Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Gloria Seruwagi Seruwagi
ID:
Knowledge, adherence and the lived experiences of refugees in COVID-19: A comparative assessment of urban and rural refugee settings in Uganda
REFNo: SS511ES

General objective
We seek to study refugee lived experiences, assess behavioural shifts and determine public compliance and social behaviour in both urban and rural refugee settings

Specific objectives
1. To assess knowledge or awareness of COVID-19 and local perception of risk in urban and rural refugee settings. This will also capture infodemic issues, myths, fears, etc
2. To identify local pre-post COVID attitudes and practices relating to health and social norms. This will include e.g. WASH, healthseeking behaviour, community cohesion practices
3. To explore implementers’ interpretation and enforcement of COVID-19 guidelines.
4. To determine the feasibility of, and adherence to, COVID-19 preventive measures.Will include local interpretations, experiences, innovations, improvisations and explanatory factors
5. To identify community resources, systems and assess their efficacy in the COVID-19 response. E.g. this will cover essential systems and services including health, social care and community leadership
6. To compare urban and rural refugees in line with Objectives 1-5

Uganda 2020-07-30 2023-07-30 Social Science and Humanities Non-degree Award
David Meya Bisagaya
ID: UNCST-2019-R000837
 Alternative Meningitis therapies Phase II Trial for Cryptococcal Meningitis (AMPLYX-CM)
REFNo: HS583ES

To determine the safety and efficacy for all drugs for the treatment of cryptococcal meningitis Primary: 1) “Early Fungicidal Activity” (EFA), which is the rate of CSF yeast clearance quantified by the change of log10 Cryptococcus CFU/mL CSF/day as measured by serial quantitative CSF fungal cultures over the first ~2 weeks 2) Incidence of Grade 3-5 laboratory Adverse Events 3) Incidence of Grade 3-5 Clinical Adverse Events or SAEs Secondary: 4) 18-week survival time as time to event analysis a. 2 and 10 week survival time will be presented 5) Among 2-week survivors, 18-week hospital-free survival time 6) Tolerability: all cause drug discontinuation, study withdrawal, or lost-to-follow-up 7) 3-month quantitative neurocognitive performance Z-score 8) Pharmacokinetic studies of APX001A concentrations in blood, CSF, and other bodily fluids/tissues; and with respect to concomitant medicines.
Uganda 2020-07-28 2023-07-28 Medical and Health Sciences Non-degree Award
Gertrude Nakigozi
ID:
Mental Health and Cognition in HIV Infection in Rakai, Uganda
REFNo: HS634ES

Aim 1: Examine separate and interactive effects of HIV and psychosocial determinants on CNS dysfunction in PLWH. Hyp 1. Exposure to sexual/physical trauma or violence will interact with HIV in this population and will be associated with greater impairments/decline in declarative memory, cognitive control, and NVS.

Aim 2: Examine effects of psychosocial determinants on ART adherence in PLWH. Hyp 2. Exposure to sexual/physical trauma or violence will interact with impairments/decline in declarative memory, cognitive control, and NVS will adversely affect ART adherence).

Exploratory Aim 3: Determine biomarkers that relate most strongly and reliably to CNS dysfunction in the context of HIV and/or psychosocial determinants. Hyp 3: Different biomarkers of neuronal damage damage (e.g., neurofilament protein light chain-NFL) and CNS inflammation will relate to patterns of impairment/decline in declarative memory, cognitive control, motor, and NVS in the context of HIV and/or exposure to sexual/physical trauma or violence.

Uganda 2020-07-28 2023-07-28 Medical and Health Sciences Non-degree Award
WILLIAM  MUSAMBA
ID:
Sub-ethnic Identities and Political Conflict in Uganda: The Case of Busoga (1900 to 1967)
REFNo: SS485ES

1)To analyze the influence of British colonial rule on the ethno-political conflicts in Busoga, 2)To assess the position of the Kyabazingaship (Paramount Chieftaincy) in the ethno-political conflicts in Busoga, 3)To examine the nature of political activism of the civic movements in Busoga namely, Young Busoga Association, the Abataka Association and the Abataka Mwoyo Gwa Busoga (Landlords are the Heart of Busoga), 4)To explore the attitude of post-colonial national leadership towards the ethno-political conflicts in Busoga.

Uganda 2020-07-28 2023-07-28 Social Science and Humanities Degree Award
Martha Namusobya Sarah
ID:
Prevalence and factors associated with chronic pulmonary aspergillosis (CPA) among pulmonary tuberculosis (PTB) patients with persisting pulmonary symptoms in Uganda.
REFNo: HS739ES

1. To determine the prevalence of CPA among patients receiving treatment for PTB.
2. To determine factors associated with CPA among patients receiving treatment for PTB.
3. To determine the impact of CPA on health-related quality of life among patients receiving treatment for PTB.


 Uganda 2020-07-28 2023-07-28 Medical and Health Sciences Non-degree Award
George Kwizera
ID:
HUMAN CAPITAL AND AGRICULTURAL TRANSFORMATION ON RURAL POVERTY REDUCTION IN UGANDA. A CASE OF KISORO DISTRICT
REFNo: SS442ES

1. To establish how education can ensure rural poverty reduction in Kisoro District
2. To explore the effect of training on rural poverty reduction in Kisoro District.
3. To examine how agricultural transformation can ensure rural poverty reduction in Kisoro District
4. To determine the relationship between agricultural transformation and human capital on rural poverty reduction in Kisoro District.

 Uganda 2020-07-27 2023-07-27 Social Science and Humanities Degree Award
Tanner Regan
ID:
Enhancing Voluntary Property Tax Compliance through SMS: A Field Experiment in Kampala, Uganda
REFNo: SS457ES

The overall aim of the research is to identify whether increasing public information on individual’s tax compliance has an effect on tax morale and compliance in the city of Kampala. These findings should help to inform the KCCA in the design of policy changes to increase tax revenues through higher voluntary compliance.

The central question of this research asks, “Does public reporting of tax payments raise compliance?”. We consider two channels of effect through which public reporting can influence compliance. The first is a direct effect; “How does an individual change their compliance behaviour when they know that this will be publicly reported?” and the second considers the effects of such a policy on tax morale; “How do tax payers change their behaviour when they observe others being publicly reported?”.

We address other questions to better answer the central question. In order to gain a further understanding of the underlying mechanisms and optimal policy, we will also ask:

• Whether the type of public reporting matters; “How does public reporting affect compliance behaviour when only compliers are reported, or when only non-compliers are reported?”
• Whether peer group matters for public compliance; “How does public reporting affect compliance behaviour when reporting is done on a village level vs a city level?”.
• Whether taxpayers are more likely to be influenced by knowledge of compliance of high property worth/’influential’ individuals

We are particular keen to understand how the effects of providing public information on compliance compare with other means of improving voluntary compliance in a context of limited trust in government. These additional methods will be identified based on focus group discussions that will be held between April and May 2020.

Canada 2020-07-27 2023-07-27 Social Science and Humanities Non-degree Award
Saul Nsubuga Hannington
ID:
Using a mobile App for contact tracing and monitoring of symptoms for early detection of COVID-19 infection in Uganda
REFNo: HS742ES

1) To develop a mobile App to facilitate early detection of COVID-19 infection in Uganda 2) To determine the acceptability and usability of the App 3) To use the App to document daily symptoms related to COVID-19 4) To use the App to trace and record daily contacts and movements made by people
 Uganda 2020-07-27 2023-07-27 Medical and Health Sciences Non-degree Award
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
 Diagnostic performance of STANDARDTM E TB-Feron ELISA and STANDARDTM F TB-Feron FIA (IFN-r) for tuberculosis diagnosis in a Ugandan population
REFNo: HS783ES

General Objective: To evaluate the diagnostic performance of STANDARDTM E TB-Feron ELISA and STANDARDTM F TB-Feron FIA (IFN-r) in a Ugandan setting.
Specific Obectives;
1. Evaluate the performance of TB-Feron blood collection tubes, STANDARDTM E TB-Feron ELISA, and STANDARDTM F TB-Feron FIA (IFN-r).
2. Compare the performance agreement and correlation of STANDARDTM E TB-Feron ELISA and STANDARDTM F TB-Feron FIA (IFN-r) with QuantiFERON-TB Gold Plus.

 Uganda 2020-07-27 2023-07-27 Medical and Health Sciences Non-degree Award
Fred Wabwire-Mangen
ID: UNCST-2021-R013549
 IMPROVING QUALITY AND UTILIZATION OF MATERNAL, NEONATAL AND CHILD HEALTH DATA THROUGH OPEN DATA KIT TECHNOLOGY AND COMMUNITIES OF PRACTICE IN UGANDA
REFNo: HS605ES

Broad objective: To pilot the open data kit technology and communities of practice to improve quality and utilization of MNCH data.

Sub-study one objectives
1. To determine the current knowledge and practices of health workers at EmONC health facilities regarding the assessment and management of mothers and newborns.
2. To use the knowledge and practice findings to prioritize, plan and implement QoC improvements regarding assessment and management of mothers and newborns through communities of practice in the participating health facilities

Sub-study two objectives
1. To assess the quality (completeness, accuracy, scope, reliability, relevance and timeliness) of MNCH data at sub-national and national level.
2. To assess the capacity at sub-national level to process (collect, capture, clean, analyse, interpret) and submit MNCH data to the DHIS2 as well as utilize at facility level to show trends in MNCH outcomes.
3. To develop and pilot the practicability and feasibility of an Open Data Kit (ODK) application customized for MNCH data collection and transmission to a consolidated server.
4. To create a community of practice to support a multi-level system for health data capture staff and implementers to continuously document, learn and share experiences on collection, analysis and utilization of MNCH data and indicators.

 Uganda 2020-07-23 2023-07-23 Medical and Health Sciences Non-degree Award
Peter  Kawungezi Chris
ID:
First Mile Community Health Program monitoring and evaluation
REFNo: HS643ES

1. To evaluate the impact of Continuing Medical Education on participants and trainees
2. To evaluate the impact of Post graduate Community Rotations on Trainees, and Community health facilities
3. To evaluate the impact of Faculty Community Health Mentorship on Faculty and Community health facilities
4. To evaluate the impact of Community Health Research Grants on Post graduate trainees and Faculty
5. To evaluate the impact of Community placement extension grants on undergraduate students and the community.

 Uganda 2020-07-23 2023-07-23 Medical and Health Sciences Non-degree Award
John Baguma Muhunga Kule
ID: UNCST-2023-R007146
 Control Environment, Credit Management Systems and Financial Performance of Savings and Credit Cooperatives in Mid-Western Uganda.
REFNo: SS513ES

1. To establish the relationship between control environment and financial performance of SACCOs in Mid-Western Uganda.
2. To ascertain the association between credit management systems and financial performance of SACCOs in Mid-Western Uganda.
3. To determine whether accountability mediates the affiliation between control environment and financial performance of SACCOs in Mid-Western Uganda.
4. To establish whether accountability mediates the relationship between credit management systems and financial performance of SACCOs in Mid-Western Uganda.
5. To establish the bond between accountability and financial performance of SACCOs in Mid-Western Uganda.
 Uganda 2020-07-23 2023-07-23 Social Science and Humanities Degree Award
Annet Nankwanga
ID:
Improving Makerere University Staff Health and Well-being through Streamlined Physical Activity Programs (Mak Active Project)
REFNo: HS592ES


The Project aims at improving the health and wellbeing of Makerere University staff through implementing well organized physical activity programs.
Uganda 2020-07-22 2023-07-22 Medical and Health Sciences Non-degree Award
Abel Wilson Walekhwa Wilson
ID: UNCST-2021-R011571
 WATER QUALITY ANALYSIS OF IMPROVED WATER SOURCES AND ASSOCIATED FACTORS IN KIBUKU DISTRICT, EASTERN UGANDA
REFNo: HS641ES

•To assess the quality of water from improved water sources
•To determine the factors influencing quality of surface water sources
•To establish the community knowledge, attitude and practices about water quality of improved water sources

 Uganda 2020-07-22 2023-07-22 Medical and Health Sciences Non-degree Award
Andrew Obuku Ekii
ID: UNCST-2024-R002288
 A PILOT STUDY TO EVALUATE THE FEASIBILITY OF IDENTIFYING, ENROLLING AND FOLLOWING ACUTE AND EARLY HIV-1 INFECTED INDIVIDUALS
REFNo: HS674ES

1. Evaluate the ability to detect persons with acute and early HIV-1 infection at selected voluntary counselling and testing centres in Masaka, Bukomansimbi, Kalungu, Lwengo, Sembabule, Lyantonde, Kyotera and Rakai Districts.
2. Evaluate participant retention rates within the six months of study follow up
3. Evaluate the proportion of GeneXpert HIV-1 Viral Loads reactive and Rapid Alere Determine HIV-1/2 non reactive individuals
 Uganda 2020-07-22 2023-07-22 Medical and Health Sciences Non-degree Award
Agnes Ssali Nanfuka
ID:
Investigating the social, health and economic vulnerabilities and resilience of children of women at high risk of HIV in Kampala, Uganda
REFNo: SS463ES

To determine the prevalence of HIV in children (aged 12-24 years) and their mothers who engage in sex for money or commodities at the GHWP clinic in Kampala, Uganda
2. To determine points of vulnerability and resilience in children of high-risk women through life course histories of a selected sample of children attending GHWP clinic
3. To understand the pathways through which contextual, structural and mental health challenges affect biomedical and behavioural HIV prevention and treatment outcomes of women who engage in sex for money or commodities in Kampala and their children

 Uganda 2020-07-22 2023-07-22 Social Science and Humanities Non-degree Award
Richard Mugambe Kibirango
ID:
Development of a behavioural intervention to foster proper urban waste management in Kampala City- Uganda.
REFNo: HS718ES

1. To explore the existing policies and interventions related to waste segregation and recycling so as to understand the facilitators and barriers; campaign activities, tools and touch points to inform the intervention package/ development.
2. To explore the facilitators and barriers to waste segregation at source and recycling in Kampala city.
3. To develop and adapt a behavioural intervention to foster waste segregation at source and recycling in Kampala city using findings from ‘1’ and ‘2’.
4. To pilot the intervention and evaluate its feasibility and acceptability for sustainable implementation at scale in fostering waste segregation and recycling in Kampala City.

 Uganda 2020-07-22 2023-07-22 Medical and Health Sciences Non-degree Award
Joseph Ssenyonga
ID:
Effects of violence and maltreatment on the development and well-being of children: Experimental approaches to studying the causal effects of maltreatment reduction (The EVIDENCE – Studies)
REFNo: SS444ES

The research project will be guided by the following objectives:
1. To assess the prevalence of common forms of violence in the school experienced by secondary school students in Southwestern Uganda.
2. To evaluate the disciplinary measures that are commonly used by teachers at secondary schools in Southwestern Uganda
3. To examine teachers’ and students’ perspectives on commonly used and perceived disciplinary measures.
4. To investigate the consequences of violence discipline measures used in schools in Southwestern Uganda.
5. To implement and evaluate the feasibility and effectiveness of the training program Interaction Competencies with Children for Teachers [ICC-T] that aims to prevent harsh discipline and violent disciplinary measures at secondary schools in Southwestern Uganda.

 Uganda 2020-07-17 2023-07-17 Social Science and Humanities Non-degree Award
Edward Mukooza
ID:
Health Risk Associated with Near-Road Ambient Air Concentration of Particulate Matter in Mukono Municipal Council, Uganda
REFNo: HS651ES

i- To measure the mean concentrations of near-road particulate matter PM2.5 in the period May 2020 to April 2021 in Mukono municipality, Uganda.
ii- To describe Mukono municipality’snear-road populations’ exposure to PM2.5 .
iii- To assess the healthrisk associated with the near-road concentrations of PM2.5, in Mukono municipality, Uganda.

 Uganda 2020-07-17 2023-07-17 Medical and Health Sciences Degree Award
Travis  Curtice Benjamin
ID:
Public Health, Trust, and Livelihoods: The Case of COVID19 in Uganda
REFNo: SS465ES

The key objectives of this study are to explore 1) how support for, and trust in state institutions shape individuals’ responses to public health crisis caused by the Coronavirus; and 2) more generally, the effect of COVID19 on income and livelihoods in a low-income country setting.

Overall Objectives
The coronavirus continues to spread across the globe. While there have been several early assessments of individuals' concerns and behavior in response to the shifting landscape of the pandemic, most work thus far has concentrated in OECD countries. We therefore know far too little about the impact of the Coronavirus on everyday life in low-income countries, where the virus has made a late entry. Focusing on the case of (rural) Uganda, our proposed study aims to close this gap. Results from this study will provide important insights into the relationship between trust in the government and public health and the impact of the public health crisis on migration, money transfers, and economic and food insecurity.

We propose to conduct a short phone survey that builds on a recently completed randomized control trial (RCT). The follow-up survey will allow us to test whether trust in political institutions are important not only in shaping individuals’ attitudes (e.g., their assessment of governments mitigating actions), but also their preventative health behaviors in response to the novel Coronavirus in Uganda. We are also interested in documenting how the Coronavirus is affecting the livelihood and wellbeing of the rural poor in a low-income country setting, where Covid-19 research has been sparse.

 USA 2020-07-17 2023-07-17 Social Science and Humanities Non-degree Award
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