR192ES

The principles of patient autonomy, non-maleficence, beneficence, and justice will be employed. Institutional safeguards, such as human subjects review committees and policies governing organisational ethics, will be followed. To this end, we shall seek ethical approval from the Makerere University School of Biomedical Sciences Research Ethics Committee and the Uganda National Council for Science and Technology. We shall also seek permission from the Ministry of Health as well as the management of the health units from which the data will be collected. We will provide verbal and written explanations of the study, including the aim, the level of participation required, potential risks of involvement, and the approximate duration of participation. The consent will include full verbal (in case of illiteracy) and written/signed informed consent from all individuals and groups before accepting to be interviewed. We will seek written permission to record interviews, and access meeting minutes, reports, and other relevant documents from relevant persons prior to including them in the research. Participants will be asked to give verbal consent and confirm this by reading and signing the consent form (included in the appendix). The key informants, including service users, will be free to withdraw consent at any time without giving an explanation and without this negatively affecting the care they receive. Data collectors will translate information into the relevant local language where required. We will seek verbal consent from participants who struggle to read and write, and the next of kin will sign the consent form on behalf of the user. We will only include participants 18 years of age and older who can provide consent on their own. The participant information sheet will explicitly state that participation in this study is purely voluntary. Participants can withdraw at any time, up to 14 days after data collection, without giving the reason for their withdrawal from the study. Their decision to withdraw from the study will not affect the services they receive. Participants will have up to 48 hours after receiving full details about the study, to consider participating in the research and ask questions.
 Uganda 2023-02-22 8:38:27 2026-02-22 Engineering and Technology Non-Clinical Trial Non-degree Award
Josephine Ayebare
ID:
An E-participation Model and Mobile Application Prototype for Inclusive Governance and Policy Development in Rural Uganda: Participatory Approach
REFNo: SS1621ES

To evaluate the usefulness of the model designed in objective 2 in achieving participation objectives through assessing the mobile application prototype designed in objective 3.,To co-design a mobile application prototype with the rural population stakeholders of Isingiro district in Uganda for based on the model developed in objective 2. ,To co-design a multi-dimensional model with the rural population e-participation stakeholders of Isingiro district in Uganda using the social-technical contextual factors and their SWOT analysis identified in objective 1. ,To identify and analyse the socio-technical contextual factors that influence political e-participation in rural Uganda. ,Aims to design and develop a multidimensional e-participation model and a mobile application prototype suitable for promoting e-participation among the rural population in Isingiro district in Uganda.,
 Uganda 2023-02-21 13:17:02 2026-02-21 Social Science and Humanities Non-Clinical Trial Degree Award
Harriet Mayanja-Kizza
ID: UNCST-2021-R013074
 PHASE 2C CLINICAL TRIAL OF NOVEL, SHORT-COURSE REGIMENS FOR THE TREATMENT OF PULMONARY TUBERCULOSIS: CRUSH-TB (Combination Regimens for Shortening TB Treatment)
REFNo: HS2650ES

Primary objective
(1) To compare the efficacy of each experimental regimen to the efficacy of standard treatment, using the intermediate endpoint of time to culture negative in liquid media.

Secondary objectives
(1) To compare the proportion of participants with a grade 3 or higher adverse event in each experimental arm with the control arm
(2) To describe the proportion of participants experiencing lack of sustained cure during treatment or follow-up to 52 weeks in each experimental arm as compared to control and make predictions as to how these regimens would perform in future phase III trials.
(3) To compare the efficacy of each experimental regimen to the efficacy of standard treatment, using the intermediate endpoint of time to culture negative in solid media
(4) To compare the proportion of participants in each arm who convert liquid and solid sputum cultures to negative by (a) 8 weeks of treatment and (b) 12 weeks of treatment
(5) To describe the rate of all-cause study drug discontinuation in each arm
(6) To compare time to sputum culture positivity curves through 17 weeks in the Mycobacterial Growth Indicator Tube (Bactec MGIT960) across arms
(7) To describe the proportion of participants experiencing lack of sustained cure during treatment or follow-up up to 78 weeks in each experimental arm as compared to control and make predictions as to how these regimens would perform in future phase III trials.
(8) To describe the population PK of bedaquiline and its M2 metabolite, with or without rifabutin co-administration (PK#1)
(9) To conduct pharmacokinetic/pharmacodynamics study of the test drugs to determine relationships between pharmacokinetic parameters (AUC, Cmax) and outcome measures (time to culture negativity or rate of change in TTP) using non-linear mixed effects models, adjusting for key covariates that may affect outcomes (e.g. companion drugs, HIV status, cavitary disease) (PK#2)

 Uganda 2023-02-21 13:13:53 2026-02-21 Medical and Health Sciences Clinical Trial Non-degree Award
KIRABO NAKASIITA NKAMBWE
ID:
Mindset, Teaching and Learning Strategies in Sciences among Secondary School Students in Wakiso District: The mediating effect of Interest
REFNo: SS1591ES

6. To assess the moderating effect of teaching strategies on the relationship between mindset and learning strategies in sciences among O level students in Wakiso district,5. To assess the mediating effect of interest on the relationship between mindset and learning strategies in sciences among O level students in Wakiso district ,4. To determine the relationship between mindset and learning strategies in sciences among O level students in Wakiso district ,3. To assess the relationship between interest and learning strategies in sciences among O level students in Wakiso district ,2. To examine the relationship between mindset and interest in sciences among O level students in Wakiso district ,1. To establish the science interest levels among O level students in Wakiso district,To assess the effects of mindset, interest and teaching strategies on students’ use of learning strategies in sciences among O level students in Wakiso District,
 Uganda 2023-02-21 13:08:23 2026-02-21 Social Science and Humanities Non-Clinical Trial Degree Award
Moses KIRYA Mateeke
ID:
Relationships among Core Competencies, Career Choices and Relevant influential factors based on final year Undergraduate Business Student’s Perceptions in Ugandan universities.
REFNo: SS1566ES

To empirically investigate the relationship among core competencies, career choices and relevant influential factors based on final undergraduate business student’s perception in Ugandan universities, Specifically, to explore:

1. The relationship among core competencies and career choices based on final year undergraduate business students’ perception in Uganda

2.The relevant influential factors on career choices and core competencies based on final year undergraduate business students’ perception in Uganda
 Uganda 2023-02-21 13:01:29 2026-02-21 Social Science and Humanities Non-Clinical Trial Degree Award
Jacqueline Delie Slabe
ID:
Exploring the social-political contexts of wildlife conservation in Queen Elizabeth and Kibale National Parks in Uganda
REFNo: SS1479ES

1. Understand which socio-political factors affect community-ranger relations in Queen Elizabeth and Kibale National Parks, Uganda.

2. Identify the similarities and differences between communities and park rangers in their perceptions of socio-political factors, and their potential relevance to mitigating human-wildlife conflicts and strengthening conservation of both wildlife and culture.

3. Highlight the important insights that arise in characterizing gendered similarities and differences in the way communities and park rangers value the local protected area.
USA 2023-02-21 13:00:12 2026-02-21 Social Science and Humanities Non-Clinical Trial Non-degree Award
Roy Mayega William
ID: UNCST-2022-R010983
 Uganda Non-State Schools Assessment
REFNo: HS2516ES

4. To assess the capacity of non-state pre-primary and primary schools to sustainably finance quality education.,3. To explore the oversight and regulation functions among non-state pre-primary and primary schools.,2. To understand the barriers faced by learners from traditionally marginalized groups in accessing non-state pre-primary and primary schools in urban and peri-urban centers. ,1. To determine the quality of education in non-state pre-primary and primary schools in urban and peri-urban areas of Uganda, especially in light of the recent COVID-19 pandemic.,To determine the factors that influence the quality and level of access to non-state primary and pre-primary schools in urban and peri-urban areas of Uganda. ,
 Uganda 2023-02-21 12:53:41 2026-02-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 THE SECOND UGANDA NATIONAL ANTI-TUBERCULOSIS DRUGS RESISTANCE SURVEY(DRS2)
REFNo: HS2652ES

To identify the demographic and clinical factors associated with drug resistance in Uganda including HIV, tobacco smoking, diabetes and alcoholism.,To determine circulating strains of MTB in the general population among PBCs in Uganda.,To determine the prevalence of resistance mutations to all first- and second-line drugs in use in Uganda.,To determine the prevalence and patterns of drug resistance to fluoroquinolones, Bedaquiline, Delamanid, clofazimine, amikacin, and Linezolid among patients with confirmed RR-TB in Uganda.,To determine the prevalence of resistance to HRZE among new and previously treated PBC patients in Uganda.,To measure the prevalence of RR-TB among bacteriologically confirmed pulmonary TB (PBC) patients in Uganda. ,
 Uganda 2023-02-20 13:22:01 2026-02-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Wietse Tol
ID: UNCST-2021-R013085
 AlCohol use in HumanitariAN settings: a programme of work to address alcohol use disorders and associated adversities among conflict-affected populations in UGanda and UkrainE (CHANGE)
REFNo: SS1596ES

• To identify strategies and techniques from evidence-based alcohol use therapies which can be integrated into PM+, and to develop a new intervention called PM+A (Problem Management Plus Alcohol)
• To adapt PM+A to local circumstances, and to examine the feasibility, acceptability, perceived effectiveness, and preliminary impact of PM+A
• To evaluate effectiveness and cost-effectiveness of PM+A through two single-blind randomised controlled trials in Uganda and Ukraine
• To explore the process of implementation, and to identify, characterise and explain mechanisms that promote or inhibit the delivery and take-up of PM+A in both settings
• To examine the potential for scaling-up PM+A in Uganda and Ukraine

 Netherlands 2023-02-17 12:18:30 2026-02-17 Social Science and Humanities Clinical Trial Non-degree Award
Silver Onyango
ID: UNCST-2022-R009337
 Ambient air pollution and lung health in rural sub-Saharan Africa: The impact of biomass on vulnerable populations
REFNo: HS2657ES

Characterize the relationship between chronic ambient air pollution exposure and lung function trajectory and structural abnormalities. Validate satellite-based calculations of PM2.5 and test inexpensive optical particle counters for future monitoring,Characterize ambient air pollution levels and sources in rural southwestern Uganda ,Characterize the effect of ambient air pollution and sources on lung function among vulnerable people in rural south western Uganda. ,
 Uganda 2023-02-15 17:05:50 2026-02-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jerome  Kabakyenga Kahuma
ID: UNCST-2021-R013729
 BACKTRACK: A technology enabled care pathway delivered by clinical officers and nurses to manage low back pain
REFNo: HS2636ES

BACKTRACK will enable the clinical officer or nurse to identify the cases that should be referred onwards for specialist assessment and intervention such as physiotherapy,BACKTRACK will enable the clinical officer or nurse in dispatching evidence based self-management advice,BACKTRACK will enable the clinical officer or nurse to safely identify LBP cases that are amenable to self-management,to develop and evaluate a digital clinical decision support system (DCDSS) called BACKTRACK. ,to improve access to rehabilitation for people with low back pain to reduce its disability burden, and to improve functional and participatory outcomes (such as return to work or school).,
 Uganda 2023-02-15 16:53:46 2026-02-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Charles Bawate
ID: UNCST-2022-R009806
 Determinants and impact of health education intervention on patients' adherence to Arteminsinin-based combination therapy treatment in Kamuli District, Uganda
REFNo: HS2576ES

General Objective
To assess the determinants and the impact of health education intervention on patients' adherence to ACT treatment in kamuli District, Uganda.

Specific Objectives
1. To determine the level of patients' adherence to ACT in the case management of malaria in Kamuli District, Uganda.
2. To determine the factors influencing patients' adherence to malaria ACT treatment in Kamuli District, Uganda.
3. To establish the impact of a health education intervention on the patients' adherence to malaria ACT treatment in kamuli District, Uganda.
 Uganda 2023-02-15 16:35:05 2026-02-15 Medical and Health Sciences Non-Clinical Trial Degree Award
Jackline  Kiwelu Estomihi Mayende
ID:
Evidence-based information practice framework for maize postharvest handling by rural smallholder farmers in Uganda.
REFNo: SS1435ES

1. Evaluate the current status
of evidence-based
information practices by
maize smallholder farmers in
Uganda concerning maize
postharvest handling.
2. Describe the evidence
information practice needs
for rural smallholder farmers
as far as maize postharvest
handling is concerned.
3. Explain the access and use
of the available maize postharvest
handling evidence-based
information practice.
4. Describe difficulties that
smallholder farmers and
extension service librarians
are experiencing with the
available maize postharvest
handling evidence-based
information practice in terms
of access and use.
5.
5. Propose evidence-based
information practice
framework for maize
postharvest handling by rural
smallholder farmers in
Uganda.
 Tanzania 2023-02-15 16:33:01 2026-02-15 Social Science and Humanities Non-Clinical Trial Degree Award
Casey Crow Lynn
ID:
Exploring Sexual and Reproductive Health and Rights Amongst Refugees with Disabilities in Uganda
REFNo: SS1611ES

4. To identify barriers and facilitators to accessing SRHR-related services with the aim of improving uptake and informing future service provision.,3. To explore how disability, migration, and access to sexual and reproductive health influence lived experience from micro (individual, family, intimate relationships), to meso (school, community, NGOs, healthcare), to macro (societal, policy) levels. ,2. To describe how refugees with disabilities navigate and resist violence, stigma, and marginalisation of their sexual and reproductive health and rights.,1. To explore the ways disability and migration interact in the process of seeking sexual and reproductive health services.,To explore the SRHR-related lives, needs, contexts, and access to services amongst refugees with disabilities in Uganda.,
 USA 2023-02-14 17:15:17 2026-02-14 Social Science and Humanities Non-Clinical Trial Degree Award
JOHNBAPTIST BWANIKA
ID:
A Research study to understand the impact and cost-effectiveness of a digital health platform for iCCM in Uganda
REFNo: HS2645ES

Specific objectives
1.Determine the impact of the eCHIS intervention on OPD attendance (due to malaria, pneumonia and diarrhoea) among children under five,
2.Determine the impact of the eCHIS intervention on hospitalisation (due to malaria, pneumonia and diarrhoea) among children under five,
3.Determine the impact of the eCHIS intervention on malaria related mortality in the community and health facilities among children under five,
4.Determine if translating the eCHIS into the local language improves VHTs’ service delivery (satisfaction, confidence, accuracy, interpretation, and quality),
5.Determine the cost-effectiveness of implementing the eCHIS intervention.

Secondary objectives
1.To assess the data quality of VHT monthly digital reports,
2.To assess use of digital dashboards for decision-making at HF and district level,
3.To assess the proportion of the devices still functioning each month throughout the study and document reasons why they malfunctioned,
4.To assess maintenance requirements

Uganda 2023-02-14 16:58:01 2026-02-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ham Wasswa Matovu
ID:
ASSESSMENT OF POST INTENSIVE CARE UNIT OUTCOMES AND FACTORS ASSOCIATED WITH 90-DAY MORTALITY AMONG ADULT PATIENTS
REFNo: HS2143ES

1. To determine the factors associated with 90-day mortality of patients discharged from three tertiary hospital ICUs in Kampala.,2. To determine the physical functional status of ICU survivors at 90 days following discharge from three tertiary hospital ICUs in Kampala.,1. To determine the 90-day mortality rate of patients discharged from three tertiary hospital ICUs in Kampala.,To determine the 90-day mortality rate, functional status and risk factors for mortality among patients discharged from 3 tertiary hospital ICUs in Kampala.,
 Uganda 2023-02-14 14:38:03 2026-02-14 Medical and Health Sciences Non-Clinical Trial Degree Award
Elvaida Agnes Tagulwa Twesigye
ID:
QUALITY ASSURANCE PRACTICES AND STUDENTS’ EMPLOYABILITY IN PUBLIC UNIVERSITIES IN UGANDA: A CASE OF KYAMBOGO UNIVERSITY
REFNo: SS868ES

1. To analyse the curriculum review process and students’ employability.
2. To assess the role of career education in promoting students’ employability.
3. To measure the extent to which Industrial training enriches students’ employability.
4. To evaluate employability skills and competences students need within the changing expectations of the labour market.
5. To assess Institutional Leadership and the functioning of Quality Assurance practices at Kyambogo University.

 Uganda 2023-02-14 14:23:34 2026-02-14 Social Science and Humanities Non-Clinical Trial Degree Award
Jerome  Kabakyenga Kahuma
ID: UNCST-2021-R013729
 A Process Evaluation of an Adolescent and Youth Sexual Reproductive Health and Rights Intervention in Bushenyi and Rubirizi Districts, UGANDA
REFNo: HS1003ES

The ultimate project outcome is improved comprehensive sexual and reproductive health for adolescents and youth in southwest Uganda through delivery of an adolescent SRHR package using the MamaToto Approach.
The primary objectives of the project are:
1) To strengthen district health systems so they can improve provision of genderresponsive and adolescent-friendly comprehensive sexuality education and sexual and reproductive health services in target district(s) in SW Uganda.
2) To strengthen health center service delivery in order to increase utilization of genderresponsive and adolescent-friendly comprehensive sexuality education and sexual and reproductive health services in target district(s) in SW Uganda.
The immediate project outcomes are:
1. Increased readiness of districts to govern, plan, manage, supervise, and report on adolescent and youth-friendly sexual and reproductive health and rights (AYSRHR)
2. Increased readiness of health facilities to deliver AYSRHR activities
3. Increased readiness of districts, health facilities, and communities to train, supervise, and monitor a network Village Health Teams (VHTs) and community AYSRHR activities
4. Increased readiness of community agents (VHTs) to promote AYSRHR

Uganda 2023-02-14 14:06:36 2026-02-14 Medical and Health Sciences Non-degree Award
Paul Alele Erasmus
ID: UNCST-2022-R009266
 Postgraduate medical trainees’ perceptions of their learning environment and characteristics associated with career engagement in a resource-limited setting
REFNo: SS1615ES

To identify, using a focus group discussion, the contributions of postgraduate medical trainees’ perceptions of the learning environment to their engagement during training,To examine, using the Postgraduate Hospital Educational Environment Measure (PHEEM), how postgraduate medical trainees in a resource-limited setting perceive their learning environment,The main objective of this proposal is to examine postgraduate medical trainees’ perceptions of the learning environment in relation to their emotional climate (wellness, burnout and other negative behaviors) and career engagement.,
 Uganda 2023-02-13 11:16:19 2026-02-13 Social Science and Humanities Non-Clinical Trial Non-degree Award
Polycarp Omara
ID: UNCST-2022-R011110
 INSTRUCTIONAL SUPERVISION AND TEACHER COMPETENCE ENHANCEMENT IN SECONDARY SCHOOLS IN ARUA, UGANDA
REFNo: SS1598ES

To propose teacher competence profile for secondary school teachers in Uganda.,To examine the relationship between non-directive supervision and teacher competence enhancement in secondary schools in greater Arua.,To examine the relationship between collaborative supervision and teacher competence enhancement in secondary schools in greater Arua.,To establish the relationship between directive supervision and teacher competence enhancement in secondary schools in greater Arua. ,To explore the status of teacher competence in secondary schools in Arua, Uganda.,To establish the different dimensions of instructional supervision employed in secondary schools in Arua, Uganda.,This study aims to explore the impact of instructional supervision on the enhancement of teacher competence in secondary schools in Arua, Uganda.,
 Uganda 2023-02-13 11:12:24 2026-02-13 Social Science and Humanities Non-Clinical Trial Degree Award
Maxensia owor
ID: UNCST-2021-R014003
 IMPAACT 2036: Phase I/II Study of the Safety, Tolerability, Acceptability, and Pharmacokinetics of Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in Virologically Suppressed Children Living with HIV-1, Two to Less Than 12 Years of Age. Version 1.0, 22 September 2022. DAIDS study protocol ID: 38932
REFNo: HS2599ES

iii. Cohort 2: To describe the maintenance of viral suppression and immunologic activity of 48 weeks of CAB + RPV (oral and injectable) or 44 weeks of CAB LA + RPV LA (injectable only),iv. Cohort 2: To describe HIV-1 genotypes and phenotypes for children who experience virologic failure during 48 weeks of CAB + RPV (oral and injectable) or during 44 weeks of CAB LA + RPV LA (injectable only),ii. Cohort Cohort 2: To describe the safety and repeat-dose pharmacokinetics of 48 weeks of CAB + RPV (oral and injectable) or 44 weeks of CAB LA + RPV LA (injectable only),i. Cohort 2: To describe tolerability and acceptability of 48 weeks of CAB + RPV (oral and injectable) and 44 weeks of CAB LA + RPV LA (injectable only),ii Cohort 1: To assess the safety of the oral lead-in of CAB + RPV, and the safety of CAB + RPV (oral and injectable) through Week 24,i.Cohort 1: To describe the repeat-dose pharmacokinetics of CAB + RPV (oral and injectable) through Week 24,
 Uganda 2023-02-13 11:10:13 2026-02-13 Medical and Health Sciences Clinical Trial Non-degree Award
Josphat Muchangi Martin
ID: UNCST-2022-R010507
 Impact of the intervention ‘Financial Inclusion Improves Sanitation and Health 2022-2024’. A randomized controlled trial in Kenya and Uganda
REFNo: SS1587ES

To determine the cost-effectiveness of the FINISH model (creating earning opportunities, job market participation) and amount of leverage funds generated. ,To explore the perspectives, attitudes, and practices of various stakeholders (communities, governments, entrepreneurs, and financiers) regarding the FINISH model.,To estimate the impact of the FINISH model on health (diarrhoea occurrence, hygienic behaviour) and social (school attendance, sanitation) outcomes. ,To evaluate the impacts of the FINISH interventions in Kenya and Uganda.,
 Kenya 2023-02-13 11:06:11 2026-02-13 Social Science and Humanities Non-Clinical Trial Non-degree Award
Denis Bwayo
ID:
Risk factors, genetics and mortality among patients with dilated cardiomyopathy in Uganda
REFNo: HS2444ES

1. To investigate risk factors, genetics, and moratlity among patients diagnosed with DCM in Uganda Delete
2.To determine the underlying genetics and inheritance characteristics of DCM in Uganda Delete
3. To determine the incidence and predictors of all-cause mortality 12 months after DCM diagnosis in Uganda
 Uganda 2023-02-13 11:04:24 2026-02-13 Medical and Health Sciences Non-Clinical Trial Degree Award
Victoria Nankabirwa
ID: UNCST-2021-R011871
 Use of the Global Scale for Early Development (GSED) within Preventing Infant Malnutrition with Early Supplementation (PRIMES) Trial
REFNo: HS2263ES

1) To obtain preliminary estimates of the correlation between Global Scale for Early Development (GSED) scores and MRI findings (total brain and white matter volumes) in infants at 6 and 12 months of age.
2) To assess user feedback about the Hyperfine LF MRI device.
3) To determine whether the Hyperfine LF MRI device is feasible and acceptable among healthcare personnel and caregivers of infants undergoing LF MRI.

 Uganda 2023-02-13 11:01:02 2026-02-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Winnie  Muyindike R
ID: UNCST-2021-R013558
 A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure for Individuals on TLD in Sub-Saharan Africa.(RESOLVE)
REFNo: HS2620ES

Aim 2: Use simulation modeling to examine the clinical impact, costs, and cost-effectiveness of strategies to improve viral suppression after virologic failure on TLD. We will populate the previously validated Cost-Effectiveness of Preventing AIDS Complications-International (CEPAC-I) model with the novel clinical trial data from Aim 1 to project long-term clinical outcomes and cumulative lifetime costs. We will then compare the cost-effectiveness of the three strategies evaluated in Aim 1 for addressing virologic failure among people treated with first-line TLD in Uganda or South Africa. ,Aim 1: Conduct a randomized clinical trial to determine the optimal strategy for management of virologic failure on first-line TLD in SSA. We will recruit 648 adolescents and adults with two viral loads >1,000 copies/mL while on first-line TLD for at least 12 months, who are in care at one of six public-sector HIV clinics in Uganda or South Africa. We will randomize participants to one of the following strategies, stratified by clinic and prior NNRTI-exposure: a) Maintenance on TLD with switch to protease inhibitor (PI)-based second-line ART if virologic failure persists past six months; b) Individualized Care, with regimen choice based on results of genotypic resistance tests and urine tenofovir assays; or c) Immediate Switch to PI-based second-line ART. The primary outcome will be viral suppression (<50 copies/mL) at 48 weeks post-enrollment using the FDA snapshot definition. We hypothesize that rates of viral suppression at 48 weeks will be higher in the Individualized Care arm than in the Maintenance on TLD and Immediate Switch arms.,
 Uganda 2023-02-09 11:06:56 2026-02-09 Medical and Health Sciences Clinical Trial Non-degree Award
Bruno Sserunkuuma
ID:
PREVALENCE AND FACTORS ASSOCIATED WITH ADVERSE MATERNAL OUTCOMES OF SPINAL INDUCED HYPOTESION AMONG WOMEN UDERGOING CEASAREAN DELIVERIES AT MBARARA REGIONAL REFERRAL HOSPITAL.
REFNo: HS2562ES

General objective.
To determine the prevalence and factors associated with adverse maternal outcome of spinal induced hypotension among women undergoing caesarean deliveries at Mbarara Regional Referral Hospital
Specific objectives
1.To determine the prevalence of mothers that develop spinal induced hypotension undergoing caesarean deliveries at Mbarara Regional Referral Hospital.
2.To determine the factors associated with spinal induced hypotension among mothers undergoing caesarean deliveries at Mbarara Regional Referral Hospital
3.To describe the adverse maternal outcomes among women with spinal induced hypotension


 Uganda 2023-02-07 11:14:38 2026-02-07 Medical and Health Sciences Non-Clinical Trial Degree Award
DIANA NABUKENYA KASOZI
ID:
TIME TO TREATMENT INITIATION AMONG PATIENTS TREATED FOR DR-TB IN UGANDA
REFNo: HS2653ES

1. To determine the socio-demographic factors associated with drug-resistant tuberculosis (DR-TB) treatment delay among DR-TB patients in order to achieve a successful or unsuccessful treatment outcome in Uganda.
2. To investigate what clinical factors associated with DR-TB treatment delay among DR-TB patients in order to attain a successful or unsuccessful treatment outcome in Uganda.
3. Describe the structural factors associated with DR-TB treatment delay among DR-TB patients in order to achieve a successful or unsuccessful treatment outcome in Uganda.
4. To estimate the mean and median time to DR-TB treatment from the time of DR-TB diagnosis for patients on DR-TB treatment in Uganda.

Uganda 2023-02-06 17:25:58 2026-02-06 Medical and Health Sciences Non-Clinical Trial Degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
 The Impact of HIV on the Breast Cancer Tumor Microenvironment
REFNo: HS2651ES

Compare the molecular profile of breast cancer tissue and blood using targeted sequencing from HIV+ women and HIV- women to identify potential HIV-associated features driving increased tumor aggressiveness.,Assess if the presence, spatial distribution, and/or the cellular phenotype of immune cells in the breast TME are consistent with HIV- associated immune dysfunction in WLWH compared to HIV- women,Identify features of HIV-associated immune dysfunction in blood and tumor tissue from WLWH with breast cancer that could promote tumorigenesis and progression.,
 Uganda 2023-02-06 17:24:00 2026-02-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Shannon McMorrow
ID:
Photovoice assessment of integration, health, and healthcare experiences of urban Congolese refugee women in Kampala, Uganda
REFNo: HS2655ES

To generate in-depth, contextual evidence to inform policy and program improvements for Congolese refugee women in Kampala to prevent further marginaliation and negative health outcomes.
 USA 2023-02-06 17:19:40 2026-02-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Afiz Kibuuka Kibuuka
ID: UNCST-2021-R012755
 A Phase 3, multicenter, randomized, double-blind, 24-week study of the clinical and antiviral effect of S-217622 compared with placebo in non-hospitalized participants with COVID-19
REFNo: HS2642ES

The main intent of the study is to evaluate the efficacy of S-217622 vs. placebo. The study will be conducted in the setting of the locally available standard-of-care COVID-19 treatment. High-risk and low-risk participants will be analyzed together for the primary analysis and separately for secondary analyses. The following primary, secondary, and exploratory objectives will be addressed in the modified intent-to-treat (mITT) population, except for the safety analyses, which will be analyzed in the Safety population, and pharmacokinetic (PK) analyses, which will be analyzed in the PK population.
 Uganda 2023-02-06 17:17:04 2026-02-06 Medical and Health Sciences Clinical Trial Non-degree Award
Acidri Bileti Emmanuel
ID:
UNIVERSITY INFRASTRUCTURE AND CURRICULUM IMPLEMENTATION IN PUBLIC UNIVERSITIES IN NORTHERN UGANDA
REFNo: SS1600ES

Purpose of the study The purpose of this study is to investigate how the university infrastructure influences curriculum implementation in public universities in Northern Uganda. Objectives of the study 1)To assess administrators’ perception on the current status of curriculum implementation in public universities in Northern Uganda. 2) To establish how physical infrastructure influence curriculum implementation in public universities in Northern Uganda. 3) To determine how didactic infrastructure influence curriculum implementation in public universities in Northern Uganda. 4) To examine how services infrastructure influence curriculum implementation in public universities in Northern Uganda.
Uganda 2023-02-06 17:11:43 2026-02-06 Social Science and Humanities Non-Clinical Trial Degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 PERFORMANCE EVALUATION OF THE COBAS HIV-1 NUCLEIC ACID TEST FOR USE ON THE COBAS 4800 SYSTEM USING DBS FOR DETECTION OF HIV-1.
REFNo: HS2661ES

To verify the performance (sensitivity and specificity) of cobas HIV-1 Nucleic acid test for use on the cobas 4800 System against routine Cobas Ampliprep/Taqman HIV-1 Qualitative Test Version 2.0 (DBS) - for early diagnosis of HIV-1 in exposed infants. ,
 Uganda 2023-02-06 17:08:26 2026-02-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Gloria  Nabaasa
ID:
Treatment of Moderate Acute Malnutrition with Local Foods- Documentation and Costing of Approaches in Uganda: A Case Study in Kamuli, Masaka and Karamoja region
REFNo: HS2663ES

To document how local food-based approaches to treating MAM are implemented in different contexts and understand the results of those efforts as a contribution to ongoing global efforts to develop programmatic guidance in relation to the forthcoming WHO guidelines which will include recommendations on how to address MAM.,i. Determine the contextual factors (e.g., availability of and access to local foods) that influence the success or appropriateness of use of local food-based approaches in various settings in Uganda ii. Assess the difference between local food-based program structures and TSFP that follow the generic CMAM protocol in terms of core program components, admission and discharge criteria, referral and follow-up procedures, and reporting on outcomes iii. Established types of locally available foods are used to treat children with MAM and how does the nutritional value of the ration/recipe compare to the SNF standards set by WFP and the MAM Decision Tool.,
 Uganda 2023-02-06 17:04:40 2026-02-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Juliet Namugambe Sanyu
ID:
Quality of Antimalarials and Antibiotics in Private Medicine Outlets in Bugisu Region, Eastern Uganda
REFNo: HS2667ES

6. To assess perceptions of medicine sellers on quality of antimicrobials and how that influences their prescribing decisions in private medicine outlets in Bugisu, Eastern Uganda. ,5. To describe the methods used to identify poor-quality antimicrobials and the reporting systems used by private medicine outlets in Bugisu sub-region, Eastern Uganda.,4. To assess the conditions in premises associated with SF antimalarials and antibiotics in private rural and urban medicine outlets in Bugisu region, Eastern Uganda.,3. To assess the knowledge and practices of outlet owners associated with SF antimalarials and antibiotics in private rural and urban medicine outlets in Bugisu region, Eastern Uganda.,2. To assess the prevalence of substandard and falsified (SF) antimalarials and antibiotics offered for sale in the authorized and unauthorized private medicine outlets in Bugisu region, Eastern Uganda.,1. To assess the prevalence of substandard and falsified (SF) antimalarials and antibiotics offered in sale in private rural and urban medicine outlets in Bugisu region, Eastern Uganda,This study aims to measure the prevalence of substandard and falsified antimalarials and antibiotics in private medicine outlets of Bugisu sub-region in Eastern Uganda and explore the characteristics of rural, urban, authorised and unauthorised outlets and their influence on observed quality, as well as the medicine sellers perception on quality of medicines in the region.,
 Uganda 2023-02-06 16:50:57 2026-02-06 Medical and Health Sciences Non-Clinical Trial Degree Award
Grace Mulyowa Kitunzi
ID: UNCST-2022-R009761
 An Image Diagnostic tool for supporting clinicians managing Dermatitis Cruris Pustulosa et Atrophicans among Patients Presenting to Mbarara and Kabale Regional Referral Hospitals
REFNo: SIR186ES

• To improve diagnosis of DCPA through a machine learning model trained from locally obtained images.,
 Uganda 2023-02-06 16:44:23 2026-02-06 Engineering and Technology Non-Clinical Trial Non-degree Award
Kevin Arbuckle
ID:
Using community engagement to improve snakebite prevention measures in rural Uganda
REFNo: HS2326ES

The project aims to improve awareness and implementation of prevention measures against snakebite envenoming in rural communities in Uganda. In doing so our ultimate aim is to reduce the burden of snakebite envenoming in these high risk areas, using our local connections and community-integration approach to ensure the project continues to deliver this aim long after the end of the funding period.

We will achieve our aim via the following specific objectives:-
- Gain an understanding of current community knowledge and attitudes surrounding snakes and snakebite via interviews and surveys.
- Use the information from the first objective to prepare appropriate materials for co-creation workshops with the local community to promote awareness of local snakes and snakebite risk, implementation of prevention strategies, and discussion of appropriate responses in the event of a bite, all with attention given to targeted and specific solutions to local challenges and context.
- Donation of appropriate resources to assist local communities in reducing the risk of snakebite, such as appropriate footwear to prevent accidental bites on exposed feet and handling equipment to enable trained members of the community to move snakes away from high-risk locations such as school premises and homes (see final objective).
- Implement a 'train-the-trainer' programme to train the co-applicant in safe removal of snakes from premises and to enable him to take advantage of his teacher-training to pass these skills onto other willing members of the community. This will ultimately lead to a sustained network of members of the local community who can maintain risk reduction in the longer term.
 UK 2023-02-06 16:42:29 2026-02-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Noella Okalany Akwi Regina
ID: UNCST-2022-R011085
 Congenital Cytomegalovirus Infection in Eastern Uganda
REFNo: HS2668ES

To determine the short-term neurodevelopmental outcomes and hearing impairment associated with congenital cytomegalovirus among infants in Eastern Uganda.,To determine the incidence of, and risk factors for postnatally acquired cytomegalovirus among infants in Eastern Uganda.,To describe the factors associated with congenital cytomegalovirus infection in neonates in Eastern Uganda.,To determine the prevalence of congenital cytomegalovirus infection among neonates in Eastern Uganda,To investigate the burden of congenital cytomegalovirus and its outcomes among infants in Eastern Uganda.,
 Uganda 2023-02-06 16:21:08 2026-02-06 Medical and Health Sciences Clinical Trial Degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
 IMPAACT 2028: Long-Term Clinical, Immunologic, and Virologic Profiles of Children who Received Early Treatment for HIV; DAIDS Study ID #38693
REFNo: HS2417ES

To characterize the long-term clinical, immunologic, and Virologic profiles of children who received early treatment for perinatally-acquired HIV
 Uganda 2023-02-06 16:17:13 2026-02-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kathy Burgoine
ID: UNCST-2022-R011521
 Impact of prophylactic Continuous Positive Airway Pressure in the Delivery Room (DR-CPAP) on neonates <1500g in a low-resource setting: A feasibility trial
REFNo: HS2605ES

- To determine the acceptability of DR-CPAP to healthcare workers in a low-resource setting - To determine the post-intervention acceptability of using a two-stage consent process in neonatal emergencies in the delivery room in this setting - To evaluate the feasibility of a third-party allocation process for randomisation by determining the time to randomization - To evaluate feasibility of initiating DR-CPAP in a low-resource setting in infants with birthweight 800-1500g within 15 minutes of delivery - To determine the safety of initiating DR-CPAP in a low-resource setting - To estimate the sample size to be used for future evaluation in the full trial - To assess the feasibility of secondary outcome measures to be used in the full trial
UK 2023-02-02 12:18:23 2026-02-02 Medical and Health Sciences Clinical Trial Non-degree Award
Rachel Kawuma Mary Kagawa
ID: UNCST-2022-R009107
 Understanding digitally driven risk networks to inform user-centric target product profiles (TPP) for next-generation HIV vaccines (DigiTaPP Study)
REFNo: SS1519ES

Objective 1: To understand HIV prevention product development pipeline and potential vaccine attributes through scientific consultations with vaccine experts and product developers
Sub-objectives:
1. To understand current status of HIV vaccine development pipeline and potential HIV vaccine candidates along with potential product attributes;
2. To explore how communities are being involved in the development process, especially whether the preferences of potential end-users are being considered in TPP development.

Objective 2: To understand the nature and characteristics of HIV risk networks (or sexual networks of target populations at risk for HIV), across digital and physical spaces to inform strategies for engaging all potential end-users
Sub-objectives:
1. To identify the nature and types of physical and virtual platforms used by relevant target populations, explore their stated reasons for using them, and their interconnections;
2. To explore the differences in risk behaviours, current prevention practices and preference for prevention products (including vaccines) among the end-users from physical and digital networks.

Objective 3: To understand preferences of potential end-users (from digital and physical networks) through elicitation research towards informing HIV vaccine target product profile
Sub-objectives:
1. To understand end-users’ preferences for product characteristics and delivery sites;
2. To understand perceived benefit, perceived burden and self-efficacy that may influence product attribute preferences and delivery options;
3. To understand interpersonal and social influences that may influence product attribute preferences and delivery options.
 Uganda 2023-02-02 11:58:48 2026-02-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Peter Kisaakye
ID:
Measuring the incidence of abortion and the quality of postabortion care in refugee settings in Uganda
REFNo: SS1589ES

1. To measure the incidence of abortion in refugee settings in Uganda
2. To determine the severity of abortion-related complications in refugee settings in Uganda
3. To assess the capacity of the health system to offer post-abortion care to people living in refugee settings in Uganda

Uganda 2023-02-01 12:38:01 2026-02-01 Social Science and Humanities Non-Clinical Trial Non-degree Award
JANE  AMUGE
ID:
Implementing the Cooperative Resilience Measurement Index (CRMI) for Cooperatives in Uganda
REFNo: SS1592ES

1. Build the capacity of the cooperatives to establish prioritisation and ownership of the resilience investment.
2. Interrogate the value proposition of the CMRI to enhance cooperative sustainable resilience and competitiveness in Uganda.
3. To test the value proposition of the Coop Profiler to ensure adoption of the CMRI amongst cooperatives in Uganda
4. Publish a paper on the resilience capacity of agribusiness cooperatives in Uganda with policy recommendations

Uganda 2023-02-01 12:17:53 2026-02-01 Social Science and Humanities Non-Clinical Trial Non-degree Award
Margaret Lubwama
ID: UNCST-2019-R000636
 Gastrointestinal colonization with drug resistant bacteria in Ugandan patients with cancer and HIV
REFNo: HS2437ES

The overall purpose of the study is to determine the prevalence of ESBL and CRE gastrointestinal colonization in patients with newly diagnosed cancer at the time of chemotherapy initiation and determine how colonization changes over the first month after chemotherapy is initiated. The aims of the study are; 1. To define the association between HIV status and prevalence of gastrointestinal colonization with multidrug resistant organisms (MDROs) among patients with cancer in Uganda. 2. To assess the factors associated with incident MDRO colonization in the first 30-days after initiation of chemotherapy. 3. To investigate whether gastrointestinal colonization with an MDRO is associated with an increased risk of developing a bacterial bloodstream infection with that organism.
Uganda 2023-01-31 12:02:29 2026-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Annet Mbabazi
ID:
A mixed-methods study exploring the effect of workplace environment on the well-being of academic staff at Makerere university.
REFNo: SS1548ES

i. To assess the effectiveness of the perceived work climate on the well-being of academic staff at Makerere University.
ii. To explore the perception of supervisory relationships on the well-being of academic staff at Makerere University.
iii. To investigate the effect of peer group interaction on the well-being of academic staff at Makerere University.


 Uganda 2023-01-30 15:16:32 2026-01-30 Social Science and Humanities Non-Clinical Trial Degree Award
CHRISTINE ATUHAIRWE KIM
ID:
Predictors of HIV viral suppression, survival, and health-related quality of life (HR-QoL) among the Older infected persons in Uganda
REFNo: SS1396ES

1)To examine factors associated with virological failure among older infected persons on ART in Uganda.
2)To examine factors associated with survival among older infected persons on ART in Uganda.
3)To establish lifestyle factors associated with the Health-Related Quality of Life among older infected persons who have been on ART for at least 5 years in Uganda.

 Uganda 2023-01-30 15:07:26 2026-01-30 Social Science and Humanities Non-Clinical Trial Degree Award
Shelley Jones
ID:
Child Rights Education in Diverse Global Contexts and Times of Crises - A decolonizing, participatory action research project with educators, children, and community members in Canada and Uganda
REFNo: SS1326ES

Our objective is to investigate ways to understand and leverage a contextualized approach to child rights education (in accordance with Article 29(d) of the United Nations Convention on the Rights of the Child (UNCRC) and 11(2) of the African Charter for the Rights and Welfare of Children (the Charter) in three diverse global contexts. We ask, what processes support educators in different contexts achieve impactful child rights education that empowers children to learn about and exercise their rights, particularly during times/situations of crises? Sub-questions include: 1) How can children’s voices and experiences be centered to inform our understanding of effective child rights education?; 2) How can parents and community members work with educators and children to promote and uphold children’s rights?; 3) How can child rights education best contribute to identifying and advocating for measures to ensure the well-being of all children is prioritized, especially during crises?
 Canada 2023-01-30 14:58:26 2026-01-30 Social Science and Humanities Non-Clinical Trial Non-degree Award
Lauben Muhangane
ID:
MODELLING CATCHMENT LAND USE/ LAND COVER CHANGE AND ITS IMPACT ON THE FLOW OF RIVER RWIZI, SOUTH- WESTERN UGANDA
REFNo: NS436ES

To contribute to the evaluation of sustainable management options in order to improve the flow and quality of river Rwizi in the future,4. To determine the land management options most likely to improve the water flow of river Rwizi.,3. To model land use / land cover change of the catchment by 2040,2. To examine the trend in river flow over the past thirty years in ten year intervals ,1. To determine land use / land cover change rate and trend of the Rwizi catchment districts over the past thirty years in ten year intervals.,
 Uganda 2023-01-30 14:40:05 2026-01-30 Natural Sciences Non-Clinical Trial Degree Award
Jasper Nidoi
ID: UNCST-2021-R012079
 Improving TB case detection using a GeNder sensitive TB screening InTErvention in urban public health facilities in Uganda (IGNITE)
REFNo: HS2648ES

General objective The overall objective of this study is to codesign and evaluate a health facility-based TB screening intervention designed to increase active TB case detection by improving access to TB screening and care services, particularly among men, over a one-year study period. Specific 1) To codesign a health facility-based TB screening intervention targeting men 2) To evaluate the acceptability, appropriateness and feasibility of a health facility-based TB screening intervention targeting men 3) To evaluate the effectiveness of a health facility-based TB screening intervention targeting men in increasing the number of TB cases identified and initiated on treatment by sex over a one-year study period 4) To evaluate the cost-effectiveness of a health facility-based TB screening intervention targeting men
Uganda 2023-01-25 9:48:04 2026-01-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Emmanuel Sendaula
ID: UNCST-2020-R014767
 Pan-African Utilization of Lay Assessment Systems (PAULAS) Pilot Project
REFNo: HS2630ES

The self-reported Check-Up instrument will be used to collect data across the following domains: functional status, cognition, mood, communication, disease diagnoses, mental health, well-being, loneliness, and social engagement.,Collect health, well-being, and quality of life information on older people in central Uganda using the InterRAI Check-Up instrument. ,Assess the validity and reliability of the InterRAI Check-Up instrument in community-dwelling older adults in central Uganda.,
 Uganda 2023-01-25 9:45:06 2026-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jude Ssenyonjo
ID:
Elicitation research for primary HIV prevention among female sex workers in Uganda.
REFNo: HS2635ES

The study objective is to identify individual and provider-level barriers and facilitators to primary HIV prevention among female sex workers (FSWs) in an urban setting.,
 Uganda 2023-01-25 9:42:47 2026-01-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Arthur  Mpimbaza
ID: UNCST-2022-R008866
 Evaluating malaria case management at public and private health facilities in the Busoga, Lango, Acholi, West Nile and Karamoja sub-regions, Uganda
REFNo: HS2585ES

General objective
The general objective of this study is to assess the capacity of the health services delivery system to provide malaria case management services in five high burden sub-regions in Uganda.
1.3.2 Specific objectives
1. To determine the readiness of public and private health facilities to provide malaria case management services to patients in five high burden sub-regions in Uganda.
2. To determine the readiness of drug shop to provide malaria case management services to patients in five high burden sub-regions in Uganda.
3. To assess healthcare worker competencies in malaria case management standards at public health facilities in five high burden sub-regions in Uganda.
4. To assess drug shop vendor competencies in malaria case management standards in five high burden sub-regions in Uganda

 Uganda 2023-01-25 9:39:44 2026-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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