Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
BRIGHT  NDAHIRO
ID: UNCST-2024-R015220
ECOLOGICAL RISK ASSESSMENT OF HEAVY METALS AND POTENTIAL USE OF SELECTED MACROPHYTES IN PHYTOREMEDIATION AND MANAGEMENT OF LAKE GEORGE, UGANDA
REFNo: NS1001ES

General objective
Assess the ecological risk of heavy metal contamination in selected macrophytes, associated water and sediments of Lake George, Uganda
Specific objectives
The specific objectives are to:
1.Determine the distribution and diversity of macrophytes on L. George
2.Determine the pattern of multi elemental concentration (Cu, Ni, Pb and Zn, Co and their variations in wetland plant species of different growth forms, in corresponding water and sediments of Lake George.
3.Apply ecological pollution indices to assess pollution load in the sediments and macrophytes.
4.Identify the selected macrophytes potential use as bio-indicators and for phyto-extraction and phyto-stabilization of heavy metal contamination

Uganda 2025-08-26 15:33:18 2028-08-26 Natural Sciences Non-Clinical Trial Degree Award
Edwin Nuwagira
ID: UNCST-2021-R013488
EFFICACY AND TOLERABILITY OF SHORT-COURSE INTERMITTENT INTRAVENOUS LIPOSOMAL AMPHOTERICIN B VERSUS ORAL POSACONAZOLE FOR CHRONIC PULMONARY ASPERGILLOSIS: A PHASE IIA, PROSPECTIVE, MULTI-CENTRE, RANDOMIZED, CONTROLLED, OPEN-LABEL, FEASIBILITY TRIAL
REFNo: HS6400ES

5. Assess recruitment and retention of patients with CPA on a trial to inform design and sample size for a definitive efficacy trial.,4. To assess adherence to posaconazole therapy,3. To evaluate the utility of different trial endpoints (change in Aspergillus IgG antibody titer, radiological improvement, step test and weight) across groups.,2. To compare 12-month all-cause mortality in each arm,1. To measure emergence of isolates of Aspergillus with resistance/reduced susceptibility to posaconazole in both arms. ,1. Compare the efficacy and tolerability of 1) short course, high dose of intravenous liposomal amphotericin B, 2) short course, high dose of intravenous liposomal amphotericin B followed by daily posaconazole, or 3) posaconazole alone for the treatment of CPA for 6 months.,
Uganda 2025-08-26 13:48:03 2028-08-26 Medical and Health Sciences Clinical Trial Non-degree Award
Barnabas Bakamutumaho
ID: UNCST-2021-R012636
Countrywide Enhancement of Sentinel Congenital Rubella Surveillance and Intensified Case Identification for Burden Monitoring Following Measles-Rubella Vaccine Introduction in Uganda and Neighboring Countries
REFNo: HS6410ES

Objective: The long-term goal is to sustain systematic CRS case-based sentinel surveillance countrywide to understand the burden of rubella infections causing congenital disabilities and to assess the public health control and prevention interventions such as the vaccines.

Specific aim 1: To support laboratory based CRS diagnosis in clinically suspected cases
Specific aim 2: To monitor vaccine impact in Uganda's routine immunization program
Specific aim 3: To monitor and characterize genotypes associated with CRS
Specific aim 4: To monitor molecular epidemiology of CRS in East African region

Uganda 2025-08-26 13:35:01 2028-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Michael Emenyu Richard
ID: UNCST-2025-R018382
Assessing awareness and attitudes of nurses/midwives on effective referral protocols of cleft lip and or palate children; a case study of Teso Sub-Region in Eastern Uganda
REFNo: HS5973ES

Main objective/ purpose To assess the level of awareness and attitudes of nurses/midwives on effective referral protocols for cleft lip and or palate children in Teso sub-region, Eastern Uganda. Specific Objectives i. To assess the level of awareness of nurses/midwives on effective referral protocols for cleft lip and palate children. ii. To determine the attitudes of nurses/midwives on effective referral protocols for cleft lip and palate children. iii. To assess the referral protocol/policy for cleft lip and or palate children in Uganda being implemented/used across the health facilities in Teso sub-region. iv. To determine the socio-demographics of nurses/midwives on effective referral protocols for cleft lip and or palate children.
Uganda 2025-08-26 13:23:57 2028-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Clara Wekesa
ID: UNCST-2021-R013282
Correlation between particulate matter and immuno-biochemical markers among people living with HIV and fibrotic liver disease in urban Uganda
REFNo: HS6060ES

Primary objectives:
• To examine the relationship between PM exposure and serum levels of biochemical and haematological parameters (liver chemistry profile, platelet count, fasting blood glucose, glycated hemoglobin and lipid profiles)
• To examine the relationship between PM exposure and serum levels of pro-fibrotic cytokines
Secondary objectives:
• Correlation coefficient between PM and fatty liver change measurements
• Correlation coefficient between PM and fatty liver stiffness measurements

Uganda 2025-08-26 13:19:27 2028-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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