Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Noah Sendawula
ID:
Youth Livelihood Programme & Empowerment in Wakiso District
REFNo: SS430ES

Main Objective: To assess the effectiveness of Youth Livelihood Programme on Youth Empowerment in Wakiso District.
Specific:
i-To investigate the extent to which YLP has been able to provide vocational skills for youth self-employment in Wakiso District
ii- To analyse the extent to which YLP financial support has enabled youth establish income generation activities in Wakiso district
iii- To examine the extent to which YLP has been able to increase levels of entrepreneurship among youth in Wakiso District.
iv- To extablish the extent to which knowledge & information has been provided for positive mindset change among youth in Wakiso district
Uganda 2020-03-18 2023-03-18 Social Science and Humanities Degree Award
Peter Byansi Kayiira
ID:
Leadership and Management Practices that Support Accountability for Results in Health Support Organizations in Uganda
REFNo: HS585ES

Inquire into the management and leadership practices that health leaders in Uganda’s public and nonprofit health support organizations use and have found effective in nurturing accountability for the achievement of results that matter most to employees, the organization, customers, and donors, hereinafter referred to as key stakeholders
Uganda 2020-03-18 2023-03-18 Medical and Health Sciences Degree Award
Robert Kairania
ID:
Performance of the Asanteâ„¢ HIV-1 Rapid Recencyâ„¢ Assay in recent HIV infections detection and incidence estimation in a Ugandan setting using the Rakai Community Cohort Study
REFNo: HS534ES

Main aim: To determine the performance of the Asanté™ HIV-1 Rapid Recency™ assay in identification of HIV-1 recent infections and incidence estimation in a Ugandan setting with A and D predominant subtypes.

Specific aims
I. To evaluate the diagnostic performance of the Asanté™ HIV-1 Rapid Recency™ assay in identification of recent infections in a setting with A and D predominant subtypes.
II. To establish the false recency rate (FRR) of the Asanté™ HIV-1 Rapid Recency™ assay.
III. To determine factors associated with being misclassified as recent by the Asanté™ HIV-1 Rapid Recency™ assay.
IV. To compare HIV incidence estimated using the Asanté™ HIV-1 Rapid Recency™ assay from a cross-sectional survey with that observed longitudinally in an observational cohort in Rakai.

Uganda 2020-03-16 2023-03-16 Medical and Health Sciences Non-degree Award
Gerry McGivern
ID:
Strengthening health professional regulation in Kenya and Uganda
REFNo: SS336ES

The research aims to develop evidence about how health professional regulation is enacted and experienced by doctors and nurses in Ugandan and Kenyan and ways it might be improved.
UK 2020-03-12 2023-03-12 Social Science and Humanities Non-degree Award
Aala Abdelgadir
ID:
Mosque Mapping Survey
REFNo: SS385ES

Religious institutions play an important role in the daily lives of Ugandans, as in other African countries. Yet, we understand little about the influence of religious institutions on social and political outcomes. This project focuses on the sway of Muslim religious institutions in shaping the opinions and behaviors of congregants. Specifically, we will study how mosques communicate with congregants, what types of messages they deliver, and how messages shape the attitudes and behaviors of congregants.

The research objectives of this project are to:
• Examine variation in sermons, including topics, religious citations, and tone.
• Assess how mosque and imam characteristics influence the nature of sermons.
• Explore how sermons shape congregant religious, social, and political attitudes and behaviors.

USA 2020-03-12 2023-03-12 Social Science and Humanities Degree Award
Scholastic Ashaba
ID: UNCST-2023-R007613
Transition readiness among adolescents living with HIV in Uganda
REFNo: HS512ES

Aim 1: Use qualitative research to elaborate a conceptual model of transition readiness for perinatally-infected ALHIV in Mbarara, Uganda (n=up to 50 in-depth interviews).
Aim 2:Develop and validate a transition readiness scale for perinatally-infected ALHIV (n=340)
Uganda 2020-03-12 2023-03-12 Medical and Health Sciences Non-degree Award
Catherine Abbo
ID:
The Ugandan Early Childhood Phenoscreening Project
REFNo: HS544ES

1. To evaluate the psychometric properties of selected parent-report questionnaires among a community sample of infants and toddlers in Uganda.
2. To identify homogenous subgroups or behavioural risk profiles in a community sample of infants and toddlers
3. To determine the average age of autism spectrum disorder diagnosis in children attending mental health clinics in Mulago and Butabika hospitals
Uganda 2020-03-12 2023-03-12 Medical and Health Sciences Non-degree Award
Stephen  Ojiambo Wandera
ID: UNCST-2021-R012147
Alcohol use, Intimate Partner Violence (IPV) & HIV Risk among Young People in fishing communities on the shores of Lake Victoria, Uganda
REFNo: SS421ES

Aim of the study
The aim of the study is to determine the factors associated with HIV risk among young people in fishing communities on the shores of Lake Victoria, in eastern Uganda.
Objectives of the study
1. To estimate the association between alcohol use and HIV risk among young people in in the fishing communities on the shores of Lake Victoria, Uganda
2. To determine the association between intimate partner violence (IPV) victimization (females) and perpetration (males) and HIV risk among young people in the fishing communities on the shores of Lake Victoria, Uganda

Uganda 2020-03-12 2023-03-12 Social Science and Humanities Non-degree Award
Alex  Muganzi Muganga
ID: UNCST-2019-R000710
Project Evaluation Protocols for Kampala Region mechanism
REFNo: HS553ES

Evaluation Objective 1: To evaluate the targeted HTS models to improve earlier identification of HIV positive and negative individuals, and Linkage of PLHIV in community and facility sites in scale up districts and linkage and promotion of HIV prevention among HIV negative individuals.

Evaluation Objective 2: To evaluate innovative approaches that increase adherence, ART retention and viral load suppression among adult and pediatric HIV clients.

Evaluation objective 3: To determine if there is improved identification of TB infected individuals., effective scale up of comprehensive TB/HIV services at individual sites site, and progress towards reduction of TB burden among HIV/TB co-infected clients within the CDC supported regions and districts.

Evaluation objective 4. To evaluate innovative PMTCT & HEI approaches that increase identification of HIV positive and syphilis infected pregnant & breastfeeding women (PBFW), enhance immediate ART uptake, adherence and retention, viral load suppression and syphilis treatment among PBFW, reduce MTCT rates of HIV & Syphilis and ensure documentation of 18 month final outcome status for all HIV Exposed infants.

Evaluation objective 5: To evaluate innovative interventions that are designed to improve data quality and data utilization for program evidence-based decision making at facility and district level.

Evaluation objective 6 : To determine if there was increase access of comprehensive OVC services.

Evaluation objective 7: To determine if the strengthening of the existing laboratory network and its quality management systems increased the ART initiation and ART monitoring at facility and district level.

Evaluation Objective 8: To determine if the relationship between district level performance reviews and HR performance had an effect on district performance including access, coverage, retention and loss to follow up.

Evaluation objective 9: To determine if Kampala region mechanism approaches resulted in increased coverage with voluntary medical male circumcision.


Uganda 2020-03-12 2023-03-12 Medical and Health Sciences Non-degree Award
Anthony Makhoba
ID:
MODELING A BCG BIRTH DOSE VACCINATION PROGRAM FOR IMPROVED HEPATITIS B CONTROL IN UGANDA
REFNo: HS415ES

1. To determine the rate of BCG birth dose vaccination among newborns at St. Francis Hospital Nsambya and Mbarara Regional Referral Hospital.
2. To determine the time to BCG vaccination among newborns at St. Francis Hospital Nsambya and Mbarara Regional Referral Hospital
3. To establish reasons for missed/delayed BCG vaccination among newborns at St. Francis Hospital Nsambya and Mbarara Regional Referral Hospital and to propose means of improvement.
4. To document the human costs of birth dose vaccination i.e. the nurse time required to obtain maternal consent, to draw up and administer the vaccine and complete the immunization record.

Uganda 2020-03-11 2023-03-11 Medical and Health Sciences Non-degree Award
Sudi Mohamed Ali
ID:
Cervical Cancer: Late presentation and associated factors at Mbarara Regional Referral Hospital.
REFNo: HS485ES

1. To determine the proportion of women with cervical cancer that presents late at Mbarara Regional Referral Hospital. 2. To determine the factors associated with late presentation among women with cervical cancer at Mbarara Regional Referral Hospital. 3. To explore the factors associated with health care seeking from onset of symptoms to diagnosis among women with cervical cancer at Mbarara Regional Referral Hospital.
Kenya 2020-03-11 2023-03-11 Medical and Health Sciences Degree Award
Richard  Muhumuza
ID:
INTEGRATED PREVALENCE MAPPING OF SCHISTOSOMIASIS AND SOIL TRANSMITTED HELMINTHIASIS AMONG COMMUNITIES IN MAYUGE DISTRICT: IMPLICATIONS FOR NTD ELIMINATION PROJECT 2019-2021
REFNo: HS434ES

2. Study objectives
2.1 General objective/Goal
The establish the prevalence of Schistosomiasis and STH infections among school going children and surrounding communities in Mayuge district

Specific objectives
1. To build capacity of Laboratory assistants and technicians on sample (Stool) collection and microscopic analysis
2.To collect sample (Stool) collect from the selected schools
3. To conduct Microscopic analysis for collected samples


Uganda 2020-03-09 2023-03-09 Medical and Health Sciences Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
Assessment of Public Knowledge, Attitudes, and Practices Related to Ebola Virus Disease Prevention and Treatment in Uganda
REFNo: HS531ES

1. Measure district-level estimates in six districts in Uganda of the public’s knowledge, beliefs, attitudes, and practices related to Ebola Virus Disease (EVD) risks due to the ongoing and widespread EVD outbreak in DRC; and
2. Identify socio-behavioral and health system barriers that may hinder the containment of an EVD outbreak in Uganda given the complex socio-political and security context of the protracted outbreak in neighboring DRC.

Nigeria 2020-03-09 2023-03-09 Medical and Health Sciences Non-degree Award
REBECCA NANTANDA
ID: UNCST-2019-R001533
Improving neonatal outcomes through early detection and management of hypoxaemia: The role of routine pulse oximetry
REFNo: HS132ES

1.To evaluate the effect of routine pulse oximetry on neonatal outcomes in the first 24 hours of life. 2.To determine the utility of pulse oximetry compared to clinical signs in detection of hypoxaemia in neonates with possible serious bacterial infections at lower level facilities 3.To assess the feasibility and acceptability of routine pulse oximetry by healthcare workers and caretakers of newborn babies. 4.To determine the cost-effectiveness of routine pulse oximetry in identifying neonates with hypoxaemia. 5.To describe the maternal factors that predict hypoxaemia in the newborn babies
Uganda 2020-03-06 2023-03-06 Medical and Health Sciences Non-degree Award
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
Advancing Tissue and Organ Biobanking in Uganda
REFNo: HS572ES

General objective: To establish a tissue and organ biobank at Makerere University to serve as a catalyst for research in organ collection, biobanking and transplantation in Uganda.
Specific Objective :
1. To train personnel and develop standard operating procedures for collection, processing and storage of human ova, sperm and umbilical cord blood.
2. To collect, process and store human ova, sperms and umbilical cord blood.
3. To develop a publicly accessible catalog of HLA typed viable human tissue and organs.
4. To explore the ethical, legal and societal issues (ELSI) in human tissue and organ biobanking

Uganda 2020-03-03 2023-03-03 Medical and Health Sciences Non-degree Award
ROSE ATIM
ID:
Law, Culture and Reality: Women Navigating Post Conflict Marital Relations in Northern Uganda
REFNo: SS423ES

1. Investigate the legal implication of the institution of marriage on women born in internally displaced peoples camps and victims of sexual violence of the LRA conflict;
2. Interrogate if cohabitation as an alternative to ‘legal’ marriage is becoming institutionalized among women born in internally displaced peoples camps and victims of sexual violence of the LRA Conflict;
3. Analyse the effectiveness of legal and informal marital protection mechanisms in a post conflict society;
4. Interrogate the future of the law in customary marital unions.

Uganda 2020-03-03 2023-03-03 Social Science and Humanities Degree Award
Jackson Mukonzo
ID: UNCST-2021-R013916
SAFETY AND EFFICAY OF DOLUTEGRAVIR AND EFV 400 FOR PREGNANT AND BREAST FEEDING WOMEN; A RANDOMISED NON INFERIORITY CLINICAL TRIAL ACRONYM: PREGART
REFNo: HS515ES

PRIMARY OBJECTIVE; to identify safer and more effective ART regimen for pregnant and breast feeding women by comparing three alternative first line ART regimens for their safety and efficacy using randomized clinical trial.

SECONDARY OBJECTIVE; To provide evidence based recommendations for safe and effective first line ART regimens for prevention of mothers to child transmission and treatment of HIV infected pregnant and breast feeding women living in resource limited setting.

Uganda 2020-02-25 2023-02-25 Medical and Health Sciences Non-degree Award
Coleen Sabatini
ID: UNCST-2019-R001321
Outcomes Following Surgical Release of Gluteal Fibrosis in Children of Eastern Uganda
REFNo: HS561ES

This study is a longitudinal case series to evaluate if surgical release of gluteal fibrosis in Ugandan children has a sustained benefit. We will examine the two-year outcomes after surgical release of gluteal fibrosis in children undergoing surgical intervention for gluteal fibrosis.

USA 2020-02-25 2023-02-25 Medical and Health Sciences Non-degree Award
NAASSON TUYIRINGIRE
ID:
Metabolomics Approaches to Elucidate the Mechanisms of Action of Antimycobacterial Medicinal Plants
REFNo: HS422ES

The main objective is to elucidate the mechanisms of action of antimycobacterial medicinal plants using metabolomics. The specific objectives are:
1. To determine the metabolome of M.tb subjected to medicinal plant extracts with antimycobacterial activity as compared to control culture
2. To optimize an analytical metabolomics workflow to facilitate reproducible measurements of bacterial metabolome with extract treatment or without the treatment
3. To elucidate the metabolic pathways affected by plant extracts
4. To identify the macromolecule targets of plant extracts

Rwanda 2020-02-21 2023-02-21 Medical and Health Sciences Degree Award
Jean Damascene Niyonsenga
ID:
Exercise and well-being: NCD risks and constraints to Physical Activity and sports participation among Ugandan rural and urban secondary school students
REFNo: HS490ES

1. To examine the correlation between NCDs risk factors and level of physical activity/sports participation, type of eaten food, and lung function among both rural and urban secondary school students in Mbarara, uganda
2. To establish constraints to PA/sports participation of secondary school students in rural and urban schools in Mbarara, Uganda.
3. To examine the relationship between internal motivation and external support for PA/sports participation for secondary school students in rural and urban schools of Mbarara, Uganda.
4. To determine the commonest sustained injuries and to establish the proportion attributable to PA/sports among rural and urban secondary school students in Mbarara, Uganda.
5. To compare constraints and injuries identified by secondary school students from rural and urban schools in Mbarara, Uganda.

Rwanda 2020-02-21 2023-02-21 Medical and Health Sciences Non-degree Award
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