Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Damalie Nalwanga
ID: UNCST-2021-R013217
 Exploring understanding, attitudes and practices of frontline health workers and caretakers regarding the relationship between severe pneumonia and malnutrition in children in the context of COVID-19
REFNo: SS803ES

1.To assess the level of understanding of frontline health workers and caretakers regarding the relationship between severe pneumonia and malnutrition in the context of COVID -19
2.To assess the attitudes of frontline health workers and caretakers regarding the relationship between severe pneumonia and malnutrition in the context of COVID -19
3.To assess the practices of frontline health workers and caretakers regarding the relationship between severe pneumonia and malnutrition in the context of COVID -19

 Uganda 2021-06-16 2024-06-16 Social Science and Humanities Non-degree Award
Emmy Okello
ID: UNCST-2020-R009792
 Active Case Detection and Decentralized Dynamic Registry to Improve the Uptake of Rheumatic Heart Disease Secondary Prevention (ADD-RHD)
REFNo: HS1323ES

Primary Objective:
To develop and refine a technology-enabled approach to increase uptake of secondary prevention (ADD-RHD) that is sustainable and replicable at scale to improve outcomes for people living with RHD.

Secondary Objectives:
Aim 1: Optimize the ADD-RHD ACT Platform to maximize case retention and delivery of secondary prophylaxis.
Aim 2: Roll out and evaluate the implementation of the ACT Platform.
Aim 3: Assess the adequacy of current policy and regulatory guidance in Uganda for the adoption of new technologies for health in general, and for rheumatic heart disease diagnosis and management and to describe system and policy constructs necessary for the successful approval of new health technology.
Aim 4: Estimate costs, cost-effectiveness, and budget impact of the ACT platform intervention.

 Uganda 2021-06-16 2024-06-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Julius Okuni Boniface
ID: UNCST-2019-R000963
 A MULTI-COUNTRY, SINGLE-BLINDED, PHASE 2 STUDY TO EVALUATE RAPID DETECTION SYSTEMS OF SARS-COV-2
REFNo: HS1425ES

1. To determine the clinical sensitivity of the test assays compared to the real-time RT-PCR-based method.
2. To determine the specificity of the test assays compared to the real-time RT-PCR-based method.

 Uganda 2021-06-16 2024-06-16 Medical and Health Sciences Clinical Trial Non-degree Award
William Worodria Ofuti
ID: UNCST-2022-R010915
 The effect of household air pollution on lung function recovery in COVID-19 disease
REFNo: SS892ES

Main objective
- The overall aim of the study is to measure the effect of air pollution on lung function recovery after COVID-19 pneumonia.

-Measure the effect of air pollution exposure on lung function recovery after COVID-19.

Specific Objectives

- Measure the effect of mobility on air pollution exposure and lung function recovery after COVID-19.
-
 Uganda 2021-06-16 2024-06-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Moses  Mulumba
ID: UNCST-2021-R013832
 An Ethnographic Analysis of the Right to Health Based Monitoring of and Advocacy for the Progressive Realization of Universal Health Coverage in Uganda
REFNo: SS793ES

Study Goal

The goal of the project is to establish the extent to which OPERA plus PAR supports the localization of the right to health

Specific objectives
To build the capacity of civil society and influential academia on the use of the OPERA framework

To explore the current levels of enjoyment of the right to health in Uganda

To assess state commitments and efforts to fulfill the right to health including the use of adequate resources

To examine constraints to the state's compliance to fulfill the right to health.
 Uganda 2021-06-14 2024-06-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Christine  Wiltshire Sekaggya
ID: UNCST-2019-R000578
 Establishing the prevalence of COVID19 infection among patients attending TB clinic, and the effect of COVID19 on TB clinical care in Kampala
REFNo: HS1304ES

Primary objective: 1. To determine the prevalence of COVID-19 infection amongst adult patients attending TB clinics Secondary objectives 1. To determine the prevalence of previous COVID-19 infection amongst adult patients attending TB clinics 2. To explore the experiences of patients attending TB clinic during the COVID-19 pandemic 3. To explore the experiences of healthcare workers in relation to TB care provision during the COVID-19 pandemic
Uganda 2021-06-11 2024-06-11 Medical and Health Sciences Non-degree Award
Arthur Bagonza
ID:
EFFECTIVENESS OF SUPPORT GROUPS ON IMPROVING LIVELIHOOD OF PEOPLE WITH ALBINISM IN UGANDA
REFNo: SS882ES

1. To map and profile all PWA and service providers of PWA in three regions (Northern, Western and Central) Uganda.

2. To construct a model of group support for PWA in three regions of Uganda based on views of PWA.

3. To determine the effectiveness of support groups on increasing access to services and inclusion of People with Albinism in mainstream development processes in Uganda.

4. To explore perceptions of key stakeholders on the use of support groups in increasing access to services and inclusion in mainstream development processes for PWA in Uganda


 Uganda 2021-06-11 2024-06-11 Social Science and Humanities Non-Clinical Trial Non-degree Award
Romeo Gichohi wahome
ID:
EFFECTIVENESS OF IMPROVISED CARDBOARD SPLINTS AS AN ALTERNATIVE TO PLASTER OF PARIS IN THE EMERGENCY TREATMENT OF LOWER LIMB FRACTURES
REFNo: HS1357ES

General Objective
1. To determine whether improvised cardboard
splints are a viable effective
alternative to plaster of Paris splints
for lower limb fractures in Mbarara
Regional and Referral
Hospital.
Specific Objectives
1. To compare the clinical effectiveness of immobilization between improvised cardboard
and plaster of Paris splint in lower limb fractures.
2. To compare the time and resource costs between improvised cardboard and plaster of
Paris in splinting of lower limb fractures.
 Kenya 2021-06-11 2024-06-11 Medical and Health Sciences Non-Clinical Trial Degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
 Accelerating Anti-Tick Vaccine Production Using Computational Approaches and Validation with An In-Vivo Model
REFNo: NS165ES

The specific objectives of this study will be to;
i.Create an open access queryable database of candidate anti-tick vaccine protein from I. scapularis proteome
ii.Identify single and chimeric antigenic anti-tick peptides basing on tick-specific amino acid sequences
iii.Evaluate the immunogenicity of five of the most promising antigenic single and chimeric anti-tick peptides in a laboratory animal [three months New Zealand rabbits] model
Uganda 2021-06-10 2024-06-10 Natural Sciences Non-degree Award
Jerome  Kabakyenga Kahuma
ID: UNCST-2021-R013729
 Smart discharges to improve post-discharge health outcomes in children below 6 months old
REFNo: SS855ES

To determine the effectiveness of a Smart Discharge program on post-discharge health seeking behavior and mortality among children under 6 months of age admitted with a proven or suspected infection.
 Uganda 2021-06-08 2024-06-08 Social Science and Humanities Non-Clinical Trial Non-degree Award
Musa Sekikubo
ID: UNCST-2021-R014010
 A multi-Centre, randomised, placebo controlled, double-blind, parallel group study to evaluate the safety, tolerability and immunogenicity of two doses of Group B Streptococcus vaccine (GBS-NN/NN2) in women who are pregnant and living with HIV and women who are pregnant and do not have HIV
REFNo: HS1390ES

Objectives
Primary Objectives:
Safety:
To evaluate the safety and tolerability of the GBS-NN/NN2 vaccine in women living with HIV and women without HIV and their newborn babies from vaccination up to delivery/birth.
Immunological:
To compare the transfer rate of vaccine- specific immunoglobulin G (IgG) antibody concentrations from the mother to the baby at birth in women living with HIV with the transfer rate in women without HIV. This endpoint will be used to determine the sample size calculation.
Secondary Objectives
Safety: The safety and tolerability of the GBS-NN/NN2 vaccine in the mother and baby over the first 6 months post-partum, as assessed at 6 months of age.
Immunological: The secondary immunological objectives are:
• To compare IgG antibody responses, specific to the GBS-NN/NN2 vaccine, induced by the first and second vaccine doses over time in pregnant women living with HIV and pregnant women without HIV.
• To evaluate the concentration of IgG antibodies specific for the GBS-NN/NN2 vaccine up to 6 months post-delivery in the mother and baby in women with and without HIV.
• To determine the concentrations of vaccine specific IgG to GBS-NN/NN2 in cord blood at delivery in babies born to women with and without HIV.
Exploratory Objectives
• To compare between groups the isotype composition of the vaccine specific antibodies; in particular IgG and IgA as well as their subclasses, i.e. IgG1-4, IgA1 and IgA2 in maternal and cord blood.
• To compare between groups the vaccine specific IgG antibodies to Rib, Alp1, Alp2 and AlpC, GBS-NN and GBS-NN2 in maternal and cord blood.
• To compare between groups the functional activity of vaccine specific antibodies from cord blood in an opsonophagocytic killing assay (OPkA) and other in vitro assays in selected samples.

 Uganda 2021-06-08 2024-06-08 Medical and Health Sciences Clinical Trial Non-degree Award
Flavia Matovu Kiweewa
ID: UNCST-2021-R013337
 Using Recency Assays to estimate incident HIV infections among Adolescent Girls and Young Women in Hoima and Mityana/Mubende Districts, Uganda Version 2.0 dated 14 April 2021: Gilead Protocol Number :CO-US-985-6117(eStimating hIv incidEnce amoNg Agyw (SIENA) Study)
REFNo: HS1439ES

Primary Objective
i) To estimate the proportion of incident recent HIV infections among AGYWs aged 16-25 years in Hoima and Mityana/ Mubende districts, Uganda.
Secondary Objective
ii) To compare HIV incidence estimated using the Asanté™ HIV-1 Rapid Recency POC kit with that obtained using the Sedia™ HIV-1 LAg-Avidity EIA and the Abbott ARCHITECT HIV Ag/Ab Combo assays.
 Uganda 2021-06-08 2024-06-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sifiso Lukhele Mbhekeni
ID:
GENOMIC EVIDENCE OF THE ROLE OF COMMUNICATION SIGNALS IN MEDIATING REPRODUCTIVE ISOLATION AT CONTACT ZONES
REFNo: NS117ES

1. Identify the threshold of variation in communication signals above which species boundaries are maintained.
2. Determine the importance of divergence time and time since secondary contact on levels of interbreeding.
 South Africa 2021-06-04 2024-06-04 Natural Sciences Non-Clinical Trial Degree Award
Irene Ayakaka
ID:
Feasibility of integrating Leprosy systematic contact follow up and Post Exposure Prophylaxis (PEP) into the Routine Leprosy Control Program in Uganda: A case study of Arua and Koboko districts
REFNo: HS1046ES

Objectives
The overall goal of the study will be to contribute to the elimination of leprosy in Uganda and to describe how best to carry out PEP with Single Dose Rifampicin (SDR) in Uganda.

Specific objectives
1. To assess the feasibility of leprosy post exposure prophylaxis in Arua and Koboko; two high burden districts in Uganda
2. To administer single dose rifampicin to eligible contacts of leprosy patients at their homes
3. To assess the factors associated with successful contact investigation for Leprosy in Arua and Koboko districts
4. To describe opportunities and synergies that can be leveraged in the districts to integrate contact investigation with other on-going community-based activities

Secondary Objectives
1. To perform leprosy data verification in Arua and Koboko districts in Uganda.
2. To assess acceptability of leprosy-contact investigation in households and in the community in Arua and Koboko districts.
3. To document the contribution of contact tracing to early leprosy diagnosis and prevention of grade2 disabilities

 Uganda 2021-06-04 2024-06-04 Medical and Health Sciences Non-degree Award
Danielle Barrington-Francis Jennifer
ID:
Children and their caregivers’ experiences with incontinence
REFNo: SS806ES

3. Prepare and disseminate results, recommendations and methodologies that can be used in developing more holistic, effective and inclusive humanitarian programming.,2. Collect data on attitudes towards and experiences of incontinence from children (aged five to 11), their caregivers and enabling actors through interviews, focus groups and collaborative story book methodology in Adjumani District; and,1. Develop and assess a collaborative story book methodology to engage children (aged five to 11) in humanitarian contexts in discussions of sensitive topics;,
 Australia 2021-06-04 2024-06-04 Social Science and Humanities Non-Clinical Trial Non-degree Award
Ceriano Mbiika
ID:
Systems Approach to ICT/Telecom Network Energy Management for Sustainability in Sub-Saharan Africa.
REFNo: SIR56ES

• To analyze the strategic, policy and regulatory frameworks employed by other countries and borrow ideas to address energy management challenges for Telecom networks in SSA. • To investigate the weaknesses in the current telecom network energy management approaches across SSA and explore complex emergent properties. • To investigate the effects and influences of economic-socio-ecological factors on the management of telecom power across Sub-Saharan Africa. • To investigate and analyze a suitable methodology and technique from the field of systems thinking that can be applied for problem structuring of current telecom network energy management across SSA. • To formulate a novel framework for guiding the management of sustainable/efficient energy solutions in ICT/Telecom networks across SSA • To use the proposed framework to contribute innovative solutions and suggestions to the energy complex problems in order to achieve holistic benefits to all the energy system’s stakeholders.
 Uganda 2021-06-04 2024-06-04 Engineering and Technology Non-Clinical Trial Degree Award
SABRINA KITAKA BAKEERA
ID: UNCST-2020-R014290
 SEARCH: SMS Electronic Adolescent Reminders for Completion of HPV vaccination in Uganda
REFNo: SS822ES

This protocol is solely for text and voice phone message and intervention development for a subsequent feasibility trial to improve adherence to HPV vaccination schedules in Kampala City., 2: Develop and pre-test HPV vaccine reminders with the target population, 1: Identify desired HPV vaccine text message reminder content (and parallel automated phone reminders) using key informant interviews ,
 Uganda 2021-06-04 2024-06-04 Social Science and Humanities Non-Clinical Trial Non-degree Award
WINTERS MUTTAMBA
ID:
A HEALTH SYSTEMS ANALYSIS AND MODELLING OF METHODS TO MAXIMIZE UPTAKE AND UTILIZATION OF ADVANCED DIAGNOSTICS IN LOW- AND MIDDLE-INCOME COUNTRIES – THE CASE OF COVID-19
REFNo: HS1337ES

1.To quantify the degree of uptake & utilization of COVID-19 diagnostic tests in Uganda, Rwanda, Kenya and UK
2.Map the pathways of uptake and ramping up COVID-19 testing in the study countries.
3.To characterise micro level and macro level factors affecting uptake and utilisation of COVID-19 diagnostic tests in Uganda, Kenya, Rwanda and UK
4.Modelling data obtained in 1) and 2) to identify best models for maximizing uptake of advanced diagnostic tests in health emergencies.
Uganda 2021-06-04 2024-06-04 Medical and Health Sciences Non-degree Award
Ivaibi Charles
ID:
SELECTED CORRELATES OF WORK ENVIRONMENT AND HEALTH SERVICES DELIVERY IN HEALTH CENTRES IN BUSOGA REGION,EASTERN UGANDA
REFNo: SS798ES

(a) To establish the relationship between Support Supervision and Health Services Delivery at Health Centers in Busoga region.
(b) To study the relationship between Physical Work Environment and Health Services Delivery at Health Centers in Busoga region.
(c) To get in-depth information about the relationship between Information Management and Health Services Delivery at Health Centers in Busoga region.
(d) To design a model that will guide effective Health Services Delivery at Health Centers in Busoga region.
 Uganda 2021-06-04 2024-06-04 Social Science and Humanities Non-Clinical Trial Degree Award
Catherine Namuga
ID:
INVESTIGATING THE POTENTIAL OF BIOACTIVE GAUZE DRESSING IMPREGNATED WITH HERB-LOADED NANOPARTICLES IN FACILITATING WOUND HEALING
REFNo: HS1393ES

The main aim of this work is to functionalise the gauze dressing using herb loaded nanoparticles to enable faster wound healing in excision wound models established in rats.

Specific objectives
1) To determine the antibacterial activity of Bidens pilosa L., Hoslundia opposita Vahl and Ageratum conyzoides L., plant extracts.
2) To determine the effect of the most efficacious antibacterial herbal extract on wound healing rate using excision wound models in rats.
3) To determine the effect of nano encapsulation of the herbal extract using biopolymers, on its antibacterial activity and wound healing rate.
4) To evaluate the effect of incorporating herb loaded nanoparticles into the gauze dressing on its antibacterial activity and wound healing rate.
5) To assess the effect of the herb loaded nanoparticles on the performance characteristic of the gauze dressing.

Uganda 2021-06-04 2024-06-04 Medical and Health Sciences Non-Clinical Trial Degree Award
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