Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
JOAN KEMPANGO
ID:
“Assessment of Factors Associated with Acquisition of Clinical Competences Among Undergraduate Nursing Students in Ugandan Universities”
REFNo: HS639ES

1) To determine the involvement of clinical mentors in the undergraduate acquisition of clinical skills;
2) To investigate clinical mentors preparedness in facilitating undergraduate student’s clinical skills
3) To assess student perception of the learning environment in a clinical set-up among undergraduate nursing students in Uganda;
4) To identify the available learning resources for the acquisition of clinical skills among undergraduate nursing students in Uganda;
5) To establish the influence of institutional factors on competence acquisition by the undergraduate nurses in Uganda.
6) To establish the effect of student factors on clinical competence acquisition by the undergraduate nurses in Uganda.

Uganda 2020-10-22 2023-10-22 Medical and Health Sciences Degree Award
Mary  Nanteza Bridget
ID:
Does recombination of polio viruses with locally circulating enteroviruses play a role in acute flaccid paralysis and vaccine-derived polioviruses?
REFNo: HS770ES

1. General Objective
To identify polio mutations that are common to AFP, and cVDPV cases.

2. Specific Objective
i) To determine if polio/non-polio recombination has occurred in AFP cases
ii) To characterize primary recombination events in the polio virus genome that are associated with AFP, and
iii) To compare the recombination events common in AFP with published cVDPVs and characterize the events that could be common in VDPVs.

Uganda 2020-10-22 2023-10-22 Medical and Health Sciences Non-degree Award
Munshi Sulaiman
ID:
Evaluation of the Disability-Inclusive Ultra-Poor Graduation Programme (DIG) in Uganda
REFNo: SS529ES

1. To estimate the impact of the Ultra-Poor Graduation programme on poverty, livelihood and social participation of people with disabilities and their families, compared to controls who do not receive the intervention.
2. To estimate the impact of the Ultra-Poor Graduation programme on poverty, livelihood and social participation of people with disabilities and their families, compared to people without disabilities who received the intervention
Bangladesh 2020-10-22 2023-10-22 Social Science and Humanities Non-degree Award
Cristina Clerici
ID:
The Parallel Pandemic of Domestic Violence Against Women in Uganda: is the Lockdown to Blame?
REFNo: SS553ES

Our project seeks to study the relationship between IPV and the relative economic conditions of spouses in Uganda, by exploiting the implementation of COVID-19 containment measures as a source of exogenous variation in the woman's relative income.
Italy 2020-10-22 2023-10-22 Social Science and Humanities Degree Award
Pontiano  Kaleebu
ID: UNCST-2020-R019901
PERCEPTIONS OF HEALTHCARE WORKERS REGARDING LOCAL INFECTION PREVENTION AND CONTROL PROCEDURES FOR COVID-19
REFNo: HS867ES

Primary aim: To better understand health care worker perceptions of infection prevention and control procedures to prevent Covid-19 transmission.

Objectives:
1. To evaluate healthcare worker perceptions of their preparedness to ensure effective infection prevention and control of Covid-19 in healthcare settings, and to evaluate healthcare worker’s level of trust in their healthcare organization/facility.

2. To consider how these factors vary
a. Across age, staff role, and length of clinical experience;
b. Between respondents whose hospital is receiving suspected/ confirmed patients and those whose hospitals are not;
c. Between those who have direct experience of treating Covid-19 patients and those who have not.
d. Across different regions in the country that have dealt with other epidemics other than COVID19.
e. Between countries in different global regions where this survey is conducted.

Uganda 2020-10-22 2023-10-22 Medical and Health Sciences Non-degree Award
Imran Rasul
ID:
Firm Dynamics and Worker Resilience to the COVID-19 Shock in Uganda
REFNo: SS565ES

The overall objective of this prpject is to study the effects of the Covid-19 shock on SMEs and workers in Uganda. The study will aim at answering the following research questions:
1. What firm-level characteristics predict firm survival and growth in an expansionary business cycle? Do the same characteristics predict firm resilience to the shock of COVID-19?
2. How do markets evolve during periods of economic growth, in terms of the number of firms, firm size distribution, and level of competition? How does the COVID shock affect the structure and level of competition within markets?
3. How do different types of skills training affect workers’ resilience to the economic shock caused by COVID-19?

UK 2020-10-22 2023-10-22 Social Science and Humanities Non-degree Award
Fred Wabwire-Mangen
ID: UNCST-2021-R013549
Assessing the Burden of Asymptomatic SARS-COV-2 Infection among Patients Seeking Health Care at Health care facilities in Uganda
REFNo: HS889ES

To determine the prevalence of SARS-CoV-2 among a sample of patients seeking health care and HCWs at participating surveillance sites who do not meet the case definition for COVID-19.
Uganda 2020-10-22 2023-10-22 Medical and Health Sciences Non-degree Award
ANNETTEE NAKIMULI OLIVIA
ID: UNCST-2022-R011194
In-depth case study of large referral maternity wards in four countries in sub-Saharan Africa: a case study of Kawempe National Referral Hospital and Mulago Specialized Women and Neonatal Hospital in Uganda
REFNo: HS907ES

1) To document the preparedness and response to COVID-19 among large maternity/newborn wards in four countries in sub-Saharan Africa over time
2) To serve as a platform for exchange of information and experiences across the contexts studied.

Uganda 2020-10-22 2023-10-22 Medical and Health Sciences Non-degree Award
Joyce Kambugu Balagadde
ID: UNCST-2020-R014996
A regional approach to improved childhood cancer drug access in East Africa: Understanding access and coordinating procurement
REFNo: HS681ES

1. Undertake detailed institutional and health system data collection to obtain key metrics of drug availability and price in participating jurisdictions 2. Describe policies and practices related to childhood cancer drug procurement and provision in partner jurisdictions 3. Analyse the key determinants of childhood cancer drug access in the health system context 4. In partnership with national governments, establish agreements and mechanisms for coordinated procurement of essential childhood cancer medicines, based on evidence-based estimates of need.
Uganda 2020-10-21 2023-10-21 Medical and Health Sciences Non-degree Award
Brian Kanaahe Mwebaze
ID:
“Understanding And Addressing The Sexual Reproductive Health And Rights Needs Of Young Women And Girls In Humanitarian Settings In Nigeria And Uganda"
REFNo: SS611ES

1.Synthesize existing literature on the Sexual Reproductive Health and Rights challenges of young refugee women and girls, highlighting promising solutions and best practice service delivery models.
2.Conduct participatory, mixed methods formative research to generate evidence on the Sexual Reproductive Health and Rights knowledge and challenges of young women and girls in the target refugee settings.
3.Assess existing service provision models against global standards and best practice guidelines for adolescent/youth friendly Sexual Reproductive Health and Rights services in humanitarian settings with a comparison between refugees and Internally Displaced Persons (IDPs).
4.Support existing Sexual Reproductive Health and Rights initiatives in refugee camps in the target countries to use emerging evidence to improve advocacy for, demand for, and provision of Sexual Reproductive Health and Rights services for adolescent girls.
Uganda 2020-10-21 2023-10-21 Social Science and Humanities Non-degree Award
Harriet Mpairwe
ID: UNCST-2025-R017439
Psychosocial well-being and urbanisation among adults in Uganda: A pilot study
REFNo: HS831ES

1. To assess the feasibility of collecting data on psychosocial factors among adults in urban (Kampala) and rural (Mpigi and Wakiso) Uganda
2. To establish the hair cortisol concentration assay in our immunology laboratory
3. To assess the acceptability of scalp hair sample collection for research purposes

Uganda 2020-10-19 2023-10-19 Medical and Health Sciences Non-degree Award
Fred Ssewamala
ID: UNCST-2020-R014060
Suubi4STEM: A signature program to advance STEM education in Africa
REFNo: SS475ES

Objective 1. Test the feasibility, acceptability, and preliminary impact of innovative Suubi4STEM intervention in promoting educational STEM opportunities and life options for young people in Uganda.

Objective 2. Qualitatively examine participants’ and facilitators’ intervention experiences and identify individual, family and institutional-level facilitators and barriers to Suubi4STEM intervention implementation and participation. Objective 3. Evaluate the cost of implementing Suubi4STEM. Objective4. Disseminate program findings to promote the Suubi4STEM intervention on a larger scale

Uganda 2020-10-16 2023-10-16 Social Science and Humanities Non-degree Award
Mandela Wangoola Robert
ID:
FACTORS INFLUENCING TRYPANOSOMA BRUCEI RHODESIENSE STABILITY IN CATTLE RESERVOIR IN LANGO SUB REGION
REFNo: NS135ES

General Objective
• Evaluate the factors influencing Trypanosoma brucei rhodesiense infections persistence and stability in the cattle reservoir in Lango sub region
Specific objectives
(i) To determine the prevalence of bovine trypanosomiasis in Lango sub region.
(ii) Assess the stability of T. b rhodesiense in naturally infected cattle in Lango sub region
(iii) Evaluate risk factors leading to continued cattle trypanosomiasis infection in Lango sub region

Uganda 2020-10-16 2023-10-16 Natural Sciences Degree Award
Sara Nsibirwa
ID: UNCST-2021-R012889
Antimicrobial resistance in trauma and burn patients with blood stream or wound infections – an observational cohort study from Kampala, Uganda
REFNo: HS815ES

The primary aims:
• To determine the prevalence of blood stream due to specific bacterial and fungal pathogens resistant to first choice empirical treatment in trauma and burn patients.
• To determine the prevalence of wound infections due to bacterial and fungal pathogens resistant to first choice empirical treatment in trauma and burn patients
The secondary aims:
• To describe the proportion of burns and trauma patients requiring a switch of antibiotic or antifungal treatment following wound swab and blood culture results.
• To describe the clinical outcomes of trauma and burn patients with blood stream and wound infections due to bacterial and fungal pathogens resistant to first choice empirical treatment
• To identify risk factors for the development of wound and blood stream infections due to resistant bacterial and fungal pathogens among trauma and burn patients.


Uganda 2020-10-15 2023-10-15 Medical and Health Sciences Non-degree Award
Emmanuel Gusango Humphrey
ID:
Constructivist informed teaching and preparation of students in Primary Teachers Colleges of South Eastern Region in Uganda
REFNo: SS498ES

i. Explore the constructivist principles used in the instruction of students in Primary Teachers Colleges.
ii. Examine the constructivist practices applied to the school practice supervisory process in Primary Teachers Colleges.
iii. Examine the implementation of coaching in the preparation of students’ professional growth.

Uganda 2020-10-14 2023-10-14 Social Science and Humanities Degree Award
Robert Tweyongyere
ID:
Optimizing SMART Dairy Technologies for Efficient Sustainable Productivity of Dairy Farmers in Uganda
REFNo: A80ES

Specific objectives
1. Determine the dairying problems and constraints, current solution options and priority list of solutions which are gender sensitive across age and space.
2. Determine the dairy farmers’ cattle feeding and breeding practices in the milk sheds of Uganda
3. Determine local feed ingredients nutrient profile for optimal dairy feed ration formulation
4. Develop a farmers’ community based breeding program
5. Increase Farmers’ access to elite genetics by artificial breeding technologies (artificial insemination(AI) and Embryo transfer(ET))
6. Determine the nutritional-metabolic profiles among the dairy cattle in selected DaFaN clusters to Optimize cost-effective forage production, preservation and utilization
7. Determine animal health and breeding profile parameters generated by ruminal or collar sensor technology for effective monitoring of individual animals on farms in Uganda

Uganda 2020-10-14 2023-10-14 Agricultural Sciences Non-degree Award
Robert Newton Edward
ID: UNCST-2023-R006537
Community surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and of coronavirus disease-2019 (COVID-19) in high risk and general populations.
REFNo: HS823ES

1. To measure the changing incidence and prevalence of SARS-CoV-2 over time and, associated mortality. 2. To assess the impact of co-morbidities on acquisition and survival of SARS-CoV-2. 3. To examine in greater depth the public understanding of COVID-19 and the experience of the surveillance exercise.
UK 2020-10-14 2023-10-14 Medical and Health Sciences Non-degree Award
Robert Tweyongyere
ID:
EFFECTIVENESS OF ANTHELMINTICS IN CATTLE AND GOATS IN MIXED FARMING COMMUNITIES IN MBARARA, KIRUHURA SEMBABULE AND NAKASONGOLA DISTRICTS
REFNo: A83ES

General Objective:
To assess effectiveness of dewormers and generate information that would support decision on improving management of anthelmintics in Uganda

Specific objectives:
1. To document the knowledge, attitude and deworming practices of selected livestock farmers in Mbarara, Kiruhura, Sembabule and Nakasongola districts
2. Determine the worm burden among cattle and goats on the selected farms
3. To determine the ‘clinical efficacy’ of five identified dewormers commonly available to the farmers

Uganda 2020-10-14 2023-10-14 Agricultural Sciences Non-degree Award
Simon Peter Kibira Peter Sebina
ID: UNCST-2019-R000492
Improving quarantine in Uganda as a key measure to combat COVID-19: Compliance, experiences, gaps and opportunities
REFNo: HS832ES

1. To determine compliance with COVID-19 quarantine measures among self and institutional quarantined persons in Uganda.

2. To determine factors associated with compliance with COVID-19 quarantine measures among self and institutional quarantined persons in Uganda.

3. To explore experiences and coping mechanisms among self and institutional quarantined persons in Uganda.

4. To identify gaps in the management and opportunities for improvement of the quarantine process in Uganda.
 

Uganda 2020-10-14 2023-10-14 Medical and Health Sciences Non-degree Award
Victoria Nankabirwa
ID: UNCST-2021-R011871
A multicenter, phase III, double-blind, randomised, active-controlled study to evaluate the efficacy and safety of VPM1002 in comparison to BCG in prevention of Mycobacterium tuberculosis infection in newborn infants
REFNo: HS838ES

Primary objectives
1. To demonstrate that VPM1002 is non-inferior to BCG SII in providing protection against incident Mtb infection
2. To demonstrate that vaccination with VPM1002 is superior to BCG SII in providing protection against incident Mtb infection

Secondary objectives
1. To compare the safety and tolerability profile of VPM1002 and BCG SII administered as a single dose to newborn infants
2. To compare the protective efficacy of VPM1002 versus BCG SII against TB disease
3. To compare the protective efficacy of VPM1002 versus BCG SII against sustained Mtb infection

Exploratory objectives
1. To evaluate the immunological response to vaccination with a single dose of VPM1002 compared to BCG SII in a subset (immunogenicity cohort) of HIV-exposed and HIV-unexposed newborn infants in terms of the following parameters:
o Concentration of Interferon (IFN)-γ in the supernatant after antigen re-stimulation as determined by ELISA
o CD4+ and CD8+ T-cells after antigen stimulation as determined by Fluorescence-activated cell staining/Intracellular cytokine staining (FACS/ICS)
o Transcriptomics
o Antibody production
2. To evaluate occurrence of QuantiFERON® Gold Plus In-tube test (QFT) conversion, where conversion is defined using alternative QFT thresholds (e.g. > 4 IU/ml); and sustained QFT conversion, where sustained conversion is defined as QFT ≥ 4IU /ml maintained for approximately 6 months following initial QFT conversion, compared across trial arms in all participants.
3. To determine the mortality rate in children receiving VPM1002 compared to BCG SII

Uganda 2020-10-14 2023-10-14 Medical and Health Sciences Non-degree Award
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