Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Zubair Lukyamuzi
ID: UNCST-2021-R013107
Feasibility and Acceptability of a Barbershop Based HIV Prevention Initiative Among Heterosexual Men in Kalangala Islands, Uganda: A Cluster Randomized Trial
REFNo: HS3430ES

1. To compare completion of self-initiated HIV testing between intervention and control groups
2. To evaluate the preliminary effectiveness of the intervention on change in behaviors associated with HIV acquisition
3. To compare interest in or use of HIV prevention services between intervention and control groups
4. To evaluate the preliminary effectiveness of the intervention on incident STIs
Uganda 2024-01-08 13:20:21 2027-01-08 Medical and Health Sciences Clinical Trial Non-degree Award
Tumuhimbise Jasper Mpiriirwe
ID:
HEAD TEACHERS’ LEADERSHIP PRACTICES AND FINANCIAL PERFORMANCE IN CHURCH OF UGANDA FOUNDED SECONDARY SCHOOLS IN NAMIREMBE DIOCESE
REFNo: SS2126ES

4. To explore the influence of head teachers’ stakeholder collaboration on financial performance in the Church of Uganda Founded Secondary Schools in Namirembe Diocese. ,3. To analyze the influence head teacher’s team leadership practices on financial performance in Church of Uganda Founded Secondary Schools in Namirembe Diocese in Namirembe Diocese.,2. To assess the influence of head teachers’ values on financial performance in Church of Uganda Founded Secondary Schools in Namirembe Diocese. ,1. To examine the influence of head teachers’ vision on financial performance of Church of Uganda Founded Secondary Schools in Namirembe Diocese.,The general objective of the study is to examine the influence of head teachers’ leadership practices on financial performance of Church of Uganda Founded Secondary Schools (CFSs) in Namirembe Diocese. ,
Uganda 2024-01-08 13:18:02 2027-01-08 Social Science and Humanities Non-Clinical Trial Degree Award
Joyce Kambugu Balagadde
ID: UNCST-2020-R014996
Feasibility of Nanopore Sequencing for Classification of Pediatric Malignancies in Low Resource Settings
REFNo: HS3397ES

Expand upon our adapted unbiased Nanopore sequencing classification platform while verifying the feasibility of classification of pediatric solid tumors using GEP. Hypothesis: Unbiased Nanopore sequencing can be implemented and can accurately classify pediatric cancer in low and middle income countries,Establish technical and human resources needed to carry out local, real-time sequencing on Nanopore platforms through optimizing existing supply chains in collaboration with Nanopore and establishing standardized virtual and in-person training of local research, laboratory, and information technology support.,Optimize and validate, within the context of use in low and middle income countries, the efficacy unbiased Nanopore sequencing platform for pediatric cancer classification after integrating a Cloud-based computational analysis pipeline. Hypothesis: Using a Cloud-based unbiased Nanopore sequencing approach, clinical laboratories in LMIC can perform sequencing with Cloud based analytical support, accurately classify pediatric cancer diagnosis and genomic subtypes.,To determine the feasibility of implementing and utilizing Nanopore sequencing for classification of pediatric malignancies, as determined by technical quality, data management, and classification accuracy.,
Uganda 2024-01-08 13:16:49 2027-01-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Tonny Ssekamatte
ID: UNCST-2022-R010961
Climate change health vulnerability and adaptation assessment (VAA) for sound management of climate change-related health risks in Uganda
REFNo: HS3168ES

6. To use evidence from objectives 1-5 to inform the development of a National Health Adaptation Plan (H-NAP) for effective mitigation, adaptation and response to climate change in the health sector.,5. To understand how monitoring and evaluation of mitigation, adaptation and response measures to climate-change related risks and impacts on the health sector in Uganda should be done,4. To explore what should be done to effectively mitigate, adapt and respond to climate change-related risks and impacts in the health sector in Uganda,3. To identify policies, programmes and adaptation mechanisms that should be prioritized to address current and projected health risks in the health sector in Uganda,2. To describe and quantify the potential impacts (present and future) of climate change on the health sector in Uganda,1. To describe and quantify climate-change related risks (present and future risks) on the health sector in Uganda,To conduct a national health climate change vulnerability and adaptation assessment to identify health risk factors and gaps for sound management of climate change-related health risks in Uganda,
Uganda 2024-01-08 13:15:39 2027-01-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Richard Sanya Edwin
ID: UNCST-2023-R006836
The Next Generation Vaccine Card: Innovative Technology to Improve Vaccine Equity in Kagando, a Rural Setting in Uganda
REFNo: HS3515ES

To implement and evaluate using cluster-randomised and pre/post intervention approaches, the ‘next generation digital vaccine card’ in Kagando Uganda I. Implement the digital vaccine card intervention in rural Uganda II. Evaluate the implementation process and effectiveness of the intervention III. Evaluate the impact of the intervention on equity at the individual and village levels. IV. Conduct an economic evaluation of the intervention.,To co-design and develop a ‘next generation digital vaccine card’ for childhood vaccinations I. Design and build a prototype digital vaccine card and registry II. Use iterative feedback to refine the digital vaccine card and registry III. Develop a Minimum Viable Product (MVP) that meets the desired stakeholder specifications,To evaluate the current routine childhood vaccination landscape in Kagando Uganda I. Assess baseline routine childhood immunisation data quality at the facility level using WHO standard indicators II. Assess equity in routine childhood immunisation coverage and timeliness using household survey data III. Collect and analyse qualitative data to understand current knowledge, attitudes, and practices of vulnerable populations from patient and provider perspectives.,To develop and evaluate a ‘digital vaccine card’ and registry that will facilitate the electronic collection of individual data at health facilities to allow improved monitoring of vaccine coverage and timeliness by both healthcare providers and parents/caregivers, in turn improving vaccine equity in rural Uganda. ,
Uganda 2024-01-08 13:14:20 2027-01-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hakim Sendagire
ID:
Clinical, Hematological and Biochemical predictors of outcome in patients admitted with Sudan Ebola virus disease during the 2022 Uganda Ebola Outbreak (CHEBE Study)
REFNo: HS2961ES

General Objective
To evaluate the clinical presentation, treatment, clinical chemistry, immune chemistry, hematology and other laboratory predictors of clinical outcome in patients admitted with Sudan Ebola virus disease during the 2022 Uganda Ebola Outbreak
Specific Objectives
1. To evaluate the clinical presentation of patients at the time of admission in the ETU and treatment offered during admission as predictors of outcome among Sudan EVD patients admitted in hospital during the 2022 Ugandan Ebola Outbreak (CHEBE Study).
2. To describe the clinical chemistry, immune chemistry, hematology and other laboratory predictors of outcome in patients admitted with Sudan Ebola virus disease during the 2022 Uganda Ebola Outbreak (CHEBE Study).
3. To determine the association between laboratory profiles, comorbidities and clinical outcomes among patients admitted with Sudan Ebola virus disease during the 2022 Uganda Ebola Outbreak (CHEBE Study).

Uganda 2024-01-08 13:13:08 2027-01-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Elisa van Dongen Maria Angela
ID:
Belief-based poverty traps and the effects of material and psychological interventions: Evidence from a lab-in-the-field experiment in rural Uganda
REFNo: SS2137ES

This research aims to empirically study the effects of aid on beneficiaries' and non-beneficiaries' agency beliefs and effort decisions.
Netherlands 2024-01-08 13:12:25 2027-01-08 Social Science and Humanities Non-Clinical Trial Non-degree Award
JOSELYN RWEBEMBERA
ID: UNCST-2021-R013915
Building the Foundation for Effective Sore Throat Treatment in Uganda.
REFNo: HS3473ES

Objective 1: Co-design a sore throat treatment program model using a community based participatory research approach to ensure a culturally and contextually appropriate and effective strategy for primary prevention of RHD.

Objective 2: Describe the current health seeking behavior of children who have a sore throat, including barriers and facilitators to seeking care within the formal healthcare system.

Objective 3: Describe the current approach by health care workers to a child presenting with sore throat, including barriers and facilitators to guideline-based care for children with sore throats.
Uganda 2024-01-08 13:11:15 2027-01-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Daudi Jjingo
ID:
AI for Health Equity: Transforming Pandemic Preparedness in Uganda (HEAL)
REFNo: HS3524ES

Primary objective: To leverage advanced Large Language Models (LLMs) like GPT-4 to convert the Uganda Ministry of Health pandemic preparedness guidelines and the National Action Plan for Health Security (NAPHS) into an interactive, conversation-based tool, accessible in a native African language. Secondary objective: To validate the effectiveness of the dynamic AI platform encompassing language adaptation, user satisfaction and perception, seamless implementation in clinical settings, and tangible impact on clinical decision-making by conducting focused field testing involving a group of 60 healthcare professionals.
Uganda 2024-01-08 13:08:26 2027-01-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph Kirabira
ID: UNCST-2019-R001427
ADAPTATION, FEASIBILITY AND ACCEPTABILITY OF CAREGIVER PEER-SUPPORTER FACILITATED HIV STATUS DISCLOSURE INTEVERNTION FOR CHILDREN IN EASTERN UGANDA – A TASK SHIFTING MODEL
REFNo: HS3547ES

To assess the feasibility and acceptability of the CPS facilitated disclosure intervention ,1. To culturally adapt a clinic-based pediatric HIV status disclosure intervention into CPS facilitated HIV status disclosure intervention among CLHIV and their caregivers in Uganda,To culturally adapt and assess the feasibility and acceptability of a CPS-facilitated HIV status disclosure intervention among caregivers of CLHIV at Jinja Regional Referral Hospital in Eastern Uganda. ,
Uganda 2024-01-08 13:07:36 2027-01-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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