Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
James Nyonyintono Mwangwa
ID: UNCST-2023-R005636
 Feasibility of Use of the PATH bCPAP Kit including Oxygen Blenders in a Neonatal Population in Uganda
REFNo: HS650ES

Primary Objectives: 1. To assess the operational feasibility of using the PATH bCPAP kit including, when appropriate, in-line oxygen blending on neonatal patients. 2. To assess the usability and acceptability of the PATH bCPAP kit with oxygen blenders by healthcare workers. Secondary Objective: 1. To report clinical characteristics, demographics and outcomes of patients treated with the PATH bCPAP kit and blenders in a newborn care unit in rural Uganda.
 Uganda 2021-07-19 2024-07-19 Medical and Health Sciences Non-degree Award
Esther Buregyeya
ID: UNCST-2020-R014116
 Using a behavioural approach to design an antimicrobial stewardship intervention in healthcare facilities in Kampala, Mukono and Luwero Districts, Uganda
REFNo: HS1303ES

1. To explore the barriers to and facilitators for rational use of antibiotics and setting up AMS programs in HCFs in Uganda.
2. To develop, pilot an AMS behavioural intervention and assess its acceptability, feasibility and effect to foster appropriate antibiotic prescription in HCFs in Uganda.
3. To assess the cost of the intervention in fostering rational use of antibiotics in Uganda.

 Uganda 2021-07-16 2024-07-16 Medical and Health Sciences Non-degree Award
Shevin  Jacob Thomas
ID:
AN OBSERVATIONAL STUDY TO ASSESS THE UTILITY OF BEDSIDE ULTRASOUND SCAN IN SEPSIS TREATMENT AMONG HOSPITALIZED ADULTS IN UGANDA
REFNo: HS1499ES

General objective: To describe the potential utility of bedside ultrasound scanning in evaluating adult patients with suspected sepsis admitted to hospitals in Uganda Specific objectives: 1. Estimate the proportion of patients admitted to the medical emergency unit with suspected sepsis who have ultrasound findings consistent with intravascular fluid depletion. 2. Estimate the proportion of patients admitted to the medical emergency unit with suspected sepsis who have ultrasound findings suggestive of intolerance to high volume intravenous fluid. 3. Estimate the proportion of patients admitted to the medical emergency unit with suspected sepsis who have ultrasound findings that identify a potential source of infection. 4. Determine the feasibility of delivering POCUS to evaluate non-pregnant adult patients with sepsis by clinicians who are not specialized in radiology.
USA 2021-07-16 2024-07-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Conrad Muzoora Kihembe
ID: UNCST-2019-R001432
 Determination of Adequate TUberculosis Regimen in Adults and adolescents hospitalised with HIV-associated severe immune suppression (Acronym: DATURA).
REFNo: HS1487ES

Primary objective: To estimate the impact of an intensified initial phase of tuberculosis (TB) treatment on mortality at 48 weeks among HIV-infected adults and adolescents hospitalised for TB with CD4 ≤ 100 cells/μL in comparison with the standard TB regimen. Secondary objectives: To estimate the impact of an intensified initial phase of TB treatment, in comparison with the standard TB regimen, on: ¥ Mortality at weeks 8 and 24 ¥ Adverse events, including: - All grade 3-4 events - Selected grade 2 events of interest - Drug-related adverse events - AIDS defining illnesses - Paradoxical TB-associated immune reconstitution inflammatory syndrome (IRIS) ¥ TB treatment success ¥ TB recurrence ¥ Antiretroviral treatment (ART) response in terms of virological success and immunological response ¥ Adherence to TB treatment and ART ¥ Peak plasma concentrations of rifampicin and isoniazid (and its N-acetyl-metabolite) at day 3, day 7 and week. ¥ Plasma concentrations of efavirenz and dolutegravir at week 4 (i.e. 2 weeks after the onset of ART)
Uganda 2021-07-16 2024-07-16 Medical and Health Sciences Clinical Trial Non-degree Award
Davis Ntulume Roland
ID:
A Cross Sectional Study on Exploring the Lifestyle of Makerere University Staff With an Aim of developing a Bespoke Healthy Living Program for people in Academia
REFNo: HS1500ES

Our main goal is to identify and understand the key factors that attribute a typical working day of Makerere University and inhibitors of following a heathy living programme and use this feedback
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to design a contextually appropriate and bespoke programme for adoption in the field of academia and other sectors at large. This will be achieved in the following sub aims:
1. To establish the dietary and physical activity patterns of overweight and obese staff at Makerere University College of Health Sciences staff.
2. To support overweight and obese individuals to adopt an energy restricted diet and weekly physical exercise while establishing the behavioural and social determinants of compliance to the programme.
3. To establish the effect of change on food and activity body weight and health status and recommend a bespoke healthy living programme that puts into consideration the routine, perceptions and inhibitors to living a healthy lifestyle that works for Academic staff nationwide.
 Uganda 2021-07-16 2024-07-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jude Ssempebwa
ID:
COVID-19 and the Youth Question in Africa: Piloting a Vertically Integrated Social Accountability and Advocacy Framework in the IGAD Region (COYOQA)
REFNo: SS921ES

1. To carry out a comprehensive gender analysis of the current social mobilization of youth in informing, co-designing and supporting COVID-19 pandemic emergency preparedness and response, capacity, key gaps and support needs among IGAD Member States (Ethiopia, Kenya and Uganda).
2. To build the capacity of male and female Youth Volunteers for Behavior Change (YOV4BC) in emergency preparedness, response (disaster risk reduction and management) and building resilience to impacts of COVID-19 so that they are well informed, resourced and educated about COVID-19 and its prevention measures.
3. To partner with the youth to take action within their communities through developing and institutionalizing a standardized and harmonized COVID-19 Vertically Integrated Social Accountability and Advocacy Framework for monitoring the IGAD Regional Response Strategy(IRRS) for COVID-19 Pandemic in Kenya, Uganda and Ethiopia.
4. To investigate and track gender differentiated sectoral socio-economic impacts of COVID-19 on youth and their communities and document community perceptions and response strategies.
5. To facilitate meaningful policy engagement between male and female youth and policy makers through enhanced national, sub-national and regional knowledge sharing platforms.

 Uganda 2021-07-16 2024-07-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Roselline Achola
ID:
Decision making about Family Planning use by refugee and host populations in Adjumani district, Uganda
REFNo: SS809ES

1.To explore decision making processes for FP use by refugee and host population in Adjumani district
2.To establish factors associated with FP use by women and men in the refugee and host populations in Adjumani
3.To develop and evaluate an intervention to increase FP use by refugee and host populations

Uganda 2021-07-15 2024-07-15 Social Science and Humanities Non-Clinical Trial Degree Award
Richard Munana
ID:
Chronic Kidney Disease among Patients with Diabetes and Hypertension in Nakaseke District Rural Uganda: Assessing Patient Characteristics and the Diagnostic Performance of Saliva Urea Nitrogen Strips in Chronic Kidney Disease Diagnosis When Combined with a Chronic Kidney Disease Case Finding Questionnaire and Machine Learning.
REFNo: HS1387ES

1) To determine the diagnostic performance of Saliva Urea Nitrogen (SUN) strips when combined with a chronic kidney disease case-finding questionnaires and machine learning in the diagnosis of chronic kidney diseases among patients with diabetes and or hypertension in Nakaseke district, rural Uganda. 2)To establish a Chronic Kidney Disease patients’ cohort based in the Rural Uganda Non-Communicable Disease (RUNCD) Cohort in Nakaseke, Uganda.
 Uganda 2021-07-15 2024-07-15 Medical and Health Sciences Non-Clinical Trial Degree Award
Betty OKOT
ID: UNCST-2021-R013938
 Echoes of Antiquity in Acholiland: The Return to Te-Kwaro (Tradition) after the Civil War in Northern Uganda: RefNo:GUREC-2021-57
REFNo: SS833ES

ii. Highlight how memories, practices and unwritten laws reinforce land rights through links and attachment to the past actively conveyed in return migrations; ,3.Examine the roles and disputed effectiveness of traditional chiefs as latter-day custodians of traditional laws in modern times.,1. Recapture and retell the past through specific stories of return to abandoned homesteads ,
 Uganda 2021-07-15 2024-07-15 Social Science and Humanities Non-Clinical Trial Non-degree Award
Charles Kiyaga
ID:
Establishing universal screening and early interventions for SCD within the selected clinical networks for prevention of early mortality in Uganda.
REFNo: HS1362ES

Primary Objectives

a)To pilot newborn screening for SCD within the clinical networks of Jinja and Lira regional referral hospital in Uganda.

b)To register patient data and medical history of babies diagnosed with SCD within the first three months of life in a shared database.

c)To initiate antibacterial and antimalarial prophylaxis among the identified SCD infants within the first three months of life.

d)To ensure that the identified SCD infants are each immunized against pneumococcus and Haemophilus influenzae type b.

e)To monitor each patient at required intervals (every three months until age two years; every four to six months from age three to five years) and update patient record in registry after each visit.

f)To estimate the incidence of SCD among infants and children identified in Jinja and Lira regional referral hospitals and identify the specific hemoglobin genotypes.

Secondary Objectives

a)To measure the 5-year survival rate of children enrolled in the newborn screening cohorts.

b)To assess the costs of newborn screening and early interventions for each site or network

 Uganda 2021-07-14 2024-07-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan Babirye
ID: UNCST-2021-R013201
 Using realist evaluation principles to explore existing local innovations for improving timely attendance of first antenatal care among slum dwellers of Kampala, Uganda
REFNo: SS869ES

1) To identify the existing local innovations for increasing timely attendance of first antenatal care visit and their perceived success.
2) To describe the theories of change for the innovations perceived to be successful at increasing timely attendance of first antenatal care visit.
3) To explore the underlying mechanisms (generalizable contextual factors) that favored success of innovations perceived to be successful at increasing timely attendance of first antenatal care visit among slum dwellers.

Uganda 2021-07-14 2024-07-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Naome Wandera Namakula
ID:
Assessing the effectiveness of a course for men on Women’s Land Rights Social Norms in Kenya, Tanzania and Uganda- Endline Assessment in Uganda
REFNo: SS889ES

To document the current status of knowledge, attitudes, self-efficacy, intentions and perceptions of peer norms related to women’s land and property rights among men that participated in the SYFF course in Kenya and Uganda. The changes at end-line, if any, in knowledge, attitudes, self-efficacy, intentions and perceptions of peer norms related to women’s land and property rights among participants in the SYFF course in each country will be compared to baseline status.
 Uganda 2021-07-14 2024-07-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Janet SEELEY
ID:
Menstrual health interventions, schooling and mental health symptoms among Ugandan students (MENISCUS): a school-based cluster-randomised trial.
REFNo: HS1525ES

1. To evaluate whether the MENISCUS intervention improves educational attainment and reduces mental health symptoms (primary outcomes) among Secondary girls in Uganda.

2. To evaluate whether the MENISCUS intervention improves: i) knowledge of puberty and menstruation; attitudes towards menstruation (girls and boys); ii) menstrual practices at last menstrual period (LMP); iii) knowledge and practice of pain management during LMP; iv) self-efficacy in addressing menstrual needs experiences at LMP; v) quality of life and happiness; vi) school and class absence during menses (nested cohort); vii) school and class absence overall (nested cohort); viii) prevalence of urogenital infections (bacterial vaginosis, vaginal yeast and urinary tract infections)
3. To evaluate the costs of setting up and running the intervention package, the unit cost per female student reached, and the incremental cost-effectiveness of the intervention per unit increase in selected policy-relevant outcomes, relative to optimised usual care
4. To assess whether the intervention was implemented with fidelity, and to understand the contextual factors affecting implementation, the acceptability to participants, and the intervention mechanisms. We will achieve this through a process evaluation including quantitative indicators and qualitative data collected from in-depth interviews and focus group discussions.
5. To assess the policy environment around menstrual health in Uganda, focusing on how implementing the intervention contributes to, and aligns with, the attainment of the Government policy objectives on menstruation management in schools. We will assess the policy/regulatory frameworks to which the outcomes of the intervention contribute, identify the supportive and constraining factors to the implementation of the policy guidelines and how the findings of the intervention inform refinement of current policy.

 UK 2021-07-14 2024-07-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Damalie Nakanjako
ID: UNCST-2019-R000383
 Mobile Phone-based patient follow-up Package with Medical Intervention for HIV-infected adults to promote social distancing during and after the COVID19 pandemic lockdown crisis
REFNo: HS945ES

Objectives
1.To pilot use of a Mobile Phone-based patient follow-up Package with virtual Medical Interventions (PMI) among adults receiving antiretroviral therapy (ART) at the Mulago ISS clinic.
2.To determine the effect of a PMI on the number of physical clinical visits by patients receiving ART at the Mulago ISS clinic during the one-year study period.
3.To determine the effect of PMI on continuity of ART medication during the COVID19 pandemic crisis period.
4.To determine the acceptability of the PMI approach to follow up of patients receiving long-term ART by patients and care providers at the Mulago ISS clinic

Uganda 2021-07-13 2024-07-13 Medical and Health Sciences Non-degree Award
Christina Bergey Marie
ID: UNCST-2020-R014338
 Genetic survey of bloodborne pathogens and investigation of malaria response in sanctuary chimpanzees
REFNo: NS139ES

Our proposed study has three main objectives:

1. To determine which blood-borne pathogens sanctuary chimpanzees carry, with a particular interest in those which can be transmitted from human to chimpanzee (anthroponoses) and vice versa (zoonoses);

2. To diagnose malaria infection in sanctuary chimpanzees and determine which malaria parasite species are present, with a particular interest in human malaria that may be infecting the chimpanzees; and

3. To describe the genetic mechanisms underlying the chimpanzee immune system response to malaria, and contrast this with that of humans.
 USA 2021-07-13 2024-07-13 Natural Sciences Non-degree Award
Anthony  Fuller
ID:
Assessment of Accuracy, Precision, and Feasibility of a Handheld Near-Infrared Light Device (InfraScanner 2000™) in Detecting Subdural and Epidural Hematomas in Patients Admitted to Mbarara Regional Referral Hospital
REFNo: HS1010ES

Aim 1: Determine whether the InfraScanner 2000™ detects epidural and/or subdural hematomas with adequate precision relative to CT scans to be used as a diagnostic tool for epidural and/or subdural hematomas.

Aim 2: Use these findings to inform the feasibility of conducting a future trial in which the InfraScanner 2000™ is used as a stand-alone diagnostic tool for intracranial hematomas, and therein, to determine candidacy for decompressive craniotomies in patients who suffer TBIs in places where CT scans are not available.
 USA 2021-07-13 2024-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Vittorio Bassi
ID:
Covid-19 and the value of relationships in informal economies
REFNo: SS633ES

The overall goal of the study is to implement two exploratory phone surveys of a representative sample of Micro, Small and Medium enterprises (MSMEs) and their employees in Uganda. The survey is designed to document challenges firms are facing in investing and hiring workers during the covid-19 pandemic. In addition, the first phone survey will also embed a nudging experiment aimed at helping workers search for jobs and regain employment in the wake of the pandemic. This is an urgent study that forms a continued commitment of the researchers under BRAC Uganda partnership with Ministry of Trade, Industry and Cooperatives under Directorate of Micro and Small Medium Enterprises (MSMEs) to provide insights and learning on how the covid-19 shock has affected firm owners and employees’ relationships during the lockdown.
 Italy 2021-07-13 2024-07-13 Social Science and Humanities Non-degree Award
Ismay Milford Milford
ID:
The ‘Information Sector’ in East Africa, 1950s-70s: The professionalisation of journalism, broadcasting and information officers
REFNo: SS730ES

This project is a history of the ‘information sector’ as it emerged in dialogue with global patterns over the period of decolonisation in East Africa (c. 1950s-70s). I understand information not as a given technology inevitable to the language of the developmentalist state in mid-twentieth century Africa, but as a culturally constructed and moulded idea through which we can access connections that East African people of various ‘information professions’ forged with the wider world. This is in some sense a pre-history of the global debates around information that resulted in the call for a ‘New World Information and Communication Order’ in the 1970s. It argues that East Africa played an important role in the disciplinary shift from ‘information science’ to ‘mass communication’, and in the understandings of knowledge production that informed postcolonial theory.
UK 2021-07-13 2024-07-13 Social Science and Humanities Non-degree Award
Pierre ABOMO
ID:
Strengthening national capacity for tsetse control in Uganda
REFNo: SS725ES

1) Conduct semi-structured interviews with key personnel at COCTU and the District level to fully understand the current level of execution of the action plan for strengthening the capacity to for implementing tsetse control in Uganda

2) Conduct participatory workshops at COCTU and the District level to collaboratively assess the progress towards the establishment of a stronger and independent tsetse control system in Uganda (based on findings from objective 1).
UK 2021-07-13 2024-07-13 Social Science and Humanities Non-degree Award
Eddie Wampande Mujjwiga
ID:
An evaluation of African swine fever presentation and distribution in Uganda
REFNo: NS266ES

i. Conduct a serologic, clinical, pathological, and molecular diagnostic survey of swine at a large slaughterhouse near Entebbe and Kampala, Uganda to understand the relationship between the disease status and the diagnostic status of the animals as related to Africa swine fever.
ii. Conduct a serologic analysis slaughterhouse swine to measure the immune response against exposure to the Ornithodoros moubata tick, the ASF reservoir vector in Africa.
iii. Conduct trace back to hotspots to evaluate biosecurity and conduct training of veterinarians and producers on the clinical and pathological signs of Africa swine fever.
iv. Sequence PCR positive samples to better characterize the ASF genotype and strain and its disease presentation.
v. Discuss the findings with the Ministry of Agriculture, Animal Industries, and Fisheries.

 Uganda 2021-07-13 2024-07-13 Natural Sciences Non-degree Award
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