Payal Chakraborty
ID:
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Characterizing Treatment/Management and Patient Outcomes of Epilepsy in Uganda: A Prospective Cohort Study
REFNo: HS99ES
1. Characterize management of epilepsy in Mulago National Referral Hospital (MNRH), Butabika National Mental Hospital (BNMH), and Mbarara Regional Referral Hospital (MRRH).
1a. To assess treatment options available for epilepsy patients by site (MNRH, BNMH, and MRRH).
1b. To assess knowledge, attitudes, and other factors associated with treatment barriers.
2. Characterize treatment outcomes in hospital-based epilepsy care, specifically at MNRH, BNMH, and MRRH.
2a. To determine etiological risk factors and common seizure patterns associated with epilepsy that present in patients at study sites.
2b. To determine the seizure severity, quality of life, and seizure outcomes among patients with epilepsy.
2c. To determine the adherence levels and factors associated with non-adherence of anti-epileptic drugs.
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USA |
2018-02-21 |
2021-02-21 |
Medical and Health Sciences |
|
Degree Award |
|
Alicia Rich Michelle
ID:
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Chimpanzee Highways: Gene Flow and Connectivity at Itwara Forest Reserve
REFNo: NS36ES
This study will focus on a chimpanzee metapopulation, which likely spans several protected areas in western Uganda by utilizing Itwara Forest Reserve (hereafter ‘Itwara’) as a connective corridor. Contrasting environments characterize at least two of those areas; closed-forest habitat dominates Itwara Forest Reserve (Howard 1991), while closely neighboring Toro-Semliki is usually described as an “open habitat,†(Hunt and McGrew 2002). Initial observations suggest that chimpanzees utilize a connective corridor of ~4 km between those two reserves, not only for rare dispersal events, but also for regular ranging within a single community’s territory (Rich et al. in prep). Here we are proposing to test whether chimpanzees do use a connective corridor between the two reserves, where the chimpanzee-selected corridor is, and what motivates travel through it (i.e. dispersal, foraging, etc.). We will examine the evolutionary and conservation-based implications of corridor-use by Toro-Semliki/Itwara chimpanzees and lay the groundwork for long term, multi-species connectivity research in and around Itwara Forest Reserve using indirect methods. If chimpanzees are using this corridor, then we will expand our research to examine other potential connective corridors that extend from Itwara Forest Reserve into other protected areas such as Kibale National Park and Muhangi Forest Reserve.
|
USA |
2018-02-21 |
2021-02-21 |
Natural Sciences |
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Non-degree Award |
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Mohammed Lamorde
ID: UNCST-2019-R001293
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Pharmacokinetic and pharmacodynamic evaluation of etonogestrel dose escalation with efavirenz-based antiretroviral therapy in HIV-infected Ugandan women (DoublET)
REFNo: HS163ES
Primary objective:
To compare the rate of ovulation (by weekly endogenous progesterone at months 3, 6, and 12) when women receive two 68 mg ENG implants (dose-escalated) compared to one 68 mg ENG implant (standard dose) in combination with EFV-based ART.
Secondary objectives:
1. To determine cervical mucus quality (by collecting weekly WHO cervical mucus scores at months 3, 6, and 12) when women receive two 68 mg ENG implants (dose-escalated) compared to one 68 mg ENG implant (standard dose) in combination with EFV-based ART.
2. To compare the PK parameters of two ENG implants (136 mg total) with combined EFV use versus the standard dose 68 mg ENG implant with no ART (historical controls in the same population using the same laboratory1) over 6 months of combined use.
3. To evaluate the safety and tolerability of two ENG implants with combined EFV-based ART use.
4. To describe the relationship between ENG concentrations and participant specific variables, specifically body weight, albumin, sex hormone binding globulin, pharmacogenetic polymorphisms, and ART concentrations.
5. To describe the long term feasibility and tolerability of increased dose ENG (136mg) subdermal implant use in HIV-infected women receiving EFV-based ART after weeks 96 and 144 of combined use.
|
Nigeria |
2018-02-21 |
2021-02-21 |
Medical and Health Sciences |
|
Non-degree Award |
|
Emmanuel Isingoma
ID: UNCST-2019-R001057
|
Prevalence of Brucella antibodies in livestock in Karamoja, northeastern Uganda
REFNo: A28ES
1. To determine by district the prevalence of Brucella antibodies in cattle, goats and sheep in Karamoja sub-region
2. To determine the distribution of Brucella antibodies by sex of the different species of livestock
3. To determine the distribution of Brucella antibodies by age of the different species of livestock
|
Uganda |
2018-02-21 |
2021-02-21 |
Agricultural Sciences |
|
Degree Award |
|
Karolina Werner
ID:
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From Statebuilding to Localized Governance: Exploring African governance structures
REFNo: SS56ES
The project focuses on understanding the legal integration of informal/traditional authorities into the governance of states in sub-Saharan Africa. The objective is to better understand the unique systems of governance present on the continent, providing a comparative study of four countries (Uganda, Zambia, Mozambique, Botswana) with varying degrees of integration.
|
Canada |
2018-02-13 |
2021-02-13 |
Social Science and Humanities |
|
Degree Award |
|
Godfrey Zari Rukundo Zari
ID: UNCST-2019-R001500
|
Implementation and Adaptation of a Web-Based Clinical Education Program for Mental Health Providers in Uganda
REFNo: HS59ES
The objective of the study is to assess the acceptability and utility a of western-developed online CBT course in advancing knowledge of cognitive-behavioral interventions among staff and graduate students in the department of psychiatry at Mbarara University/Mbarara Hospital in southwestern Uganda. Because this is the first time the course is being offered in this manner in Uganda, it is necessary to first pilot and adapt the training modules to our local setting.
|
Uganda |
2018-02-13 |
2021-02-13 |
Medical and Health Sciences |
|
Non-degree Award |
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Anna Stadelman Michelle
ID:
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Assessing Lung Function and Quality of Life in Ugandans after Completion of Multi-Drug Resistant Tuberculosis Treatment (ALFU-MDR TB)
REFNo: HS122ES
To evaluate the impact of MDR TB and its treatment on pulmonary
function in survivors of MDR TB.
To establish the impact of MDR TB and its treatment on the quality of life
of MDR TB survivors.
To assess the effect of HIV and MDR TB co-infection on pulmonary
function in MDR TB survivors.
|
USA |
2018-02-13 |
2021-02-13 |
Medical and Health Sciences |
|
Non-degree Award |
|
Yahaya Gavamukulya
ID: UNCST-2019-R001017
|
Green Synthesis and Biochemical Evaluation of Anticancer Activities of Silver Nanoparticles Conjugated Ethanolic Extracts of Leaves of Annona muricata (Graviola)
REFNo: NS43ES
General Objective
To undertake green synthesis and biochemical evaluation of anticancer activities of AgNPs-conjugated ethanolic extracts of leaves of Annona muricata (Graviola).
Specific Objectives
1. To conduct LCMS analysis of the ethanolic extracts of leaves of Annona muricata and undertake green synthesis and characterization of the extracts’ mediated AgNPs.
2. To investigate the effects of the AgNPs-conjugated ethanolic extracts of leaves of Annona muricata on the biological properties (morphology, migration, growth, and death) of selected cancer cell lines using selected assays.
3. To evaluate the effects of the AgNPs-conjugated ethanolic extracts of leaves of Annona muricata on the transcriptome for expression of cancer associated genes in selected cancer cell lines using RNA-Seq analysis.
4. Evaluation of the in vivo anticancer activities of the AgNPs-conjugated ethanolic extracts of leaves of Annona muricata against chemically induced tumours in mice models.
|
Uganda |
2018-02-13 |
2021-02-13 |
Natural Sciences |
|
Degree Award |
|
Helen Liebling Jane
ID:
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Sexual and Gender-Based Violence and Torture Experiences of South Sudanese Refugees in Northern Uganda: Health and Justice Responses
REFNo: SS126ES
Specific objectives are to:(1) examine the experiences of South Sudanese refugees and impact of Sexual and Gender-Based Violence (SGBV) and torture on their lives (2) analyse reproductive and psychological health,and justice needs of refugees from their own and service providers’ perspectives
and (3) evaluate responses to refugees by state justice, health services and key
stakeholders.
|
UK |
2018-02-13 |
2021-02-13 |
Social Science and Humanities |
|
Non-degree Award |
|
Helen Byakwaga
ID: UNCST-2019-R001168
|
Study of Newly Diagnosed Kaposi's Sarcoma
REFNo: HS157ES
1) Describe the clinical and laboratory characteristics of HIV-infected patients who develop KS.
2) Determine survival after KS occurrence in both ART-treated and ART-untreated HIV-infected patients.
|
Uganda |
2018-02-13 |
2021-02-13 |
Medical and Health Sciences |
|
Non-degree Award |
|
Stephen Kyakulumbye
ID:
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A framework for developing citizen-centric e-government applications in developing contexts: The design-reality gap
REFNo: IS9ES
To document a feasible participatory design methodology for citizen e-government applications.
|
Uganda |
2018-02-13 |
2021-02-13 |
Social Science and Humanities |
|
Degree Award |
|
Mohammed Lamorde
ID: UNCST-2019-R001293
|
Steady-state pharmacokinetics of efavirenz (Sustiva/Stocrin) 400 mg once daily in the presence of rifampicin and isoniazid (Rifinah or the local generics)
REFNo: HS161ES
Primary Objective: To evaluate the steady-state pharmacokinetics of efavirenz (Sustiva/Stocrin) 400 mg once daily during co-administration with rifampicin and isoniazid (Rifinah or local generic)
Secondary Objectives:
1. To assess the safety and tolerability of efavirenz (Sustiva/Stocrin) 400 mg once daily during co-administration with rifampicin and isoniazid (Rifinah or local generic)
2. To investigate the association between genetic polymorphisms in drug disposition genes and drug exposure.
|
Nigeria |
2018-02-06 |
2021-02-06 |
Medical and Health Sciences |
|
Non-degree Award |
|
Mohammed Lamorde
ID: UNCST-2019-R001293
|
A PHARMACOKINETIC EVALUATION OF ETONOGESTREL IMPLANT IN HIV-INFECTED WOMEN ON DARUNAVIR VERSUS RIPILVIRINE-BASED ANTIRETROVIRAL THERAPY (DRIVE-I)
REFNo: HS145ES
Primary objective:
To compare the PK of ENG (68 mg) contraceptive implant over 6 months in Ugandan HIV-infected women receiving DRV-based ART or RPV-based ART versus historical controls
Secondary objectives:
(1) To predict the disposition of ENG over the subsequent 2.5 years of intended use through PK modeling of ENG concentrations beyond 12 months of use in HIV-infected women using DRV- or RPV-based ART
(2) To describe the PK exposure over 12 months of ENG contraceptive implant in Ugandan HIV-infected women receiving DRV-based ART or RPV-based ART
(3) To describe the pharmacokinetics of DRV 12 hours post-dose (C12) and RPV 24 hours post-dose (C24) prior to and during 12 months of combined use with ENG.
(4) To describe the safety and tolerability of combined use of DRV/RTV or RPV and ENG during 12 months of combined use.
(5) To describe the relationship between ENG concentrations and participant specific covariates including body weight, albumin, sex-hormone binding globulin and pharmacogenetic factors.
|
Nigeria |
2018-01-29 |
2021-01-29 |
Medical and Health Sciences |
|
Non-degree Award |
|
Mohammed Lamorde
ID: UNCST-2019-R001293
|
A PHARMACOKINETIC EVALUATION OF LEVONORGESTREL IMPLANT IN HIV-INFECTED WOMEN ON DARUNAVIR VERSUS RIPILVIRINE-BASED ANTIRETROVIRAL THERAPY (DRIVE-II)
REFNo: HS146ES
Primary objective: To compare the PK of LNG (150 mg) contraceptive implant over 6 months in Ugandan HIV-infected women receiving DRV-based ART or RPV-based ART versus historical controls.
Secondary objectives:
(1) To compare the PK of LNG over 12 months among women receiving DRV-based ART or RPV-based ART versus historical controls
(2) To predict the disposition of LNG over the subsequent 4 years of intended use through PK modeling of LNG concentrations beyond 12 months of use in HIV-infected women using DRV- or RPV-based ART
(3) To describe the pharmacokinetics of DRV 12 hours post-dose (C12) and RPV 24 hours post-dose (C24) prior to and during 12 months of combined use with LNG.
(4) To describe the safety and tolerability of combined use of DRV/r or RPV and LNG during 12 months of combined use.
(5) To describe the relationship between LNG concentrations and participant specific covariates including body weight, albumin, sex-hormone binding globulin and pharmacogenetic factors.
|
Nigeria |
2018-01-29 |
2021-01-29 |
Medical and Health Sciences |
|
Non-degree Award |
|
Charlotte Hawkins
ID:
|
The Anthropology of Smartphones and Smart Ageing
REFNo: SS141ES
This project will investigate fundamental changes in people’s relationship to age and health associated with the global rise of the smartphone. The aim is to combine an intellectual challenge in understanding the contemporary nature of age and the impact of new media, with an applied challenge to use this knowledge to help make mHealth (mobile health) interventions more effective. mHealth has potential both for helping those with limited access to professional care but also threatens to bypass and undermine professional medical services. Our aim is to complement technology-led mHealth interventions with ethnography-led participatory design, consisting of a three-way collaboration between mHealth professionals, our ethnographically informed team and our informants in the field. We aim to demonstrate how such collaborations can lead to more culturally appropriate mHealth interventions and more effective improvements in people’s lives.
|
UK |
2018-01-29 |
2021-01-29 |
Social Science and Humanities |
|
Degree Award |
|
Rose Gawaya
ID:
|
Challenges faced by women’s organisations in the AID space: Case studies in South Africa and Uganda
REFNo: SS90ES
The purpose of the research is to explore how women’s organisations access and utilise development aid. Access and utilisation of development aid impact on how women’s organisations achieve their organisational goals to address problems faced by women.
The specific study objectives are to:
1.Determine how women’s organisations define and respond to the development aid space.
2.Identify what functions determine the participation of women in the development aid space.
3.Examine how access and utilisation of development aid contributes to feminist agendas.
|
Uganda |
2018-01-16 |
2021-01-16 |
Social Science and Humanities |
|
Degree Award |
|
Charles Okuonzi
ID:
|
Follower Voice Behavior and Leadership Competencies of Owner-managers in SMEs in Uganda
REFNo: SS142ES
The objective of thestudy is to establish the relationship between follower voice behaviour and leadership competencies of Ugandan SME owner-managers. The study is purely academic and shall involve owner-managers from 65 SMEs and 500 of their followers as respondents
|
Uganda |
2018-01-11 |
2021-01-11 |
Social Science and Humanities |
|
Degree Award |
|
Afra Nuwasiima
ID:
|
Incentives for Increased Access to Comprehensive Family Planning for Urban Youth Using a Benefits Card: A Pilot Study
REFNo: HS98ES
1) To evaluate the effectiveness of the FPBC program in increasing uptake of comprehensive family planning services among urban youth aged 18 to 30 years.
2) To evaluate the acceptability and usability of the FPBC program among the urban youth aged 18 to 30 years
3) To estimate the cost-effectiveness and potential budget impact of the FPBC program on the taxpayer.
4) To pilot test a corporate social responsibility financing model that will pay for and potentially sustain the FPBC program.
|
Uganda |
2018-01-08 |
2021-01-08 |
Medical and Health Sciences |
|
Non-degree Award |
|
Jeroen Lorist
ID:
|
(Re-)ordering Meaning and Masculinities in Holland and Uganda: the Gender Transformative Approach
REFNo: SS127ES
For many years research and development interventions towards gender equality have focused on women and their empowerment. Recently discourse seems to have shifted to include the engagement of men and boys towards gender equality. Through multi-sited ethnography this project examines how the idea of the Gender Transformative Approach travels and is (re-)ordered between different nodes of a distributed knowledge network. Rutgers, a Dutch NGO, acts as a major node in this global knowledge network and is the main ethnographic site (i.e. organizational ethnography of the NGO in Holland). Other research sites are Uganda and Malawi, where Rutgers' development partners operationalise GTA through various development interventions.
Objective of the study is to find out, through multi-sited ethnography, what the Gender Transformative Approach really does. Is the engagement of men for gender equality really changing gender relations to be more equal, as it claims it is, or is it old wine in new bottles as some within the women’s movement claim (i.e. is it doing more than women’s empowerment?). The study will also hold a critical development perspective and will critically look at any unintended effects of the interventions.
|
Netherlands |
2018-01-08 |
2021-01-08 |
Social Science and Humanities |
|
Degree Award |
|
Jennifer Driscoll Jane
ID:
|
Child Protection arrangements in sub-Saharan African states: a preliminary investigation into the interaction between informal child protection arrangements and formal intervention services and the effect of formal systems and agency interventions on indi
REFNo: SS94ES
a) preliminary investigations to gather the views of community leaders, local government officials, representatives of (I)NGOs, and (if possible) policy-makers from national government as to
i) the key issues in relation to the protection of children at community level in Uganda;
ii) particular challenges identified in relation to the interaction of formal child protection systems, community arrangements and (I)NGO interventions in the communities participating in the study;
iii) examples of best practice and innovative work which has proven successful in promoting effective joint local arrangements in those communities; and
b) to seek participants’ specific advice as to the focus and methods that should be employed in development of a larger bid and the geographical area of study (within sub-Saharan Africa).
|
UK |
2017-12-20 |
2020-12-20 |
Social Science and Humanities |
|
Non-degree Award |
|
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