Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Hiroyuki Takeshima
ID:
Introducing market-oriented horticulture farming in refugee hosting areas of Uganda: An intervention that builds resilience against emergency
REFNo: SS946ES

The objective of the proposed study is to introduce training programs to farmer groups in Northern Uganda, that aim to improve the market profitability of horticulture and thus increase incomes and employment for small farmers in these refugee-hosting regions in Uganda. Such investments are urgently needed to stabilize livelihoods in this region that has suffered through the combinations of challenges posed by the influx of refugees and other challenges including desert locust invasions, and health and economic risks caused by the COVID-19 pandemic. Specifically, the training program target fostering of lead farmers who will then further train other farmers within the community, and transform farmers’ mindset to “produce strategically to sell” rather than “produce and then sell”. Disseminating knowledge through lead farmers (also sometimes known as “model farmers” “village agents”) to a wider group of farmers has been considered an important way to reach and enhance the capacity and mindset of farmers at scale. The program will contribute to stabilizing and boosting farm incomes in vulnerable, refugee-hosting communities and will build the resilience of local livelihoods to COVID-19. The study then collects data on farmers’ market interaction activities and farm production practices before and after the training programs to assess the impacts of these training programs.
 Japan 2021-08-11 2024-08-11 Social Science and Humanities Non-Clinical Trial Non-degree Award
HAPPY WALUSAGA.G. ANNET
ID:
Patients’ Perceptions and Factors Influencing Choice of differentiated service delivery (DSD) models of care in Kampala, Uganda: A Case Study of Immune Suppression Syndrome (ISS)-Clinic Mulago
REFNo: SS957ES

1.To determine the prevalence of utilization of Community clients Led ART model of care among HIV/AIDS clients at ISS clinic- Mulago
2.To determine the factors associated with patients choice of CCLAD model of care among HIV/AIDS clients at ISS clinic- Mulago
3.To explore patients’ perceptions regarding the HIV differentiated models of care

 Uganda 2021-08-11 2024-08-11 Social Science and Humanities Non-Clinical Trial Non-degree Award
Charity Okaba
ID:
Addressing barriers to HIV self-testing in the Private sector among young sexually active females and males in Uganda: A human centred design framework to developing private sector HIVST demand creation, distribution, and linkage models
REFNo: SS955ES

PSI and the Busara Center for Behavioral Economics will conduct qualitative market research that will use targeted questions to gather opinions on barriers and enablers of HIV self-testing in the private sector to uncover insights, opportunities, motivators, and unmet needs. Specifically, the research will employ in-depth interviews and focus group discussions to gather insights on both demand and supply aspects of HIVST as these relate to sexually active females and males of ages 18- 29.

Focus group discussions and in-depth interviews shall be conducted among potential beneficiaries, sexually active females and males of 18 – 29 years to better understand the perceptions and attitudes, barriers and motivators of these groups towards HIV self-testing and responding to the questions with regards to the design of interventions, including delving into the issues or experiences that exacerbate behavioral biases, thereby affecting uptake of HIVST by these populations. The focus group discussions shall consider individuals with experience of using HIV self-test kits and those without experience.
We will also conduct in-depth interviews with private pharmacists, pharmaceutical technologists, and retailers of community drug shops for an understanding of the service provider perspective in selling HIV self-test kits to the target population. In addition, we will also conduct in-depth interviews with manufacturers and distributors of HIV self-test kits to understand supply side barriers and interventions that may hinder or facilitate uptake of HIVST by the target population. Further, we will conduct in-depth interviews with Ministry of Health officials in charge of managing the national HIVST programs including regulatory mechanisms to understand policy and regulatory side barriers and interventions for rolling out HIVST in the private sector.
Uganda 2021-08-10 2024-08-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Hannah Kibuuka
ID: UNCST-2020-R014355
 A parallel-group, Phase III, multi-stage, modified double-blind, multi-armed study to assess the efficacy, safety, and immunogenicity of two SARS-CoV-2 Adjuvanted Recombinant Protein Vaccines (monovalent and bivalent) for prevention against COVID-19 in adults 18 years of age and older
REFNo: HS1638ES

1. To assess, in participants who are SARS-CoV-2 naïve, the
clinical efficacy of the CoV2 preS dTM-AS03 vaccines for
the prevention of symptomatic COVID-19 occurring ≥ 14
days after the second injection.

2. To assess the safety of the CoV2 preS dTM-AS03 vaccines
compared to placebo throughout the study.
 Uganda 2021-08-10 2024-08-10 Medical and Health Sciences Clinical Trial Non-degree Award
Twalib Aliku Olega
ID: UNCST-2019-R000474
 Uganda Heart Institute Cardiac Catheterization Registry: Patient profile, procedural complications and long-term outcomes
REFNo: HS1081ES

1) to determine the clinical and demographic profile of patients undergoing cardiac catheterization at the UHI
2) to describe complications associated with adult and pediatric cardiac catheterization procedures performed at the UHI and
3) to describe the immediate and intermediate outcomes of patients undergoing adult and pediatric interventional cardiac catheterization at the UHI

 Uganda 2021-08-09 2024-08-09 Medical and Health Sciences Non-degree Award
Stephen Sabiiti
ID:
CLINICAL AND HEMATOLOGICAL OUTCOMES OF CHILDREN WITH SICKLE CELL ANEMIA TREATED WITH LOW FIXED-DOSE HYDROXYUREA AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS1314ES

1. To describe the clinical and hematological
features of children with sickle cell
anemia at initiation of low fixed-dose
hydroxyurea at MRRH.
2. To describe the changes in hematological
indices after initiation of low fixed dose
hydroxyurea among children with sickle
cell disease at MRRH.
3. To describe the incidence of sickle cell
anemia related clinical events among
children with sickle cell disease treated
with low fixed-dose hydroxyurea at MRRH.
4. To identify factors associated with the
changes in hemoglobin level among children
with sickle cell anemia treated with
low fixed-dose hydroxyurea at MRRH.
 Rwanda 2021-08-06 2024-08-06 Medical and Health Sciences Non-Clinical Trial Degree Award
Elizabeth Kemigisha Kemigisha
ID:
Adolescents’ Perspectives of sexual wellbeing and consent MUST-2021-37
REFNo: HS1438ES

1) To contribute to the understanding about how local and contextual factors such as predominant religion, socially acceptable norms, cultural practices and political sentiment can influence sexual wellbeing of adolescents (10 to 24 year olds) in LMIC’s, 2) To explore adolescents’ understanding of, and perspectives on, sexual wellbeing, capturing different aspects of sexuality development during adolescence, including the evolving capacity to sexual consent,
 Uganda 2021-08-06 2024-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ADOA DENNIS
ID:
Development and Evaluation of a Psychosocial Risk Assessment Tool for Predicting Attrition From HIV Care And Treatment Amongst Adolescents Aged 15-19 Years in Uganda
REFNo: HS1501ES

To assess the feasibility of HCWs administering the psychosocial risk assessment tool to ALHIV aged 15-19 years during routine ART visits to determine risk for attrition ,To evaluate the ability of the tool to predict risk of attrition of ALHIV aged 15-19 years at 3-months, following their enrollment date,Assessment and validation of the risk assessment tool, To develop a psychosocial risk assessment tool,To develop a psychosocial assessment tool for predicting attrition of adolescents aged 15-19 years from HIV care. ,
 Uganda 2021-08-06 2024-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Achilles Katamba
ID: UNCST-2019-R000540
 EVALUATION OF TRUENAT MTB-RIF DX AND TRUENAT MTB ASSAYS IN COMPARISON TO GENEXPERT MTB/RIF ULTRA FOR THE DIAGNOSIS OF PULMONARY TUBERCULOSIS
REFNo: HS1526ES

Primary:
• Assess sensitivity and specificity of Truenat™ MTB-RIF Dx and Truenat™ MTB assays in raw sputum compared to the WHO-endorsed GeneXpert® MTB/RIF Ultra using culture as the gold standard

Secondary:
• Assess the operational feasibility of Truenat™ MTB-RIF Dx and Truenat™ MTB assays
• Determine and compare costs between the Truenat™ MTB-RIF Dx and Truenat™ MTB assays, and Xpert MTB/RIF Ultra
 Uganda 2021-08-06 2024-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Allan Lugaajju
ID:
Community-Based Cardiovascular Disease risk factors assessment in Wakiso and Mpigi districts
REFNo: HS1556ES

1. To determine the prevalence of cardiovascular disease risk factors (hypertension, dyslipidemia, obesity, diabetes, physical inactivity, diet, and age) in Wakiso and Mpigi districts
2. To determine the status of cardiac function of the study participants in Wakiso and Mpigi districts.
3. To explore determinants of life-style factors (physical activity, tobacco and alcohol use) through interviews and focus group discussions
 Uganda 2021-08-06 2024-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert Kent Kirya Robert
ID:
Validity and Reliability of Force Inventory in Ugandan Secondary Schools
REFNo: NS275ES

Based on the constructed rationale, this study aims to present the quality of the FCI to the Ugandan context in terms of its validity, reliability, level of difficulty, powers of discrimination, and distractors of items.,The main purpose of the study is to establish the validity and reliability of Force Inventory in Ugandan Secondary Schools. ,
 Uganda 2021-08-05 2024-08-05 Natural Sciences Non-Clinical Trial Degree Award
Jolly Magulu
ID: UNCST-2021-R013833
 Psychiatric comorbidities of Epilepsy and treatment gaps among children and adolescents attending children\'s outpatient of Butabika National Referral Mental Hospital in Kampala, Uganda
REFNo: HS1465ES

General objective
To determine the prevalence of psychiatric comorbidities of epilepsy and determine the diagnostic deficit and treatment gaps among children and adolescents attending children’s Outpatient at Butabika National Referral mental hospital in Kampala, Uganda.

Specific objectives
1.) To determine the prevalence of psychiatric co-morbidities of epilepsy among children and adolescents attending children’s Outpatient at Butabika National Referral mental hospital.
2.) To determine the proportion of children and adolescents with untreated psychiatric comorbidities of epilepsy attending children’s Outpatient of Butabika National Referral mental hospital.
3.) To establish the patient factors associated with untreated psychiatric comorbidities among children and adolescents with epilepsy attending children’s Outpatient of Butabika National Referral mental hospital.
4.) To find out clinician reflections untreated psychiatric comorbidities among children and adolescents with epilepsy attending children’s Outpatient of Butabika National Referral mental hospital.
 Uganda 2021-08-05 2024-08-05 Medical and Health Sciences Non-Clinical Trial Degree Award
Robert Kent Kirya Robert
ID:
Developing a Circular Motion Concept Inventory for evaluating understanding of students of Ugandan Secondary Schools.
REFNo: NS274ES

iii) To evaluate the students’ conceptual change using the circular motion concept inventory's pre-test and post-test scores. ii) Use the circular motion concept inventory to examine the level of conceptual understanding of secondary school students. i) To adapt and validate the statistical indices of circular motion concept inventory.
 Uganda 2021-08-05 2024-08-05 Natural Sciences Non-Clinical Trial Degree Award
Susan Kironde Kizito
ID:
THE ROLE, KNOWLEDGE, ATTITUDE AND PRACTICES OF TRADITIONAL HEALERS IN THE MANAGEMENT OF SNAKE BITES: A CASE OF GULU AND KAMULI DISTRICTS, UGANDA
REFNo: HS1434ES

1.Describe the role of traditional healers in the management of snakebites. 2.Assess the knowledge traditional healers have on snakes, snake bite symptoms and signs, and management of snakebite envenoming. 3.Describe the attitude traditional healers have about snakes, and the modes of first aid they use for management of snakebites. 4.Document traditional healers’ practices when providing first aid to snakebite victims. 5.Establish the willingness of traditional healers to contribute towards establishing a community surveillance system for snakebites in Uganda.
Uganda 2021-08-04 2024-08-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Pontiano Kaleebu
ID: UNCST-2021-R013577
 An open label, Phase 2 study to evaluate the safety and immunogenicity of an Ad26.ZEBOV booster dose in Human Immunodeficiency Virus Positive (HIV+) adults previously vaccinated with the Ad26.ZEBOV, MVA-BN-Filo vaccine regimen
REFNo: HS1350ES

• To assess the safety and tolerability of a Ad26.ZEBOV booster dose in HIV positive adults previously vaccinated with the Ad26.ZEBOV, MVA-BN-Filo vaccine regimen.

• To assess humoral responses induced by the booster dose against EBOV glycoprotein (GP), as measured by Filovirus Animal Non-Clinical Group (FANG) Enzyme-Linked Immunosorbent Assay (ELISA) at 7 and 21 days.

 Uganda 2021-08-04 2024-08-04 Medical and Health Sciences Clinical Trial Non-degree Award
Sarah Zalwango Karen
ID: UNCST-2021-R005660
 Identifying adolescents at high risk of neurocognitive disorder: Development and validation of composite risk index.
REFNo: HS1532ES

a. To develop a CRI by combining intake data on nutrition, immune parameters and HIV status and their interactions and perform internal and external validation of CRI as predictor of ND at 12 months. We hypothesize that the CRI evaluated at intake will successfully predict progressive/incident ND 12 months later.

b. To further internally and externally validate CRI for “out-of-time-window” prediction from 24 to 36 months. We hypothesize that the CRI developed at intake but evaluated at 24 months will successfully predict progressive/incident ND at 36 months.

c. For HEU and HIV-infected children, to refine CRI into CRI-HEU and CRI-HIV, respectively, by including type of maternal ART, viral genome parameters, current cART regimen/adherence (as applicable), and their interactions. We hypothesize that the CRI-HEU and CRI-HIV developed at intake and evaluated at intake and 24 months will successfully predict ND and ND/HAND respectively, 12 months later.

 Uganda 2021-08-04 2024-08-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mary Goretti Nakabugo Goretti
ID: UNCST-2021-R013051
 DEVELOPING SUSTAINABLE MODELS FOR COMMUNITY-BASED PRESCHOOLS IN UGANDA
REFNo: SS714ES

The purpose of this study is to identify and refine models of ECCE provision which can help to increase its availability and enhance its quality in the context of Uganda. It is intended that these models should involve community ownership and management as far as possible and should be suitable for public subsidy in the future.

The main research questions are as follows and will apply to a variety of cases selected for in-depth and comparative study:

1. What structures, practices and resources can enable the preschool to be controlled by, and accountable to, representatives of a local community or other relevant community?

2. What structures, resources and system of funding can help to make the preschool accessible and affordable to all or most households in the locality? How far can these elements be sourced within the community?

3. What are the essential human and physical resources for the preschool to be of acceptable quality and how should the standards for these be stated for purposes of management and evaluation? How far can the community provide these resources?

4. Given the existing provision of resources, what should be the priorities for improving leadership, teaching and care in the preschool?

5. How can the preschool best be linked with schools, health and social welfare services and existing demand-side interventions?

 Uganda 2021-08-03 2024-08-03 Social Science and Humanities Non-degree Award
ANN NANTEZA SENGENDO
ID:
Assessment of integrated control of East Coast fever (ECF) by induction of acquired immunity in Ankole cattle after natural infection by early diagnosis and early treatment
REFNo: A134ES

Mainobjective
To investigate the performance of early diagnosis and early treatment of ECF as a method of reducing calf mortality and enhancing conditions for the development of endemic stability
Specific objectives
i. To determine the prevalence of ECF based on microscopic, ELISA and PCR methods.
ii. To determine the efficiency of early symptom diagnosis and early chemotherapy approach in treating natural ECF cases and induction of protective immunity against ECF in Ankole cattle in an endemic area.
iii. To design a diagnostic regimen/protocol that farmers can use to minimize cattle losses due to ECF by integrating early case symptom detection and early treatment in the routine control strategy in an endemic area.


 Uganda 2021-08-03 2024-08-03 Agricultural Sciences Non-Clinical Trial Non-degree Award
Kenneth Rubango
ID:
Feasibility Study of Nanomedicine in Uganda
REFNo: HS1485ES

Design a nanomedicine promotion package that will be shared with Makerere University, the Ministry of Health and the other healthcare providers. ,Study and evaluate the effectiveness of nanomedicine towards the existing medical education in the selected medical schools. Under this aim, the teaching staff e.g Assistant lecturers, Lecturers, Associate Professors or Professors will be interviewed for the necessary information.,Engage employers and employees in designing the feasibility study towards nanomedicine at their workplaces. Under this aim, the employers e.g Administrators, Principals or Human resource managers will be interviewed for the necessary information.,Assess employer’s willingness to support interventions geared at promoting nanomedicine at their workplaces. Under this aim, the employers e.g Administrators, Principals or Human resource managers will be interviewed for the necessary information.,Conduct formative research to assess existing and needed support for nanomedicine in the selected medical schools. Under this aim, the Key Informant person from each medical school will be interviewed. ,To design and evaluate the feasibility study of nanomedicine in the selected Ugandan medical schools.,
 Uganda 2021-08-03 2024-08-03 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Cally Tann
ID: UNCST-2023-R008021
 Transitioning a Bundle for Early Detection and Intervention for Children with Developmental Disability to Scale for Low-Resource Settings
REFNo: SS910ES

WS1: To develop harmonised training materials to promote and support high fidelity implementation of the PDC and ABAaNA EIP at scale.
WS2: To further develop the Ubuntu multi-media web platform including development of a pilot mobile tablet application to promote programme accessibility and fidelity.
WS3: To identify existing approaches to livelihood support for caregivers of children with developmental disability in low- and middle-income countries to inform the development of a livelihoods component to the EIP.
WS4: To develop a scale-up strategy, business model and marketing strategy to disseminate the PDC and EIP approaches to a wider audience.
WS5: To define a sustainable monitoring, evaluation and learning strategy to track implementation of the PDC and EIP at scale

 UK 2021-08-03 2024-08-03 Social Science and Humanities Non-Clinical Trial Non-degree Award
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