Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
STEVEN SEBBALE
ID: UNCST-2023-R006063
 PARTICIPATION OF FEMALE DOCTORATE HOLDERS IN SCIENCE, TECHNOLOGY AND INNOVATION: AN EXAMINATION ON GENDER EQUITY, INCLUSIVITY AND INTERSECTIONALITY IN UGANDA
REFNo: SS3712ES

a) To examine the demographic and professional characteristics of female doctorate holders in Uganda
b) To assess the intersectional challenges faced by female doctorate holders in Uganda
c) To provide data-driven insights for integrating intersectionality into UNCST’s grants system
 Uganda 2025-03-18 13:09:22 2028-03-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Richard Wismayer
ID: UNCST-2019-R000483
 The microbiome as an aetiological factors in colorectal carcinoma in Ugandan patients
REFNo: HS5644ES

1. To investigate the frequency of carriage of faecal P. micra in Ugandan CRC patients and controls by 16S rRNA sequencing and PCR and assess its potential as a non- invasive biomarker compared to other bacteria (Study 1).

2. To explore the associations of P.micra and F.nucleatum, the general tumour microbiome, the intra-tumour immune response and the tumour MSI status within the tumour itself. P.micra and F.nucleatum will be determined by PCR, the tumour microbiome by 16S rRNA sequencing and the tumour immune response both pathologically and by the numbers of infiltrating lymphocytes a key prognostic marker. MSI and MSS status will also be identified (Study 2).

3. To analyse the bacterial content of faeces using 16S rRNA sequencing in relation to the clinical features and MSI/MSS status of CRC in Ugandan patients and controls using network analysis in Ugandan patients. To identify bacteria positively and negatively associated with Ugandan bowel cancer carriage (Study 3).

4. To determine the prevalence of cancer related stool toxins, pks, FadA, and ETBF in Ugandan colorectal cancer patients and controls using quantitative PCR assays on faeces (Study 4).

5. To compare the above findings with those of CRC patients and controls from the international microbiome network in Ghana, India, Vietnam, Argentina and England (Study 5).

 Malta 2025-03-18 13:03:54 2028-03-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Shahiid Kiyaga
ID: UNCST-2021-R007055
 Genetic Diversity and Transmission Intensity Heterogeneity of Plasmodium falciparum in Malaria Endemic Regions in Uganda
REFNo: HS5697ES

General Objective
To analyze the genetic diversity of P. falciparum and the heterogeneity in malaria transmission intensity in high-endemic areas of Uganda.
Specific Objectives
1. To assess the genetic diversity and population substructure of P. falciparum in high endemic areas of Uganda by quantifying allelic variation and estimating population structure parameters using F_ST (fixation index) and principal component analysis (PCA).
2. To characterize the heterogeneity in transmission intensity in high endemic areas of Uganda using P. falciparum targeted amplicon genomic data and malaria epidemiological parameters.
3. To develop and apply advanced machine learning models to predict geographical origins of P. falciparum parasites in Uganda using whole-genome sequence data.
 Uganda 2025-03-14 19:14:47 2028-03-14 Medical and Health Sciences Non-Clinical Trial Degree Award
Racheal Ninsiima
ID: UNCST-2020-R014564
 Effect of blockchain technology on the performance of barley farmers in eastern Uganda
REFNo: A536ES

i) To determine farmers’ behavioural intention to accept BCT in Uganda’s eastern barley producing region.
ii) To examine the factors that influence adoption and extent of use of BCT among barley farmers in eastern Uganda.
iii) To determine the effect of BCT on barley farmers’ productivity and gross margin in eastern Uganda
iv) To develop suitable BCT implementation framework among barley farmers in eastern Uganda.

 Uganda 2025-03-14 19:13:35 2028-03-14 Agricultural Sciences Non-Clinical Trial Degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 SURVEY, SAFETY AND EFFICACY OF HERBAL PRODUCTS USED FOR MALARIA PROPHYLAXIS AND TREATMENT IN UGANDA.
REFNo: HS5468ES

To conduct a survey of herbal medicinal products used for malaria prophylaxis and treatment, evaluate their safety and prophylactic efficacy among school-age children (8-15yrs) in Kibuku district, Uganda.
1. To identify herbal medicinal products used by communities for malaria prophylaxis and treatment in Uganda.
2. To evaluate the artemisinin content of herbal medicinal products used by communities for malaria prophylaxis and treatment in Uganda.
3. To determine the antiplasmodial activity (IC50) of herbal medicinal products used for malaria prophylaxis and treatment in Uganda.
4. To evaluate the safety of herbal medicinal products used for malaria prophylaxis among school age children (8-15 years) in Kibuku district in eastern Uganda.
5. To determine malaria incidence among school age children (8-15 years) receiving selected herbal medicinal products for malaria prophylaxis compared to monthly Dihydroartemisinin-Piperaquine (DP) in Kibuku district in eastern Uganda.
6. To determine prevalence of parasitaemia among school age children (8-15 years) receiving selected herbal medicinal products for malaria prophylaxis compared to monthly Dihydroartemisinin-Piperaquine (DP) in Kibuku in eastern Uganda.

 Uganda 2025-03-14 19:08:33 2028-03-14 Medical and Health Sciences Clinical Trial Non-degree Award
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