Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Ilemobayo  Fasogbon Victor
ID: UNCST-2023-R008569
 DEVELOPMENT AND EVALUATION OF AN APTAMER-BASED LATERAL FLOW BIOSENSOR FOR RAPID DETECTION OF Mycoplasma bovis P48 PROTEIN
REFNo: HS4931ES

Evaluation of the aptamer-based biosensor using M. bovis infected milk samples,Construction of the aptamer-based biosensor after optimizing the inherent conditions and components,Characterization of the binding affinity and specificity of the aptamer-target interactions,Selection and optimization of the most sensitive aptamer for application in the lateral flow biosensor through molecular interaction studies on previously reported P48 protein aptamers.,he research aim to develop and evaluate an aptamer-based lateral flow biosensor for the rapid and accurate detection of the Mycoplasma bovis P48 protein in infected samples,
 Nigeria 2024-12-23 12:36:24 2027-12-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Paul Matovu
ID: UNCST-2024-R004929
 The Phylogeny of East African Chlorophytum Ker-Gawl. (Asparagaceae), Phylogeography and Conservation of species found in Uganda
REFNo: NS756ES

1. To establish the phylogeny of Chlorophytum species in the FTEA region and put them in a global context.
2. To unravel the phylogenetic and morphological delimitation of problematic taxa and species complexes within Chlorophytum.
3. To establish the spatial phylogeny of Chlorophytum species that occur in Uganda
4. To establish the conservation status of Chlorophytum species in Uganda

Uganda 2024-12-23 12:34:57 2027-12-23 Natural Sciences Non-Clinical Trial Degree Award
Francis Ssali
ID: UNCST-2021-R012134
 A5409: A Phase 2 Randomized, Adaptive, Dose-Ranging, Open-Label Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis (RAD-TB)
REFNo: HS4036ES

1.2 Primary Objectives

1.2.1 To compare MGIT liquid culture TTP slope over the first 6 weeks of treatment for each experimental treatment arm to the SOC arm.

1.2.2 To compare new Grade 3 or higher adverse events (AEs) (safety) over the first 8 weeks of treatment for each experimental treatment arm to the SOC arm.

1.3 Secondary Objectives

1.3.1 To compare time to stable culture conversion by MGIT liquid culture by week 8 for each experimental treatment arm to the SOC arm.

1.3.2 To compare MGIT liquid culture TTP slope over the first 8 weeks of treatment for each experimental treatment arm to the SOC arm.

1.3.3 To compare new Grade 3 or higher AEs (safety) over 26 weeks of treatment for each experimental treatment arm to the SOC arm.

1.3.4 To compare discontinuations of anti-TB drugs for any reason prior to 8 and 26 weeks of treatment for each experimental treatment arm to the SOC arm.

1.3.5 To determine the dose- and exposure-response relationships between experimental drug estimated pharmacokinetic (PK) parameters with safety and efficacy.

1.3.6 To compare a composite of efficacy and safety outcomes using a risk-benefit approach for each experimental treatment arm to the SOC arm.

1.3.7 To compare MGIT liquid culture TTP slope over the first 6 weeks of treatment for Arms 3A-3B and Arms 4A-4B compared to Arm 2.

1.3.8 To compare durable cure by 52 weeks after treatment initiation in each experimental treatment arm to the SOC arm.


 Uganda 2024-12-23 12:34:14 2027-12-23 Medical and Health Sciences Clinical Trial Non-degree Award
Hakimu Sseviiri
ID: UNCST-2024-R004881
 Formalizing and Elevating Workforce Visibility for Marginalized Sanitation Workers in Kampala, Uganda: Unravelling the intended and Unintended Consequences.
REFNo: SS2816ES

4. To co-design multi-stakeholder pathways towards effective formalization, integration and recognition of sanitation workers. ,3. To analyze the multi-dimensional intended and unintended impacts of formalizing and increasing the visibility of the workforce for the most marginalized workers. ,2. To identify and characterize actors involved in the formalization and visibility raising processes in Kampala city. ,1.To determine the different sanitation workers’ formalization and visibility raising initiatives overtime. ,To unravel the intended and unintended consequences of sanitation workers formalization and visibility enrichment in Kampala city, Uganda. ,
 Uganda 2024-12-23 12:29:36 2027-12-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
George Alaneme Uwadiegwu
ID: UNCST-2024-R003261
 ARTIFICIAL INTELLIGENCE PREDICTIVE MODELLING OF MECHANICAL AND RHEOLOGICAL PROPERTIES OF GEOPOLYMER-CONCRETE MADE FROM BLENDED BAGASSE AND BANANA-PEEL-ASH
REFNo: SIR365ES

i. To characterize Bagasse ash (BA) and Banana peel ash (BPA) as a geopolymer precursor
ii. To ascertain the optimal combination of the concrete mixture incorporating Bagasse ash (BA) and Banana peel ash (BPA) to replace ordinary Portland cement.
iii. To determine the mechanical and rheological properties of Bagasse ash (BA) and Banana peel ash (BPA) and blended geopolymer concrete matrix.
iv. To develop soft computing predictive models of ANN, GEP and ANFIS to explore the relationships between the Alkalis-activated binder blend and the rheological and mechanical strength response.
v. To compare and validate the models developed in (iv).

 Nigeria 2024-12-23 12:28:18 2027-12-23 Engineering and Technology Non-Clinical Trial Degree Award
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