Fred Wabwire-Mangen
ID: UNCST-2021-R013549
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Assessing the Burden of Asymptomatic SARS-COV-2 Infection among Patients Seeking Health Care at Health care facilities in Uganda
REFNo: HS889ES
To determine the prevalence of SARS-CoV-2 among a sample of patients seeking health care and HCWs at participating surveillance sites who do not meet the case definition for COVID-19.
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Uganda |
2020-10-22 |
2023-10-22 |
Medical and Health Sciences |
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Non-degree Award |
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ANNETTEE NAKIMULI OLIVIA
ID: UNCST-2022-R011194
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In-depth case study of large referral maternity wards in four countries in sub-Saharan Africa: a case study of Kawempe National Referral Hospital and
Mulago Specialized Women and Neonatal Hospital in Uganda
REFNo: HS907ES
1) To document the preparedness and response to COVID-19 among large maternity/newborn wards in four countries in sub-Saharan Africa over time
2) To serve as a platform for exchange of information and experiences across the contexts studied.
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Uganda |
2020-10-22 |
2023-10-22 |
Medical and Health Sciences |
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Non-degree Award |
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Joyce Kambugu Balagadde
ID: UNCST-2020-R014996
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A regional approach to improved childhood cancer drug access in East Africa: Understanding access and coordinating procurement
REFNo: HS681ES
1. Undertake detailed institutional and health system data collection to obtain key metrics of drug availability and price in participating jurisdictions
2. Describe policies and practices related to childhood cancer drug procurement and provision in partner jurisdictions
3. Analyse the key determinants of childhood cancer drug access in the health system context
4. In partnership with national governments, establish agreements and mechanisms for coordinated procurement of essential childhood cancer medicines, based on evidence-based estimates of need.
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Uganda |
2020-10-21 |
2023-10-21 |
Medical and Health Sciences |
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Non-degree Award |
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Brian Kanaahe Mwebaze
ID:
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“Understanding And Addressing The Sexual Reproductive Health And Rights Needs Of Young Women And Girls In Humanitarian Settings In Nigeria And Uganda"
REFNo: SS611ES
1.Synthesize existing literature on the Sexual Reproductive Health and Rights challenges of young refugee women and girls, highlighting promising solutions and best practice service delivery models.
2.Conduct participatory, mixed methods formative research to generate evidence on the Sexual Reproductive Health and Rights knowledge and challenges of young women and girls in the target refugee settings.
3.Assess existing service provision models against global standards and best practice guidelines for adolescent/youth friendly Sexual Reproductive Health and Rights services in humanitarian settings with a comparison between refugees and Internally Displaced Persons (IDPs).
4.Support existing Sexual Reproductive Health and Rights initiatives in refugee camps in the target countries to use emerging evidence to improve advocacy for, demand for, and provision of Sexual Reproductive Health and Rights services for adolescent girls.
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Uganda |
2020-10-21 |
2023-10-21 |
Social Science and Humanities |
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Non-degree Award |
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Harriet Mpairwe
ID: UNCST-2025-R017439
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Psychosocial well-being and urbanisation among adults in Uganda: A pilot study
REFNo: HS831ES
1. To assess the feasibility of collecting data on psychosocial factors among adults in urban (Kampala) and rural (Mpigi and Wakiso) Uganda
2. To establish the hair cortisol concentration assay in our immunology laboratory
3. To assess the acceptability of scalp hair sample collection for research purposes
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Uganda |
2020-10-19 |
2023-10-19 |
Medical and Health Sciences |
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Non-degree Award |
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Fred Ssewamala
ID: UNCST-2020-R014060
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Suubi4STEM: A signature program to advance STEM education in Africa
REFNo: SS475ES
Objective 1. Test the feasibility, acceptability, and preliminary impact of innovative Suubi4STEM intervention in promoting educational STEM opportunities and life options for young people in Uganda.
Objective 2. Qualitatively examine participants’ and facilitators’ intervention experiences and identify individual, family and institutional-level facilitators and barriers to Suubi4STEM intervention implementation and participation.
Objective 3. Evaluate the cost of implementing Suubi4STEM.
Objective4. Disseminate program findings to promote the Suubi4STEM intervention on a larger scale
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Uganda |
2020-10-16 |
2023-10-16 |
Social Science and Humanities |
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Non-degree Award |
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Mandela Wangoola Robert
ID:
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FACTORS INFLUENCING TRYPANOSOMA BRUCEI RHODESIENSE STABILITY IN CATTLE RESERVOIR IN LANGO SUB REGION
REFNo: NS135ES
General Objective
• Evaluate the factors influencing Trypanosoma brucei rhodesiense infections persistence and stability in the cattle reservoir in Lango sub region
Specific objectives
(i) To determine the prevalence of bovine trypanosomiasis in Lango sub region.
(ii) Assess the stability of T. b rhodesiense in naturally infected cattle in Lango sub region
(iii) Evaluate risk factors leading to continued cattle trypanosomiasis infection in Lango sub region
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Uganda |
2020-10-16 |
2023-10-16 |
Natural Sciences |
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Degree Award |
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Sara Nsibirwa
ID: UNCST-2021-R012889
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Antimicrobial resistance in trauma and burn patients with blood stream or wound infections – an observational cohort study from Kampala, Uganda
REFNo: HS815ES
The primary aims:
• To determine the prevalence of blood stream due to specific bacterial and fungal pathogens resistant to first choice empirical treatment in trauma and burn patients.
• To determine the prevalence of wound infections due to bacterial and fungal pathogens resistant to first choice empirical treatment in trauma and burn patients
The secondary aims:
• To describe the proportion of burns and trauma patients requiring a switch of antibiotic or antifungal treatment following wound swab and blood culture results.
• To describe the clinical outcomes of trauma and burn patients with blood stream and wound infections due to bacterial and fungal pathogens resistant to first choice empirical treatment
• To identify risk factors for the development of wound and blood stream infections due to resistant bacterial and fungal pathogens among trauma and burn patients.
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Uganda |
2020-10-15 |
2023-10-15 |
Medical and Health Sciences |
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Non-degree Award |
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Emmanuel Gusango Humphrey
ID:
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Constructivist informed teaching and preparation of students in Primary Teachers Colleges of South Eastern Region in Uganda
REFNo: SS498ES
i. Explore the constructivist principles used in the instruction of students in Primary Teachers Colleges.
ii. Examine the constructivist practices applied to the school practice supervisory process in Primary Teachers Colleges.
iii. Examine the implementation of coaching in the preparation of students’ professional growth.
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Uganda |
2020-10-14 |
2023-10-14 |
Social Science and Humanities |
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Degree Award |
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Robert Tweyongyere
ID:
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Optimizing SMART Dairy Technologies for Efficient Sustainable Productivity of Dairy Farmers in Uganda
REFNo: A80ES
Specific objectives
1. Determine the dairying problems and constraints, current solution options and priority list of solutions which are gender sensitive across age and space.
2. Determine the dairy farmers’ cattle feeding and breeding practices in the milk sheds of Uganda
3. Determine local feed ingredients nutrient profile for optimal dairy feed ration formulation
4. Develop a farmers’ community based breeding program
5. Increase Farmers’ access to elite genetics by artificial breeding technologies (artificial insemination(AI) and Embryo transfer(ET))
6. Determine the nutritional-metabolic profiles among the dairy cattle in selected DaFaN clusters to Optimize cost-effective forage production, preservation and utilization
7. Determine animal health and breeding profile parameters generated by ruminal or collar sensor technology for effective monitoring of individual animals on farms in Uganda
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Uganda |
2020-10-14 |
2023-10-14 |
Agricultural Sciences |
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Non-degree Award |
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Robert Newton Edward
ID: UNCST-2023-R006537
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Community surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and of coronavirus disease-2019 (COVID-19) in high risk and general populations.
REFNo: HS823ES
1. To measure the changing incidence and prevalence of SARS-CoV-2 over time and, associated mortality.
2. To assess the impact of co-morbidities on acquisition and survival of SARS-CoV-2.
3. To examine in greater depth the public understanding of COVID-19 and the experience of the surveillance exercise.
|
UK |
2020-10-14 |
2023-10-14 |
Medical and Health Sciences |
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Non-degree Award |
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Robert Tweyongyere
ID:
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EFFECTIVENESS OF ANTHELMINTICS IN CATTLE AND GOATS
IN MIXED FARMING COMMUNITIES IN MBARARA, KIRUHURA SEMBABULE AND NAKASONGOLA DISTRICTS
REFNo: A83ES
General Objective:
To assess effectiveness of dewormers and generate information that would support decision on improving management of anthelmintics in Uganda
Specific objectives:
1. To document the knowledge, attitude and deworming practices of selected livestock farmers in Mbarara, Kiruhura, Sembabule and Nakasongola districts
2. Determine the worm burden among cattle and goats on the selected farms
3. To determine the ‘clinical efficacy’ of five identified dewormers commonly available to the farmers
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Uganda |
2020-10-14 |
2023-10-14 |
Agricultural Sciences |
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Non-degree Award |
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Simon Peter Kibira Peter Sebina
ID: UNCST-2019-R000492
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Improving quarantine in Uganda as a key measure to combat COVID-19: Compliance, experiences, gaps and opportunities
REFNo: HS832ES
1. To determine compliance with COVID-19 quarantine measures among self and institutional quarantined persons in Uganda.
2. To determine factors associated with compliance with COVID-19 quarantine measures among self and institutional quarantined persons in Uganda.
3. To explore experiences and coping mechanisms among self and institutional quarantined persons in Uganda.
4. To identify gaps in the management and opportunities for improvement of the quarantine process in Uganda.
 
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Uganda |
2020-10-14 |
2023-10-14 |
Medical and Health Sciences |
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Non-degree Award |
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Victoria Nankabirwa
ID: UNCST-2021-R011871
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A multicenter, phase III, double-blind, randomised, active-controlled study to evaluate the efficacy and safety of VPM1002 in comparison to BCG in prevention of Mycobacterium tuberculosis infection in newborn infants
REFNo: HS838ES
Primary objectives
1. To demonstrate that VPM1002 is non-inferior to BCG SII in providing protection against incident Mtb infection
2. To demonstrate that vaccination with VPM1002 is superior to BCG SII in providing protection against incident Mtb infection
Secondary objectives
1. To compare the safety and tolerability profile of VPM1002 and BCG SII administered as a single dose to newborn infants
2. To compare the protective efficacy of VPM1002 versus BCG SII against TB disease
3. To compare the protective efficacy of VPM1002 versus BCG SII against sustained Mtb infection
Exploratory objectives
1. To evaluate the immunological response to vaccination with a single dose of VPM1002 compared to BCG SII in a subset (immunogenicity cohort) of HIV-exposed and HIV-unexposed newborn infants in terms of the following parameters:
o Concentration of Interferon (IFN)-γ in the supernatant after antigen re-stimulation as determined by ELISA
o CD4+ and CD8+ T-cells after antigen stimulation as determined by Fluorescence-activated cell staining/Intracellular cytokine staining (FACS/ICS)
o Transcriptomics
o Antibody production
2. To evaluate occurrence of QuantiFERON® Gold Plus In-tube test (QFT) conversion, where conversion is defined using alternative QFT thresholds (e.g. > 4 IU/ml); and sustained QFT conversion, where sustained conversion is defined as QFT ≥ 4IU /ml maintained for approximately 6 months following initial QFT conversion, compared across trial arms in all participants.
3. To determine the mortality rate in children receiving VPM1002 compared to BCG SII
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Uganda |
2020-10-14 |
2023-10-14 |
Medical and Health Sciences |
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Non-degree Award |
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Victoria Nankabirwa
ID: UNCST-2021-R011871
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SARS-CoV-2 infection and COVID-19 in women and their infants in Kampala, Uganda
REFNo: HS915ES
Overall aim
To describe how the COVID-19 epidemic and Uganda's countermeasures affect women and their newborns, especially newborns of HIV-1 positive mothers, and to test whether BCG vaccination offers protection against SARS-CoV-2 infection and COVID-19.
Specific objectives
1. To investigate if BCG vaccination of HIV-1 exposed infants at birth or at 14 weeks of age protects them against SARS-CoV-2 infection and COVID-19 until 14 weeks of age or against COVID-19 between 15 and 52 weeks of age, respectively.
2. To estimate the evolving prevalence of SARS-CoV-2 infection and of COVID-19 among HIV-1 positive as well as among HIV-1 negative women who have recently given birth, and describe their association with hospitalization on the day of birth, complications during delivery, low birth weight, and other adverse outcomes
3. To estimate the evolving 14-week cumulative incidence of SARS-CoV-2 infection and of COVID-19 among mothers and babies, and evaluate whether maternal HIV-1 infection affects maternal and infant risk of developing COVID-19 of varying severity
4. To evaluate the impact of wide-ranging preventive measures to control COVID-19 on women giving birth during the epidemic, their children, and their families
|
Uganda |
2020-10-14 |
2023-10-14 |
Medical and Health Sciences |
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Non-degree Award |
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Emanuel Peter L
ID:
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Development of Standardized Herbal Formulation: Synergy between Momordica charantia, Aloe vera and Abelmoschus esculentus for Glycemic Control
REFNo: NS119ES
Objectives
1. To establish ethnomedical use of M. charantia and A. esculentus among indigenous community in Tanzania.
2.To establish physicochemical and stability parameters of freeze dried aqueous extracts of the three plant species separately in pre-formulation studies.
3. To evaluate efficacy of combined freeze dried extracts in different ratios of doses of M. charantia, A. esculentus and A. vera in vivo.
4. To establish safety profile of best optimal dose combination of M. charantia, A. esculentus and A. vera on healthy Wistar female rats.
5. To design a solid pharmaceutical dosage form of the optimal dose combination and evaluate its stability, safety and efficacy in vivo.
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Tanzania |
2020-10-12 |
2023-10-12 |
Natural Sciences |
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Degree Award |
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Christine Aanyu
ID:
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EQUITABLE MATERNAL CARE FOR WOMEN WITH DISABILITY (EMeralD) STUDY
REFNo: HS722ES
1) Specific Aim 1. Conduct an analysis of disability, pregnancy and birth outcomes, and maternal health care utilization data for pregnant women with disabilities in Uganda.
2) Specific Aim 2. Understand the needs and perceptions of pregnant women with disabilities and identify availability of, and barriers to accessing, maternal health care services.
3) Specific Aim 3. Formulate and develop a model for disability-friendly services for pregnant women.
|
Uganda |
2020-10-07 |
2023-10-07 |
Medical and Health Sciences |
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Non-degree Award |
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David Serwadda -
ID:
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Characterizing community exposure to SARS-CoV-2 in Uganda, and assessing biological determinants of virus spread
REFNo: HS878ES
1.Assess the diagnostic sensitivity and specificity of the CoronaChekTM rapid COVID-19 IgM/IgG lateral flow test (CoronaChekTM by Hangzhou Biotest Biotech Co Ltd) for anti- SARS-CoV-2 antibodies detection in Uganda.
2.Conduct enhanced surveillance of COVID19-like symptoms in the context of an existing population cohort and assess the predictive value of prevailing symptoms for COVID-19 exposure based on rapid serological testing in this region.
3.Determine rates of sero-reactivity/positivity among key health care workers at high-volume health centers III and IV and also among PCR-negative contacts of confirmed COVID-19 cases in the region.
4.Explore ‘prior importation of COVID-19 infection in Ugandaâ€/ pre-existing sero-reactivity (may due to ‘related’ coronavirus strains/shared epitopes) in purposively selected archived sera, prioritizing from truck drivers and commercial sex workers that was collected before the lockdown in Uganda / Rakai region.
|
Uganda |
2020-10-06 |
2023-10-06 |
Medical and Health Sciences |
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Non-degree Award |
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Richard Idro
ID: UNCST-2021-R013599
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Dihydroartemisinin-Piperaquine or Sulphadoxine-Pyrimethamine for the Chemoprevention of Malaria in Children with Sickle Cell Anaemia in eastern and southern Africa: a double blind randomised trial (the CHEMCHA trial)
REFNo: HS709ES
Primary objective
The general objective is to determine the efficacy and safety of malaria chemoprevention with weekly single day courses of DP compared to monthly single courses of SP in children with SCA in eastern and southern Africa.
Secondary objectives
1. Assess the feasibility and stakeholder perceptions on the uptake (acceptability) and the potential for future roll-out of weekly DP vs monthly SP.
2. Determine the safety of cumulative dosing of DP, especially on cardiac function.
3. Monitor the development of malaria parasite resistance to DP in clinical isolates over time.
Assess patients’ health-related quality of life, cost-effectiveness, equity and economic implications of using weekly courses of DP vs monthly courses of SP as chemoprevention in SCA.
5. Assess acceptability of weekly courses of DP for malaria chemoprevention in SCA vs monthly courses of SP as chemoprevention in SCA.
6. Conduct policy advocacy to engage key stakeholders on policy decisions on using weekly courses of DP or monthly courses of SP for the chemoprevention of malaria in SCA.
|
Uganda |
2020-10-02 |
2023-10-02 |
Medical and Health Sciences |
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Non-degree Award |
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Richard Idro
ID: UNCST-2021-R013599
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Hydroxyurea therapy for Neurological and Cognitive Protection in Pediatric Sickle Cell Anemia in Uganda: A single arm open label trial, “BRAIN SAFE IIâ€
REFNo: HS846ES
The primary objective is to determine the impact of daily oral hydroxyurea therapy, 20- 30mg/kg/day, on the frequency and severity of Sickle Cell Vasculopathy(SCV) in a cohort of children treated for three years, as measured by 3 distinct outcomes: abnormal TCD, neurocognitive impairment and primary stroke, compared with baseline.
Secondary objectives
1.Evaluate the impact of Hydroxyurea therapy on structural SCV using MRI and MRA in a randomly selected subset of this cohort.
2.Assess changes to anemia, CRP and malnutrition status during hydroxyurea therapy, over time, compared with baseline levels.
|
Uganda |
2020-10-02 |
2023-10-02 |
Medical and Health Sciences |
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Non-degree Award |
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