Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Josephine Ayebare
ID:
An E-participation Model and Mobile Application Prototype for Inclusive Governance and Policy Development in Rural Uganda: Participatory Approach
REFNo: SS1621ES

To evaluate the usefulness of the model designed in objective 2 in achieving participation objectives through assessing the mobile application prototype designed in objective 3.,To co-design a mobile application prototype with the rural population stakeholders of Isingiro district in Uganda for based on the model developed in objective 2. ,To co-design a multi-dimensional model with the rural population e-participation stakeholders of Isingiro district in Uganda using the social-technical contextual factors and their SWOT analysis identified in objective 1. ,To identify and analyse the socio-technical contextual factors that influence political e-participation in rural Uganda. ,Aims to design and develop a multidimensional e-participation model and a mobile application prototype suitable for promoting e-participation among the rural population in Isingiro district in Uganda.,
Uganda 2023-02-21 13:17:02 2026-02-21 Social Science and Humanities Non-Clinical Trial Degree Award
Harriet Mayanja-Kizza
ID: UNCST-2021-R013074
PHASE 2C CLINICAL TRIAL OF NOVEL, SHORT-COURSE REGIMENS FOR THE TREATMENT OF PULMONARY TUBERCULOSIS: CRUSH-TB (Combination Regimens for Shortening TB Treatment)
REFNo: HS2650ES

Primary objective
(1) To compare the efficacy of each experimental regimen to the efficacy of standard treatment, using the intermediate endpoint of time to culture negative in liquid media.

Secondary objectives
(1) To compare the proportion of participants with a grade 3 or higher adverse event in each experimental arm with the control arm
(2) To describe the proportion of participants experiencing lack of sustained cure during treatment or follow-up to 52 weeks in each experimental arm as compared to control and make predictions as to how these regimens would perform in future phase III trials.
(3) To compare the efficacy of each experimental regimen to the efficacy of standard treatment, using the intermediate endpoint of time to culture negative in solid media
(4) To compare the proportion of participants in each arm who convert liquid and solid sputum cultures to negative by (a) 8 weeks of treatment and (b) 12 weeks of treatment
(5) To describe the rate of all-cause study drug discontinuation in each arm
(6) To compare time to sputum culture positivity curves through 17 weeks in the Mycobacterial Growth Indicator Tube (Bactec MGIT960) across arms
(7) To describe the proportion of participants experiencing lack of sustained cure during treatment or follow-up up to 78 weeks in each experimental arm as compared to control and make predictions as to how these regimens would perform in future phase III trials.
(8) To describe the population PK of bedaquiline and its M2 metabolite, with or without rifabutin co-administration (PK#1)
(9) To conduct pharmacokinetic/pharmacodynamics study of the test drugs to determine relationships between pharmacokinetic parameters (AUC, Cmax) and outcome measures (time to culture negativity or rate of change in TTP) using non-linear mixed effects models, adjusting for key covariates that may affect outcomes (e.g. companion drugs, HIV status, cavitary disease) (PK#2)

Uganda 2023-02-21 13:13:53 2026-02-21 Medical and Health Sciences Clinical Trial Non-degree Award
KIRABO NAKASIITA NKAMBWE
ID:
Mindset, Teaching and Learning Strategies in Sciences among Secondary School Students in Wakiso District: The mediating effect of Interest
REFNo: SS1591ES

6. To assess the moderating effect of teaching strategies on the relationship between mindset and learning strategies in sciences among O level students in Wakiso district,5. To assess the mediating effect of interest on the relationship between mindset and learning strategies in sciences among O level students in Wakiso district ,4. To determine the relationship between mindset and learning strategies in sciences among O level students in Wakiso district ,3. To assess the relationship between interest and learning strategies in sciences among O level students in Wakiso district ,2. To examine the relationship between mindset and interest in sciences among O level students in Wakiso district ,1. To establish the science interest levels among O level students in Wakiso district,To assess the effects of mindset, interest and teaching strategies on students’ use of learning strategies in sciences among O level students in Wakiso District,
Uganda 2023-02-21 13:08:23 2026-02-21 Social Science and Humanities Non-Clinical Trial Degree Award
Moses KIRYA Mateeke
ID:
Relationships among Core Competencies, Career Choices and Relevant influential factors based on final year Undergraduate Business Student’s Perceptions in Ugandan universities.
REFNo: SS1566ES

To empirically investigate the relationship among core competencies, career choices and relevant influential factors based on final undergraduate business student’s perception in Ugandan universities, Specifically, to explore:

1. The relationship among core competencies and career choices based on final year undergraduate business students’ perception in Uganda

2.The relevant influential factors on career choices and core competencies based on final year undergraduate business students’ perception in Uganda
Uganda 2023-02-21 13:01:29 2026-02-21 Social Science and Humanities Non-Clinical Trial Degree Award
Jacqueline Delie Slabe
ID:
Exploring the social-political contexts of wildlife conservation in Queen Elizabeth and Kibale National Parks in Uganda
REFNo: SS1479ES

1. Understand which socio-political factors affect community-ranger relations in Queen Elizabeth and Kibale National Parks, Uganda.

2. Identify the similarities and differences between communities and park rangers in their perceptions of socio-political factors, and their potential relevance to mitigating human-wildlife conflicts and strengthening conservation of both wildlife and culture.

3. Highlight the important insights that arise in characterizing gendered similarities and differences in the way communities and park rangers value the local protected area.
USA 2023-02-21 13:00:12 2026-02-21 Social Science and Humanities Non-Clinical Trial Non-degree Award
Roy Mayega William
ID: UNCST-2022-R010983
Uganda Non-State Schools Assessment
REFNo: HS2516ES

4. To assess the capacity of non-state pre-primary and primary schools to sustainably finance quality education.,3. To explore the oversight and regulation functions among non-state pre-primary and primary schools.,2. To understand the barriers faced by learners from traditionally marginalized groups in accessing non-state pre-primary and primary schools in urban and peri-urban centers. ,1. To determine the quality of education in non-state pre-primary and primary schools in urban and peri-urban areas of Uganda, especially in light of the recent COVID-19 pandemic.,To determine the factors that influence the quality and level of access to non-state primary and pre-primary schools in urban and peri-urban areas of Uganda. ,
Uganda 2023-02-21 12:53:41 2026-02-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
THE SECOND UGANDA NATIONAL ANTI-TUBERCULOSIS DRUGS RESISTANCE SURVEY(DRS2)
REFNo: HS2652ES

To identify the demographic and clinical factors associated with drug resistance in Uganda including HIV, tobacco smoking, diabetes and alcoholism.,To determine circulating strains of MTB in the general population among PBCs in Uganda.,To determine the prevalence of resistance mutations to all first- and second-line drugs in use in Uganda.,To determine the prevalence and patterns of drug resistance to fluoroquinolones, Bedaquiline, Delamanid, clofazimine, amikacin, and Linezolid among patients with confirmed RR-TB in Uganda.,To determine the prevalence of resistance to HRZE among new and previously treated PBC patients in Uganda.,To measure the prevalence of RR-TB among bacteriologically confirmed pulmonary TB (PBC) patients in Uganda. ,
Uganda 2023-02-20 13:22:01 2026-02-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Wietse Tol
ID: UNCST-2021-R013085
AlCohol use in HumanitariAN settings: a programme of work to address alcohol use disorders and associated adversities among conflict-affected populations in UGanda and UkrainE (CHANGE)
REFNo: SS1596ES

• To identify strategies and techniques from evidence-based alcohol use therapies which can be integrated into PM+, and to develop a new intervention called PM+A (Problem Management Plus Alcohol)
• To adapt PM+A to local circumstances, and to examine the feasibility, acceptability, perceived effectiveness, and preliminary impact of PM+A
• To evaluate effectiveness and cost-effectiveness of PM+A through two single-blind randomised controlled trials in Uganda and Ukraine
• To explore the process of implementation, and to identify, characterise and explain mechanisms that promote or inhibit the delivery and take-up of PM+A in both settings
• To examine the potential for scaling-up PM+A in Uganda and Ukraine

Netherlands 2023-02-17 12:18:30 2026-02-17 Social Science and Humanities Clinical Trial Non-degree Award
Silver Onyango
ID: UNCST-2022-R009337
Ambient air pollution and lung health in rural sub-Saharan Africa: The impact of biomass on vulnerable populations
REFNo: HS2657ES

Characterize the relationship between chronic ambient air pollution exposure and lung function trajectory and structural abnormalities. Validate satellite-based calculations of PM2.5 and test inexpensive optical particle counters for future monitoring,Characterize ambient air pollution levels and sources in rural southwestern Uganda ,Characterize the effect of ambient air pollution and sources on lung function among vulnerable people in rural south western Uganda. ,
Uganda 2023-02-15 17:05:50 2026-02-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jerome  Kabakyenga Kahuma
ID: UNCST-2021-R013729
BACKTRACK: A technology enabled care pathway delivered by clinical officers and nurses to manage low back pain
REFNo: HS2636ES

BACKTRACK will enable the clinical officer or nurse to identify the cases that should be referred onwards for specialist assessment and intervention such as physiotherapy,BACKTRACK will enable the clinical officer or nurse in dispatching evidence based self-management advice,BACKTRACK will enable the clinical officer or nurse to safely identify LBP cases that are amenable to self-management,to develop and evaluate a digital clinical decision support system (DCDSS) called BACKTRACK. ,to improve access to rehabilitation for people with low back pain to reduce its disability burden, and to improve functional and participatory outcomes (such as return to work or school).,
Uganda 2023-02-15 16:53:46 2026-02-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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