Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Joseph Baluku B
ID: UNCST-2019-R000612
Prevalence of Sputum Positive Tuberculosis and associated Factors among Individuals found at Bars in Kampala Slums
REFNo: HS459ES

Primary Objective: To determine the prevalence of sputum positive TB among individuals found at bars in Kampala slums
Secondary Objectives:
1. To evaluate factors associated with sputum positive TB individuals found at bars in Kampala slums.
2. To determine the prevalence of HIV infection among individuals found at bars in Kampala slums
3. To determine the prevalence of TB/HIV co-infection among individuals at bars in Kampala Slums

Uganda 2019-12-13 2022-12-13 Medical and Health Sciences Non-degree Award
Jayne Webster
ID:
Process Evaluation of Integrated Immunisation & Family Planning Projects in Benin, Kenya, Malawi and Uganda
REFNo: SS367ES

1. Assess FP method acceptance and continuation in women who access immunisation and/or family planning services 2. Test associations between FP method acceptance and continuation and integration attributes 3. Assess the quality and responsiveness of integrated immunisation and FP delivery 4. Determine implementation fidelity, causal mechanisms and context in integrated immunisation and family planning 5. Develop an overall programme theory of what works, for who, how and in what circumstances the integrated delivery of immunisation and family planning
UK 2019-12-13 2022-12-13 Social Science and Humanities Non-degree Award
Namara  Khadija Asiimwe
ID:
INFORMATION TECHNOLOGY ALIGNMENT AND ORGANIZATIONAL PERFORMANCE IN THE SERVICE SECTOR IN UGANDA. A CASE STUDY OF UMEME (U) LIMITED
REFNo: SS378ES

i.To establish the relationship between IT governance and organizational performance in Umeme Limited
ii.To establish the relationship between IT investment and organizational performance at Umeme Limited.
iii.Assess the effect IT implementation has on organizational performance at Umeme Limited.

Uganda 2019-12-13 2022-12-13 Social Science and Humanities Degree Award
Shevin  Jacob Thomas
ID:
STUDY OF WASH AND ANTIMICROBIAL RESISTANCE IN UGANDA (SWAR-U)
REFNo: HS489ES

Primary objective: To describe the transmission dynamics and ecological niches of ESBL-E and ESBL-K within selected households from Kampala and Hoima

Secondary objectives:
To evaluate the drivers of Water, Sanitation, and Hygiene (WASH) practices and their relation to the faecal-oral transmission of extended spectrum beta-lactamase producing Eschericia coli and Klebsiella pneumoniae

To create a dynamic agent-based model to evaluate the drivers of antimicrobial resistance transmission in Uganda, through the incorporation of microbiological resistance data (ESBL-E and ESBL-K) and WASH observational data obtained from all households included in the SWAR-U study

USA 2019-12-13 2022-12-13 Medical and Health Sciences Non-degree Award
Innocent Ssemanda
ID:
IMPLEMENTATION FIDELITY OF TRICHIASIS SURGERY PROGRAME IN NORTHEASTERN UGANDA
REFNo: HS497ES

To assess and describe implementation fidelity of Trichiasis surgery programme and associated factors, to outcomes in Northeastern Uganda.
Uganda 2019-12-13 2022-12-13 Medical and Health Sciences Degree Award
Simon L'Allier
ID:
Behavioral endocrinology of male dispersal in vervet monkeys (Chlorocebus pygerythrus) at Lake Nabugabo, Uganda
REFNo: NS84ES

Evolutionary causes and consequences (or the “why”) of dispersal are fairly well established, bein respectively inbreeding avoidance and increased reproductive success (Bowler & Benton, 2005). However, the environmental, social, individual, and physiological proximate mechanisms underlying individual dispersal decisions, and their consequences, are still poorly understood. Previous studies have mainly focused on the individual’s physiological response to
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dispersal events (before and after) and looked at the social outcome (e.g., dominance rank) rather than the processes leading to that outcome. For this research, my objectives are to examine how the numerous potential costs of dispersal drive individual dispersal decisions as to when, where, and how they transfer (lone or parallel). I will assess the environmental, social, and physiological causes and consequences of dispersal in vervet monkeys at Lake Nabugabo. My hypotheses and predictions are summarized in Table 2. Dominance rank is often established once a male immigrates into another group. The males’ ability to take over a group and the attainment of a high dominance rank might be dependent on when, where, and how they disperse. My research contributes to a broader understanding of how the immediate environmental, social, and individual factors affect the way they transfer.
Canada 2019-12-12 2022-12-12 Natural Sciences Degree Award
Eliab Kweyunga Horub
ID:
Mathematical Models for the dynamics of banana xanthomonas wilt and the banana weevil, Cosmopolites Sordidus, (Germar) and control Interventions
REFNo: A58ES

1. to quantify the role of symptomless but infectious plants in the persistence of banana xanthomonas wilt;

2. evaluate the effectiveness of existing control options against the banana weevil;

3. use optimal control theories to originate a combination of controls that will ensure management of the pest and disease at minimal cost in terms of time, funds and environmental damage;
Uganda 2019-12-09 2022-12-09 Agricultural Sciences Degree Award
Sarah Lofgren
ID: UNCST-2019-R001647
The Growth Study- Group Therapy In HIV For Depression In Uganda
REFNo: HS493ES

Determine if depression, which persists after depression treatment at 26 weeks, is associated with increased innate inflammation in a prospective cohort of HIV-infected Ugandans receiving SSRIs in which group psychotherapy is initiated.
USA 2019-12-09 2022-12-09 Medical and Health Sciences Non-degree Award
David Lawrence S
ID:
THE LIVED EXPERIENCE OF PARTICIPANTS IN AN AFRICAN RANDOMISED TRIAL (LEOPARD)
REFNo: SS386ES

AIM: To document the AMBITION participant experience in order to build an understanding of how to improve trial delivery for future participants in the trial. OBJECTIVES From the perspective of the participant: 1. To build an understanding of the factors that enhance or diminish a clinical trial experience. From the perspective of the next-of-kin of a participant: 2. To build an understanding of the factors that enhance or diminish a clinical trial experience. From the perspective of the researcher: 3. To build an understanding of the factors that are perceived to enhance or diminish a trial participant’s experience of a clinical trial. 4. To compare the individual researcher’s experience of the conceptualisation, development, initiation and implementation of a multi-centred clinical trial in Africa.
UK 2019-12-09 2022-12-09 Social Science and Humanities Degree Award
SIMON BYONANUWE
ID:
“Prevalence, bacterial pathogens and factors associated with premature rupture of membranes at Kampala International University Teaching Hospital”.
REFNo: HS503ES

Main objective: To determine the prevalence, bacterial pathogens and factors associated with premature rupture of membranes at Kampala International University Teaching Hospital.

Specific objectives:
1. To determine the prevalence of premature rupture of membranes at Kampala International University Teaching Hospital.
2. To determine the obstetric and gynaecologic factors associated with premature rupture of membranes at Kampala International University Teaching Hospital.
3. To identify bacterial pathogens commonly associated with premature rupture of membranes at Kampala International University Teaching Hospital.
4. To assess antibacterial susceptibility patterns of the isolated bacterial pathogens.


Uganda 2019-12-09 2022-12-09 Medical and Health Sciences Degree Award
PETER SPENCER SIMNER
ID:
Etiology of Nodding Syndrome: an Epileptic Disorder of East African Children
REFNo: HS410ES

Increase understanding of the role of environmental exposures, notably to specific neurotropic viruses, as risk factors for Nodding syndrome.
USA 2019-12-04 2022-12-04 Medical and Health Sciences Non-degree Award
Willy Ssengooba
ID: UNCST-2022-R001801
PERFORMANCE OF ALTERNATIVE MEASURES OF RESPONSE TO THERAPY DURING THE INITIAL 12 WEEKS OF MDR-TB TREATMENT
REFNo: HS471ES

1. To examine the correlations of FDA smear microscopy, PMA-Xpert Ct value &16s rRNA (MBLA) with MGIT-TTP as a reference standard.
2. To evaluate the ability of FDA smear microscopy, PMA-Xpert Ct value, MBLA in predicting 12-weeks MGIT culture conversion (outcome).
3. To evaluate the influence of patient clinical characteristics, baseline resistance profiles, adherence and HIV-status to the performance of the alternative measures of response.

Uganda 2019-12-04 2022-12-04 Medical and Health Sciences Degree Award
Jimmy Otim
ID:
Bridewealth and the Future of Customary Marriages in postwar Acholi society
REFNo: SS377ES

To examine the cultural relevance of bride wealth practices in shaping customary marriages across generations in Acholi society
To find out the changes which have occurred overtime to bride wealth practices in shaping customary marriages
To investigate how marriages are contracted in the face of scarcity of cattle and increasing bride wealth payments in postwar Acholi society
To explore perceptions and attitudes of men and women towards bridewealth practices, cohabitation, and children born out of wedlock
Uganda 2019-12-04 2022-12-04 Social Science and Humanities Degree Award
Gerardo Zarazua de Rubens
ID:
Cleaning the air through cooking: providing alternative energy solutions for cooking practices in the Bidibidi Refugee Settlement in Yumbe district in Uganda
REFNo: SS390ES

The project focuses on investigating emissions and respiratory impact between traditional fuel burning cooking methods (solid biomass/ charcoal/ firewood) and solar voltaic clean cooking methods within the Bidibidi Refugee Settlement in northern Uganda. The aim is to evaluate the type and level of impact of each technology, in particular the effects on the environment in the form of air pollution and impacts such as deforestation, wellbeing (health and economic creation) and safeguarding.
Mexico 2019-12-04 2022-12-04 Social Science and Humanities Non-degree Award
Peter Kirabira Simon
ID: UNCST-2020-R014690
Active Reporting of Adverse drug reactions of antiretroviral drugs among adults living with HIV in East Africa: a pilot study on using SMS
REFNo: HS431ES

2. Objectives 2.1 Main objective: To test the feasibility and acceptability of Mhealth system to create awareness on importance of reporting adverse drug reactions of antiretroviral therapy among adults living with HIV in Tanzania and Uganda
2.2 Specific objectives
1. To investigate feasibility of the SMS system among health care workers by measuring practicality, actual fit, utility, trialability,
2. To investigate acceptability of the system among health care workers by measuring and comfort, relative advantage and credibility
3. To investigate feasibility of the system among PLHIV by measuring practicality, actual fit utility, trialability.
4. To investigate acceptability of the system among PLHIV by measuring comfort, relative advantage and credibility.
5. To describe the perceptions/attitudes of HCWs towards the use of m-health to improve ADR reporting.
6. To investigate the technical feasibility of the system by measuring sent, received and replied messages.
7. To give an overview of reported ADRs among adults living with HIV in KCMC and Majengo in Moshi and Nsambya in Kampala

Uganda 2019-11-27 2022-11-27 Medical and Health Sciences Non-degree Award
Assumpta  Barigye
ID:
Records Management Practices and Administrative Staff Performance in Private Universities in Uganda: A case of Nkumba University and Uganda Christian University
REFNo: SS370ES

1. to examine how Records Management Practices impact on Administrative Staff Performance in NU and UCU

2. to establish how Records Creation contributes to Administrative Staff Performance in NU and UCU

3. to determine how Records Maintenance ensures Administrative Staff Performance in NU and UCU

4. to access the extent to which Records Disposal Contributes to Administrative Staff performance in NU and UCU

5. to analyze the extent to which Reward Management moderates the relationship between Records Management Practices and Administrative Staff Performance in NU and UCU

Uganda 2019-11-27 2022-11-27 Social Science and Humanities Degree Award
Mukisa Ayub
ID:
Gender and adaptive capacity to climate change among small holder farmers in Karamoja sub region
REFNo: SS379ES

i) To evaluate the effects of drought on crops and livestock for men and women in Nabilatuk District
(ii) To establish the resources for men and women in crop and livestock farming
(iii) To assess infrastructure and technological capacities of men and women in livestock and crop farming.
(iv) To identify governance, institution, and networks for men and women in crop and livestock farming.
v) To find out adaptation/resilience practices for men and women in crops and livestock farming

Uganda 2019-11-27 2022-11-27 Social Science and Humanities Degree Award
Denish Calmax Angol
ID:
Antibacterial Use and Resistance in Under Five Children in Post Conflict Northern Uganda
REFNo: HS362ES

General study objective
•To assess the burden, drivers of inappropriate antibacterial prescriptions and resistance patterns of the pathogens among under five children attending care in selected public health facilities in Lango sub-region, northern Uganda.
Specific objectives
•To determine microbiologically, the burden and drivers of inappropriate prescription of antibacterials for under 5-year outpatient children presenting with acute diarrhoea at public health facilities in Lango sub-region (Sub-study I)
•To determine microbiologically, the burden and drivers of inappropriate prescription of antibacterials for under 5-year outpatient children presenting with UTRIs at public health facilities in Lango sub-region (Sub-study II)
•To determine the proportion of bacterial species and their resistance among under 5 year inpatient children with systemic infections at Lira Regional Referral Hospital (Sub-study III)
•To determine the prescribers’ knowledge, attitudes and practices regarding antibacterial prescription with respect to the available guidelines for under 5-year outpatient children with acute diarrhoea and URTIs at public health facilities in Lango sub-region (Sub-study IV)
Uganda 2019-11-19 2022-11-19 Medical and Health Sciences Degree Award
Gerald Mboowa
ID:
UNDERSTANDING TRANSMISSION DYNAMICS AND ACQUISITION OF ANTIMICROBIAL RESISTANCE AT REFERRAL HOSPITALS AND COMMUNITY SETTINGS IN EAST AFRICA
REFNo: HS411ES

i. To determine the prevalence, antimicrobial resistance profiles and the common phenotypic mechanisms of resistance in bacteria isolated from study participants from the orthopaedic ward at Mulago hospital, hospital environments and corresponding community settings.
ii. To describe the emergence, transmission networks, and epidemiology of drug resistant bacteria in the orthopaedic ward at Mulago hospital, hospital environments and corresponding community settings.
iii. To investigate behaviors/practices that influence the emergence and spread of drug resistant bacteria in the orthopaedic ward at Mulago hospital, hospital environments and corresponding community settings.

Uganda 2019-11-19 2022-11-19 Medical and Health Sciences Non-degree Award
ERIC WOBUDEYA
ID: UNCST-2019-R001047
DEVELOPMENT OF A DIAGNOSTIC PREDICTION SCORE FOR TUBERCULOSIS IN HOSPITALIZED CHILDREN WITH SEVERE ACUTE MALNUTRITION
REFNo: HS445ES

Primary Objective
To develop a diagnostic prediction score for TB in hospitalized children with SAM
Secondary Objectives
1. To assess the prevalence of TB among hospitalized children with SAM.
2. To describe the symptoms and clinical characteristics of TB disease in hospitalized children with SAM.
3. To develop a first-step screening prediction score to identify children with presumptive TB among hospitalised children with SAM
4. To propose a stepwise diagnostic algorithm based on the score(s) developed
5. To assess the diagnostic performance and the added value in a diagnostic prediction score for TB in hospitalized children with SAM of the following tests:

a. Ultra performed on one NPA and one stool sample
b. Chest radiography features as assessed by the simplified TB-Speed CXR reading tool
c. Abdominal ultrasound
d. QuantiFERON®-TB Gold In-Tube (QFT) IGRA
e. Monocyte-to-lymphocyte ratio (MLR)
f. CRP
6. To assess the feasibility of collecting NPA and stool in children with SAM
7. To assess the safety and tolerability of NPA collection in children with SAM
8. To assess mortality and weight gain at 6 months in children with SAM, with or without anti-TB treatment
9. To assess the effect of bacteriological features (Xpert and/or culture-confirmed TB) and other key patient characteristics (age, HIV status, initial severity markers, percentage weight gain, and CXR features) on TB treatment outcome.

Uganda 2019-11-19 2022-11-19 Medical and Health Sciences Non-degree Award
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