Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
REBECCA NANTANDA
ID: UNCST-2019-R001533
Assessment of feasibility, acceptability, hesitancy, safety, effectiveness and immunogenicity of COVID-19 vaccines among children in Uganda
REFNo: HS2910ES

1. To assess the feasibility and acceptability of COVID-19 vaccination of children in Uganda.
2. a) To determine the prevalence of hesitancy to COVID-19 vaccination for children in
Uganda.
b) To describe the drivers of hesitancy for vaccination of children against COVID-19 in
Uganda.
3. To assess the safety of COVID-19 vaccines among children aged 12-17 years in Uganda.
4. To determine immunogenicity the BioNTecg/Pfizer of among children aged 12-17 years in Uganda.
5. To determine the effectiveness of COVID-19 vaccines among children aged 12-17 years in Uganda.

Uganda 2023-08-18 9:40:38 2026-08-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adoke Yeka
ID: UNCST-2021-R004300
A pilot study evaluating the feasibility, acceptability and impact of use of highly sensitive malaria RDTs (NxTek™) vs ordinary malaria RDTs on malaria incidence in Uganda: a cluster-randomised trial
REFNo: HS2988ES

1. To determine the impact of detecting and treating additional malaria cases on malaria morbidity, 2 years following introduction of HS-RDTs for diagnosis of malaria in Uganda.
2. To assess feasibility of use (ease of test interpretation, delivery, restocking, storage, invalid tests, and reporting rates) of HS-RDTs among implementers in Uganda.
3. To compare clinical care outcomes for malaria cases diagnosed with HS-RDTs and cRDTs in Uganda.
4. To estimate the cost-effectiveness of delivering HS-RDTs, as compared to cRDTs.

Uganda 2023-08-18 9:13:55 2026-08-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adoke Yeka
ID: UNCST-2021-R004300
An adaptive, randomized, active-controlled, open-label, sequential cohort, multicenter study to evaluate the efficacy, safety, tolerability and pharmacokinetics of intravenous cipargamin (KAE609) in adult and pediatric participants with severe Plasmodium falciparum malaria (KARISMA – KAE609’s Role In Severe Malaria)
REFNo: HS1980ES

Primary objective
To assess the efficacy of different doses of
intravenous cipargamin vs artesunate by evaluating the proportion of
participants with ? 90% reduction of parasitemia at 12 hours post
administration of the first dose.

Secondary Objectives
1. To assess the presence/absence of severe malaria related individual
signs over time
2. To evaluate parasite clearance dynamics and proportion of participants
with recrudescence and reinfection
3. To assess recovery of participants as measured by time (days and hours)
to discharge from hospital or recovery from prostration
4. To evaluate the safety and tolerability of IV cipargamin
5. To assess the risk of long term neurological sequelae for participants at
Day 29
6. The assess the risk of hemolysis (early and delayed) during the study
duration
7. To characterize the plasma pharmacokinetics of IV cipargamin

Uganda 2023-08-18 9:05:14 2026-08-18 Medical and Health Sciences Clinical Trial Non-degree Award
Juliane Etima
ID: UNCST-2022-R008983
Young Generation Alive Survey: Determining Knowledge, Aspirations, and Behaviors of Ugandan Adolescents and Young People Living with HIV.
REFNo: SS1910ES

To understand the HIV knowledge and behaviors among HIV+ and perinatally exposed adolescents and young people in Uganda with respect to achieving career aspirations, financial security, and safe intimate relationships.,
Uganda 2023-08-15 15:43:39 2026-08-15 Social Science and Humanities Non-Clinical Trial Non-degree Award
Fiona Ssozi Catherine
ID:
PATHWAYS TO CHANGE: TOWARDS GENDER JUSTICE IN SCIENCE, ENGINEERING, TECHNOLOGY AND MATHEMATICS (STEM) RESEARCH IN AFRICA (GEJUSTA)
REFNo: SIR240ES

Primary objective: Examine causes of under-representation and reframe Gender Analysis in STEM in Africa
Secondary objectives: Map under-representation, barriers and support mechanisms; explore STEA+M approaches; Develop Gender-aware design methodologies; Develop a support network for mentoring early-career female researchers

Uganda 2023-08-15 15:42:06 2026-08-15 Engineering and Technology Non-Clinical Trial Non-degree Award
Jesca Nantume
ID: UNCST-2021-R013984
EVALUATING EQUITABLE ACCESS TO HEALTH SERVICES FOR SCHISTOSOMIASIS IN COMMUNITY-BASED HEALTH CENTERS; A MIXED METHODS CROSSECTIONAL STUDY IN MAYUGE AND KALUNGU DISTRICT IN UGANDA
REFNo: SS1887ES

3. To identify and understand the barriers that hinder equitable access to health services for schistosomiasis, including socio-economic factors such as income, education level, and employment status, as well as cultural beliefs, attitudes, and practices that affect healthcare-seeking behaviors.,2. To evaluate the accessibility of health services for schistosomiasis in terms of geographical proximity, transportation, cost, and waiting times for individuals seeking diagnosis, treatment, and follow-up care.,1. To assess the availability of health services for schistosomiasis in community-based health centers in Mayuge and Kalungu Districts, Uganda, including the availability of diagnostic tools, treatment options, and healthcare professionals trained in schistosomiasis management.,The main aim of the study is to assess and evaluate the level of equitable access to health services for schistosomiasis in community-based health centers in Mayuge and Kalungu Districts, Uganda, by considering various factors such as availability, accessibility, utilization, and quality of services. The objective is to gain a comprehensive understanding of the barriers and facilitators that impact equitable access to schistosomiasis healthcare services, including the influence of socio-economic factors, cultural beliefs, knowledge and awareness levels, and gender dynamics.,
Uganda 2023-08-15 15:40:28 2026-08-15 Social Science and Humanities Non-Clinical Trial Non-degree Award
Alison Elliott
ID: UNCST-2023-R006524
Understanding the role of, and relationship between, structural, social and biological determinants of vaccine response to improve vaccine impact in Kenya and Uganda: a formative study.
REFNo: HS2901ES

1. To conduct a scoping review exploring how social, structural and biological drivers interact to influence vaccine response. 2. To undertake formative ethnographic case studies to investigate these interactions in two communities where biological factors are known to influence vaccine response. 3. To map stakeholders and influencers critical to vaccine impact in Uganda and Kenya. 4. To work with stakeholders and communities to co-design the VAnguard community surveys to be conducted in year 2 of the programme
UK 2023-08-10 15:46:52 2026-08-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sylivia Namwano
ID: UNCST-2023-R008071
A pragmatic early detection and warning model for reduction of landslide effects for communities at risk
REFNo: SIR243ES

To evaluate the efficiency, reliability, effectiveness and usability of the designed pragmatic early detection and warning model for reduction of landslide effects for communities at risk,To establish ideal characteristic of an effective and efficient landslide early detection and warning systems for communities at risk,To design a pragmatic early detection and warning model for reduction of landslide effects for communities at risk,
Uganda 2023-08-10 15:22:18 2026-08-10 Engineering and Technology Non-Clinical Trial Degree Award
Brian Mikka
ID:
Prevalence and factors associated with low-level viremia in HIV patients on NNRTIs substituted to dolutegravir-based regimen at Kitebi health center
REFNo: NS627ES

To determine the factors associated with LLV among PLHIV who were substituted to DTG-based regimens at Kitebi health centre.,To determine the prevalence of LLV among PLHIV substituted to DTG-based regimen at Kitebi health centre.,To determine the prevalence and factors associated with low-level viremia among patients substituted from NNRTIs to dolutegravir- based first-line regimen at Kitebi health centre.,
Uganda 2023-08-10 15:19:55 2026-08-10 Natural Sciences Non-Clinical Trial Degree Award
Ruth Namazzi
ID: UNCST-2020-R014305
Full Assessment of Clinical Transfusion Support (FACTS): An assessment of hematologic diseases among blood transfusion recipients and donated units at a pediatric regional referral hospital in Uganda
REFNo: HS2908ES

To determine the prevalence of SCA among children requiring blood transfusions at the children’s ward of the Jinja Regional Referral Hospital (JRRH) • To determine the prevalence of malaria parasitemia among children requiring blood transfusions at the children’s ward of the Jinja Regional Referral Hospital • To determine the prevalence of malaria parasitemia among donated, transfused blood units • To determine the incidence of iron deficiency among transfusion recipients donated, transfused blood units • To determine the RBC RhCE and Kell antigen profile on donated units and transfusion recipients
Uganda 2023-08-10 13:53:54 2026-08-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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