Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Alex  Muganzi Muganga
ID: UNCST-2019-R000710
Project Evaluation Protocols for Kampala Region mechanism
REFNo: HS553ES

Evaluation Objective 1: To evaluate the targeted HTS models to improve earlier identification of HIV positive and negative individuals, and Linkage of PLHIV in community and facility sites in scale up districts and linkage and promotion of HIV prevention among HIV negative individuals.

Evaluation Objective 2: To evaluate innovative approaches that increase adherence, ART retention and viral load suppression among adult and pediatric HIV clients.

Evaluation objective 3: To determine if there is improved identification of TB infected individuals., effective scale up of comprehensive TB/HIV services at individual sites site, and progress towards reduction of TB burden among HIV/TB co-infected clients within the CDC supported regions and districts.

Evaluation objective 4. To evaluate innovative PMTCT & HEI approaches that increase identification of HIV positive and syphilis infected pregnant & breastfeeding women (PBFW), enhance immediate ART uptake, adherence and retention, viral load suppression and syphilis treatment among PBFW, reduce MTCT rates of HIV & Syphilis and ensure documentation of 18 month final outcome status for all HIV Exposed infants.

Evaluation objective 5: To evaluate innovative interventions that are designed to improve data quality and data utilization for program evidence-based decision making at facility and district level.

Evaluation objective 6 : To determine if there was increase access of comprehensive OVC services.

Evaluation objective 7: To determine if the strengthening of the existing laboratory network and its quality management systems increased the ART initiation and ART monitoring at facility and district level.

Evaluation Objective 8: To determine if the relationship between district level performance reviews and HR performance had an effect on district performance including access, coverage, retention and loss to follow up.

Evaluation objective 9: To determine if Kampala region mechanism approaches resulted in increased coverage with voluntary medical male circumcision.


Uganda 2020-03-12 2023-03-12 Medical and Health Sciences Non-degree Award
Anthony Makhoba
ID:
MODELING A BCG BIRTH DOSE VACCINATION PROGRAM FOR IMPROVED HEPATITIS B CONTROL IN UGANDA
REFNo: HS415ES

1. To determine the rate of BCG birth dose vaccination among newborns at St. Francis Hospital Nsambya and Mbarara Regional Referral Hospital.
2. To determine the time to BCG vaccination among newborns at St. Francis Hospital Nsambya and Mbarara Regional Referral Hospital
3. To establish reasons for missed/delayed BCG vaccination among newborns at St. Francis Hospital Nsambya and Mbarara Regional Referral Hospital and to propose means of improvement.
4. To document the human costs of birth dose vaccination i.e. the nurse time required to obtain maternal consent, to draw up and administer the vaccine and complete the immunization record.

Uganda 2020-03-11 2023-03-11 Medical and Health Sciences Non-degree Award
Sudi Mohamed Ali
ID:
Cervical Cancer: Late presentation and associated factors at Mbarara Regional Referral Hospital.
REFNo: HS485ES

1. To determine the proportion of women with cervical cancer that presents late at Mbarara Regional Referral Hospital. 2. To determine the factors associated with late presentation among women with cervical cancer at Mbarara Regional Referral Hospital. 3. To explore the factors associated with health care seeking from onset of symptoms to diagnosis among women with cervical cancer at Mbarara Regional Referral Hospital.
Kenya 2020-03-11 2023-03-11 Medical and Health Sciences Degree Award
Richard  Muhumuza
ID:
INTEGRATED PREVALENCE MAPPING OF SCHISTOSOMIASIS AND SOIL TRANSMITTED HELMINTHIASIS AMONG COMMUNITIES IN MAYUGE DISTRICT: IMPLICATIONS FOR NTD ELIMINATION PROJECT 2019-2021
REFNo: HS434ES

2. Study objectives
2.1 General objective/Goal
The establish the prevalence of Schistosomiasis and STH infections among school going children and surrounding communities in Mayuge district

Specific objectives
1. To build capacity of Laboratory assistants and technicians on sample (Stool) collection and microscopic analysis
2.To collect sample (Stool) collect from the selected schools
3. To conduct Microscopic analysis for collected samples


Uganda 2020-03-09 2023-03-09 Medical and Health Sciences Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
Assessment of Public Knowledge, Attitudes, and Practices Related to Ebola Virus Disease Prevention and Treatment in Uganda
REFNo: HS531ES

1. Measure district-level estimates in six districts in Uganda of the public’s knowledge, beliefs, attitudes, and practices related to Ebola Virus Disease (EVD) risks due to the ongoing and widespread EVD outbreak in DRC; and
2. Identify socio-behavioral and health system barriers that may hinder the containment of an EVD outbreak in Uganda given the complex socio-political and security context of the protracted outbreak in neighboring DRC.

Nigeria 2020-03-09 2023-03-09 Medical and Health Sciences Non-degree Award
REBECCA NANTANDA
ID: UNCST-2019-R001533
Improving neonatal outcomes through early detection and management of hypoxaemia: The role of routine pulse oximetry
REFNo: HS132ES

1.To evaluate the effect of routine pulse oximetry on neonatal outcomes in the first 24 hours of life. 2.To determine the utility of pulse oximetry compared to clinical signs in detection of hypoxaemia in neonates with possible serious bacterial infections at lower level facilities 3.To assess the feasibility and acceptability of routine pulse oximetry by healthcare workers and caretakers of newborn babies. 4.To determine the cost-effectiveness of routine pulse oximetry in identifying neonates with hypoxaemia. 5.To describe the maternal factors that predict hypoxaemia in the newborn babies
Uganda 2020-03-06 2023-03-06 Medical and Health Sciences Non-degree Award
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
Advancing Tissue and Organ Biobanking in Uganda
REFNo: HS572ES

General objective: To establish a tissue and organ biobank at Makerere University to serve as a catalyst for research in organ collection, biobanking and transplantation in Uganda.
Specific Objective :
1. To train personnel and develop standard operating procedures for collection, processing and storage of human ova, sperm and umbilical cord blood.
2. To collect, process and store human ova, sperms and umbilical cord blood.
3. To develop a publicly accessible catalog of HLA typed viable human tissue and organs.
4. To explore the ethical, legal and societal issues (ELSI) in human tissue and organ biobanking

Uganda 2020-03-03 2023-03-03 Medical and Health Sciences Non-degree Award
ROSE ATIM
ID:
Law, Culture and Reality: Women Navigating Post Conflict Marital Relations in Northern Uganda
REFNo: SS423ES

1. Investigate the legal implication of the institution of marriage on women born in internally displaced peoples camps and victims of sexual violence of the LRA conflict;
2. Interrogate if cohabitation as an alternative to ‘legal’ marriage is becoming institutionalized among women born in internally displaced peoples camps and victims of sexual violence of the LRA Conflict;
3. Analyse the effectiveness of legal and informal marital protection mechanisms in a post conflict society;
4. Interrogate the future of the law in customary marital unions.

Uganda 2020-03-03 2023-03-03 Social Science and Humanities Degree Award
Jackson Mukonzo
ID: UNCST-2021-R013916
SAFETY AND EFFICAY OF DOLUTEGRAVIR AND EFV 400 FOR PREGNANT AND BREAST FEEDING WOMEN; A RANDOMISED NON INFERIORITY CLINICAL TRIAL ACRONYM: PREGART
REFNo: HS515ES

PRIMARY OBJECTIVE; to identify safer and more effective ART regimen for pregnant and breast feeding women by comparing three alternative first line ART regimens for their safety and efficacy using randomized clinical trial.

SECONDARY OBJECTIVE; To provide evidence based recommendations for safe and effective first line ART regimens for prevention of mothers to child transmission and treatment of HIV infected pregnant and breast feeding women living in resource limited setting.

Uganda 2020-02-25 2023-02-25 Medical and Health Sciences Non-degree Award
Coleen Sabatini
ID: UNCST-2019-R001321
Outcomes Following Surgical Release of Gluteal Fibrosis in Children of Eastern Uganda
REFNo: HS561ES

This study is a longitudinal case series to evaluate if surgical release of gluteal fibrosis in Ugandan children has a sustained benefit. We will examine the two-year outcomes after surgical release of gluteal fibrosis in children undergoing surgical intervention for gluteal fibrosis.

USA 2020-02-25 2023-02-25 Medical and Health Sciences Non-degree Award
NAASSON TUYIRINGIRE
ID:
Metabolomics Approaches to Elucidate the Mechanisms of Action of Antimycobacterial Medicinal Plants
REFNo: HS422ES

The main objective is to elucidate the mechanisms of action of antimycobacterial medicinal plants using metabolomics. The specific objectives are:
1. To determine the metabolome of M.tb subjected to medicinal plant extracts with antimycobacterial activity as compared to control culture
2. To optimize an analytical metabolomics workflow to facilitate reproducible measurements of bacterial metabolome with extract treatment or without the treatment
3. To elucidate the metabolic pathways affected by plant extracts
4. To identify the macromolecule targets of plant extracts

Rwanda 2020-02-21 2023-02-21 Medical and Health Sciences Degree Award
Jean Damascene Niyonsenga
ID:
Exercise and well-being: NCD risks and constraints to Physical Activity and sports participation among Ugandan rural and urban secondary school students
REFNo: HS490ES

1. To examine the correlation between NCDs risk factors and level of physical activity/sports participation, type of eaten food, and lung function among both rural and urban secondary school students in Mbarara, uganda
2. To establish constraints to PA/sports participation of secondary school students in rural and urban schools in Mbarara, Uganda.
3. To examine the relationship between internal motivation and external support for PA/sports participation for secondary school students in rural and urban schools of Mbarara, Uganda.
4. To determine the commonest sustained injuries and to establish the proportion attributable to PA/sports among rural and urban secondary school students in Mbarara, Uganda.
5. To compare constraints and injuries identified by secondary school students from rural and urban schools in Mbarara, Uganda.

Rwanda 2020-02-21 2023-02-21 Medical and Health Sciences Non-degree Award
Robert Kairania
ID:
Exploration of psychological distress and cross-cultural adaptation of a mental health measure for people living with HIV in Rakai, Uganda
REFNo: SS408ES

Aim 1: To characterize local manifestations of psychological distress among people living with HIV in rural communities in Rakai, Uganda

Aim 2: To identify and cross-culturally adapt appropriate mental health measurement instruments based on findings from Aim 1.

Aim 3: To validate the adapted mental health measurement instrument within the rural Rakai population.

Uganda 2020-02-21 2023-02-21 Social Science and Humanities Non-degree Award
Vincentina Achora
ID:
Postpartum haemorrhage in Northern Uganda: Community perspectives; burden and associated factors; Health Facilities preparedness for its management; and outcomes
REFNo: HS518ES

1. To explore the community perspectives of PPH in Lira district.
2. To assess the level of health facilities preparedness for management of labour, delivery and postnatal care in prevention of PPH in Lira district.
3. To describe the burden and factors associated with PPH among mothers delivering in Lira district and Lacor Referral hospital.
4. To describe the factors associated with outcomes of PPH among mothers delivering in Lira district and Lacor Referral hospital.

Uganda 2020-02-21 2023-02-21 Medical and Health Sciences Degree Award
Maria Nakku Elizabeth Mirembe
ID:
Women in Higher Education: An Ethnographic Case Study of Women Lecturers and Administrator Experience in Selected Universities in Uganda
REFNo: SS410ES

1. To investigate how women lecturers and administrators advance the institutional mission of teaching, scholarship, and service in selected universities in Uganda
2. To explore how the culture of higher education shape and affect women leadership
3. To examine the obstacles and challenges do women experience as lecturers and administrators in higher education
4. To assess common attributes and strategies support women’s success in higher education teaching and administration in Uganda


Uganda 2020-02-21 2023-02-21 Social Science and Humanities Degree Award
Lawrence Mugisha
ID:
Developing Monitoring System for Quantifying and Mapping Antimicrobials used in Livestock Farming Systems in Uganda
REFNo: HS538ES

1. To determine the proportions of different types of antimicrobials imported into Uganda for use in livestock production systems.
2. To determine the volumes of antimicrobial medicines imported into Uganda for use in livestock production systems.
3. To map and create an inventory of manufacturers, importers, distributors and medicine stockists of antimicrobials used in livestock production systems in Kampala, Wakiso and Mukono districts.
4. To develop an information technology (IT) monitoring system for monitoring importation, distribution and consumption of antimicrobials used in livestock production systems

Uganda 2020-02-21 2023-02-21 Medical and Health Sciences Non-degree Award
Herbert Muyinda
ID: UNCST-2019-R000373
Cango Lyec (Healing the Elephant) Study: Determining HIV Vulnerabilities and Designing Targeted Interventions to Improve Clinical outcomes among conflict affected Adolescent girls and young women under 25 in Northern Uganda
REFNo: HS521ES

1. Estimate prevalence and incidence of HIV, Hepatitis B, and syphilis, and identify associated risk factors among conflict-affected young women in Northern Uganda

2. Investigate associations between posttraumatic stress, resilience, and depression with HIV incidence among conflict-affected young women in Northern Uganda

3. Pilot feasibility and acceptability of comprehensive mHealth package to support engagement in HIV care among conflict-affected young women living with HIV in Northern Uganda

Uganda 2020-02-19 2023-02-19 Medical and Health Sciences Non-degree Award
Dathan  Byonanebye Mirembe
ID:
Impact of Mobile Health Interactive Software on Tuberculosis Treatment Outcomes: The Call for Life (CFLU-TB) Project
REFNo: HS524ES

To determine the effect of CFLU-TB on TB treatment success (treatment completion and cure rates) in patients with TB receiving care at three public health facilities in Uganda.
1. To compare TB cure rates (six months) in patients with microbiologically diagnosed TB in the intervention and control arms.
2. To compare treatment completion (six months) in patients clinically diagnosed with TB in the intervention and control arms.
3. To determine the effect of enhanced TB treatment support with CFLU-TB on retention at 2 and 6 months in patients receiving TB treatment at Kisenyi Health Center IV.
4. To assess perception of patients’ care providers (treatment buddies) and other stakeholders towards the CFLU-TB.
5. To determine the cost-effectiveness of the CFLU-TB intervention.
6. To compare adherence rates between patients in the intervention arm and control arms.
7. To determine the effect of CFLU-TB on adherence to clinic appointments.
8. To compare knowledge about TB/HIV in patients enrolled in the intervention and control arms.
9. To determine Drug-resistant TB rates in the intervention and control arms.
10. To determine the uptake of the CFLU-TB tool in patients and their care providers (treatment buddies).


Uganda 2020-02-19 2023-02-19 Medical and Health Sciences Non-degree Award
Fredrick Mutungi
ID:
CONTEXT-FITTING MOBILE SERVICES FOR MONITORING THE DELIVERY OF PUBLIC HEALTH SERVICES
REFNo: SIR20ES

1. To identify the performance indicators of mobile services for monitoring the delivery of public health services.
2. To establish the performance of existing mobile services used for monitoring the delivery of public health services.
3. To find out the contextual factors affecting the performance of mobile services for monitoring the delivery of public health services.
4. To design a model for guiding development of context-fitting mobile services for monitoring delivery of public health services.
5. To establish performance improvements anticipated with the use of context-fitting mobile services when monitoring the delivery of public health services.

Uganda 2020-02-19 2023-02-19 Engineering and Technology Degree Award
John Mark Bwanika
ID:
Utilization Of Telehealth (Tele-care) To Improve Post-Clinic Therapy For Youths with HIV and Depression- A Feasibility Study.
REFNo: HS539ES

-Design and develop mobile/web content for post-clinic telecare for young adult HIV patients with depression.

-Assess feasibility and acceptability of the telehealth intervention Package (Telecare) for depression among HIV young adult patients as well as their post-intervention self-efficacy.

Uganda 2020-02-19 2023-02-19 Medical and Health Sciences Non-degree Award
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