Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Sarah Kiguli
ID: UNCST-2021-R013020
 Observational Study to Assess the Incidence of Malaria among Children Living with Sickle Cell Disease in Jinja Regional Referral Hospital Eastern Uganda.
REFNo: HS5583ES

General Objective
To describe the epidemiology of malaria in SCD patients in Uganda.

Specific objectives:
Primary Objective
1. To determine the incidence of malaria cases in SCD patients over a 12-month period.
1. Secondary objectives
2. To determine the incidence of asymptomatic parasitemia aged 6 months -17 years attending Jinja Regional Referral Hospital Sickle Cell Clinic over a 12-month period?.
3. To determine the incidence of submicroscopic parasitemia aged 6 months -17 years attending Jinja Regional Referral Hospital Sickle Cell Clinic over a 12-month period?.
4. To determine the severity of malaria in SCD patients, including the prevalence of WHO-defined severe malaria complications such as cerebral malaria, respiratory distress, and severe anemia aged 6 months -17 years attending Jinja Regional Referral Hospital Sickle Cell Clinic over a 12-month period?.
5. To determine the frequency of sickle cell disease complications associated with a malaria case.
6. To identify temporal patterns in malaria incidence aged 6 months -17 years attending Jinja Regional Referral Hospital Sickle Cell Clinic over a 12-month period
7. To examine the risk and protective factors associated with malaria susceptibility and severity among malaria-infected SCD patients using malaria chemoprophylaxis.

Exploratory endpoints:

8. To investigate and determine the parasite molecular diversity among SCD patients attending Jinja Regional Referral Hospital?
9. To examine and determine the antimalarial parasite drug resistance patterns among SCD patients


 Uganda 2025-03-04 10:54:17 2028-03-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
HIRALY ASABAHEBWA
ID: UNCST-2024-R016374
 A QUALITATIVE STUDY EXPLORING THE EXPERIENCES OF UNIVERSITY STUDENTS LIVING WITH HIV AND COMPLETING A UNIVERSITY-LEVEL QUALIFICATION IN KAMPALA, UGANDA
REFNo: SS3684ES

To explore the experiences of newly HIV-diagnosed university students in Kampala, Uganda ,
 Uganda 2025-03-04 10:29:29 2028-03-04 Social Science and Humanities Non-Clinical Trial Degree Award
ISMAHIL ADENIYI ADEKUNLE
ID: UNCST-2024-R002602
 EFFECTS OF ETHYL-ACETATE FRACTION OF Bidens pilosa LEAVES ON TESTES AND PITUITARY GLAND OF MALE MICE EXPOSED TO BISPHENOL A
REFNo: HS5372ES

The purpose of this study is to evaluate the impact of B. pilosa on testicular integrity and the pituitary gland of male mice exposed to BPA.
1.3.1 Specific Objectives
i. To assess the effect of B. Pilosa on spermatogenic metrics of the testes such as sperm motility, sperm count, morphology, agglutination, and vitality using routine and extended semen analysis.
ii. To determine the impact of B. pilosa on serum concentration of follicle-stimulating hormone, testosterone, and luteinizing hormone using enzyme-linked immunosorbent assay (ELISA) following BPA exposure.
iii. To assess the changes in testicular oxidative stress biomarkers (such as CAT, SOD, and GSH) and lipid peroxidation using MDA.
iv. To assess the histology, histochemical, and immunohistochemical changes in the testes and pituitary gland following treatment with B. pilosa in BPA exposure using Masson Trichrome, Periodic Acid Schiff (PAS), Hematoxylin and Eosin (H&E), Caspase 3, antiproliferating cell nuclear antigen (PCNA), Bcl-2, alpha-smooth muscle actin (α-SMA), and Bax.

 Nigeria 2025-03-03 11:40:21 2028-03-03 Medical and Health Sciences Clinical Trial Degree Award
Agapitus Kato Babumba
ID: UNCST-2021-R013866
 Linking infectious disease front-liners control efforts with central public health authorities in the African Great Lakes region (Great-Life) project
REFNo: HS5293ES

Study Objectives: The study objectives and their specific objectives are outlined in A to D below. OBJECTIVE A – CAPACITY BUILDING This objective involves testing the integrated nanopore sequencing capacity (DNA and RNA—single isolates and metagenomics) in the study area. Specific objectives: ● Set -up sampling, sequencing, and simple bioinformatic/epidemiological capacity in Bidibidi Health Centre. ● Set up advanced bioinformatics/ epidemiological capacity at UVRI and cascade it to the study area health facilities ● Build capacity in genomic data interpretation and risk communication in genomic epidemiology. OBJECTIVE B - BIOINFORMATICS, EPIDEMIOLOGY, AND INFRASTRUCTURE This objective involves the testing of standardized laptop analysis and compression of the data generated from nanopore runs, including base calling and standard analysis for use at the frontline health facility (Bidibidi HC III). Following analysis, the analytic data (now the size of kilobytes) can be easily and in real-time shared with stakeholders. Specific objectives: ● Develop a common understanding of the key data analytics and infrastructure needs. ● Set up a project-specific frontline laptop-based data-entering and bioinformatic pipeline. ● Set up a central data portal for storing, aggregating, and sharing raw data and analytic output. ● Provide operational user support to the use-case scenarios and external users ● Support high-throughput computation capacity OBJECTIVE C – TRAINING IN RESEARCH TRANSLATION SKILLS, AND EQUITABLE PARTNERSHIP One of the key elements of this project is to generate data that should be transformed into information that will result in public health actions and social impact in the country. The project will involve key stakeholders from the health facility and local and central governments to meet this goal. The stakeholders will be trained in research data interpretation and utilization. The stakeholders will use the training obtained from this project to develop measures and policies. Specific objectives: ● Conduct training of public health authorities and researchers in public health uptake of genomic epidemiological data ● Determine how obtained data will result in local and national guidelines for individual patient treatment ● Determine how data will influence local, national, and regional public health interventions ● Investigate how cross-border disease outbreaks can be coordinated between national and regional authorities OBJECTIVE D - EPIDEMIOLOGICAL AND GENOMIC INVESTIGATIONS The objectives will be fulfilled by conducting three use cases ● Real-time diagnostic and characterization of diarrheal and persistent malaria cases ● Environmental surveillance for antimicrobial resistance genes in the study area. ● Horizon scanning for pathogens of novel unknown infections of epidemic nature (Disease X identification)
Uganda 2025-02-28 17:30:31 2028-02-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Karim Nanyiri
ID: UNCST-2024-R002952
 Role of Mother Tongue in Learning Productive and Receptive Skills in English language: An Analysis of Perceptions of Stakeholders in Secondary Schools of Bugisu Sub-Region, Eastern Uganda
REFNo: SS3393ES

Objectives of the Study

The study will be guided by the main objective and specific objectives.

Main Objective of the Study

The main objective of the study is to investigate the role of mother tongue in learning productive and receptive skills in English language through the analysis of perceptions of stakeholders in secondary schools of Bugisu sub-region, eastern Uganda.

Specific Objectives of the Study

The study will be conducted with the following specific objectives;

1. To determine the influence of students’ productive skills in mother tongue on the learning of productive skills in English language.
2. To determine the influence of students’ receptive skills in mother tongue on the learning of receptive skills in English language.
3. To explore students’ perception of the role of mother tongue in learning productive skills in English language.
4. To explore students’ perception of the role of mother tongue in learning receptive skills in English language.
5. To explore teachers’ perception of the role of mother tongue in learning productive skills in English language.
6. To explore teachers’ perception of the role of mother tongue in learning receptive skills in English language.
7. To explore the barriers encountered by lower secondary school students in the learning of productive and receptive skills in English language.

Uganda 2025-02-28 16:02:44 2028-02-28 Social Science and Humanities Non-Clinical Trial Degree Award
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