Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
joseph  mwizerwa
ID:
Strengthening academic advancement for enrolled nurses: Developing a new program framework for enrolled nurses in Uganda.
REFNo: HS375ES

1.Explore experiences, aspirations and needs of ENs in Uganda with respect to advancing their nursing careers.
2.Identify the barriers and facilitators for academic advancement of ENs within Uganda.
3.Examine the suitability of Ugandan EN advancement programs in meeting EN education needs.
4.Critically examine international educational programs developed for ENs (or similar level nurses) career progression, to assess their applicability to the Ugandan context.
5.Develop a new academic advancement framework for ENs in Uganda and generate consensus for it.

Uganda 2019-05-28 2022-05-28 Medical and Health Sciences Degree Award
Annabel  Morales-Smith
ID:
Assessing local attitudes towards tourism and conservation at Bwindi Impenetrable national park, Uganda
REFNo: SS302ES

This master’s research aims to investigate if park tourism can improve attitudes of residents involved in small-scale tourism enterprises towards protected area conservation, by delivering economic development; using Bwindi Impenetrable National Park (BINP) in Uganda as a case study.
The research objectives are:
• Measure expectations of residents involved in small-scale tourism enterprises based on their experiences of park tourism.
• Evaluating if recent interventions to enhance small-scale tourism enterprises have increased economic benefits from park tourism and if this has improved attitudes towards PA conservation.
• Assess the sustainability of these interventions.
The research hypothesis is: ‘Local attitudes towards protected area conservation improve when residents involved in small-scale tourism enterprises receive benefits from park tourism’.
And the research questions I will ask to test this hypothesis & achieve the aim of this project are:
• What expectations do residents involved in small-scale tourism enterprises have of park tourism?
• Do local attitudes towards protected area conservation improve when residents involved in small-scale tourism enterprises receive benefits from tourism?
• Do people feel they are sufficiently trained to continue without further interventions?

UK 2019-05-21 2022-05-21 Social Science and Humanities Degree Award
Henry Kajumbula Mawerere
ID: UNCST-2019-R001531
IDENTIFICATION OF VIRULENCE FACTORS, TRANSMISSION PATTERNS AND ANTIBIOTIC RESISTANCE MECHANISMS OF EAST AFRICAN Vibrio cholerae ISOLATES BY WHOLE GENOME SEQUENCING
REFNo: HS338ES

Aim: To obtain whole genome sequences (WGS) of Vibrio cholera O1 isolated in various parts of Uganda from 2014 to 2018 and use the data to determine the evolution, spread, antimicrobial resistance mechanisms and pathogenesis of the isolates

Specific objectives:
1. Determine patterns of spread of V.cholerae O1 in Uganda and within the East African region using WGS
2.Infer relatedness and evolution of strains of V.cholerae O1 isolated in Uganda and the East African region from WGS data
3.Identify any uniqueness in virulence genes or their expression among strains of V.cholerae isolated in Uganda and the East African region from WGS data
4.Identify genes of antimicrobial resistance and infer prevailing mechanisms of antimicrobial resistance among V. cholerae O1 isolated in Uganda

Uganda 2019-05-14 2022-05-14 Medical and Health Sciences Non-degree Award
Catriona  Waitt John
ID: UNCST-2019-R001068
INVESTIGATION OF THE PHARMACOKINETICS OF ATAZANAVIR IN PREGNANT WOMEN, INDIVIDUALS AT EXTREMES OF BMI, CHILDREN AND ADOLESCENTS. AN OBSERVATIONAL STUDY NESTED WITHIN THE VIRTUAL CONSORTIUM
REFNo: HS351ES

Primary Objectives
1. To describe the pharmacokinetic parameters of ATV currently used in the clinical care of HIV-infected pregnant and postpartum women, children and adolescents, and individuals with obesity or malnutrition.
2. To compare these parameters to those observed in non-pregnant HIV-infected adults on second-line ART who enter a dose escalation study of ATV/r + RIF as WP2 of the VirTUAL programme
Secondary Objectives
1. To use nonlinear mixed-effects modelling to describe sources of variability on the pharmacokinetics of ATV

UK 2019-05-14 2022-05-14 Medical and Health Sciences Non-degree Award
PALLAVI PRABHAKAR
ID:
Reproductive and maternal health care provision for refugees and host populations in Northern Uganda
REFNo: SS296ES

This study aims to undertake: 1.A policy analysis to examine access and health financing arrangements for Sexual , Reproductive and Maternal Healthcare (SRMH) and the delivery of these services for refugees and host populations in Uganda, in the context of transition from an acute emergency to a development response model. 2.An impact , process and economic evaluation of the BRAC ELA programme which aims to train the adolescent girls on issues related to health, nutrition, financial literacy, and life skills.
India 2019-05-14 2022-05-14 Social Science and Humanities Non-degree Award
Daniel  Atwine Warren
ID:
Community Intervention for Tuberculosis Active Contact Tracing and Preventive Therapy - A Cluster Randomized Study (CONTACT)
REFNo: HS329ES

To compare the proportion of household child TB contacts eligible for PT (<5 years and HIV-infected children 5-14 years without active TB) who initiate and complete PT using facility-based and decentralized community-based models of care for contact screening and management.
Uganda 2019-05-07 2022-05-07 Medical and Health Sciences Non-degree Award
Shallon  Atuhaire
ID:
Self-fulfilling Prophecies and Self-efficacy: Association with Community Reintegration and Rehabilitation of Obstetric Fistula Patients in Kitovu Hospital, Uganda
REFNo: HS361ES


i. To identify self-fulfilling prophecies among repaired and unrepaired obstetric fistula patients in Kitovu Mission Hospital.
ii. To assess the highest level of self-efficacy among repaired and unrepaired obstetric fistula patients in Kitovu Mission Hospital.
iii. To determine the role played by self-fulfilling prophecies in community reintegration and rehabilitation of obstetric fistula in Kitovu Mission Hospital.
iv. To measure the association between obstetric fistula patients’ levels of self-efficacy and their rehabilitation in Kitovu Mission Hospital.
v. To explore the extent to which obstetric fistula patients of different fistula repair statuses are involved in rehabilitation in Kitovu Mission Hospital.

Uganda 2019-05-07 2022-05-07 Medical and Health Sciences Degree Award
Musa Kayondo
ID:
PELVIC ORGAN PROLAPSE IN SOUTHWESTERN UGANDA: PATTERNS, IMPACT ON QUALITY OF LIFE, SURGICAL OUTCOMES AND THE PREDICTING FACTORS, OF PATIENTS ATTENDING MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS368ES

1. To determine the patterns of POP in the Gynecology department of MRRH.
2. To establish the quality of life (physical, social, emotional and sexual function) before and after surgery among women with POP at MRRH.
3. To determine the outcomes of surgical treatment and related prognostic factors of POP at MRRH.

Uganda 2019-05-07 2022-05-07 Medical and Health Sciences Degree Award
Katia  Peterson
ID:
A quasi-experimental study of Interpersonal Group Therapy (IPT) treatment attribution on decreasing depression severity among depressed women in Iganga District, Makuutu Sub County and Mukono District, Kimenyedde Sub Counties
REFNo: SS297ES

General objective

To establish a baseline prevalence of depression and determine the period and treatment effects of depression severity between depressed women in Iganga (Makuutu Sub County) and Mukono District (Kimenyedde Sub Counties).

Specific objectives
1. Determine the prevalence of depression in Makuutu Sub County (Iganga) and Kimenyedde Sub Counties (Mukono).
2. Determine the change in depression severity, as measured by the PHQ-9, within control subjects at six months and one year follow up.
3. Determine the change in depression severity, as measured by the PHQ-9, between control and treatment subjects at six months and one-year follow up.
4. Determine the change in well-being as measured by the “Well-being Indicator Survey” within control subjects and between control and treatment subjects at six months and one year follow up.

USA 2019-05-07 2022-05-07 Social Science and Humanities Non-degree Award
NICHOLAS BARI NDAHURA BARI
ID:
EFFECTIVENESS OF NUTRITION EDUCATION ON GLYCAEMIC CONTROL IN PEDIATRIC TYPE 1 DIABETES MELLITUS PATIENTS IN UGANDA
REFNo: HS186ES

1. To assess the level of knowledge of nutrition management of T1DM among caregivers of T1D children (3-12 years) at selected T1DM clinics in Uganda. 2. To determine the dietary intake and adequacy of T1D children (3-12 years) at selected T1DM clinics in Uganda. 3. To develop a nutrition education training module for caregivers and T1D children (3-12 years) at selected T1DM clinics in Uganda. 4. To determine the effectiveness of nutrition education on HbAlc levels, knowledge of nutrition management of T1DM and dietary practices among caregivers and T1D children (3-12 years) at selected T1DM clinics in Uganda.
Uganda 2019-04-30 2022-04-30 Medical and Health Sciences Degree Award
Isaac  Kimbowa
ID:
ANTIMICROBIAL STEWARDSHIP PRACTICES AND QUALITY OF ANTIBACTERIAL USE IN CHILDREN UNDER-FIVE IN SELECTED HEALTH FACILITIES IN UGANDA
REFNo: HS339ES

1. To determine the structure and functional roles of MTCs in optimizing antibacterial use in management of childhood infections in under-five children in selected RRHs and PNFP health facilities in Uganda (sub-study I).
2. To determine stewardship practices guiding optimizing antibacterial use in management of infections in under five children in selected Health facilities in Uganda (sub-study II)
3. To determine extent of off-label and unlicensed use of antibacterial among children -five in paediatrics wards of selected RRHs and PNFPs in Uganda (Study III)
4. To determine the extent of antibacterial exposure to neonates during perinatal period among women delivering in selected regional referral hospitals in Uganda (Study IV).

Uganda 2019-04-24 2022-04-24 Medical and Health Sciences Degree Award
Julia Downing
ID:
Children’s, Adults and Health Professionals Understanding Illness, Death and Dying in Uganda
REFNo: HS276ES

The study aims to gain an understanding of children, adults and health professionals understanding of illness, death and dying in order to inform the provision of palliative care services in Uganda. The objectives of the study are to understand the following questions: I. What are Ugandan adults understanding of illness, death and dying? II. What are Ugandan children’s understanding of illness, death and dying? III. What is the understanding of Ugandan health professionals with regards to illness, death and dying?
UK 2019-04-16 2022-04-16 Medical and Health Sciences Non-degree Award
Adam Hewitt Smith
ID: UNCST-2019-R001658
A cluster randomised trial to determine whether increased postoperative surveillance of adult African surgical patients reduces postoperative mortality
REFNo: HS298ES

Primary objective - To determine whether increased postoperative surveillance reduces in-hospital mortality in high-risk adult surgical patients aged 18 years and over in Africa. Primary outcome measure - In-hospital mortality, censored at 30 days if the patient is still alive and in-hospital. Secondary objective - To determine whether increased postoperative surveillance reduces the incidence of the composite of severe in-hospital complications and mortality in high-risk adult surgical patients aged 18 years and over in Africa. Secondary outcome measure - Composite of severe in-hospital complications and mortality, censored at 30 days if the patient is still alive and in-hospital.
UK 2019-04-16 2022-04-16 Medical and Health Sciences Non-degree Award
miriam nantamu
ID:
Biosciences in nursing education: assessment of the level of explicit knowledge on antibiotic resistance (ABR) among preregistration nursing students in Uganda.
REFNo: HS313ES

Specific objectives
1. To assess the current level of knowledge on ABR among 3rd and 4th year nursing pre-registration nursing students in Uganda.
2. To identify the factors associated with the current level of bioscience knowledge among 3rd and 4th year pre-registration nursing students in Uganda.

Uganda 2019-04-16 2022-04-16 Medical and Health Sciences Degree Award
Sabine Haller
ID:
Species Identification of Non-Tuberculous Mycobacteria in the Ugandan Population
REFNo: HS330ES

Primary Objective:
To describe the non-tuberculous mycobacteria (NTM) species isolated in the Ugandan population.
Secondary Objective:
To describe patient characteristics and outcomes.

Switzerland 2019-04-16 2022-04-16 Medical and Health Sciences Non-degree Award
Anna Agnes Ojok Arach
ID:
Perinatal death: risk factors, postpartum depression, lived experiences and cultural perspective in lira, Uganda
REFNo: HS356ES

The study has the following objectives:

1. To determine the incidence and risk factors of perinatal deaths in Lira,

2. To examine the association between perinatal death and postpartum depression among women in Lira,

3. To describe the lived experience of women and partners who experienced perinatal death in Lira

4. To explore the cultural perspective of the Lango community on perinatal death.

Uganda 2019-04-16 2022-04-16 Medical and Health Sciences Degree Award
Prof. Dr. med. Hans Konrad Biesalski
ID:
Dietary Intake and Nutritional Situation of Women of Reproductive Age (20-50 Years Old) in Lango Sub-Region of Northern Uganda: Implementation of Calculator for Inadequate Micronutrient Intake (CIMI) Program
REFNo: HS319ES

The main objective of this study is to assess the dietary intake and nutritional status of women of reproductive age in the predominantly rural North of Uganda. Therefore, the innovative
nutrition software called Calculator for Inadequate Micronutrient Intake (CIMI) will be used and validated with the obtained data.

Research objectives:
(1) To evaluate the dietary intake and nutritional status of women of reproductive age (20-50 years old) from Lango Sub-Region in Northern Uganda.
(2) To adapt CIMI program to the country Uganda and to compare CIMI with the software NutriSurvey for its ability to analyze dietary nutrients intake (Fe, Zn and Vitamin A and protein) and energy content in the study region. For the validation of CIMI, a new localization (appropriate to Ugandan Food) will be implemented in the nutrition software before.
(3) To identify the main causes of poor food consumption patterns of Ugandan women of reproductive age.
Germany 2019-04-03 2022-04-03 Medical and Health Sciences Degree Award
Nasur Buyinza
ID:
NURSE - LED INTEGRATED PALLIATIVE CARE FOR MULTI DRUG RESISTANT TUBERCULOSIS PATIENTS TAKING ANTI MULTI DRUG RESISTANT TB THERAPY IN UGANDA – A RANDOMIZED CONTROLLED TRIAL
REFNo: HS275ES

I.To determine health professionals’ views on an appropriate model of integrated palliative care for MDR TB patients and their families alongside TB treatment II.To model a feasible integrated palliative care intervention for MDR TB using staff views and existing literature III.To test the effectiveness of the new model as compared to existing care in an RCT design IV.To determine patients’ post intervention perceived mechanism of action V.To identify a minimum palliative care package for MDR TB patients
Uganda 2019-04-03 2022-04-03 Medical and Health Sciences Non-degree Award
David Meya Bisagaya
ID: UNCST-2019-R000837
Single dose liposomal amphotericin for asymptomatic cryptococcal antigenemia (ACACIA)
REFNo: HS284ES

Study Objectives Primary Objectives: 1. To assess 24-week efficacy of single dose liposomal amphotericin in the treatment of asymptomatic cryptococcal antigenemia for meningitis-free survival. Secondary Objectives: 1 . To determine safety and tolerability of single-dose liposomal amphotericin for the treatment of asymptomatic cryptococcal infection. 2- To determine 24-week survival in those who receive the intervention compared to those who receive standard of care. 3. To evaluate cost and cost-effectiveness of single dose liposomat amphotericin for the treatment of asymptomatic cryptococcal antigenemia
Uganda 2019-04-03 2022-04-03 Medical and Health Sciences Non-degree Award
Daniel Stein
ID:
Unconditional Cash Transfers in Kiryandongo Refugee Settlement, Uganda
REFNo: SS281ES

Due to limited evidence on the effect of large, one-off unconditional cash transfers in refugee contexts, the commissioning organization GiveDirectly has requested IDinsight to conduct a rigorous impact evaluation. The research study aims to answer the following core research questions:
1. What is the impact of large, unconditional cash transfers on refugee households for outcomes such as income, assets, consumption, enterprise, food security and psychological wellbeing?
2. What do any changes caused by the cash transfers mean for the lives of refugee households and how did those changes come about?
3. What is the effect of cash transfers on host communities, and their relationship with the refugee communities?
USA 2019-03-26 2022-03-26 Social Science and Humanities Non-degree Award
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