Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Davis Hafashimana Simon
ID: UNCST-2025-R018006
An investigation into the variability of Hemileia vastatrix on Robusta coffee in Uganda
REFNo: A591ES

Objectives 1. To assess the genetic diversity of Hemileia vastatrix on Robusta coffee in Uganda 2. To make a linkage of any observed diversity to disease distribution in Uganda
Uganda 2025-04-11 14:11:00 2028-04-11 Agricultural Sciences Non-Clinical Trial Non-degree Award
Venantius Bbaale Kirwana Bbaale
ID: UNCST-2024-R002370
RISKY SEXUAL BEHAVIOUR AMONG YOUNG PEOPLE IN UGANDA’S ISLANDS, AN ANALYSIS OF SEXUALITY INFORMATION SOURCES AND COMPLETENESS.
REFNo: SS3785ES

4-Evaluate the level of completeness of sexuality information from various sources to young people in Uganda\'s island communities,3-Compare current and preferred sources of sexuality information sources among young people in the Uganda Island communities,2-Assess the barriers young people in island communities face in accessing sexuality information from different sources.,1-Explore young people’s perceptions of risky sexual behavior in the Uganda Island communities.,Examine young people’s perceptions of risky sexual behavior and how sexuality information sources and completeness influence sexual behavior, in Uganda Island communities.,
Uganda 2025-04-11 14:09:55 2028-04-11 Social Science and Humanities Non-Clinical Trial Degree Award
Javan Tindyebwa
ID: UNCST-2025-R017192
ETHICAL LEADERSHIP, LEADER ACCOUNTABILITY, STAKEHOLDER PARTICIPATION, AND EDUCATION SERVICE QUALITY AT MAKERERE UNIVERSITY IN UGANDA
REFNo: SS3802ES

To examine the extent to which Stakeholder Participation mediates the relationship between Ethical Leadership and Education Service Quality in MUK in Uganda.,To establish the effect of Ethical Leadership on Education Service Quality in MUK in Uganda. ,To establish the effect of Stakeholder Participation on Education Service Quality in MUK in Uganda., To establish the effect of Leadership Accountability on Education Service Quality in MUK in Uganda,To examine the relationship between ethical leadership and leader accountability, and service quality and how these relationships are mediated by stakeholders at Makerere University.,
Uganda 2025-04-11 14:04:32 2028-04-11 Social Science and Humanities Non-Clinical Trial Degree Award
EDIMOND SERWANGA
ID: UNCST-2025-R017659
ASSESSING THE SITUATION OF TEACHERS IN PRIMARY AND SECONDARY SCHOOLS IN UGANDA
REFNo: SS3797ES

General objective To assess the teaching and learning situation of primary and secondary school teachers in both refugee and non-refugee settings across Uganda's West Nile and Karamoja sub-regions. 1.2.2. Specific objectives The study aims to address the following specific objectives: (i) To explore how teachers create, promote and utilise a supportive teaching environment that enhances their professional growth and well-being. (ii) To establish school and community practices that enhance child protection, well-being, and inclusion. (iii) To assess teachers’ practices on classroom management, instruction and assessment. (iv) To establish teachers’ understanding of the curriculum and how it informs teachers’ practices. (v) To establish language support strategies used by teachers to promote learning in schools.
Uganda 2025-04-09 17:19:38 2028-04-09 Social Science and Humanities Non-Clinical Trial Non-degree Award
Lolem Lucy Chegem
ID: UNCST-2024-R004656
Nature and Degree of Karamojong Pastoral Community Participation and Integration in Wildlife Conservation Interventions in Kidepo Valley National Park, North Eastern Uganda
REFNo: SS3755ES

1. To conduct a policy review towards the establishment of national (Uganda) wildlife conservation policies and guidelines on community participation and integration of Indigenous peoples' social and cultural practices
2. To examine the Karamojong Indigenous and traditional wildlife conservation values, practices, and livelihood needs associated with KVNP
3. To explore the nature of the Karamojong participation in wildlife conservation practices in the management of KVNP
4. To determine the degree of the Karamojong participation in wildlife conservation activities in KVNP
5. To explore the nature of the Karamojong integration in wildlife conservation practices in the management of KVNP
6. To determine the degree of the Karamojong integration in wildlife conservation activities in KVNP

Uganda 2025-04-09 17:01:55 2028-04-09 Social Science and Humanities Non-Clinical Trial Degree Award
REBECCA NANTANDA
ID: UNCST-2019-R001533
Optimization and testing of ALRITE, a clinical decision support tool for management of respiratory illnesses in young children in primary care health facilities in Uganda
REFNo: HS5721ES

To pilot test ALRITE in 4 Ugandan health facilities after an optimization phase of iterative testing and ALRITE improvement.

1. To optimize ALRITE for health worker use through multiple cycles of reversal single-case experiments29,30* with 6-8 health workers per cycle.
2. Pilot-test study feasibility and the effectiveness of the optimized ALRITE tool on the diagnosis and management of wheezing illness and pneumonia in young children using interrupted time series (ITS) design.
3. Assess outcomes of implementation following ALRITE deployment and determinants of successful adoption using a sequential quant-> QUAL mixed methods design.
Uganda 2025-04-09 16:40:46 2028-04-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Peter Olds
ID: UNCST-2023-R006240
Evaluation of NT-proBNP in outpatient heart failure care in southwestern Uganda
REFNo: HS5796ES

Main Objective 1. Create and evaluate an algorithm for nurses using a point-of-care biomarker of heart failure (N-terminal-pro hormone B-type natriuretic peptide, NT-proBNP) to support heart failure management in Uganda. Specific Objectives 1. Identify an average baseline NT-proBNP for patients with HFrEF in the MRRH outpatient cardiology clinic. 2. Develop and compare the use of an algorithm for diuresis based on the NT-proBNP with standard of care diuretic plans for patients with HFrEF in the MRRH outpatient cardiology clinic 3. Evaluate the feasibility and acceptability of implementing an NT-proBNP based algorithm for heart failure care in Uganda
USA 2025-04-09 16:31:41 2028-04-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jennifer Serwanga
ID: UNCST-2024-R002056
VacICoP: Chimpanzee Adenovirus Type 3-Vectored Marburg Glycoprotein (GP)-Expressing Vaccine (ChAd3-MARV)-Induced Correlates of Protection
REFNo: HS5469ES

This study aims to identify the immune correlates of protection (ICoPs) against Marburg virus disease (MVD) through comprehensive analyses of humoral and cellular responses in both vaccinated and infected individuals. ICoPs will be identified by studying human and non-human
primates (NHPs) that have either survived infection, succumbed to it, or been successfully immunised. The research aims to expedite regulatory approval and licensure by identifying the most effective and durable ICoPs against MVD.
Key objectives and deliverables include:
1. Identifying the MVD ICoPs
2. Detailed humoral and cellular immune profiles distinguishing protective from nonprotective anti-MARV immunity
3. Reference reagents and scalable high-throughput screening assays
4. Predictive statistical models for forecasting vaccination effectiveness
5. Integrated clinical, immunological, and demographic datasets
6. Regulatory guidance for new vaccines approval
7. Global collaborative data exchange framework
Uganda 2025-04-09 16:29:46 2028-04-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Erisa Mwaka Sabakaki
ID: UNCST-2019-R001625
Stakeholder perceptions and ethical considerations in gene therapy clinical trials for sickle cell disease in Uganda
REFNo: SS3570ES

Aim 1: To determine stakeholder perceptions of somatic gene therapy for SCD. We shall engage patient support and advocacy groups to ascertain knowledge gaps, expectations, and preferences regarding gene therapy. This will facilitate patient education and smooth implementation of research and development of affordable and accessible gene therapy in LMICs.

Aim 2: To examine the ethical, legal, and social considerations in somatic gene therapy clinical trials for SCD in a resource-limited setting. We shall use deliberative focus group discussions and key informant interviews to explore the ethical and social considerations in somatic gene therapy research in low-resource settings.

Uganda 2025-04-09 16:28:31 2028-04-09 Social Science and Humanities Non-Clinical Trial Non-degree Award
Willbroad Byamukama
ID: UNCST-2022-R010646
RURAL LANDLESSNESS AND FOOD INSECURITY IN UGANDA; A CASE OF KIGEZI SUB-REGION (KABALE, RUBANDA, RUKIGA, AND KISORO DISTRICTS)
REFNo: A561ES

iii. To establish workable strategies to address food insecurity in Kigezi sub-region (Kabale, Rubanda, Rukiga, and Kisoro).,ii. To examine the effect of rural landlessness on food insecurity in Kigezi region (Kabale, Rubanda, Rukiga, and Kisoro).,i. To examine the causes of rural landlessness in Kigezi sub-region (Kabale, Rubanda, Rukiga, and Kisoro).,The purpose of the study is to examine the effect of rural landlessness and food insecurity in, Uganda case of Kigezi region and come up with strategies to increase food security in Kigezi sub region with the rural landlessness.,
Uganda 2025-04-09 16:09:36 2028-04-09 Agricultural Sciences Non-Clinical Trial Non-degree Award
DICKSON NIWASASIRA
ID: UNCST-2024-R003949
The Effectiveness of Electronic Media on Utilization of Health Services in a Rural Setting
REFNo: SS3705ES

I. Establish the electronic media channels used by different demographic segments of the rural population to access health information.
II. Determine the impact of electronic media on overall utilization of facility- based Health services in a rural setting.
III. Establish the effectiveness of different electronic media channels on utilization of facility-based health services among different demographic segments of the rural population.

Uganda 2025-04-08 7:35:22 2028-04-08 Social Science and Humanities Non-Clinical Trial Degree Award
Glenn Ogolah
ID: UNCST-2025-R017145
Asset Financing and Micro Leasing in Agriculture
REFNo: SS3726ES

1. Examining barriers and opportunities in asset financing and micro-leasing
adoption for smallholder farmers and microenterprises:
a. Identifying and analyzing the barriers and opportunities affecting the access of
asset financing solution amongst smallholder farmers
b. Examine gender differences in barriers to accessing asset financing for
smallholder farmers
c. Explore interactions among key stakeholders, including farmers,
microenterprises, SACCOs, and MFIs, to assess their roles and influences in
the asset financing landscape
2. Examining the role of clean energy assets in meeting farmers most urgent needs:
a. Identifying and analyzing the barriers and opportunities affecting the adoption
of clean energy assets by farmers
b. Exploring available productive assets in the market and their distribution
channels for rural farmers

Kenya 2025-04-07 7:58:51 2028-04-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Josephine  BIRUNGI
ID: UNCST-2024-R003480
A Roadmap towards the successful deployment of a fixed dose combination of Artemether-Lumefantrine+Amodiaquine (FDC ALAQ) in Uganda (DeTACT Study)
REFNo: SS3706ES

Main Objective: to identify and address obstacles in implementation and deployment of FDC ALAQ at an early stage, and contribute to the smooth introduction of FDC ALAQ in Uganda.
Specific Objectives:
To identify and engage with key national stakeholders involved in Malaria control and introducing new antimalarials in Uganda;
ii. To obtain understanding into relevant policy, regulatory and implementation procedures of new antimalarials and to identify areas that require strategic attention before any new antimalarials are introduced in Uganda;
iii. To develop a practical roadmap that can be used for the effective introduction and deployment of FDC ALAQ in Uganda aiming to control and contain artemisinin resistance in Uganda.

Uganda 2025-04-03 16:55:55 2028-04-03 Social Science and Humanities Non-Clinical Trial Non-degree Award
Robinson Amanyiraho
ID: UNCST-2024-R016357
Impact of the Growing Expertise in E-health Knowledge and Skills (GEEKS) Program in Reducing Immunization Defaulters and Enhancing Timely Reporting of Vaccine-Preventable Disease Cases in Uganda
REFNo: HS5737ES

Goal:
The goal of this study is to evaluate the contributions and sustainability of GEEKS Cohort 1 projects, while also providing actionable recommendations to enhance the effectiveness of current and future implementations of the GEEKS program.
Specific Objectives
1.
To document and analyze the contributions of GEEKS Cohort 1 projects in strengthening Vaccine Preventable Disease Surveillance (VPDS) and routine immunization coverage.
2.
To assess the sustainability of GEEKS Cohort 1 projects and identify factors influencing their long-term impact.
3.
To provide evidence-based recommendations for strengthening the design and implementation of current and future GEEKS program initiatives.
Uganda 2025-04-02 9:37:17 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Geofrey Musinguzi
ID: UNCST-2024-R015961
HIV Prevention Program Outcomes: Measurement of accessibility, and utilization of key HIV prevention services and linkage to care among adolescent girls and young women, female sex workers, and people who inject drugs in Uganda – A Rapid Coverage Survey
REFNo: HS5730ES

Main objective
The survey’s main objective is to measure the HIV prevention program outcomes among key and priority populations, particularly the AGYW, FSWs, and PWIDs, to inform ongoing and future HIV prevention programs (among such populations) in Uganda.

Specific objectives
1. To assess access to key HIV prevention services and products among AGYW, FSWs, and PWIDs in Uganda.
2. To assess the utilization of key HIV prevention products and services among AGYW, FSWs, and PWIDs in Uganda.
3. To measure the proportion of HIV-positive AGYW, FSWs, and PWIDs linked to HIV/AIDS, STD care and desired health services.

Uganda 2025-04-02 9:35:25 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Stella Achen
ID: UNCST-2025-R016855
PARTICIPATORY INTERVENTION RESEARCH TO ADDRESS CHILD EXPLOITATION IN KARAMOJA, UGANDA
REFNo: SS3733ES

i. Explore the main forms of exploitation and modern slavery in Napak and Moroto Districts;
ii. Assess interventions and program components that should be prioritized concerning child exploitation, bearing in mind the major intersecting issues such as gender discrimination, food security, and climate change;
iii. Explore the traditions, narratives, and cultural beliefs that could be mobilized as assets to the program; and lastly,
iv. Map out the key actors and influencers in the child exploitation debate.

Uganda 2025-04-02 9:26:44 2028-04-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Sebastian Linnemayr
ID: UNCST-2021-R012696
R01 Study “INcentives and ReMINDers to Improve Long-term Medication Adherence” (INMIND)
REFNo: SS3732ES

Main Objective
1. We propose to optimize an adaptive intervention using the INMIND approach in a Stage III efficacy randomized trial using a two-stage SMART design in Uganda. All clients (including the control group) will receive information about the importance of behavioral routines, as is part of the standard adherence counseling for treatment initiators and create personalized ART adherence anchoring strategies. We will first enroll patients into an Wisepill use only phase for one month. We will then randomize them to receive either usual care / information only or low-cost daily text messages. All clients will have the opportunity to select a new anchoring plan in the first two months, so that they then have another 4-month period during which to establish a routine. Those who if fail to take their ART pills very regularly, meaning at the same time for at least 80% of the days at the end of month three will be re-randomized to one of two more intensive interventions for the subsequent three months: monthly or monthly escalating prizes.

The Specific Aims are to:
SA1 (Primary): Test the first-stage main effect of Messages vs. Control on the maintenance of ART adherence (primary outcome) and viral suppression (secondary outcome).
SA2 (Secondary): Examine (a) the second-stage main effect of receiving monthly vs. monthly escalating incentives on the primary and secondary outcomes among first-stage non-responders, and (b) whether changing one’s anchoring plan at month two moderates the effect of monthly and monthly escalating incentives.
SA3. Synthesis Phase: Perform a cost-effectiveness analysis including a comparative analysis of the INMIND components among first-stage responders and non-responders and conduct information dissemination activities in Uganda after completion of the trial.

USA 2025-04-02 9:23:18 2028-04-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Henry Kyobe Bosa
ID: UNCST-2021-R013941
UNDERSTANDING THE SOCIO-ECOLOGICAL AND BEHAVIORAL DRIVERS OF MPOX DISEASE IN AFRICA
REFNo: HS5719ES

General Objective
To assess the state of knowledge, attitudes, and practices, including socio-ecological and behavioral determinants of health considerations, regarding MPXV acquisition and vaccine uptake in Uganda.
Specific Objectives
1. To assess the determinants of the Mpox disease spread and modes of transmission
2. To determine the community’s knowledge, attitude, practices, and perception on Mpox disease
3. To evaluate health-seeking behavior for Mpox disease
4. To identify the barriers and facilitators to Mpox vaccine uptake

Uganda 2025-04-02 9:21:50 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Walter Akwat
ID: UNCST-2024-R003452
Uganda Multi-Sectoral Needs Assessment (MSNA) 2024
REFNo: SS3727ES

• Conduct a thorough inter-sectoral analysis to assess the magnitude and
severity of humanitarian needs and conditions among refugee and host
community households across all 13 formal refugee settlements across
the country and refugee concentrations in Kampala.
• Identify variations in humanitarian needs across different areas of study,
population groups, and household vulnerability profiles.
• Compare key findings of the 2024 MSNA with the Vulnerability and
Essential Needs Assessment (VENA) (2019) and 2018 MSNA.
• Offer insights into inter-sectoral needs to inform prioritization of refugee
response efforts and strategic planning.
Uganda 2025-04-02 9:20:09 2028-04-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Agrace Atwikirize
ID: UNCST-2024-R002716
Stressors, Coping Strategies, Hope and Academic Perfomance of Teacher-Trainees in Universities in Central Region, Uganda
REFNo: SS3485ES

i. To find out the variations of stressors with biodata among teacher-trainees in universities in Central Region, Uganda.
ii. To investigate the relationship between stressors and coping strategies among teacher-trainees in universities in Central Region, Uganda.
iii. To establish the relationship between coping strategies and academic performance among teacher-trainees in universities in Central Region, Uganda.
iv. To assess if the relationship between stress and academic performance is mediated by coping strategies among teacher-trainees in universities in Central Region, Uganda.
v. To determine the mediating effect of coping strategies and hope on the relationship between stressors and academic performance among teacher-trainees in universities in Central Region, Uganda.

Uganda 2025-04-02 9:18:20 2028-04-02 Social Science and Humanities Non-Clinical Trial Degree Award
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