Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
The Efficacy and Safety of Hydroxychloroquine for The Treatment of Non-Severe Covid-19
REFNo: HS839ES

To compare the viral clearance among adults with non-severe COVID-19 randomized to receive hydroxychloroquine plus standard of care vs. standard of care.
2. To evaluate the safety and tolerability of Hydroxychloroquine among COVID-19 patients in Uganda
Uganda 2020-08-13 2023-08-13 Medical and Health Sciences Non-degree Award
Violet Kayom Okaba
ID:
Assessment of the Process of Delivery of the Essential Newborn Care Practices in the Antenatal Care Clinic in Kawempe National Referral Hospital in Uganda
REFNo: HS752ES

Primary objectives
1. To evaluate the mothers’ knowledge on essential newborn care practices following antenatal care attendance in Kawempe National Referral hospital.
2. To determine the facilitators and barriers to delivery of the ENC practices in the ANC clinic in Kawempe National Referral hospital.

Secondary objective
1. To evaluate the uptake of the essential newborn care practices in the ANC clinic of Kawempe National Referral hospital using the RE-AIM framework.

Uganda 2020-08-12 2023-08-12 Medical and Health Sciences Non-degree Award
Mary Nabakooza
ID:
SCHOOL-BASED MENTORSHIP AND TEACHING COMPETENCIES. A COMPARATIVE STUDY OF PUBLIC AND INTERNATIONAL SCHOOLS IN WAKISO DISTRICT
REFNo: SS422ES

to examine the relation ship between school -based mentorship on lesson preparation in public schools and international schools in wakiso district.
To establish the relationship between the school -based mentorship on lesson presentation in public schools and international schools in wakiso district.
To determine the relationship between the school -based mentorship on assessing of learners'performance in public schools and international schools in wakiso district.

Uganda 2020-08-11 2023-08-11 Social Science and Humanities Degree Award
Laban Musinguzi Kashaija
ID: UNCST-2020-R014407
THE EFFECT OF COVID-19 ON THE WELL BEING OF CHILDREN IN UGANDA
REFNo: SS540ES


1. To document the nature and perpetrators of the cases of violence against children (VAC) in the wake of COVID-19 pandemic in Uganda.
2. To assess the effect of COVID-19 pandemic on children’s access to violence against children preventive and response services in Uganda.
3. To assess the effect of COVID-19 pandemic on children’s utilization of violence against children preventive and response services in Uganda.
4. To inform the child protection policy and programming process during and after this pandemic and similar future pandemics.
Uganda 2020-08-11 2023-08-11 Social Science and Humanities Non-degree Award
Muhmood Kiryowa Haruna
ID:
Periodontal disease in diabetic patients attending kiruddu referral hospital
REFNo: HS610ES

To determine the prevalence and factors associated with periodontal disease in diabetic patients attending kiruddu referral hospital
Uganda 2020-08-10 2023-08-10 Medical and Health Sciences Degree Award
Ruth Kaziga
ID:
SOCIOCULTURAL CONSTRUCTION OF BODY IMAGE AND ITS EFFECT ON SELF-ESTEEM OF OLDER BANYAKOLE ADOLESCENT GIRLS IN THE ANKOLE REGION, SOUTH WESTERN UGANDA
REFNo: SS466ES

1. To describe the self-perception of adolescent girls' construction of body image within the Ankole society
2. To explore the contradictory societal expectations of body image where the older adolescents live
3. To identify facilitators and barriers to body image and self-esteem

Uganda 2020-08-10 2023-08-10 Social Science and Humanities Degree Award
Matthew Bird Aileen
ID:
Consumer Protection Survey
REFNo: SS523ES

In this study, we aim to generate insights on consumer protection topics related to mobile telecommunications and digital finance in Uganda. Areas to be explored through this nation-wide phone survey include consumer usage and preferences regarding service providers, levels of trust, pricing awareness, challenges, fraud, dispute resolution, and the impact of COVID-19 on these topics. This project is being conducted in partnership with the Uganda Communications Commissions (UCC).
USA 2020-08-10 2023-08-10 Social Science and Humanities Non-degree Award
William Buwembo
ID:
MECHANISMS UNDERLYING DENTAL CARIES AND PERIODONTAL DISEASE IN HIV POSITIVE PERSONS ATTENDING THE MULAGO ISS CLINIC IN UGANDA
REFNo: HS552ES

General Objective
To establish the mechanisms underlying dental caries and periodontal disease in HIV positive adults attending the Mulago ISS clinic in Uganda

Specific Objectives
1. To determine the effect of HIV status on salivary gland function (flow rate, electrolytes, antimicrobial proteins content and DEFB1 single nucleotide polymorphism) in persons with or without dental caries or periodontitis.
2. To determine the abundance and diversity of the oral microbiome in HIV positive individuals with or without dental caries or periodontitis.

Uganda 2020-08-07 2023-08-07 Medical and Health Sciences Non-degree Award
Eugene Ruzagira
ID: UNCST-2023-R008282
A mixed-methods observational study to assess the feasibility of conducting COVID-19 vaccine trials among healthcare workers in Uganda
REFNo: HS807ES

I. To assess willingness to participate in COVID-19 vaccine studies and associated factors among healthcare workers in Uganda
II. To estimate the prevalence of underlying health conditions that are associated with poor COVID-19 outcomes among healthcare workers in Uganda
III. To describe the knowledge, attitudes, and practices regarding infection with SARS-CoV-2 and COVID-19 vaccine research among healthcare workers in Uganda

Uganda 2020-08-07 2023-08-07 Medical and Health Sciences Non-degree Award
Mary Ann Etling
ID:
Ethnographic analysis of children with mobility disabilities and their caregivers in Gulu district of post-conflict northern Uganda
REFNo: HS311ES

Identify ongoing needs of children with mobility disabilities and their caregivers in Gulu district.
Characterize physical, economic, social, and environmental barriers that children with mobility disabilities and their caregivers experience in Gulu district.
Investigate changes in the family and how they impact care for children with mobility disabilities in Gulu district.
USA 2020-08-06 2023-08-06 Medical and Health Sciences Non-degree Award
Ronald Moses Galiwango
ID: UNCST-2024-R015239
SARS CoV-2 Infection, Transmission, and Natural History of COVID-2019 Among Persons With and Without HIV and Tuberculosis
REFNo: HS712ES

Primary objective
• Evaluate the impact of HIV infection on presentation and outcomes of COVID-19 disease

Secondary objectives
• Evaluate household transmission of COVID-19 disease among persons with and without HIV infection
• Evaluate the impact of TB infection on presentation and outcomes of COVID-19 disease
• Among persons living with HIV, evaluate the relationship between routine biomarkers (CD4#, viral load) and outcomes of COVID-19
• Among persons living with HIV, evaluate the impact of being on antiretroviral drugs and different ARV regimens on COVID-19 outcomes
• Understand the impact of nutritional and functional status on persons with COVID-19 infection

Uganda 2020-08-06 2023-08-06 Medical and Health Sciences Non-degree Award
Raymond Tweheyo
ID: UNCST-2020-R014507
Exploring the root causes and cultural norms for healthy timing and spacing of pregnancies and assessing access to quality and voluntary family planning in central and western Uganda.
REFNo: HS787ES

Specific objectives:
1)To explore the socio-cultural norms and sexual reproductive health behaviors that influence the youth’s access to FP information and use of FP services.
2)To assess the health system readiness for provision of family planning and youth friendly services in both public and private facilities.
3)To assess the private pharmacy and drug shop readiness for provision of family planning services.
4)To assess community Village Health Team (VHT) capacity and readiness to offer FP services.

UK 2020-08-06 2023-08-06 Medical and Health Sciences Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
Assessment of safety and efficacy of COVID-19 Convalescent Plasma for treatment of COVID-19 in adults in Uganda; A randomized controlled trial (CCP TRIAL)
REFNo: HS816ES

General objective
The overall objective of this project is to assess the safety and efficacy of COVID-19 convalescent plasma in the treatment of COVID-19 in Uganda.

Primary objective
1. To determine the efficacy of COVID-19 Convalescent Plasma, as measured by time to RT-PCR negativity of COVID-19 patients treated with COVID-19 Convalescent Plasma.
Secondary objectives
1. To assess the safety of COVID-19 Convalescent Plasma in the treatment of COVID-19 patients in Uganda
2. To document the time to symptom decrease of patients with positive SARS-CoV-2 RT PCR treated with CCP compared to those on standard of care
3. To assess the ability of CCP therapy to stop progression to severe/critical forms of disease

Uganda 2020-08-05 2023-08-05 Medical and Health Sciences Non-degree Award
Jimmy Osuret
ID:
Effectiveness of safe pedestrian crossings for primary school children in Kampala, Uganda: Implications for road safety management
REFNo: HS659ES

The main objective of this study will be to assess the effectiveness of safe pedestrian crossings in reducing child pedestrian road traffic injuries and death around primary school areas so as to persuade policymakers and practitioners to prioritize child pedestrian road safety.
Uganda 2020-08-04 2023-08-04 Medical and Health Sciences Degree Award
Abel Nkolo
ID:
Multimorbidity, Healthcare Processes, versus Mortality among TB/HIV Patients on ART in Uganda
REFNo: HS692ES

1. Determine the association between multimorbidity (non-communicable disease clusters like diabetes, hypertension malnutrition, cancers etc.) and mortality among TB/HIV patients on ART?
2. Analyze the association between demographic factors (sex, age and marital status) and mortality among TB/HIV patients on ART
3. Analyze the association between the phase of TB treatment (Initiation and continuation) and mortality among TB/HIV patients on ART.
4. Determine the association between time of initiation of ART (before the start of TB treatment and after the start of TB treatment) and mortality among TB/HIV patients on ART.
5. Determine the association between the type of TB (pulmonary bacteriologically confirmed, pulmonary clinically diagnosed and extrapulmonary) and mortality among TB/HIV patients on ART.

Uganda 2020-08-04 2023-08-04 Medical and Health Sciences Degree Award
Allen Kabagenyi
ID:
Using Telehealth Services To Support The Continuity Of Family Planning Information, Access, And Utilisation During The Covid-19 Pandemic In Uganda
REFNo: HS799ES

• To conduct a survey among clients on an existing telehealth platform to identify the information gaps and challenges of accessing family planning during the COVID-19 pandemic lockdown.
• To develop an information package for improving access to family planning services
• To assemble a community advisory board (CAB) to review content of the family planning information package
• To pilot the use a telehealth platform for improving continuity and knowledge of family planning services during the COVID-19 lockdown.
• To assess the perceptions towards long-acting reversible family planning methods during the post COVID-19 lockdown. Using the telehealth platform.

Uganda 2020-08-04 2023-08-04 Medical and Health Sciences Non-degree Award
IVAN JJOOGA
ID:
‘Economic analysis of beef cattle fattening systems in Nakaseke District, Central Uganda’
REFNo: A68ES

(i) Overall objective
-To determine the economic performance of beef cattle fattening systems used in Nakaseke District.

(ii) Specific objectives

(a) To assess the profitability of different beef cattle fattening systems in Nakaseke District.
(b) To identify the major challenges hindering the adoption of better beef cattle fattening systems by fatteners.

Uganda 2020-08-03 2023-08-03 Agricultural Sciences Degree Award
Katharine  Brockett
ID:
A study of breast cancer awareness and barriers to accessing breast cancer services amongst adult inpatients and their attendants at Bwindi Community Hospital
REFNo: HS755ES

To find out participants awareness of breast cancer focusing on knowledge of risk factors, signs and symptoms and preventative measures. To ask about participants perceived barriers and identify other issues that may restrict access to breast cancer related care.
UK 2020-08-03 2023-08-03 Medical and Health Sciences Non-degree Award
Doreen Nakimuli
ID: UNCST-2021-R013668
Understanding Self Injection of DMPA-SC: Consumer Insight Research
REFNo: HS767ES

To understand where consumers get their health and family planning information from, where and how they access family planning products, what might motivate them to choose DMPA-SC self-injection, what are the barriers to choosing self-injection, what are consumers’ perceptions and attitudes towards self-injection.
Uganda 2020-08-03 2023-08-03 Medical and Health Sciences Non-degree Award
Harriet Mayanja-Kizza
ID: UNCST-2021-R013074
Evaluation of New Diagnostics and Field evaluation of point-of-care triage tests for Active Tuberculosis.
REFNo: HS688ES

The primary objective of the study is:

1. To finalise a POC-MBT TB triage test suitable for global application and to perform field-testing and validation thereof. The target for each validation process will be the World Health Organisation (WHO) target product profile 90% sensitivity and 70% specificity.

Secondary objectives:
1. To compare the efficacy of the POC-MBT’s TB diagnostic ability between certain sub-classification groups, for example by HIV-status, history of previous TB, extra-pulmonary vs pulmonary TB, and positive vs negative smear/GeneXpert® Ultra/culture.
2. To estimate the efficiency of different TB diagnostic algorithms that include the POC-MBT screening test along with clinical and/or radiological and/or sputa results.
3. To evaluate the POC-MBT as an indicator of treatment response during treatment for active TB.
4. To evaluate a prototype 3-marker gene signature on an Xpert mRNA cartridge using fingerstick blood.
5. To store samples and data to allow the testing or validation of future diagnostic candidates and algorithms, such as automated chest X-ray analysis and transcriptomic bio-signatures.

Uganda 2020-07-30 2023-07-30 Medical and Health Sciences Non-degree Award
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