Isaac Ssinabulya
ID: UNCST-2021-R004352
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ImpleMEntation of a Digital-first care deLiverY model for heart failure in Uganda (MEDLY Uganda)
REFNo: HS4581ES
In this study, we will implement a digital-first, multi-component strategy for HF (Medly Uganda) and evaluate both implementation and clinical outcomes. The primary objective is to assess the implementation and clinical effectiveness of a digital-first implementation strategy to improve HF self-care in Uganda. We will conduct a stepped-wedge, cluster randomized trial in outpatient departments at 6 Ugandan RRH. The co-primary outcomes will be the Self-Care of HF Index (implementation) and the composite of mortality and HF hospitalization (clinical effectiveness). The secondary objectives will include the following.
Conduct a mixed method process evaluation to inform iterative adjustments to the implementation process. We will use a community-engaged approach to systematically collect qualitative and quantitative process data at pre-determined time points based on the Learn-As-You-Go design and make contextually appropriate implementation adaptations. Prior to recruitment, we will also explore patients’ journeys to heart failure diagnosis in Uganda through a qualitative component by conducting in-depth interviews. The aims of this work will be to explore factors associated with patient’s journeys to heart failure diagnosis, including descriptions of initial symptoms, progression, health care referral journey, barriers and facilitators to care, and role of health education and self-care awareness.
We will assess the implementation fidelity and sustainability of Medly Uganda with a focus on reach, adoption, and maintenance. Using Medly Uganda meta data from patients (app) and providers (dashboard), we will identify patterns and predictors of usage. We will interview patients and providers to explore these findings, and ensure implementation fidelity. We will also explore patient and provider perspectives on the sustainability of Medly Uganda, using semi-structured interviews to explore patient and provider barriers and facilitators of long-term use, to surface strategies that would optimize Medly Uganda implementation over time.
We shall explore cost, cost effectiveness, and sustainability factors for Medly Uganda. We will collect and examine cost data from patients and facilities examining the unit cost (cost per HF patient treated and per HF patient controlled) of control and Medly Uganda scenarios both from a financial and societal perspective. Primary outcomes for cost effectiveness analysis will be the Incremental Cost-Effectiveness Ratio per patient treated and per death averted.
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Uganda |
2024-11-18 22:56:37 |
2027-11-18 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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MUTEEBWA LABAN
ID: UNCST-2022-R010550
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Barriers and facilitators of the intention to use, and the preferred model for HIV Self-Testing among young women in the Kampala Metropolitan Area
REFNo: HS5167ES
4. To assess factors associated with the intention to use HIVST services among AGYW in KMA.,3. To determine the preferred model for delivering HIVST services among AGYW in KMA.,2. To explore the barriers and facilitators influencing the use of HIVST services among AGYW in KMA,1. To determine the level of intention to use HIVST services among AGYW in KMA ,To determine the level of intention to use HIVST services, the influencing barriers and facilitators, associated factors and the preferred model for delivering HIVST services among AGYW in the KMA, Uganda.,
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Uganda |
2024-11-18 22:50:43 |
2027-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Hannah Kibuuka
ID: UNCST-2020-R014355
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Secondary Analysis Protocol entitled “Biomarker-guided patient stratification for diagnosis, prognosis, and monitoring of severe infectious disease at the point of need"
REFNo: HS5187ES
Transition existing host-based biomarker classifiers to protein and nucleic acid based fieldable detection devices to validate and optimize performance
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Uganda |
2024-11-18 22:47:28 |
2027-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Edgar Mulogo Mugema
ID: UNCST-2023-R008170
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Getting Malaria “off the backs†of women and children in western Uganda
REFNo: HS4758ES
The scientific objective is to demonstrate the protective effect of permethrin-treated lesus against P. falciparum malaria in infants and young children.,
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Uganda |
2024-11-18 13:40:11 |
2027-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Catherine Nabbumba
ID: UNCST-2024-R002912
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Genome wide association studies and polygenic prediction of major depressive disorder in samples of African ancestry from Uganda
REFNo: HS5159ES
1) investigate the prevalence and sociodemographic and clinical correlates of MDD among general outpatients attending care at 5 hospitals in Uganda
2) undertake a systematic review on common genetic variants associated with MDD among respondents of non-European ancestry using different datasets from PGC
3) explore common genetic variants associated with MDD in 2 African samples (ED6 study (n=150 cases, 150 controls) (A) and NeuroGAP study (n=324 cases, 876 controls) (B))
4) optimise a PRS for MDD initially developed from MDD-PGC datasets for use in the African setting of Uganda
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Uganda |
2024-11-18 13:36:01 |
2027-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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