Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Isaac Ssewanyana
ID: UNCST-2020-R014336
PERFORMANCE EVALUATION OF THE COBAS HIV-1 NUCLEIC ACID TEST FOR USE ON THE COBAS 4800 SYSTEM USING DBS FOR DETECTION OF HIV-1.
REFNo: HS2661ES

To verify the performance (sensitivity and specificity) of cobas HIV-1 Nucleic acid test for use on the cobas 4800 System against routine Cobas Ampliprep/Taqman HIV-1 Qualitative Test Version 2.0 (DBS) - for early diagnosis of HIV-1 in exposed infants. ,
Uganda 2023-02-06 17:08:26 2026-02-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Gloria  Nabaasa
ID:
Treatment of Moderate Acute Malnutrition with Local Foods- Documentation and Costing of Approaches in Uganda: A Case Study in Kamuli, Masaka and Karamoja region
REFNo: HS2663ES

To document how local food-based approaches to treating MAM are implemented in different contexts and understand the results of those efforts as a contribution to ongoing global efforts to develop programmatic guidance in relation to the forthcoming WHO guidelines which will include recommendations on how to address MAM.,i. Determine the contextual factors (e.g., availability of and access to local foods) that influence the success or appropriateness of use of local food-based approaches in various settings in Uganda ii. Assess the difference between local food-based program structures and TSFP that follow the generic CMAM protocol in terms of core program components, admission and discharge criteria, referral and follow-up procedures, and reporting on outcomes iii. Established types of locally available foods are used to treat children with MAM and how does the nutritional value of the ration/recipe compare to the SNF standards set by WFP and the MAM Decision Tool.,
Uganda 2023-02-06 17:04:40 2026-02-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Juliet Namugambe Sanyu
ID:
Quality of Antimalarials and Antibiotics in Private Medicine Outlets in Bugisu Region, Eastern Uganda
REFNo: HS2667ES

6. To assess perceptions of medicine sellers on quality of antimicrobials and how that influences their prescribing decisions in private medicine outlets in Bugisu, Eastern Uganda. ,5. To describe the methods used to identify poor-quality antimicrobials and the reporting systems used by private medicine outlets in Bugisu sub-region, Eastern Uganda.,4. To assess the conditions in premises associated with SF antimalarials and antibiotics in private rural and urban medicine outlets in Bugisu region, Eastern Uganda.,3. To assess the knowledge and practices of outlet owners associated with SF antimalarials and antibiotics in private rural and urban medicine outlets in Bugisu region, Eastern Uganda.,2. To assess the prevalence of substandard and falsified (SF) antimalarials and antibiotics offered for sale in the authorized and unauthorized private medicine outlets in Bugisu region, Eastern Uganda.,1. To assess the prevalence of substandard and falsified (SF) antimalarials and antibiotics offered in sale in private rural and urban medicine outlets in Bugisu region, Eastern Uganda,This study aims to measure the prevalence of substandard and falsified antimalarials and antibiotics in private medicine outlets of Bugisu sub-region in Eastern Uganda and explore the characteristics of rural, urban, authorised and unauthorised outlets and their influence on observed quality, as well as the medicine sellers perception on quality of medicines in the region.,
Uganda 2023-02-06 16:50:57 2026-02-06 Medical and Health Sciences Non-Clinical Trial Degree Award
Grace Mulyowa Kitunzi
ID: UNCST-2022-R009761
An Image Diagnostic tool for supporting clinicians managing Dermatitis Cruris Pustulosa et Atrophicans among Patients Presenting to Mbarara and Kabale Regional Referral Hospitals
REFNo: SIR186ES

• To improve diagnosis of DCPA through a machine learning model trained from locally obtained images.,
Uganda 2023-02-06 16:44:23 2026-02-06 Engineering and Technology Non-Clinical Trial Non-degree Award
Kevin Arbuckle
ID:
Using community engagement to improve snakebite prevention measures in rural Uganda
REFNo: HS2326ES

The project aims to improve awareness and implementation of prevention measures against snakebite envenoming in rural communities in Uganda. In doing so our ultimate aim is to reduce the burden of snakebite envenoming in these high risk areas, using our local connections and community-integration approach to ensure the project continues to deliver this aim long after the end of the funding period.

We will achieve our aim via the following specific objectives:-
- Gain an understanding of current community knowledge and attitudes surrounding snakes and snakebite via interviews and surveys.
- Use the information from the first objective to prepare appropriate materials for co-creation workshops with the local community to promote awareness of local snakes and snakebite risk, implementation of prevention strategies, and discussion of appropriate responses in the event of a bite, all with attention given to targeted and specific solutions to local challenges and context.
- Donation of appropriate resources to assist local communities in reducing the risk of snakebite, such as appropriate footwear to prevent accidental bites on exposed feet and handling equipment to enable trained members of the community to move snakes away from high-risk locations such as school premises and homes (see final objective).
- Implement a 'train-the-trainer' programme to train the co-applicant in safe removal of snakes from premises and to enable him to take advantage of his teacher-training to pass these skills onto other willing members of the community. This will ultimately lead to a sustained network of members of the local community who can maintain risk reduction in the longer term.
UK 2023-02-06 16:42:29 2026-02-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Noella Okalany Akwi Regina
ID: UNCST-2022-R011085
Congenital Cytomegalovirus Infection in Eastern Uganda
REFNo: HS2668ES

To determine the short-term neurodevelopmental outcomes and hearing impairment associated with congenital cytomegalovirus among infants in Eastern Uganda.,To determine the incidence of, and risk factors for postnatally acquired cytomegalovirus among infants in Eastern Uganda.,To describe the factors associated with congenital cytomegalovirus infection in neonates in Eastern Uganda.,To determine the prevalence of congenital cytomegalovirus infection among neonates in Eastern Uganda,To investigate the burden of congenital cytomegalovirus and its outcomes among infants in Eastern Uganda.,
Uganda 2023-02-06 16:21:08 2026-02-06 Medical and Health Sciences Clinical Trial Degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
IMPAACT 2028: Long-Term Clinical, Immunologic, and Virologic Profiles of Children who Received Early Treatment for HIV; DAIDS Study ID #38693
REFNo: HS2417ES

To characterize the long-term clinical, immunologic, and Virologic profiles of children who received early treatment for perinatally-acquired HIV
Uganda 2023-02-06 16:17:13 2026-02-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kathy Burgoine
ID: UNCST-2022-R011521
Impact of prophylactic Continuous Positive Airway Pressure in the Delivery Room (DR-CPAP) on neonates <1500g in a low-resource setting: A feasibility trial
REFNo: HS2605ES

- To determine the acceptability of DR-CPAP to healthcare workers in a low-resource setting - To determine the post-intervention acceptability of using a two-stage consent process in neonatal emergencies in the delivery room in this setting - To evaluate the feasibility of a third-party allocation process for randomisation by determining the time to randomization - To evaluate feasibility of initiating DR-CPAP in a low-resource setting in infants with birthweight 800-1500g within 15 minutes of delivery - To determine the safety of initiating DR-CPAP in a low-resource setting - To estimate the sample size to be used for future evaluation in the full trial - To assess the feasibility of secondary outcome measures to be used in the full trial
UK 2023-02-02 12:18:23 2026-02-02 Medical and Health Sciences Clinical Trial Non-degree Award
Rachel Kawuma Mary Kagawa
ID: UNCST-2022-R009107
Understanding digitally driven risk networks to inform user-centric target product profiles (TPP) for next-generation HIV vaccines (DigiTaPP Study)
REFNo: SS1519ES

Objective 1: To understand HIV prevention product development pipeline and potential vaccine attributes through scientific consultations with vaccine experts and product developers
Sub-objectives:
1. To understand current status of HIV vaccine development pipeline and potential HIV vaccine candidates along with potential product attributes;
2. To explore how communities are being involved in the development process, especially whether the preferences of potential end-users are being considered in TPP development.

Objective 2: To understand the nature and characteristics of HIV risk networks (or sexual networks of target populations at risk for HIV), across digital and physical spaces to inform strategies for engaging all potential end-users
Sub-objectives:
1. To identify the nature and types of physical and virtual platforms used by relevant target populations, explore their stated reasons for using them, and their interconnections;
2. To explore the differences in risk behaviours, current prevention practices and preference for prevention products (including vaccines) among the end-users from physical and digital networks.

Objective 3: To understand preferences of potential end-users (from digital and physical networks) through elicitation research towards informing HIV vaccine target product profile
Sub-objectives:
1. To understand end-users’ preferences for product characteristics and delivery sites;
2. To understand perceived benefit, perceived burden and self-efficacy that may influence product attribute preferences and delivery options;
3. To understand interpersonal and social influences that may influence product attribute preferences and delivery options.
Uganda 2023-02-02 11:58:48 2026-02-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Peter Kisaakye
ID:
Measuring the incidence of abortion and the quality of postabortion care in refugee settings in Uganda
REFNo: SS1589ES

1. To measure the incidence of abortion in refugee settings in Uganda
2. To determine the severity of abortion-related complications in refugee settings in Uganda
3. To assess the capacity of the health system to offer post-abortion care to people living in refugee settings in Uganda

Uganda 2023-02-01 12:38:01 2026-02-01 Social Science and Humanities Non-Clinical Trial Non-degree Award
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