Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Winfred  Tugumisirize
ID:
Participatory Budgeting and Financial Sustainability in the Local Government in Uganda: A Case Study of Kabale District
REFNo: SS2353ES

4. To establish the relationship between participatory budgeting and financial sustainability in Kabale District Local Government.,3. To assess the relationship between budget implementation and financial sustainability in Kabale District Local Government.,2. To analyze the impact of budget approval on financial sustainability in Kabale District Local Government.,1. To examine the influence of budget formulation on financial sustainability in Kabale District Local Government . ,The main objective of the study is to examine the relationship between participatory budgeting and financial sustainability of Local Governments in Uganda.,
Uganda 2024-02-26 13:47:53 2027-02-26 Social Science and Humanities Non-Clinical Trial Degree Award
LILLIAN BYERETA HAPPY
ID: UNCST-2021-R012144
To utilize simplified instruments for geriatric assessment for specialized routine care of Old People Living with HIV (HIV –OLD, HOPE)
REFNo: HS3704ES

2. To evaluate the feasibility of self-collection (with the support of a research assistant) through tablets of simplified validated tools for Quality of life, Instrumental activities of daily living (IADL), history of falls, screening for depression, and incontinence. 1. To utilize simplified instruments for geriatric assessment of OPLWH which can be potentially scaled up in routine care, particularly for the assessment of frailty, sarcopenia , physical and cognitive function. ,The overall goal of the proposal is to validate simplified tools for specialized routine care of OPLWH. ,
Uganda 2024-02-26 13:45:25 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kamoga Ronald
ID: UNCST-2019-R001524
VAGUS NERVE STIMULATION IN A RAT MODEL OF ALZHEIMER’S DISEASE-LIKE SYMPTOMS: MORPHOLOGICAL, IMMUNOHISTOCHEMICAL, MOLECULAR AND BEHAVIORAL CHANGES
REFNo: HS3781ES

1. To conduct a scoping review of literature on vagus nerve stimulation in Alzheimer's-disease and related dementias.
2. To determine behavioral changes associated with vagus nerve stimulation in a rat model of Alzheimer-like symptoms.
3. To evaluate the morphological, Immunohistochemical and molecular changes in the Hippocampus, prefrontal cortex and medial temporal cortex associated with chronic stimulation of the vagus nerve in a rat model of Alzheimer’s-like disease.

Uganda 2024-02-26 13:43:22 2027-02-26 Medical and Health Sciences Clinical Trial Degree Award
Mallory Holding Anne
ID:
Play Our Part (PoP) project primary data collection on effective engagement strategies with policymakers to support Learning through Play (LtP) in Early Childhood Education (ECE)
REFNo: SS2399ES

To gather data to help answer the PoP CoP learning question 3A: Which Engagement Strategies with Policymakers lead to the creation of enabling environments for LtP in Centre-based systems. ,Identify which advocacy approaches policymakers have found most effective.,Determine the way in which partners are currently engaging in national level advocacy activities and their definition of effectiveness.,Identify effective strategies for engaging policymakers on LtP in ECCE systems. ,
USA 2024-02-26 13:42:34 2027-02-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Sarah Lofgren
ID: UNCST-2019-R001647
Supervised Treadmill intervention to Reduce Inflammation and Depression through Exercise in HIV: The STRIDE Pilot Study
REFNo: HS3358ES

The objective of this study is to determine the feasibility and acceptability of an aerobic intervention via a treadmill among individuals with HIV and depression in Uganda.
3.1 Primary Endpoint: Feasibility and acceptability of Exercise as a treatment for depression in Ugandans with HIV. This will be measured by:
-Percent completion of the prescribed aerobic exercise intervention, as assessed by research staff logging participation.

3.2 Secondary Endpoint(s)/ Outcome(s):
- acceptability of the intervention assessed via a post intervention survey
-feasibility and acceptability of using a wearable exercise tracker to assess the volume of exercise, based on calories burned and steps achieved, during the intervention period among Ugandans with HIV and depression.
- measure the mean and standard deviation of baseline and 8-week serum BDNF and IL-6 level to estimate an effect size and power a future study.
- measure the mean and standard deviation of baseline and 8-week depression score via PHQ-9 to estimate an effect size and power a future study.
- measure the mean and standard deviation in aerobic fitness baseline and at 8 weeks measured via METS/watts achieved and total time/distance to estimate the effect size for a future intervention.
USA 2024-02-26 13:41:23 2027-02-26 Medical and Health Sciences Clinical Trial Non-degree Award
Waiswa Peter
ID: UNCST-2020-R014921
Intervention Study on Unintended Pregnancy among Teenagers in Busoga
REFNo: SS2284ES

The implementation objective is to evaluate intervention acceptability and scalability in Uganda,The intervention objective is to evaluate a novel model to reach unmarried teenagers and assess its effectiveness in reducing unmet needs for modern contraceptives among the target population,
Uganda 2024-02-26 13:39:25 2027-02-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Miriam Nakalembe
ID: UNCST-2021-R014040
Cervical Cancer Screening Utilizing Image Capture and Machine Learning to Identify Precancerous Cervical Lesions
REFNo: HS3743ES

Using pathological confirmation of CIN 2/3+ as the reference standard for pre-cancer, determine if the sensitivity and specificity of image capture of the cervix and artificial intelligence/deep machine learning/interpretation is superior to VIA, the current standard of care for cervical cancer screening in sub-Saharan Africa. ,Evaluate the quality of the cervical images captured in the clinics for use in artificial intelligence/deep machine learning.,Establish an informatics and data management infrastructure for cervical cancer that utilizes the IeDEA data platform and will allow for images and biologic data to be stored and characterized with the AIDS and Cancer Specimen Resource (ACSR) and the National Library of Medicine (NLOM). ,
Uganda 2024-02-26 13:37:44 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
NELSON NSEREKO
ID:
FROM STANDARD SWAHILI TO THE SWAHILI VARIETY SPOKEN IN UGANDA: EVOLUTION AND MORPHOSYNTACTIC VARIATIONS
REFNo: SS2348ES

i) Describe the morphosyntax of the Kiswahili variety spoken in Uganda
ii) Compare and contrast the morphosyntax of Standard Kiswahili with that of the
Kiswahili spoken in Uganda
iii) Account for the emergence of the Kiswahili variety spoken in Uganda

Uganda 2024-02-26 13:35:31 2027-02-26 Social Science and Humanities Non-Clinical Trial Degree Award
Julian Adong
ID: UNCST-2021-R013487
Retention through mHealth for adolescents and young adults with HIV in care
REFNo: HS3722ES

Test the acceptability, feasibility, and preliminary impact of the developed adolescent-tailored mHealth intervention for retention in care of AYWH who are new to or newly re-engaging in care,Iteratively develop a social media-based adolescent-tailored mHealth intervention to improve retention in care for AYWH who are new or newly re-engaging in care,Define the cognitive, environmental, and behavioural challenges and their impact on behavioural intention for AYWH who are new or newly re-engaging in HIV care,To develop and test an mHealth intervention for retention in care for adolescents and young adults with HIV,
Uganda 2024-02-26 13:34:00 2027-02-26 Medical and Health Sciences Clinical Trial Non-degree Award
alfred andama andama
ID: UNCST-2022-R011051
TONGUE SWAB TUBERCULOSIS DIAGNOSTIC YIELD STUDY
REFNo: HS3761ES

Aim 1. To determine the proportion of people presenting to primary health centers with signs and symptoms of TB who: a. can provide a sample for TB testing (sputum vs. tongue swab) b. have a valid molecular test result (sputum vs. tongue swab) c. are detected as TB-positive (sputum vs. tongue swab) d. prefer providing a sputum vs. tongue swab sample
Uganda 2024-02-26 13:32:44 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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