Grace Ahimbisibwe Miriam
ID: UNCST-2021-R012129
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Pediatric HIV Cure Collaborative Study Version 2.0 dated 16 Sep 2021
REFNo: HS2671ES
1. Identify correlates of susceptibility to proviral reactivation through immune profiling, which will be analyzed by multiparameter by flow cytometry methods, antibody profiling and transcriptomic analyses by bulk RNA-seq of PBMCs and CD4+ T cells in perinatal and adult infections.
2. To quantitatively and qualitatively characterize viral reservoirs, in children, adolescents and youth living with HIV compared with adults through determining and comparing the size, composition, and inducibility of the latent HIV reservoir in different geographic locations and subtypes, and characterizing their differences. The size will be determined by HIV DNA quantitative assays and inducibility by TILDA. The composition will be determined by near full-length sequencing for intact and defective genomes.
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Uganda |
2023-05-26 8:39:02 |
2026-05-26 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Eugene Kinyanda
ID: UNCST-2023-R008028
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Proposal to address the medium- to long-term EBOLA associated
psychological Distress and psychosocial problems in Mubende District in central Uganda
(Ebola+D Project)
REFNo: HS2870ES
To undertake a project to address the medium- to long-term EBOLA associated psychological Distress and psychosocial problems in Mubende District in central Uganda.
Aims
i) To develop, implement and evaluate the Ebola+D mental health intervention in
Mubende district
ii) To investigate the nature of mental health problems of community members
accessing the Ebola+D mental health intervention and factors associated with
treatment outcomes including immunological biomarkers
iii) To explore the EVD associated negative beliefs and lived out experiences of affected members of the community (including health care workers)
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Uganda |
2023-05-26 8:34:43 |
2026-05-26 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Kamwine Monicah
ID:
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MICROBIAL AND METAGENOMIC ANALYSIS OF BACTERIAL COMMUNITIES IN MILK PRODUCTS PRODUCED IN MBARARA CITY, UGANDA
REFNo: HS2673ES
General objective
To characterize bacterial communities in milk products produced in Mbarara City, Uganda using culture techniques and metagenomic analysis
Specific Objectives
1. To determine the presence, levels of overall bacterial contamination load and bacterial profile in different milk products produced in Mbarara city, Uganda
2. To characterize the predominant microbiota in each milk product, determine the percentage of relative abundance of main identified bacterial genera, in each of the milk products produced in Mbarara city, Uganda.
3. To determine Virulence factors of the isolated bacteria
4. To determine the antimicrobial susceptibility patterns of pathogenic bacteria isolated from milk products produced in Mbarara city, Uganda
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Uganda |
2023-05-25 12:11:40 |
2026-05-25 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Deborah Ekusai-Sebatta
ID: UNCST-2021-R003878
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REGULATION OF DATA SHARING IN INTERNATIONAL GENOMIC RESEARCH: ETHICAL, SOCIAL AND LEGAL IMPLICATIONS
REFNo: SS1730ES
3. To evaluate the ethico-regulatory frameworks governing data sharing practices of genomic research in Uganda,2. To determine stakeholder knowledge, attitudes and practices (KAP) on sharing of data in collaborative genomic research in Uganda.,1. To establish the genomic data sharing practices and perceptions in collaborative human genomic research in Low and Middle Income Countries .,To comprehend the ELSI of the data sharing in international collaborative genomic research from a regulatory stand point. This will involve an evaluation the data sharing policies and explore the knowledge, perceptions and experiences of stakeholders involved in the conduct of international genomic research,
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Uganda |
2023-05-25 12:10:10 |
2026-05-25 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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juliet cheptoris
ID:
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Experiences and perceptions of Intimate Partner Violence (IPV) among Adolescent Girls and Young Women (AGYW) enrolled in the DREAMS Project in Mukono District, Uganda, 2023
REFNo: SS1718ES
General study objective
To explore experiences and perceptions of Intimate Partner Violence (IPV) among Adolescent Girls and Young Women (AGYW) 15-24 enrolled in the DREAMS Program in Mukono District
Specific Objectives
1. To explore the knowledge and perceptions on IPV among Adolescent Girls and Young Women (AGYW) who are enrolled in the DREAMS program
2. To examine the experiences of IPV among AGYW before and after enrolling in the DREAMS program.
3. To determine the factors associated with Intimate Partner Violence among AGYW who enrolled in the DREAMS program.
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Uganda |
2023-05-25 12:08:46 |
2026-05-25 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Rosalind Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
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HIV and sexually transmitted infection international biorepository and diagnostic test performance
REFNo: HS2724ES
• To create a biorepository to test retrospectively the performance of investigational, emerging diagnostic technologies in the intended population or setting compared to a reference comparator for diagnosing HIV/STIs using frozen samples.
• To test prospectively the accuracy of investigational, emerging diagnostic technologies in the intended population or setting compared to a standard comparator for diagnosing HIV/STI infection
• To determine agreement between self-collected swabs, saliva and clinician-collected swab samples for the diagnosis of STI using a reference test in Uganda.
• To determine agreement between self-collected blood, saliva and clinician-collected blood samples for the diagnosis of HIV using a reference test in Uganda.
• Determine the proportion of non-reportable results (unresolved, indeterminate and incomplete) and turn-around time compared to reference test.
• To assess acceptability of self-collected blood samples, swab tests, and saliva for testing HIV/STI in both participants and healthcare workers in Uganda.
• To explore socio-demographic, behavioural and clinical factors associated with positive HIV and other STI diagnosis
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UK |
2023-05-25 12:07:08 |
2026-05-25 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Richard Idro
ID: UNCST-2021-R013599
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Dihydroartemisinin-piperaquine and azithromycin for the post-discharge management of children with severe anaemia in Malawi, Kenya and Uganda; A, multicentre, parallel-group, two-arm, randomised, double-blind superiority trial.
REFNo: HS2815ES
To determine if PDMC with four courses of monthly AZ treatment in combination with four months of weekly DP is superior to PDMC with weekly DP-alone in reducing non-malaria SCCV by six months post-discharge in children aged <5 years admitted with severe anaemia (Hb<5g/dl) who are ready to be discharged and are clinically stable and able to switch to oral medication,
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Uganda |
2023-05-25 12:04:54 |
2026-05-25 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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David Meya Bisagaya
ID: UNCST-2019-R000837
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Platform Trial For Cryptococcal Meningitis - PLATFORM-CM
REFNo: HS2649ES
The purpose of this study is to know whether this oral form of amphotericin (MAT2203) is safe and effective in the treatment of people sick with cryptococcal meningitis.
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Uganda |
2023-05-25 12:01:51 |
2026-05-25 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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CHRISTINE MBABAZI -MPYANGU
ID:
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Freedom of Religion or Beliefs Leadership Network (FoRBLN): A case study of Tororo district in Uganda.
REFNo: SS1308ES
Overall goal
To explore a new synthesis of theoretical models derived from a combination of work in cognitive anthropology with modes theory, social psychology with identity fusion, leadership psychology with barrier crossing leadership.
The research aims to address the following research questions
1. What role do imagistic group experiences play in fostering identity fusion Vs group identification bonds directed at the ingroup vs outgroup.
2. How far attitudes towards and experiences of barrier crossing leadership lead to improved intergroup attitudes and behaviours.
3. Whether individual empathetic abilities moderate the effects of imagistic experiences and/ or barrier crossing leadership.
4. How far the evidence from the cross cultural sample supports the theoretical model outline by modes theory.
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Uganda |
2023-05-25 11:59:07 |
2026-05-25 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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JULIET MWANGA-AMUMPAIRE
ID: UNCST-2022-R009420
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Omuyambi: Traditional healer support to improve HIV viral suppression in rural Uganda
REFNo: HS2780ES
Aim 2: Evaluate implementation of the Omuyambi intervention using a convergent, mixed methods study design guided by the Consolidated Framework for Implementation Research (CFIR). Participants for this Aim will include TH and PLWH from Aim 1, in addition to staff from affiliated HIV clinics, and Ministry of Health (MoH) AIDS Control Division Officers who will be invited to participate in in- depth interviews and structured surveys. Following the convergent mixed methods approach38, quantitative and qualitative data – including validated survey instruments, in-depth interviews, and structured observations – will be collected to evaluate context pertinent to Omuyambi implementation over a 24-month period.,Aim 1: We will compare the Omuyambi intervention versus HIV clinic-based care (control) in a cluster randomized trial to assess the effectiveness of a community-based traditional healer (TH)-facilitated support program for people living with HIV (PLWH) in Mbarara District. We will conduct a CRT of Omuyambi versus TH’s referrals for clinic-based HIV care at 40 TH cluster sites over 33 months in Aim 1. The unit of randomization is the TH; each cluster includes TH and adult PLWH who are ART naïve or defaulted from HIV care. TH who are randomized to Omuyambi will facilitate HIV support for ART naïve or nonadherent PWLH receiving care at their practice.,We propose a parallel arm cluster randomized trial to compare the intervention (Omuyambi) to the control in Aim 1 to assess the effectiveness of the intervention and use a mixed methods approach to evaluate the implementation in Aim 2.,
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Uganda |
2023-05-18 16:44:40 |
2026-05-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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