alice namatovu
ID: UNCST-2025-R017415
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EVALUATION OF THE EFFECTIVENESS OF BACTERIOPHAGE COCKTAILS AGAINST MULTI-DRUG-RESISTANT BACTERIA ON PATIENTS WITH DIABETIC FOOT ULCERS ATTENDING SELECTED REFERRAL HOSPITALS IN UGANDA
REFNo: HS5652ES
Main objective:
To assess the efficacy of bacteriophages in the management of diabetic foot wounds/ulcers in animal models and among patients attending the selected referral hospitals in Uganda.
Specific Objectives
i) To determine the biological and genotypic characteristics of lytic bacteriophages against the MDR- bacteria isolated from diabetic wounds of patients.
ii) To determine the virulence genes of the bacteria isolated from DFU patients and those genes associated with antimicrobial resistance.
iii) Determine the phage receptor genes on the MDR bacteria isolated from DFU patients.
iv). To evaluate the effectiveness of the identified Bacteriophage preparation/cocktail in the healing of induced diabetic wounds in mice.
v). To evaluate the effectiveness of the identified bacteriophage preparation/cocktail in the healing of diabetic foot wounds on patients in selected referral hospitals in Uganda.
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Uganda |
2025-09-12 16:14:57 |
2028-09-12 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Solomon Mbina Adomi
ID: UNCST-2024-R015658
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EFFECTS OF LYOPHILIZED LEAF EXTRACT OF KHAT (Catha edulis Forsk) ON HEPATORENAL SYSTEM AND LIPID METABOLISM IN HIGH FAT DIET INDUCED HYPERLIPIDEMIC MALE ALBINO WISTAR RATS
REFNo: HS5753ES
1. To characterize the bioactive compounds in lyophilized Catha edulis leaf extract using Gas chromatography-mass spectrometry (GC-MS) technique.
2. To determine the molecular interactions between bioactive compounds of Catha edulis leaf extract. and key proteins involved in lipid metabolism (leptin, adiponectin, and HMG-CoA reductase) using molecular docking analysis.
3. To determine the effect of lyophilized Catha edulis leaf extract on serum liver function parameters, (Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and
Alkaline Phosphatase (ALP), bilirubin, Albumin). in HFD-induced hyperlipidemic male
albino Wistar rats.
4. To evaluate the effect of lyophilized Catha edulis leaf extract on kidney function indices
(Urea, creatinine, serum electrolytes) in HFD-induced hyperlipidemic male albino Wistar
rats.
5. To determine the effect of lyophilized Catha edulis leaf extract on serum leptin and
adiponectin hormones levels in HFD-induced hyperlipidemic male albino Wistar rats.
6. To evaluate the effect of lyophilized Catha edulis leaf extract on serum lipid profile (Total cholesterol, High-density lipoprotein, low-density lipoproteins, and triglycerides) in HFD induced hyperlipidemic male albino Wistar rats.
7. To examine the effect of lyophilized Catha edulis leaf extract on the histology of the liver and kidney of HFD induced-hyperlipidemic male albino Wistar rats.
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Nigeria |
2025-09-12 16:13:25 |
2028-09-12 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Magololo Mutesi Fiona
ID: UNCST-2024-R015533
|
Changes in inpatient antibiotic use and antimicrobial resistance rates, through a collaborative quality improvement intervention: a study on adult surgical wards at Mulago National Referral Hospital.
REFNo: HS6321ES
4.1 Objectives.
4.1.1 General objective
To reduce irrational inpatient antibiotic use by at least 10% in the adult surgical wards of Mulago National Referral Hospital using a collaborative quality improvement intervention approach.
4.1.2 Specific Objectives.
4.1.2.1 Specific Primary objectives.
1. To determine baseline and closeout rates of irrational inpatient antibiotic use in the adult surgical wards of Mulago National Referral Hospital at Month one and Month seven respectively.
2. To describe antimicrobial resistance rates and drug susceptibility patterns of commonly isolated bacterial pathogens obtained from patients admitted to the adult surgical wards of Mulago National Referral Hospital during the 24 months preceding this study (July 2023-June 2025).
3. To determine monthly rates of irrational antibiotic use on the adult surgical wards of Mulago National Referral Hospital from Month two to Month six, during the QI intervention implementation.
4. To explore health worker perceptions and lived experiences on antimicrobial resistance, antibiotic prescription and antimicrobial stewardship as well as the impact of AMR on the adult surgical wards of Mulago National Referral Hospital, at Month one and Month seven.
5. To reduce irrational antibiotic use by 10%, through developing and implementing a collaborative quality improvement intervention to on antimicrobial stewardship on the adult surgical wards of Mulago National Referral Hospital.
5.1.2.2 Specific Secondary objectives.
6. To describe the change in monthly rates of irrational inpatient antibiotic use following a quality improvement intervention in the adult surgical wards of Mulago National Referral Hospital.
7. To describe the relationship between irrational inpatient antibiotic use rates and antimicrobial resistance rates in adult gastrointestinal surgical wards of Mulago National Referral Hospital.
8. To describe the change in antimicrobial resistance rates and drug susceptibility profiles of isolates obtained from patients admitted to the adult surgical wards of Mulago National Referral Hospital during this study, compared to those of patients admitted in 24 months before this study (24 months preceding month 1).
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Uganda |
2025-09-12 12:24:29 |
2028-09-12 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Jerry Okal Okoth
ID: UNCST-2025-R016719
|
Evaluation of the Challenge Initiative (TCI)
REFNo: SS3773ES
The objective of the deep dive is to assess whether and to what extent TCI inputs and activities have led to or contributed to intended IOs in Uganda, and the process for how those IOs were achieved. ,
|
Kenya |
2025-09-10 12:20:33 |
2028-09-10 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Othman Kakaire
ID: UNCST-2019-R000359
|
Monitoring, Learning and Evaluation for the Commercial Introduction and Scale-up of DMPA-SC in East Africa (DMPA SC MLE STUDY)
REFNo: HS6422ES
General objective: To support the monitoring, learning and evaluation of the commercial introduction of DMPA-SC in the private sector in Uganda, including identifying scalable strategies for increasing uptake of DMPA-SC.
Specific objectives:
To determine the value proposition of commercially available DMPA-SC
To explore the effective strategies to increase awareness, acceptability, and uptake of DMPA-SC and SI at pharmacies and drug shops
To understand how DMPA-SC and related services are being managed and delivered by pharmacy and drug shop providers/outlets (staffing and training, counselling, supportive supervision, etc.)
To understand the strategies and approaches that are effective in driving quality of service delivery and counselling
|
Uganda |
2025-09-09 8:31:27 |
2028-09-09 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Nazarius Tumwesigye Mbona
ID: UNCST-2019-R000664
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WEB-BASED INTERVENTION FOR ALCOHOL AND SUBSTANCE ABUSE AMONG YOUNG UNIVERSITY STUDENTS
REFNo: SS1785ES
To assess feasibility and effectiveness of the web-based intervention for prevention and treatment of ASUD problems among youth 18-24 years attending Universities in Uganda,To develop a web-based intervention for prevention and treatment of ASUD problems among youth 18-24years attending Universities in Uganda,To establish the prevalence of ASUD problems among youth 18-24years in selected Universities,To contribute to the improvement of the quality of ASUD treatment services in Uganda among the youth through the development of a web-based intervention and assess its feasibility and effectiveness for the prevention and treatment of ASUD among University students in Uganda,
|
Uganda |
2025-09-09 8:17:25 |
2028-09-09 |
Social Science and Humanities |
Clinical Trial |
Non-degree Award |
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SHARON NAMIIRO MIRIAM
ID: UNCST-2023-R006661
|
Prevalence of Human Papilloma Virus in lung cancer tumors of adult
people with and without HIV, and its association with lung cancer
stage at diagnosis.
REFNo: HS6375ES
1. To determine the prevalence of Human Papilloma Virus (HPV) in primary lung cancer
tumors of adult patients living with and without HIV
2. To compare the most prevalent HPV subtypes in the primary lung cancer samples of adult
people living with and without HIV in Uganda.
3. To determine the association of HPV with lung cancer stage among adults with and without HIV.
|
Uganda |
2025-09-09 16:45:06 |
2028-09-09 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Blasio BWAMBALE Bisereko
ID: UNCST-2020-R014574
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Influence of Terrestrial and Wetland Ecosystems on Species occurrences of Aedes and Culex Mosquitoes as vectors of Arboviruses in Northern Uganda
REFNo: NS1003ES
(i) To determine the occurrence and abundance of the species of Aedes and Culex mosquitoes in selected terrestrial ecosystems of districts in West Nile and the Acholi Sub-region in Northern Uganda
(ii) To determine the composition and abundance of the species of Aedes and Culex mosquitoes in selected wetland ecosystems of districts in West Nile and the Acholi Sub-region in Northern Uganda
(iii) To determine the prevalence of occurrence of arboviruses in the species of Aedes and Culex mosquitoes from the mentioned selected ecosystems of districts of West Nile and the Acholi Sub-region in Northern Uganda
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Uganda |
2025-09-09 16:43:05 |
2028-09-09 |
Natural Sciences |
Non-Clinical Trial |
Degree Award |
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Adoke Yeka
ID: UNCST-2021-R004300
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Randomised controlled trial to assess the efficacy of artemisinin combination therapies in a setting of emerging artemisinin resistance in Uganda.
REFNo: HS6327ES
To assess the 42-day clinical and parasitological efficacy of artemether-lumefantrine (AL) and pyronaridine-artesunate (PA) for the treatment of uncomplicated P. falciparum malaria in Uganda.
|
Uganda |
2025-09-09 16:41:47 |
2028-09-09 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Mike Mugude
ID: UNCST-2022-R010442
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FEASIBILITY AND ACCEPTABILITY OF USING THE LONG-ACTING
CABOTEGRAVIR-RILPIVIRINE INJECTIONS AMONG HIV-INFECTED ADOLESCENTS
ATTENDING BOARDING SCHOOLS IN KAMPALA CITY, UGANDA
REFNo: SS4300ES
Primary objective: To understand how the implementation of long-acting
injectable antiretroviral therapy programs can be carried out among
ALHIV who attending boarding school education in Kampala city”.
Secondary objectives:
I. To determine the willingness to use the LA-ART among ALHIV
in boarding schools in Kampala.
II. To determine the acceptability of the LA-ART among ALHIV in
boarding schools in Kampala.
III. To explore the lived experiences of ALHIV regarding the uptake of
oral ART and factors that may influence the use of the LA-ART
boarding schools.
|
Uganda |
2025-09-09 14:18:00 |
2028-09-09 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Deogratius Okengo
ID: UNCST-2025-R017738
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Youth Participation in Akiriket Activities: Pathways to Sustainable Peace in Kotido Municipality Karamoja Uganda.
REFNo: SS4252ES
i. To investigate the roles of youth within Akiriket assemblies in Kotido, Karamoja Uganda
ii. To examine the contributions of youth to sustainable peace by their participation in Akiriket
iii. To identify the challenges for youth to sustain their engagement in Akiriket peace activities
|
Uganda |
2025-09-09 14:06:52 |
2028-09-09 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
Christine Wiltshire Sekaggya
ID: UNCST-2019-R000578
|
EVALUATION OF COMMUNITY-BASED INTEGRATED SCREENING AND DIAGNOSIS OF TUBERCULOSIS,
ASTHMA AND COPD, AND ITS IMPACT ON ANTIBIOTIC PRESCRIPTIONS IN SELECTED COMMUNITIES IN
UGANDA
REFNo: HS6308ES
Sub – study one
Primary objective
1. To evaluate the barriers and facilitators of integration of community-based TB, asthma and COPD screening and diagnosis in selected rural and urban communities of Masaka and Wakiso districts.
Secondary objective
2. To describe the implementation outcomes of integrating community-based TB, asthma and COPD screening and diagnosis in selected
communities of Masaka and Wakiso districts using the RE-AIM framework.
Sub – study two
Primary Objective
1. To determine the effect of referral of patients, through community screening initiatives, on antibiotics prescriptions patterns and practices in primary health care facilities.
Secondary objectives
2. To identify factors influencing provider decisions to prescribe antibiotics to people who screen negative for TB at selected primary health facilities in Masaka, Wakiso and Rakai districts in Uganda.
3. To evaluate patients’ understanding of antibiotics prescription following a negative TB screen in selected communities in Masaka, Wakiso and Rakai districts in Uganda.
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Uganda |
2025-09-09 14:03:21 |
2028-09-09 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Martha Akulume
ID: UNCST-2023-R005452
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THE USE OF MICRO-ENTREPRENEURSHIP TO STRENGTHEN THE COMMUNITY HEALTH WORKER PROGRAM IN RURAL UGANDA
REFNo: HS6368ES
To describe the access to health care services and products within the study districts
To determine the factors that affect how CHEs execute their duties
To map geographical information on access to healthcare providers and products in selected clusters.
To determine how CHWs execute their work and the factors that affect them.
To explore stakeholder�s perception regarding the contribution of community health entrepreneurship to the community health work program
To estimate the frequency of use of CHE-services in general and for children <5 suffering from acute fever or diarrhoea
To describe the role of CHEs in the care-trajectories for children suffering from acute fever or diarrhoea
|
Uganda |
2025-09-09 14:02:05 |
2028-09-09 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Martha Naluwende
ID: UNCST-2025-R019681
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End Term Evaluation of the Make Way Programme in Uganda
REFNo: SS4114ES
The study aims to evaluate the relevance, effectiveness, coherence, and sustainability of the Make Way programme in Uganda. It will assess how well the programme addressed the SRHR needs of marginalized youth, the impact of its advocacy and capacity-building efforts, and the strength of its partnerships—especially the implementation of the “Leading from the South” approach. Additionally, the study will document lessons learned and good practices to inform future SRHR programming and policy.
|
Uganda |
2025-09-09 13:59:55 |
2028-09-09 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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MARY MUGABEKAZI
ID: UNCST-2024-R002638
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Prevalence and Risk Factors Associated with Recent and Long-Term HIV Infections Among Newly Identified HIV Positive Clients in Kyenjojo District, Western-Uganda
REFNo: HS6381ES
To find out the prevalence and risk factors associated with recent & long-term HIV infections among newly identified HIV positive clients in Kyenjojo District, Western-Uganda.,
|
Uganda |
2025-09-09 13:48:40 |
2028-09-09 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Atuhaire Rosemary
ID: UNCST-2024-R003132
|
Parenting Styles, Students’ Connectedness and Academic Adjustment among Pre- Service Teachers in Universities of South Western Uganda
REFNo: SS3370ES
7. To evaluate the mediating role of student connectedness in the associations between parenting styles and academic adjustment among pre-service teachers in universities in south western Uganda.,6. To investigate the relationship between student connectedness and academic adjustment among pre-service teachers in universities in south western Uganda.,5. To explore the correlation between parenting styles and student connectedness among pre-service teachers in universities in south western Uganda.,4. To examine the relationship between parenting styles and academic adjustment among pre-service teachers in universities in south western Uganda.,3. To assess the levels of academic adjustment among pre-service teachers in universities in south western Uganda.,2. To identify prevalent parenting styles among pre-service teachers in universities in south western Uganda.,1. To investigate how academic adjustment varies across demographic variables among pre-service teachers in universities in south western Uganda.,To investigate the associations between parenting styles, students\' connectedness, and academic adjustment among pre-service teachers in the universities of south western Uganda.,
|
Uganda |
2025-09-09 13:44:49 |
2028-09-09 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
GRACE ANKUNDA
ID: UNCST-2025-R017443
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TEACHER COMPETENCE, MOTIVATION AND ACTIVE LEARNING OF PRE-PRIMARY SCHOOL CHILDREN IN UGANDA: A CASE OF KABALE DISTRICT
REFNo: SS3854ES
1) To examine the influence of teacher competence on active learning among pre-primary school children in Kabale district.
2) To analyse the effects of teacher motivation on active learning among pre-primary school children in Kabale district.
3) To assess the influence of teacher competence on teacher motivation in pre-primary schools in Kabale District.
4) To investigate the mediating role of teacher motivation in the relationship between teacher competence and active learning among pre-primary school children in Kabale district.
|
Uganda |
2025-09-09 13:42:02 |
2028-09-09 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
MARGARET AANYU
ID: UNCST-2023-R003677
|
Adopting multidisciplinary approaches in genetic improvements, nutritional enhancements and climate change adaptation for improved production of Nile tilapia in Uganda
REFNo: A637ES
The main objective of the project is to breed Nile tilapia for improved growth and temperature resilience, and formulation of commercially competitive and environmentally safe fish feeds for sustainable production of Nile tilapia in Uganda. The specific objectives include to:
1. Study effects of elevated water temperature on the growth, survival and physiology of Nile tilapia strains from Ugandan lakes Victoria, Kyoga, Albert, and Edward
2. Select and breed Nile tilapia strains from Ugandan lakes Victoria, Albert, Edward for both improved growth and tolerance to elevated temperature.
3. Develop cost-effective and environmentally safe feeds for fast growing temperature-resilient Nile tilapia strains.
4. Popularising the fast growing Nile tilapia strain resilient to elevated water temperature and the allied feeding regimes.
|
Uganda |
2025-09-09 13:39:52 |
2028-09-09 |
Agricultural Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Joseph Lutaakome
ID: UNCST-2020-R008323
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STRIVE 002: An International Observational Study of Adults with Acute Infection
REFNo: HS6420ES
The general aim of this observational study is to is to understand more about what happens when adults are hospitalised with acute infectious diseases.
• Characterise and compare the clinical course and natural history of acute infections of interest
• Determine the percentage who die or develop other adverse outcomes during or following hospitalisation
• Identify host and pathogen risk factors for poor outcomes.
|
Uganda |
2025-09-09 13:38:25 |
2028-09-09 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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AYESIGYE JUSTUS
ID: UNCST-2025-R020078
|
SUSTAINABILITY DISCLOSURE INTEGRITY: A PROPOSED GUIDANCE FRAMEWORK FOR THE MANUFACTURING SECTOR IN UGANDA
REFNo: SS4214ES
To assess the scope, quality, comparability, and regulatory alignment of sustainability disclosure practices among sampled Ugandan manufacturing firms in order to identify strengths, gaps, and priority improvement areas To explore the existing sustainability disclosure frameworks in the context of manufacturing sector in Uganda To examine the association between disclosure regime (mandatory vs. voluntary elements) and stakeholder-perceived trustworthiness of sustainability informationTo assess and evaluate existing research methodologies and propose the adoption of an appropriate methodology that addresses the research problem To ascertain the perceptions of sustainability disclosure integrity from professionals and regulators in the context of manufacturing organisations–fieldwork To recommend a proposed guidance framework for enhancing sustainability disclosure integrity in the Ugandan manufacturing sector To conclude the study by offering recommendations and identifying areas for future research
|
Uganda |
2025-09-04 13:17:34 |
2028-09-04 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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