Isaac Ssewanyana
ID: UNCST-2020-R014336
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Clinical Performance Evaluation of Kwiq-Test HIV-1/2 (Whole Blood/Serum/ Plasma): Diagnostic sensitivity & diagnostic specificity, specimen equivalence, Anticoagulant equivalence and qualification of usability
REFNo: HS5368ES
The objectives of this study are:
1. To establish the diagnostic sensitivity and diagnostic specificity of the Kwiq HIV-1/2 test (Serum/Plasma/wholeblood) in plasma samples according to the WHO TSS-1 Part 2.1
2. To demonstrate the equivalence of serum, plasma (EDTA-K2), venous whole blood (EDTA-K2) and fingerprick whole blood collected from HIV positive patients according to WHO TSS-1 Part 1: 1.1.1.
3. To demonstrate anticoagulant equivalence of serum, venous whole blood (EDTA-K2, EDTA-K3, sodium citrate, sodium heparin), plasma (EDTA-K2, EDTA-K3, sodium citrate, sodium heparin) and fingerprick whole blood
4. To demonstrate the usability of this rapid diagnostic test when performed by the intended users. It will be assessed whether the intended users comprehend all key messages from labelling and packaging (i.e. label comprehension study) and whether they can correctly interpret pre-determined test results (i.e. result interpretation study).
To meet all the requirements as set out in the WHO TSS-1study will be conducted in Uganda
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Uganda |
2025-01-22 16:53:12 |
2028-01-22 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Peter Olds
ID: UNCST-2023-R006240
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Developing Better Control Together, a multi-faceted patient-support group for patients with hypertension in Uganda
REFNo: HS5309ES
We propose to develop a multi-faceted patient-support group for patients living with HTN in rural Uganda using an iterative approach that is tailored to the local context. We will adapt several evidence-based interventions for patient-support groups from the HIV experience to develop a comprehensive intervention for patients with HTN by including aspects of disease education, social support, financial activities, and bulk purchasing of HTN medications.
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USA |
2025-01-22 16:51:40 |
2028-01-22 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Ronald Rwankangi
ID: UNCST-2024-R016056
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Solar-Powered Irrigation Schemes for Smallholder Farmers in Uganda: Assessing Impact and Sustainability
REFNo: SIR452ES
1. To examine the impact of adopting solar-powered irrigation systems on crop
yields in horticulture among smallholder farmers in eastern Uganda.
2. To examine how farmers’ knowledge and skills in operating and maintaining
solar irrigation systems influence the adoption of solar-powered irrigation
technology among smallholder farmers.
3. To analyze the effect of stakeholder engagement on the adoption of solar-
powered irrigation technologies among smallholder farmers.
4.To assess how the Ugandan Government’s policy frameworks influence, the
adoption of solar-powered irrigation technology among smallholder farmers.
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Uganda |
2025-01-22 16:49:32 |
2028-01-22 |
Engineering and Technology |
Non-Clinical Trial |
Degree Award |
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Haruna Muwonge
ID: UNCST-2019-R000128
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Functional Role, Temporal Dynamics, and Protective Impact of IgA on Clinical Outcomes in Uncomplicated Plasmodium falciparum Malaria
REFNo: HS5353ES
General Objective
To investigate the functional role, temporal dynamics, and protective impact of IgA on clinical outcomes in adult patients with uncomplicated Plasmodium falciparum malaria in the greater Kampala region, Uganda.
Specific Objectives
1. To quantify the functional activity of serum IgA antibodies in adult patients with uncomplicated Plasmodium falciparum malaria in the greater Kampala region, Uganda, by measuring the percentage reduction in hepatocyte infection, the inhibition of merozoite invasion of erythrocytes, and the level of neutrophil activation through oxidative burst and cytokine release.
2. To characterize the temporal dynamics and persistence of IgA responses in adult patients with uncomplicated malaria in the greater Kampala region over a 42-day follow-up period, by measuring peak IgA levels (C_max), time to peak level (T_max), rate of decline (IgA half-life), and area under the curve (AUC).
3. To evaluate the association between serum IgA levels and clinical outcomes in adult patients with uncomplicated malaria in the greater Kampala region, by assessing symptom resolution time and parasite clearance time.
4. To determine the correlation between IgA levels and complement activation, as well as their association with pro-inflammatory or regulatory cytokines during and after Plasmodium falciparum infection in adult patients with uncomplicated malaria in the greater Kampala region, Uganda.
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Uganda |
2025-01-22 16:47:42 |
2028-01-22 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Dina Nabasumba
ID: UNCST-2023-R006504
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Crop production dynamics and vulnerability to food insecurity in the face of climate variability: A case of smallholder farmers in south-western Uganda
REFNo: A524ES
4. To classify the extent and factors controlling the influence of climate variability on vulnerability to food insecurity among smallholder farmers in south-western Uganda,3. To determine the influence of spatial-temporal rainfall variability on adoption patterns of land-based climate smart agricultural practices in seasonal cropping systems of smallholder farmers in south-western Uganda ,2. To establish the relationship between smallholder farmers’ knowledge, attitudes and adoption of climate smart agricultural practices in south-western Uganda,1. To assess smallholder farmers’ perceptions of climate variability and the extent to which it has altered crop selection and cultivation patterns in south-western Uganda,To establish the influence of climate variability on the crop production systems and vulnerability to food insecurity among smallholder farmers in south-western Uganda,
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Uganda |
2025-01-22 16:46:28 |
2028-01-22 |
Agricultural Sciences |
Non-Clinical Trial |
Degree Award |
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