Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Faith Nyongyera
ID: UNCST-2025-R022755
Human Resuorce Management Practices, Managerial Competences and Performance of SACCOs in South Western Uganda.
REFNo: SS5882ES

1. To find out the relationship between HRMP and performance of SACCOs in South Western Uganda.
2. To establish the link between HRMP and MC of SACCOs in South Western Uganda
3. To establish the connection between MC and performance of SACCOs in South Western Uganda.
4. To establish the mediating effect of MC in the relationship between HRMP and Performance of SACCOs in South western Uganda.

Uganda 2026-08-24 6:26:40 2029-08-24 Social Science and Humanities Non-Clinical Trial Degree Award
Evelina Griniute
ID: UNCST-2026-R024219
Who is Watching? Social Audiences and Demand for Menstrual Health Technologies
REFNo: SS5335ES

Main Research Objective
Examine how social context and information provision shape women’s demand for
various menstrual health technologies in Uganda.
Specific Objectives
• Assess how willingness to pay varies across different types of menstrual products.
• Estimate how social visibility – operationalized as whether the purchase decision is
observed by a female peer or by the woman’s husband or partner — shapes women’s
willingness to pay for different menstrual products.
• Estimate how the provision of targeted information on product attributes (in particular
long-term cost) shapes women’s willingness to pay for different menstrual products.
• Estimate how social context and information provision interact, in particular whether
social observation moderates (attenuates or amplifies) the effect of information
provision on willingness to pay.
Lithuania 2026-08-24 6:24:50 2029-08-24 Social Science and Humanities Non-Clinical Trial Non-degree Award
GLORIA CUU
ID: UNCST-2024-R002669
PLASMODIUM FALCIPARUM PHENOTYPIC AND GENETIC SUSCEPTIBILITY PROFILES TO ARTEMISININS AND PARTNER DRUGS IN SOUTHWESTERN UGANDA
REFNo: HS7271ES

1. To assess the ex vivo susceptibility of P. falciparum clinical isolates to standard antimalarial drugs in a low-malaria transmission region of southwestern Uganda.

2. To characterize genetic variation in genes mediating resistance to artemisinin and partner drugs and assess their correlation with ex vivo drug susceptibilities in P. falciparum isolates collected from low-malaria transmission regions of southwestern Uganda

3. To validate the role of candidate single nucleotide polymorphisms in PfK13 gene to artemisinin partial resistance in P. falciparum clinical isolates from southwestern Uganda

4. To assess the effect of artemisinin and partner drug mutations on fitness of P. falciparum clinical isolates from southwestern Uganda

Uganda 2026-08-24 6:22:49 2029-08-24 Medical and Health Sciences Non-Clinical Trial Degree Award
James Kakande
ID:
Endline Evaluation of the National Cancer Management and Capacity Building Project in Uganda (CANCAP-UG)
REFNo: SS5864ES

1. To assess coverage in cervical cancer screening services following project implementation.
2. To evaluate improvements in healthcare worker knowledge, competencies, and clinical capacity for cervical cancer prevention, screening, diagnosis, treatment, and referral.
3. To examine the effectiveness and efficiency of training, supportive supervision, referral systems, cancer information systems, and community engagement activities in strengthening cancer service delivery.
4. To assess changes in community awareness and utilization of cervical cancer screening services.
5. To assess the increase in level of Knowledge, Awareness and Practices (KAP) toward cervical cancer of the community and health professionals.
6. To evaluate improvements in healthcare facility readiness, referral systems, and cancer data management.
7. To assess the sustainability of the project's achievements and identify recommendations for future cancer control programs in Uganda.

Uganda 2026-08-24 15:10:45 2029-08-24 Social Science and Humanities Non-Clinical Trial Non-degree Award
Shallon Ahimbisibwe
ID: UNCST-2025-R022235
An Interpretable Kernel Hybrid Approach for Early Detection of Postpartum Depression
REFNo: SIR768ES

Main Objective
The main objective of this study is to develop, evaluate, and clinically validate an interpretable kernel hybrid machine learning–based screening tool, together with a prototype mobile application, for early identification and risk stratification of postpartum depression among postpartum women in Uganda using routinely collected health data.

Specific Objectives
i.To conduct a scoping review of machine learning approaches for postpartum depression detection in low- and middle-income countries, with emphasis on Sub-Saharan Africa, in order to map existing evidence, identify methodological gaps, and inform the design of the proposed kernel hybrid model.
ii.To design and develop a hybrid predictive model that integrates Kernelized Support Vector Machines and Gaussian Process models for accurate early detection of postpartum depression.
iii.To evaluate the performance of the proposed hybrid model using appropriate predictive metrics to assess its accuracy, robustness, and generalization to unseen data.
iv.To clinically validate the proposed kernel hybrid machine learning model and prototype mobile screening application by comparing model predictions against a reference standard defined by the Edinburgh Postnatal Depression Scale (EPDS) scores and, where available, clinician-documented postpartum depression assessments at the selected health facilities.
Uganda 2026-08-24 13:48:08 2029-08-24 Engineering and Technology Non-Clinical Trial Degree Award
Huzaifah Mutyaba
ID: UNCST-2026-R027389
Urban Waste Governance in Fort Portal City: A Rapid Evaluation of Disposal Practices and Management Structures
REFNo: HS8446ES

General Objective:

To evaluate the effectiveness of urban waste governance in Fort Portal City by examining the roles and responsibilities of institutions, prevailing waste disposal practices, identifying systemic gaps, and assessing community awareness, participation, and compliance with waste
management policies and practices.

Specific Objectives:
1.To explore the roles,responsibilities, and effectiveness of institutions and stakeholders involved in urban waste management.

2. To evaluate the prevailing waste disposal practices among households, businesses, institutions, and informal waste actors in Fort Portal City.

3. To identify governance, regulatory, infrastructural, and behavioural gaps that hinder effective waste management.

4. To explore level of community
awareness, participation, and compliance with existing waste management policies and practices.
Uganda 2026-08-24 13:46:12 2029-08-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph Magoola
ID: UNCST-2025-R017394
Evaluation of outcomes of targeted defaulter tracking on uptake of Malaria and Measles Rubella Vaccine in Uganda from September 2025 to May 2026
REFNo: HS8335ES

Purpose To assess the effectiveness of defaulter tracking support on malaria vaccine coverage and uptake in Busia, Butambala, Iganga, and Luweero districts in Uganda from September 2025 to May 2026. Specific Objectives: 1. To determine the change in coverage for malaria, oral polio, pentavalent, and measles vaccines before and after the interventions. 2. To determine changes in malaria, polio, pentavalent, and measles vaccine dropout rates before and after the interventions. 3. To determine the effectiveness of the community-led defaulter tracking system in returning identified children to immunization services. 4. To explore the perspectives of HCWs, and VHTs on factors affecting identification, follow-up, and return of children who default from routine immunization services. 5. To assess how defaulter tracking practices impact the health personnel that provide vaccination service delivery.
Uganda 2026-08-24 13:41:51 2029-08-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eugene Ruzagira
ID: UNCST-2023-R008282
A phase 1b randomised double-blinded placebo-controlled study of a Bundibugyo virus disease vaccine, ChAdOx1 Ebola BDBV Vaccine (Recombinant), in healthy participants aged 18 – 55 years in Uganda.
REFNo: HS8453ES

To assess the safety and tolerability profile of a single dose of ChAdOx1 Ebola BDBV Vaccine (Recombinant) in healthy participants To assess the immunogenicity of a single dose of ChAdOx1 Ebola BDBV Vaccine (Recombinant) in healthy participants To assess the safety and tolerability profile of a booster dose of ChAdOx1 Ebola BDBV Vaccine (Recombinant) 6 months following prime vaccination in healthy participants To assess the immunogenicity of a booster dose of ChAdOx1 Ebola BDBV Vaccine (Recombinant) 6 months following prime vaccination in healthy participants To assess the impact of prior rVSV-ZEBOV-GP or rVSV-SEBOV GP vaccination on the immunogenicity of ChAdOx1 Ebola BDBV Vaccine (Recombinant) in healthy adults
Uganda 2026-08-24 13:40:22 2029-08-24 Medical and Health Sciences Clinical Trial Non-degree Award
Maria Dieci
ID: UNCST-2024-R015211
Evaluating The effectiveness of Reducing Price Barriers to Pediatric Fever Care on Caregiver Decision-making and Illness Outcomes
REFNo: SS5757ES

The primary objective of this study is to determine the effectiveness and cost-effectiveness of pharmacy-based discounts for azithromycin and incentives for facilitated referrals, well-established practices for managing childhood fevers, on caregiver decision-making and management of childhood febrile illness among children under 5 years of age in Uganda. The unit of analysis will be at the patient level for this objective, and the primary outcome will be illness duration. The secondary objectives of this study are: To characterize the effect on care-seeking trajectories among caregivers of children under 5 following an index pharmacy visit for febrile illness. The unit of analysis will be at the patient level. To characterize the effect on provider behavior and counseling in study sites. The unit of analysis will be at the site level. To quantify out-of-pocket expenditures on diagnostic testing and medications across study arms. The unit of analysis will be at the patient level. To compare symptom severity and illness progression over the course of a pediatric fever episode between clients that accessed subsidized care compared to the status quo. The unit of analysis will be at the patient level. To assess potential indirect effects of the azithromycin and referral price reductions on prescribing practices at pharmacies that are not directly enrolled in the trial. The unit of analysis will be at the site level (surrounding pharmacies and clinics).
USA 2026-08-24 13:33:45 2029-08-24 Social Science and Humanities Non-Clinical Trial Non-degree Award
Richard Ezinga
ID: UNCST-2025-R019501
Gene Fusion-Associated Splicing Alterations, and Transcript Isoform Diversity in Acute Lymphoblastic Leukemia Patients
REFNo: HS7887ES

I. To map existing evidence on gene fusion-associated alternative splicing events, transcript isoform alterations, and analytical approaches in Acute Lymphoblastic Leukemia.
II. To identify and characterize recurrent gene fusion-associated splicing alterations and transcript isoform diversity in public ALL RNA-Seq datasets and selected eligible ALL sequences from the Uganda Cancer Institute.
III. To determine the predicted functional consequences of recurrent gene fusion-associated transcript isoforms on protein-domain architecture, molecular interaction networks, and oncogenic pathway dysregulation in Acute Lymphoblastic Leukemia Patients.
IV. To develop and validate a Nextflow-based hybrid computational pipeline for cross-platform confirmation of gene fusion-associated splicing and transcript alterations in Acute lymphoblastic leukemia.

Uganda 2026-08-24 13:30:18 2029-08-24 Medical and Health Sciences Non-Clinical Trial Degree Award
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