Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Kennedy Kassaza
ID: UNCST-2019-R000615
Development of a multiplex mismatch amplification mutation assay and ex-vivo cytokine release analysis to stratify Cryptococcal meningitis infections in Uganda
REFNo: HS3076ES

1. To determine the types of cytokines released in ex-vivo cytokines stimulation assay by antigens prepared from the alternate and reference alleles for the genes: CNAG_04922; CNAG_07837, CNAG_06422 and CNAG_00363.

2. To quantify the IL2 cytokine released and determine the relationship between C. neoformans gene alleles and levels of IL2 cytokine released

3. To design an allele specific PCR assay referred to as mismatch amplification mutation assay (MAMA PCR) for rapid detection of presence of alternate alleles for C. neoformans genes: CNAG_04922; CNAG_07837, CNAG_06422 and CNAG_00363 in clinical isolates
Uganda 2024-06-12 14:23:42 2027-06-12 Medical and Health Sciences Non-Clinical Trial Degree Award
ucama Patrick ufoymungu
ID: UNCST-2023-R006573
PERFORMANCE OF APRI SCORE COMPARED TO FIBROSCAN IN THE ASSESSMENT OF FIBROSIS AMONG ADULTS WITH CHRONIC HEPATITIS B INFECTION AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS4174ES

3. To determine the degree of agreement or disagreement between FibroScan and APRI Score in assessing the presence or absence of liver fibrosis among adults with Chronic Hepatitis B infection at the hepatitis clinic of Mbarara Regional Referral Hospital.,2. To identify the factors associated with liver fibrosis among adults with Chronic Hepatitis B infection at the hepatitis clinic of Mbarara Regional Referral Hospital.,1. To determine the prevalence of liver fibrosis among adults with chronic hepatitis B infection by using FibroScan and APRI Score at the hepatitis clinic of Mbarara Regional Referral Hospital.,To compare the performance of APRI score to Fibroscan in the assessment of fibrosis among adults with chronic hepatitis B infection at Mbarara Regional Referral Hospital.,
Burundi 2024-06-12 14:22:59 2027-06-12 Medical and Health Sciences Non-Clinical Trial Degree Award
Orla Walsh
ID:
Staff Experiences of PAIRS Training
REFNo: HS4309ES

To determine the availability and adequacy of resuscitation equipment and supplies in the selected health centres. ,To explore the experiences of staff who have received PAIRS training and compare responses of staff within these centres who have not participated in PAIRS. ,
Ireland 2024-06-12 14:22:12 2027-06-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Maria Kasirye Ella
ID:
INFLUENCE OF SIGNIFICANT DEPRESSION SYMPTOMS ON ADHERENCE TO TENOFOVIR BASED ANTIRETROVIRAL THERAPY AT 24 MONTHS AMONG 18 TO 35-YEAR-OLD WOMEN LIVING WITH HIV IN KAMPALA; A LONGITUDINAL STUDY
REFNo: HS4301ES

3. To determine the association between the longitudinal patterns of significant depression symptoms and adherence to ART in 18 to 35-year-old women living with HIV on Tenofovir-based regimens in Kampala district.,2. To assess the longitudinal patterns of significant depression symptoms in 18 to 35-year-old women living with HIV on Tenofovir-based regimens in Kampala district.,1. To determine the baseline prevalence of significant depression symptoms in 18 to 35-year-old women living with HIV on Tenofovir-based regimens in Kampala district.,• To determine the longitudinal patterns of significant depression symptoms and their influence on antiretroviral therapy adherence among 18 to 35-year-old women living with HIV on Tenofovir-based regimens in Kampala, Uganda.,
Uganda 2024-06-12 14:21:19 2027-06-12 Medical and Health Sciences Non-Clinical Trial Degree Award
Job Kalema
ID: UNCST-2021-R013087
PEER ASSESSMENT FRAMEWORK TO SUPPORT GROUP-BASED ASSESSMENT IN E-LEARNING ENVIRONMENT FOR HIGHER INSTITUTIONS OF LEARNING
REFNo: SIR341ES

To evaluate the designed peer assessment framework using the DeLone and McLean model.,To design a peer assessment framework for group-based assessment based on the requirements gathered in (i) above.,To gather the requirements of group-based assessment frameworks used in universities.,The purpose of this study is to build the peer assessment framework for group-based assessment that improves interactions in the online learning environment for Universities.,
Uganda 2024-06-12 14:20:29 2027-06-12 Engineering and Technology Non-Clinical Trial Degree Award
Nathan Kenya-Mugisha
ID: UNCST-2021-R013752
Validation of a cross-outbreak stigma scale in infectious disease outbreak-affected communities (2022 Ugandan Ebola outbreak component )
REFNo: SS2727ES

: Understand how stigma impacts outbreak control (and vice versa), and how this stigma could be validly and effectively assessed.,Use the stigma scale in three different outbreak contexts (specifically communities affected by Ebola in Uganda for purposes of this application) to measure disease-related stigma.,Co-develop and validate a cross-outbreak stigma scale,To administer and validate a stigma scale to assist with recognition and reduction of infectious disease outbreak-related stigma in affected communities (specifically communities affected by Ebola in Uganda).,
Uganda 2024-06-12 14:16:19 2027-06-12 Social Science and Humanities Non-Clinical Trial Degree Award
Leonsio Matagi
ID: UNCST-2024-R004055
The feasibility and acceptability of the co-administration of ivermectin and albendazole vs albendazole alone, in the frame of mass drug administration to school-aged children in Uganda.
REFNo: SS2755ES

To assess the feasibility (including aspects of training, materials and processes) of the co-administration of ivermectin and albendazole compared to albendazole alone at small-scale in the frame of school-based MDA in Uganda To evaluate the acceptability and identify potential barriers and enablers of the introduction of co-administered ivermectin and albendazole for beneficiaries (pupils, parents/caretakers)
Uganda 2024-06-10 8:54:51 2027-06-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Daniela Acosta
ID: UNCST-2024-R003832
Chimpanzee Intercommunity Competition: Measuring Benefits and Costs at the Group Level.
REFNo: NS826ES

I aim to investigate questions related to the causes and consequences of territorial expansion and contraction at the group level due to intergroup competition. Specifically, I am interested in (i) understanding changes in ranging patterns, habitat use, reproductive success, resource availability and social relationships before, during, and after territorial shifts; (ii) examining decision-making processes during patrolling behavior; and (iii) identifying the mechanisms in which sociality influences group level cooperation.
Colombia 2024-06-10 8:23:29 2027-06-10 Natural Sciences Non-Clinical Trial Degree Award
Picos Ariho
ID:
Preventive Diplomacy and the (De-)escalating Armed conflicts in Eastern Democratic Republic of Congo: A case of the International Conference of the Great Lakes Region.
REFNo: SS2620ES

1. Examine what accounts to the resurgence of the M23 Movement following its military defeat a decade ago.
2. Assess the diplomatic machinery potential of the M23 and armed conflicts.
3. Re-evaluate the promise of preventive diplomacy in both bilateral and multilateral relations with ending armed conflicts in Africa's great lakes region.
Uganda 2024-06-06 17:41:29 2027-06-06 Social Science and Humanities Non-Clinical Trial Degree Award
Innocent Mutyaba
ID: UNCST-2021-R012218
Identifying Predictors of Kaposi Sarcoma Immune Reconstitution Inflammatory Syndrome
REFNo: HS2151ES

We propose to utilize the ACSR ARKS study specimen biorepository and clinical database to identify predictors and biomarkers of KS-IRIS in the ARKS cohort. To determine if select clinical parameters, plasma cytokines, and KSHV burden measured at time of KS-IRIS symptom onset could serve as biomarkers of prevalent KS-IRIS. We will develop a predictive model of KS-IRIS utilizing the ARKS study to extend the findings from the HIPPOS study. To identify baseline predictors of incident KS-IRIS among adults with early-stage KS initiating ART.,
Uganda 2024-06-06 17:40:22 2027-06-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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