Irene Vries de
ID: UNCST-2024-R003372
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A pilot Study for introducing a Point of Care Ultrasound (POCUS) device (Baby Checker), supported by Artificial Intelligence (AI), in peri-urban UgandaVersion 1.3 August
REFNo: SS3581ES
Objective and Research Questions
The objective of this research is to assess the technical performance and health outcomes resulting from the introduction of the BabyChecker device in peri-urban Uganda. Specifically, the study aims to evaluate its impact on enhancing timely ANC, including routine care and referrals, thereby potentially reducing maternal and perinatal morbidity and mortality rates. This evaluation will inform developers and implementers on the effective and responsible deployment of the BabyChecker Point-of-Care Ultrasound Scan (POCUS).
2.1 Research Questions per Component
A. Technical Performance
Health Worker performance research questions:
1. What is the initial scanning performance of health workers by cadre on their first day of using BabyChecker?
2. What is the average scanning performance over the study period for health workers by cadre (e.g., certificate, diploma, degree nurses, midwives, clinical officers)?
3. Is there a correlation between the average scanning performance of health workers and their cadre or years of experience?
4. How much time do health workers require to navigate the BabyChecker application and complete a scan on their first day?
5. What is the average time required by health workers to navigate the BabyChecker application and complete a scan over the study period?
6. How well is the BabyChecker equipment maintained throughout the study period?
Artificial Intelligence (AI) research questions:
1. What is the specificity and sensitivity of BabyChecker's AI in estimating gestational age during the first and second trimesters?
2. What is the specificity and sensitivity of BabyChecker's AI in identifying non-cephalic fetal presentation and low placental localization or placenta previa during the third trimester (36+ weeks)?
B. Health Effectiveness
The hypothesis posits that the introduction of BabyChecker will increase ANC attendance during the first trimester and improve access to imaging services, leading to early detection of risk factors and subsequent referrals. The study focuses on observing changes in ANC attendance, risk factor identification, and referral initiation as direct outcomes of the POCUS intervention.
Health Effectiveness of BabyChecker (AI + Remote Read Results) research questions:
1. Does the introduction of the BabyChecker and other VHE community interventions contribute to an increase in pregnant women first attending ANC during the first trimester?
2. Does the introduction of the BabyChecker and mobilization contribute to an increase in pregnant women that come for the 8th ANC visits?
3. Does the introduction of BabyChecker contribute to an increased overall number of ANC visits?
4. Does the introduction of BabyChecker increase the detection rate of pregnancy risk factors such as multiple pregnancies, placenta previa, breech presentation, or non-longitudinal fetal positions?
5. Does the introduction of BabyChecker increase referrals for multiple pregnancies, placenta previa, breech presentation, or non-longitudinal fetal positions?
6. Do women follow through on referrals, and do these referrals lead to improved health outcomes among women in the private sector?
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Netherlands |
2025-03-14 18:58:29 |
2028-03-14 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Isaac Mugwano
ID: UNCST-2024-R002967
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IMMEDIATE AND LONG TERM OUTCOMES OF PATIENTS WITH SEVERE MITRAL STENOSIS UNDERGOING BALLOON MITRAL VALVULOPLASTY (BVM) AT THE UGANDA HEART INSTITUTE.
REFNo: HS5507ES
1. To describe the immediate (post-operative) outcomes of patients who underwent BMV at UHI during the study period.
2. To describe the long term (1 year and 5 year) outcomes of patients with severe mitral stenosis who underwent BMV at Uganda heart institute during the study period.
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Uganda |
2025-03-14 18:51:15 |
2028-03-14 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Fiona Nakabugo Kabuuka
ID: UNCST-2024-R003631
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UTILIZATION AND DETERMINANTS OF HIV TESTING AND COUNSELING SERVICES AMONG YOUTH IN KAWAALA VILLAGE, LUBAGA PARISH, LUBAGA DIVISION
REFNo: HS5339ES
To assess the health-facility determinants influencing the utilization of HIV Testing and Counseling services among youths in Kawaala village, Lubaga Parish, Lubaga Division in May 2024.,To assess the environmental related determinants influencing the utilization of HIV Testing and Counseling services among among youths in Kawaala village, Lubaga Parish, Lubaga Division in May 2024.,To determine the individual determinants influencing the utilization of HIV Testing and Counseling services among youths in Kawaala village, Lubaga Parish, Lubaga Division in May 2024.,To determine the level of utilization of HIV Testing and Counseling services among youths in Kawaala village, Lubaga Parish, Lubaga Division in May 2024.,To assess the utilization and determination of HIV testing and Counseling services youths in Kawaala village, Lubaga Parish, Lubaga Division in Kampala District in May 2024.,
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Uganda |
2025-03-14 18:37:36 |
2028-03-14 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Murezi Mereth
ID: UNCST-2023-R007640
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Effects of Lifestyle and Environmental Change on the Human Epigenome
REFNo: HS5243ES
To advance our understanding of the epigenomic mechanisms that mediate the acclimatization to major transitions in lifestyle and environment to understand how populations adapt, both in the past and in the future.
Characterize how extreme lifestyle and environmental transitions affect patterns of gene regulation.
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Uganda |
2025-03-14 18:36:41 |
2028-03-14 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Joyce Kambugu Balagadde
ID: UNCST-2020-R014996
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International classification, cancer and care: Accounting for the diagnostic potential of low- and middle-income countries
REFNo: SS3561ES
NOTES: The overall project is guided by three research questions, given here with their related objectives. Specific objectives for research activities in Uganda are also described.
RESEARCH OBJECTIVE 1: What are the “on-the-ground realities” of brain tumour diagnosis and care in Sub-Saharan Africa and how does diagnostic practice in brain tumours differ across the region?
OBJECTIVE 1: To develop three detailed empirical case studies of diagnostic work and brain tumour care in Uganda, Nigeria and South Africa that are embedded in understandings of care23, national policy, socio-technical infrastructures, and international classification.
OBJECTIVE 2: To compare empirical case studies to develop rich understandings of how practitioners in Sub-Saharan Africa use, refuse, or adapt WHO classifications, or mobilise to establish their own terms of reference.
OBJECTIVE 3: To generate critical perspectives on diagnostic value, where diagnosis might not be assumed an essential condition of good care.
RESEARCH QUESTION 2: How are the diagnostic contexts of LMICs considered by experts writing international cancer classifications?
OBJECTIVE 4: To examine how international cancer classifiers understand diagnostic approaches and infrastructures in LMICs.
OBJECTIVE 5: To examine the individual values and institutional principles that guide how classifiers consider these approaches in their decision-making about cancer classification.
RESEARCH OBJECTIVE 3: How are local medical practitioners, cancer advocates, and international organisations mobilising in a regional network to improve brain tumour outcomes across Sub-Saharan Africa?
OBJECTIVE 6: To explore how local medical practitioners, advocates, and international organisations in Sub-Saharan Africa are collaborating in a new professional network, Society for Neuro-Oncology Sub-Saharan Africa (SNOSSA), to improve brain tumour diagnosis and care across Sub-Saharan Africa.
OBJECTIVE 7: To examine how members understand unity and diversity among Sub-Saharan African countries, and establish common aspirations and strategies concerning diagnosis and classification.
OBJECTIVE 8: To explore how members understand their work on a disease which is considered rare, yet its true incidence unknown, and which is de-prioritised in national and international funding.
The specific research objective for research conducted in Uganda is to develop a thorough ethnographic understanding of how brain tumour diagnosis happens in practice; how diagnostic work relates to local sociotechnical infrastructure, national policy, and international classification; and how diagnosis relates to care and treatment decision-making.
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Uganda |
2025-03-14 18:29:40 |
2028-03-14 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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