Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Fredrickson B Wasswa
ID: UNCST-2022-R008765
MINION WHOLE GENOME SEQUENCING OF BLOOD FOR DIAGNOSIS OF MENINGITIS AT MBARARA REGIONAL REFERRAL HOSPITAL, UGANDA
REFNo: NS528ES

To determine the use of MinION WGS to identify antimicrobial resistant genes, virulence enzymatic genes and Single Nucloetide polymorphisms (SNPs) among patients with CM and TBM at MRRH, To compare the performance of full MinION flow cells with Flongle flow discs designed for smaller samples for detection of CM and TBM at MRRH. To determine the suitability of blood as an alternative to CSF for the detection Cryptococcus and MTB in patients CM and TBM using MinION WGS at MRRH,To compare Cryptococcus and TB detection from blood and CSF using MimION WGS from patients with CM and TBM at MRRH.,
Uganda 2023-05-02 22:27:01 2026-05-02 Natural Sciences Non-Clinical Trial Degree Award
Nathan Kenya-Mugisha
ID: UNCST-2021-R013752
Smart Discharges for Vulnerable Refugee Children: A Cohort Study to Validate Prognostic Algorithms for Post-discharge Readmission and Mortality among Children Living in Refugee Settings.
REFNo: HS2755ES

Primary Objective:

1. To validate, calibrate, and refine the Smart Discharges risk-prediction algorithm in a representative cohort of refugee children.

Secondary Objectives:

1. To describe the epidemiology of, and risk factors for, post-discharge mortality of children in the context of refugee settings.
2. To describe the post-discharge health seeking patterns of children in the context of refugee settings.

Uganda 2023-05-02 22:24:41 2026-05-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
James Davis KATUMBA
ID:
Uncontrolled asthma among adolescents in selected secondary schools in Kampala City: Prevalence, associated factors, in-school needs, pathways to care and effectiveness of an mHealth Self-management app
REFNo: HS2791ES

To determine the effectiveness, acceptability and feasibility of the KmAsthma self-management app in improving the control of asthma among day scholar secondary school adolescents 12-19 years old in Kampala City Uganda.,To examine pathways to asthma care and their influence on asthma control among secondary school adolescents with asthma in Kampala City Uganda ,To establish the in-school needs associated with asthma control among adolescents in selected secondary schools in Kampala City Uganda ,To determine the prevalence of and factors associated with uncontrolled asthma among adolescents in selected secondary schools in Kampala City Uganda ,To establish the prevalence of and factors associated with uncontrolled asthma, in-school needs, pathways to asthma care, and effectiveness of KmAsthma Self-management app intervention to control asthma among adolescents in selected secondary schools in Kampala City Uganda,
Uganda 2023-05-02 22:22:49 2026-05-02 Medical and Health Sciences Clinical Trial Degree Award
Martin Lukindu
ID: UNCST-2023-R008081
One-Health analysis of CCHFV transmission risk patterns in Ugandan cattle corridor and arid Northern Kenya”
REFNo: A296ES

i) Identify tick spp diversity in diverse ecosystems of Ugandan cattle corridor
ii) Assess tick blood meal sources of potential vectors collected from unique spatial regions
iii) Delineate CCHFV infection rates of tick populations in diverse ecological units
iv) Characterize the tick virome of the Ugandan cattle corridor tick populations
v) Assess CCHFV genetic diversity at fine geographical and temporal scales across ecosystems

Uganda 2023-05-02 22:19:16 2026-05-02 Agricultural Sciences Non-Clinical Trial Non-degree Award
Esau Tugume
ID: UNCST-2019-R000622
Improving the Measurement of Productivity Dispersion and Misallocation in Developing Countries
REFNo: SS1698ES

6. Generate information and knowledge required to make informed policy decisions particularly in raising the productivity of small firms. ,Determine the role of firm-to-firm interactions, either as catalysts or hindrances to growth. ,Quantify the extent of resource misallocation across firms and the role of frictions in constraining firm growth.,Evaluate the strengths and weaknesses of existing empirical approaches to measuring misallocation. ,Verify whether existing estimates of productivity and marginal product dispersion are robust to improved measurement and the accounting of firm-to-firm interactions. If not, our data will identify the source of bias,Quantify three margins of allocative efficiency of firms: (i) the within-firm allocation of inputs across products, (ii) the allocation of resources across firms located in geographical proximity to each other, i.e., that operate within informal “clusters,” as widely documented in low-income country settings, and (iii) the sector-level allocation of resources across different geographic areas (or clusters).,The primary objective of this research project is to shed light on the organization of production in low-income countries and estimate firm-product level production functions. ,
Uganda 2023-05-02 22:16:11 2026-05-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
John Kellett Gale
ID:
Can continuous non-invasive monitoring of movement predict and detect clinical deterioration of hospital patients earlier and more efficiently than traditional intermittent observations?
REFNo: HS2765ES

To determine if continuously collected accelerometer data can indicate and identify clinical deterioration of acutely ill hospitalised patients before intermittently collected vital signs.
Ireland 2023-05-02 22:11:25 2026-05-02 Medical and Health Sciences Clinical Trial Non-degree Award
Stephen Pande Legesi
ID:
Sentinel Surveillance for Adverse Events of Special Interest after Vaccination with COVID-19 Vaccines-Uganda
REFNo: HS2370ES

Primary Objectives The overall aim of this surveillance protocol is to monitor the safety of COVID-19 vaccines in UGANDA in near real-time for pre-specified AESI conditions and evaluation to inform decision making to maintain public confidence in the vaccination program Specific Objective The specific objective of this evaluation is to assess the risk of pre-defined AESI following vaccination with a COVID-19 vaccine by brand. Secondary objectives 1.To strengthen Uganda’s active AEFI Surveillance system 2.To describe lessons learned from implementing active surveillance for various COVID 19 vaccine products.
Uganda 2023-05-02 22:08:38 2026-05-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Dorcas Mandera Agatha
ID:
Accelerating Impact for Young Women in Africa (AIM) Project Process Evaluation
REFNo: SS1644ES

- To identify contextual factors and success drivers that influence the program reach and quality,- To ascertain the effectiveness of the project from the perspective of its beneficiaries.,- To assess the viability of the intervention strategy and its feasibility as assumed in the theory of change (ToC).,This process evaluation intends to assess the implementation of the AIM project to ascertain whether it works, why it works, how it works, and its potential replicability. ,
Uganda 2023-04-28 23:54:42 2026-04-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
Lawrence Osuwat Obado
ID: UNCST-2023-R008389
Assessing the Health Risk of Arsenic Burden in Human Beings and its Levels in Natural Water Sources Providing Domestic Water in Amuria District
REFNo: HS2770ES

To determine the arsenic concentration in hair samples taken from residents using water from sampled sources for domestic purposes,To determine the concentration of arsenic in the nails of residents using water from sampled sources for domestic purposes,To profile the arsenic levels of water from natural sources in areas of Amuria district in Eastern Uganda, and test for potential bioaccumulation of arsenic among the residents that use the water for domestic purposes,To determine the amount of arsenic in water collected from underground wells in Amuria District.
Uganda 2023-04-26 11:43:03 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
SSEDYABANE FRANK
ID: UNCST-2022-R011175
ASSOCIATION OF FOXP3, P16INK4A, CMYC AND SELECTED MICRO RNA SERUM EXPRESSION WITH GRADES, TREATMENT STRATEGIES AND OUTCOMES FOR CERVICAL SQUAMOUS INTRAEPITHELIAL LESIONS
REFNo: HS2722ES

1. To determine the prevalence of Cervical Intraepithelial Neoplasia among women attending the cervical cancer clinic at Mbarara Regional Referral Hospital.
2. To establish the individual and combined accuracy of FOXP3, P16ink4a, cMYC, and selected micro RNAs (miR-205, miR-9, miR-192 and miR-21) in detection of cervical squamous intraepithelial lesions among women attending the cervical cancer clinic at Mbarara Regional Referral Hospital.
3. To determine the association between serum levels of FOXP3, P16ink4a, cMYC, and selected micro RNAs (miR-205, miR-9, miR-192 and miR-21) with grades of cervical squamous intraepithelial lesions among women attending the cervical cancer clinic at Mbarara Regional Referral Hospital.
4. To determine the relationship between follow-up serum levels of FOXP3, P16ink4a, cMYC, and selected micro RNAs (miR-205, miR-9, miR-192 and miR-21) and treatment strategies as well as outcomes (clearance, persistence or progression) of cervical squamous intraepithelial lesions among women attending the cervical cancer clinic at Mbarara Regional Referral Hospital.

Uganda 2023-04-26 11:42:24 2026-04-26 Medical and Health Sciences Non-Clinical Trial Degree Award
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