Haruna Muwonge
ID: UNCST-2019-R000128
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Retrospective Analysis of RSV RTI Prevalence, Coinfections, and Risk Factors among Older Adults in Uganda: A Study Based on Sentinel Surveillance Data
REFNo: HS5423ES
Objectives
General Objective
To determine the prevalence, associated factors, and coinfection patterns of Respiratory Syncytial Virus (RSV) respiratory tract infections (RTI) among adults aged 60 and above in Uganda using sentinel surveillance data.
Specific Objectives
1. To determine the prevalence and seasonal trends of RSV RTI among older adults in Uganda using data collected from sentinel surveillance sites
2. To examine the relationship between comorbid conditions such as cardiovascular disease, diabetes, and chronic kidney disease, and the severity of RSV RTI among older adults in Uganda.
3. To determine the prevalence of coinfections with other respiratory viruses—SARS-CoV-2, Influenza A/B, and Pandemic A(H1N1) 2009—among older adults with RSV RTIs in Uganda.
4. To assess the association between coinfections with other respiratory viruses —SARS-CoV-2, Influenza A/B, and Pandemic A(H1N1) 2009— and clinical outcomes, including disease severity, hospitalization rates, and mortality, among older adults with RSV RTIs in Uganda.
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Uganda |
2025-06-30 9:14:46 |
2028-06-30 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Peter Elyanu James
ID: UNCST-2021-R013210
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OPTIMAH Study: OPTImizing Malaria And HIV treatment in a shifting landscape in Africa
REFNo: HS6165ES
PRIMARY OBJECTIVES
1. Assess the impact of HIV/DTG on weight gain (BMI) in Ugandan children ages 5 to 17 years of age over two years of follow-up.
2. Assess for PK drug-drug interactions between the two most widely used ACTs
(AL or AS-AQ) and DTG in longitudinal cohorts of HIV-uninfected children and CLHIV living in a high endemic malaria region (Busia).
3. To assess the 28- and 42-day efficacy of AL and AS-AQ for the treatment of uncomplicated malaria in children with and without HIV in a setting where artemisinin resistance has emerged.
SECONDARY OBJECTIVES
1. To assess the impacts of DTG on changes in body composition, waist circumference, and metabolic derangements over 2-years of longitudinal follow-up.
2. To assess the impact of repeated malaria infection on changes in weight gain in CLHIV on DTG (comparing HIV-infected cohorts in Busia and Kampala).
3. To determine if changes in DTG PK exposure in the presence of repeated courses of ACTs are associated with impacts on virologic control (pharmacodynamics).
4. To assess for the development of dolutegravir-associated resistance mutations over two years of follow-up.
5. To determine if changes in ACT exposure in the presence of daily DTG for HIV treatment are associated with impacts on malaria treatment outcomes.
6. To critically compare the PK exposure of artemether, artesunate, and DHA in the context of the two leading ACTs in Africa and assess for associations between the PK exposure of artemisinin derivatives as drivers of parasitologic outcomes such as parasite clearance rates for artemisinin-sensitive and resistant infections.
7. To assess levels of gametocytemia in children with and without HIV infection and with artemisinin-sensitive and -resistant infections
8. To determine if repeated course of AL and AS-AQ are associated with selection of resistance-associated mutations to the partner drugs and/or the artemisinin component.
9. To identify novel mutations in known and/or putative loci associated with resistance to artemisinins, lumefantrine, and amodiaquine using amplicon-based sequencing and/or other genotyping methods.
10. To assess the exposure of unbound DTG, lumefantrine, and DEAQ and association with clinical outcomes (viral load or parasitemia)
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Uganda |
2025-06-26 23:59:42 |
2028-06-26 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Daniel Magumba
ID: UNCST-2025-R018334
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PEDESTRIAN ROAD SAFETY IN KAMPALA: A MIXED METHODS STUDY OF THE WALKABILITY OF KAMPALA’S ROAD INFRASTRUCTURE
REFNo: HS6064ES
1.To assess the Walkability of Kampala City’s Road infrastructure.
2.To explore stakeholder perceptions on pedestrian safety and walkability of Kampala city.
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Uganda |
2025-06-26 23:54:31 |
2028-06-26 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Charlot Diepvens
ID: UNCST-2025-R017733
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Demand-side enablers and barriers to epidemic preparedness: a mixed-method approach to understand priorities, acceptance and effective strategies for Ebola vaccines
REFNo: HS6132ES
The objective of this study is to examine demand-side factors that influence (enable or hinder) epidemic preparedness, with a focus on licensed Ebola vaccines. Specifically, it aims to visually identify and map key influencing factors, and to adequately translate their effects into quantitative models. This translation is critical, as decision-makers frequently rely on models—such as disease transmission models—to guide outbreak response strategies. Modeling has the potential to demonstrate the impact of specific interventions (e.g., additional training, improved guidelines, or the provision of dedicated funding) on vaccine use.
This case study explores priorities and acceptance regarding licensed Ebola vaccines among decision makers. It also examines how these perceptions shift under different vaccination strategies, including reactive vaccination (during an outbreak) versus preventive vaccination (outside of an outbreak).
More specifically, the studies objectives are to:
1. Identify and map key influences or determinants of vaccine use in Uganda through a conceptual systems diagram (e.g., perceptions of personal risk, fear of vaccine side effects), building on key informant interviews and group model building workshops.
2. Develop and validate a quantitative simulation model evaluating the impact of various vaccination strategies and interventions on vaccine use over time.
3. Derive insights from the diagram and model to inform policy and strategic decision-making at local and national levels regarding Ebola vaccine implementation.
In short, the study will develop a visual representation of the problem space that can guide both policy and practice.
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Belgium |
2025-06-26 23:52:36 |
2028-06-26 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Joweria Nambooze
ID: UNCST-2019-R001118
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Socio-Cultural and Anthropological Perspectives on Child Feeding and Care, Food Consumption Habits, Dietary Patterns and Purchasing Behaviours in Uganda
REFNo: HS5843ES
Examine similarities and differences in caregiving practices that affect children’s nutrition across high-producing agricultural areas, pastoral regions, and urban landscapes,Explore the current perception of social behaviour change communication on complementary feeding.,Assess household dietary and food consumption behaviour,Examine caregivers\' purchasing habits and children’s food preferences, considering economic and cultural factors.,To gather comprehensive anthropological data on the dietary habits of children under 2 and the purchasing behaviours of caregivers in the districts of Kamwenge, Napak, and the urban areas of Kampala,
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Uganda |
2025-06-26 23:51:22 |
2028-06-26 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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