Bruce Kirenga J
ID: UNCST-2019-R001460
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A multiple arm, multiple stage (MAMS), phase 2B/C, open label, randomized, controlled platform trial to evaluate experimental arms including an increased dose of rifampicin, an optimized dose of pyrazinamide, moxifloxacin and sutezolid, in adult subjects with newly diagnosed, smear-positive pulmonary tuberculosis
REFNo: HS2644ES
Primary Efficacy Objective:
Rifampicin- containing experimental arms (arms 1,2)
To evaluate whether one or more of two experimental regimens based on
optimized dose rifampicin, optimized dose of pyrazinamide, and moxifloxacin
given for 12, respectively 17 weeks, are superior to standard treatment given for
26 weeks, as assessed by time to sputum culture conversion to negative in liquid
media.
Sutezolid-containing experimental arm (arm 4)
To evaluate whether the efficacy of an experimental regimen composed of
sutezolid, delamanid, bedaquiline, and moxifloxacin given for 17 weeks is
superior to standard treatment given for 26 weeks, as assessed by time to
sputum culture conversion to negative in liquid media.
Secondary Objectives This study’s secondary objectives are:
Efficacy
To assess treatment efficacy based on proportion of patients with relapse
free outcome at 12 months after randomization.
To assess treatment efficacy based on the rate of decline of bacterial load
measured by the Molecular Bacterial Load Assay
To rank the relative efficacy of the experimental four-drug combinations
for the treatment of pulmonary tuberculosis within the first twelve weeks
of treatment, and select the most efficient experimental treatment
regimen or regimens for further development.
Safety and Tolerability
To assess the frequency, severity, and type of adverse events (AEs), and AErelated
treatment discontinuations.
Pharmacokinetics
To describe the pharmacokinetics of the drugs and doses used, and to assess
possible relationships between pharmacokinetic parameters of the various drugs and between pharmacokinetic parameters and participant characteristics.
Pharmacodynamics To describe relationships between pharmacokinetic parameters on the one hand and efficacy and safety endpoints on the other hand.
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Uganda |
2023-04-11 15:27:11 |
2026-04-11 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Andrew Muhumuza
ID: UNCST-2022-R009010
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Incidence and predictors of castration resistance among patients with prostate cancer on androgen deprivation therapy at two referral hospitals in Uganda
REFNo: HS2759ES
To identify the predictors of castration resistance among prostate cancer patients on ADT at Mbarara Referral Hospital oncology unit and Uganda cancer Institute, Mulago National Referral Hospital. ,To determine the incidence of castration resistance among patients with prostate cancer on ADT at Mbarara Referral Hospital oncology unit and Uganda cancer Institute, Mulago National Referral Hospital.,To determine the incidence and predictors of castration resistance among prostate cancer patients on ADT at Mbarara Referral Hospital oncology unit and Uganda cancer Institute, Mulago National Referral Hospital.,
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Uganda |
2023-04-11 14:20:29 |
2026-04-11 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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SAM ALI
ID: UNCST-2020-R014824
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Stillbirth in High Burden Settings: Ample Room for Improvement using Biomarkers and Ultrasound Technologies (iTECH)
REFNo: HS2762ES
1. To evaluate the relation between placental histopathological lesions and biomarkers, placenta ultrasound and hemodynamic changes after stillbirth and near miss stillbirth in order to understand the underlying mechanisms and specify the prediction model.
2. To engage with important stakeholders on the value of these diagnostic technologies in the community, co-creating the project design, implementation and eventual uptake into practice guidelines.
3. To establish the predictive performance of maternal characteristics and markers emerging from this project for stillbirth and other related endpoints in non-anomalous fetuses and assess the feasibility of integrating relevant markers into clinical decision support tools.
4. To prospectively evaluate patterns of (bio)markers, maternal cardiovascular function and contemporary ultrasound markers in pregnancy, to understand their role in the chain of events and pathophysiology of stillbirth in a resource poor setting.
5. To develop and validate a prediction model for use at the point of care in low-and middle-incomes countries (LMICs) to quantify a woman’s individual risk of antepartum stillbirth based on a set of easily measurable, accessible, highly predictive and cost-effective markers, and make it freely available for healthcare providers in low-resource settings.
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Uganda |
2023-04-06 8:06:27 |
2026-04-06 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Juliana Namutundu
ID:
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IMPROVING CERVICAL CANCER SCREENING LITERACY AMONG HIV-INFECTED WOMEN IN CARE AT RURAL PUBLIC HEALTH FACILITIES IN EAST CENTRAL UGANDA
REFNo: HS2753ES
3) To assess the feasibility, acceptability and preliminary effectiveness of a cervical cancer screening literacy improvement implementation strategy for Women living with HIV in care at rural public health facilities in East Central Uganda.,2) To design a cervical cancer screening literacy improvement implementation strategy for Women living with HIV in care at rural public health facilities in East Central Uganda.,1) To conduct a multi-level assessment of barriers and facilitators of cervical cancer screening literacy among HIV-infected women in care at rural public health facilities in East Central Uganda.,
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Uganda |
2023-04-05 17:05:10 |
2026-04-05 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Margaret Nafuna Sarah
ID:
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EXAMINING MOTIVATIONAL STRATEGIES INFLUENCING PERFORMANCE OF TUTORS IN CORE PRIMARY TEACHERS’ COLLEGES IN EASTERN UGANDA
REFNo: SS1647ES
3. To analyse the challenges that may influence the effective motivation of tutors in Core PTCs in Eastern Uganda.,2. To examine the views of tutors on how motivational strategies affect their performance in Core PTCs in Eastern Uganda.,1. To investigate motivational strategies employed in Core PTCS in Eastern Uganda. ,
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Uganda |
2023-04-04 9:36:11 |
2026-04-04 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Milcah Abasabyona
ID:
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Intimacies of Identification and Lived Citizenship among the Ghetto Youths in Kampala, Uganda
REFNo: SS1654ES
Main Objective:
To investigate how citizen certification and identification influences levels of belonging to a place and space, impacts on citizen-state relationship and individual personhood.
Specific Objectives:
1. To capture the individual practical experiences of legal certification and identification processes among the Ghetto youths.
2. To examine the regulatory effects of identification documents on citizenship rights, a sense of belonging, and personhood among the Ghetto youths in Kampala.
3. To explore the different key Identification documents and their role in the day to day lives of the Ghetto Youths.
4. To trace the ways in which the undocumented Ghetto youths create alternative routes to lived citizenship and self-certification.
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Uganda |
2023-04-04 9:32:41 |
2026-04-04 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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ANYASE AMAZA RONALD
ID: UNCST-2022-R009325
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Development of a Natural Anti-Aflatoxin Product
REFNo: HS2692ES
To develop a prototype natural based anti-aflatoxin product made from Ugandan plants.,To establish a database of plants in Uganda with anti-aflatoxin potential,To determine the indigenous approaches of aflatoxin control in Uganda.,To develop a natural based anti-aflatoxin product ,
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Uganda |
2023-04-03 21:04:19 |
2026-04-03 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Scovia Mbalinda Nalugo
ID: UNCST-2020-R014259
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Professional Identity of Ugandan Nurses and Midwives: Exploring the understanding, Perceptions and Experiences among student Nurses and Midwives, Recent Graduates and Nurse Educators
REFNo: HS2712ES
Explore nurse and midwife top management in the ministry of health and nurses and midwives council perception and experiences fostering professional identity in nursing in the country.,3. Explore nurse and Midwife educators’ perceptions and experiences fostering professional identity in nursing and midwife at Mbarara University of Science and Technology and Makerere university,2. Explore challenges and barriers to professional identity formation at Mbarara University of Science and Technology and Makerere University,1. Describe the understanding of the professional identity of final year undergraduate nurses and midwives and recent graduates at Mbarara University of Science and Technology and Makerere University.,
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Uganda |
2023-04-03 21:00:42 |
2026-04-03 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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zaina Nakabuye
ID:
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Technology orientation and the export performance of SME exporting firms in Uganda.
REFNo: SS1472ES
2. To establish the relationship between knowledge absorptive capacity and export performance.
3. To examine the relationship between supply chain agility and export performance.
4. To investigate the moderation of knowledge absorptive capacity between technology orientation and export performance.
5. To investigate the moderation of supply chain agility between technology orientation and export performance.
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Uganda |
2023-04-03 20:58:43 |
2026-04-03 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Pooja Chitneni
ID: UNCST-2021-R012955
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Development and assessment of an HIV disclosure intervention for men in Uganda - Aim 1
REFNo: HS2682ES
Aim 1. Identify the unique HIV disclosure needs and preferences among MWH to support HIV disclosure. ,
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USA |
2023-04-03 20:55:31 |
2026-04-03 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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