Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
MIRIAH KEMIGISHA
ID: UNCST-2022-R009927
When Cerebrospinal Fluid (CSF) is Unfit for Definitive Surgical Diversion: A single Institution Experience from 2001 to 2022.
REFNo: HS2927ES

1.3.1 Primary Objective
To describe the evolution of care of hydrocephalus patients with CSF unfit for definitive surgery treated at CCHU from January 2001 to December 2022.
1.3.2 Specific Objectives.
1. To describe the different temporary/non definitive forms of management of hydrocephalus when CSF is un fit for definitive surgery.
2. To describe and characterize the patient populations that benefitted from each temporary/non definitive form of management.
3. To describe the complications of each temporary/non definitive form of management of hydrocephalus when CSF is un fit for definitive surgery.
4. To evaluate the changes in brain volume in hydrocephalus patients after temporary/non definitive forms of management.

Uganda 2023-09-05 14:02:43 2026-09-05 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sentrine Nasiima
ID:
Prevalence and Correlates of Mental Disorders and Work Performance Among Health Care Workers in Uganda: A Case Study from Central and South-Western Uganda (Rescue Study)
REFNo: HS3134ES

a) To investigate the pattern, prevalence and associated factors of mental disorders/problems among health workers in public health care facilities in south-western Uganda. b) To investigate the prevalence and risk factors (including mental disorder) and protective factors for poor work performance among health workers in public health care facilities in south-western Uganda; c) To explore health workers’ experience of stress including work related-stress, its impact on mental health and work performance and associated coping mechanisms. d) To explore how the COVID-19 global pandemic impacted the mental health and work performance of health workers in health facilities in south-western Uganda and how they coped with these.
Uganda 2023-09-05 14:01:30 2026-09-05 Medical and Health Sciences Non-Clinical Trial Degree Award
Lian Thomas Francessca
ID: UNCST-2022-R010668
Baseline studies for characterising the area-specific context for the control of Taenia solium infections in northern Uganda
REFNo: A263ES

1. To estimate the prevalence of porcine cysticercosis (PCC) and pig gastrointestinal parasites in Kitgum, Lamwo, Agago, and Pader districts in northern Uganda. 2. To characterise porcine cysticercosis risk factors in the four districts to support the design of interventions. 3. To understand the socioeconomic, cultural, and policy context in which T. solium control will be undertaken in Northern Uganda. 4. To identify stakeholders their roles, relationships, power dynamics, and motivations in the control of Taenia solium infections using the net-mapping methodology.
UK 2023-09-05 13:59:55 2026-09-05 Agricultural Sciences Non-Clinical Trial Non-degree Award
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
Bacterial and Host Heterogeneity in TB latency, persistence and progression
REFNo: HS3039ES

Objective 1: Determine the extent to which household transmission is responsible for co-prevalent and incident TB cases caused by Mtb strains that are genetically distinct from those isolated from the index cases within the same household. Objective 2: Investigate the in vitro immune phenotype of transmitted versus not-transmitted Mtb strains in households stratifying for HIV status. Objective 3: Characterize the innate macrophage response to high and low transmission strains and the T-cell response in persons with known household exposure to high and low transmission isolates and the impact of HIV infection. Objective 4: Identify the component of Mtb genes that aid in bacterial survival in aerosols. Objective 5: Investigate the bacterial factors underlying divergence in the host response to high and low transmission isolates. Objective 6: Determine the impact of Mtb strain phenotype (eg Mtb-HT v Mtb-LT) and host heterogeneity (risk of progression signatures, co-morbidities) on: 6.1. The distribution of stages of Mtb infection and disease in exposed HHC: the proportion of MTBI that express PREDICT29, a risk of progression signature; ACS-COR, an inflammatory signature; subclinical TB and active TB. 6.2. The risk and timing of progression from MTBI to TB. 6.3. The extent and nature (eg cavitation) of pulmonary disease in TB index cases; the duration of inflammation; and the consequent short- and long-term impairment in pulmonary function. These studies could permit the development of individualized approaches based on the host and the bacterium to diagnosis, targeting of preventive therapy, and treatment of active TB. Objective 7: Profile the lung milieu among individuals infected with either Mtb-HT or Mtb-LT in order to identify immune mediators associated with transmission heterogeneity.
Uganda 2023-08-30 16:32:02 2026-08-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
David Aziku
ID: UNCST-2023-R007595
Exploring how climate change impacts on girls’ lives, with a focus on education.
REFNo: SS1917ES

3. Determine the extent to which education – and/or other sources of information – inform girls’ (and their households’) decision-making on coping strategies and adaptative capacities.,2. Understand how climate impacts shape girls’ and households’ decision-making, coping strategies and adaptive capacities, including how girls’ education is impacted in these processes.,1. Establish the climate-induced impacts experienced by girls, their households, and their communities, with reference to how these have changed over time, whether girls think they can be adapted to and how the climate may impact on the girls’ education. ,We aim to provide evidence to inform Plan International’s wider work and agenda on climate change and education, as noted above. We propose to utilise existing evidence from our Real Choices, Real Lives study and undertake additional data collection that specifically explores the impacts of climate change (and in doing so explores adaptation, losses and damages).,
Uganda 2023-08-30 16:25:00 2026-08-30 Social Science and Humanities Non-Clinical Trial Non-degree Award
Diana Nakitto Kesi
ID:
The burden of medication errors and the barriers and facilitators to medication error reporting in Uganda. A prospective observational mixed method study
REFNo: HS3085ES

5. To explore patients’ perspectives on medication errors and medication error reporting.,4. To describe the barriers and facilitators to medication error reporting among health workers ,3. To assess the knowledge and attitude of health care workers on medication errors and medication error reporting.,2. To identify the medicines and morbidities associated with medication errors in health facilities,1. To determine the incidence of medication errors in the selected health facilities.,
Uganda 2023-08-30 16:14:41 2026-08-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sofie Bjerregaard Budhoo
ID: UNCST-2022-R010093
After Access to Justice: Exploring the development of local social dynamics and perceptions of justice in Northern Uganda after the International Criminal Court's (ICC's) Access to Justice Project
REFNo: SS1877ES

2. How will local perceptions of the ICC justice process, particularly in relation to reparations, develop over time after the end of the AJP?,1. What local patterns of behaviour and social dynamics will unfold over time in relation to the ICC justice process, particularly in relation to reparations, after the AJP has ended?,
Denmark 2023-08-30 16:11:54 2026-08-30 Social Science and Humanities Non-Clinical Trial Non-degree Award
Felix Jurua
ID: UNCST-2022-R009182
Pilot study of the Dried Tube Specimen(DTS)stability in Uganda.
REFNo: HS2763ES

To compare Asante reading of DTS prepared with a preservative (trehalose) vs vehicle after a variable period of time (1-3 months) in 20 locations.
Uganda 2023-08-30 16:07:09 2026-08-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edrisa Mutebi Ibrahim
ID:
Safety of JNK61 in Healthy Human Volunteers.
REFNo: HS2474ES

To determine the effect of JNK61 on the blood sugar levels in healthy human volunteers.,To determine the safety of JNK61 in healthy human volunteers,
Uganda 2023-08-30 16:05:54 2026-08-30 Medical and Health Sciences Clinical Trial Non-degree Award
Kevin  Mugisa Micheal
ID:
MALE INVOLVEMENT IN CONTRACEPTION NEGOTIATION AMONGST BODA-BODA RIDERS IN KAMPALA, UGANDA.
REFNo: HS3108ES

1.To examine the prevalence of boda-boda men who are initiating contraception negotiations with their sexual partners.
2.To examine the proportion of boda-boda men who are involved in contraception negotiation with their sexual partners.
3.To analyze factors associated with contraception negotiation amongst Boda-Boda riders with their sexual partners.

4.To examine the contraception use frequency amongst boda-boda riders with their sexual partners.
5.To examine contraception methods agreements amongst boda-boda riders with their sexual partners.

Uganda 2023-08-29 15:14:53 2026-08-29 Medical and Health Sciences Non-Clinical Trial Degree Award
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