Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Firminus  Mugumya
ID:
FORMATIVE RESEARCH ON EARLY CHILDHOOD DEVELOPMENT IN NAKIVAALE REFUGEE SETTLEMENT
REFNo: SS2041ES

The overall aim of the implementation research study is to co-design, implement and evaluate an innovative integrated ECD intervention that promotes positive outcomes for refugee children in Nakivaale refugee settlement. This study protocol outlines the formative research to support the development of the intervention, The specific objectives of the formative research are as follows:

1. To describe the current developmental status of children (0-5) in Nakivaale refugee settlement
2. To map formal and informal ECD services in the Nakivaale refugee settlement
3. To understand the current caregiving knowledge, attitudes and practices, in the five domains of the nurturing care framework in the refugee and host setting of Nakivaale refugee settlement;
4. The understand the enabling and influencing factors and barriers to ECD service provision and caregiving among service providers and caregivers

Uganda 2024-04-04 8:07:24 2027-04-04 Social Science and Humanities Non-Clinical Trial Non-degree Award
Joseph Kiva S.
ID:
Exploring the role of participatory communication in the promotion of maternal health care programmes: A case study of 89.2 Central Broadcasting Services FM in Uganda.
REFNo: SS2231ES

4. To find out in what ways has the programme facilitated community dialogue in the promotion of maternal health among pregnant women and mothers.,3. To explore the pregnant women/mothers’ perceptions of the participatorycommunication channels used during the health programme,2. To explore the participatory communication approaches used in the health programme,1. To find out in what ways maternal health communication occurred in radio,The general objective of this study is to explore the role of participatory communication in the promotion of maternal health care programmes,
Uganda 2024-04-04 22:25:28 2027-04-04 Social Science and Humanities Non-Clinical Trial Degree Award
Simpson Nuwamanya
ID:
Feasibility of setting up solar powered oxygen supply in Rukungiri District, Uganda and in Butembo, DRC
REFNo: HS3587ES

Main Objective
This proposal seeks to demonstrate the feasibility of solar powered oxygen cylinder filling stations to supply medical oxygen to health facilities in Rukungiri District, Uganda and in Butembo, DRC.

Specific Aims
Describe the oxygen needs (survey of oxygen demand) and willingness-to-pay (market survey) at 14 medical facilities in Rukungiri District, Uganda, and 95 facilities in Butembo, DRC.
a. Specific: The aim is narrowly defined to include cylinder demand and price point.
b. Measurable: Survey data will measure cylinder need at each facility and price point (willingness to pay).
c. Achievable: The 14 sites in Uganda and 95 sites in DRC. We anticipate this survey will take approximately 30 minutes to complete, with on-site interview. Thus, the aim is achievable.
d. Relevant: These data are important for understanding the feasibility of supplying cylinders from a solar powered oxygen filling station.
e. Time-bound: Once approved, the study is anticipated to take 3 to 6 months to complete data collection. Data analysis and write-up of results is anticipated to take another 6 months.
2. Evaluate if solar powered cylinder filling is a feasible model to improve oxygen access.
a. Specific: The aim is narrowly defined to test the feasibility of the proposed cylinder filling stations.
b. Measurable: In order to be feasible, the costs and revenues need to be defined. These will be directly measured (recorded) based on the project activities (cylinder sales, equipment procurement).
c. Achievable: With partners (LeanMed), the cylinder filling stations can be implemented. Thereafter, the evaluation will be achievable.
d. Relevant: These data are important for understanding the real-world implementation of solar powered oxygen filling stations.
e. Time-bound: Once the study is approved and equipment is shipped and installed, we will evaluate project costs and revenues over a well-defined 12-month period.

Hypothesis
The working hypothesis is that solar powered oxygen filling stations are feasible and can generate revenue to maintain the ongoing provision of oxygen in areas where access is limited.

Uganda 2024-03-29 9:38:07 2027-03-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Richard Idro
ID: UNCST-2021-R013599
Etiological role of parasitic exposure and familial susceptibility in nodding syndrome- related epilepsies
REFNo: HS3940ES

The central aim of this study is to investigate if families with nodding syndrome (NS) share common electrophysiological and clinical features forming a distinct familial epilepsy syndrome and if this phenotype is conferred by parasite, Onchocerca volvulus (OV)-associated hu-Leiomodin-1 antibodies in genetically susceptible individuals. This project provides a unique opportunity to mechanistically understand how the onchocerca parasite exposure modifies the risk for epilepsy among susceptible individuals.
Aim1: Characterize the epilepsy sub-phenotypes that aggregate within the NS-affected families. We hypothesize that a common electroclinical feature forms a distinct NS-associated familial syndrome.
Aim 2: Determine if distinct genetic polymorphism in the human host is associated with the pathogenesis of NS-and related epilepsies. Whole-exome/genome sequencing will be performed to test whether a genetic variant of major effect size co-segregates with NS and related epilepsies.
Aim 3: Evaluate the relationship between exposure to OV-associated Hu-leiomodin-1 antibody and host susceptibility that jointly confers risk for NS-and related epilepsies. We will test the hypothesis that OV -associated Hu-Leiomodin-1 antibodies in genetically susceptible individuals cause NS- related epilepsies.
Uganda 2024-03-28 19:51:45 2027-03-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Felix Oyania
ID: UNCST-2021-R013492
Understanding the Current Pediatric Radiology Imaging and Interpretation Capacity and Need In Mbarara, Uganda - A Survey
REFNo: HS3922ES

Objective 1: Needs assessment survey-To conduct a survey assessing the radiology imaging interpretation capacity and needs among medical providers involved with pediatric care in Mbarara Uganda.

Objective 2: Course Evaluation-To conduct a holistic evaluation of our future free remote pediatric surgical radiology course after at least 6 months of instruction.
Specific objectives:
Uganda 2024-03-28 19:31:48 2027-03-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Namaganda Rehema Rehema
ID: UNCST-2024-R005390
AGING WITH HIV IN UGANDA: Intersectional stigma, Ageism and adherence to ARVs among older persons in Uganda
REFNo: SS2484ES

The overall objective of this study is to investigate the experiences of living with HIV and accessing ART among older persons in Uganda. ,3. To examine experiences of intersectional stigma among older persons living with HIV ,2. To explore the intersection between Ageism and HIV stigma and how this might affect adherence and experiences of living with HIV among older persons ,1. To establish levels of adherence on ART among older persons living with HIV,
Uganda 2024-03-28 19:29:32 2027-03-28 Social Science and Humanities Non-Clinical Trial Degree Award
Nishai Moodley
ID:
Global-to-local alignment mechanisms in governing large-scale irrigation schemes in Uganda: Trade-offs and synergies in the water-energy-food nexus
REFNo: SS2481ES

The main objective of this study analyses the alignment mechanisms between international and national development actors in large-scale irrigation schemes, and how this impacts WEF access of local households in Uganda. Put simply, this study aims to analyse the alignment between donors on the global level and departments on the national level, and the influence on households on the local level.
South Africa 2024-03-28 19:22:41 2027-03-28 Social Science and Humanities Non-Clinical Trial Degree Award
Veronica Nyakato
ID: UNCST-2022-R010786
Improving the diagnosis and prognosis monitoring of children with leukemia at the Uganda Cancer Institute (UCI) by developing and implementing an algorithm for diagnosis and monitoring prognosis.
REFNo: HS3828ES

Aim 1: To understand the baseline practice of laboratory diagnosis and monitoring prognosis of patients with leukemia at the Peadiatric Oncology Unit of Uganda Cancer Institute (UCI), Kampala - Uganda. Objectives of Aim 1: 1) To describe the laboratory diagnostic pathway for children receiving care for leukemia at the Uganda Cancer Institute (UCI), Kampala, Uganda. 2) To explore the experiences of healthcare workers with the laboratory diagnosis and monitoring of prognosis of children receiving care for leukemia at the Uganda Cancer Institute (UCI), Kampala, Uganda. Aim 2: To develop an evidence-based algorithm for laboratory investigation, diagnosis, and monitoring treatment response for leukemia in children at the UCI. Objectives of aim 2: 1) To develop an evidence-based algorithm for laboratory investigation and diagnosis of children with suspected leukemia at the UCI. 2) To develop an evidence-based algorithm for laboratory monitoring of treatment response in children diagnosed with leukemia at the UCI. 3) To train healthcare workers at the UCI Peadiatric oncology Unit on the newly developed algorithms for laboratory diagnosis and treatment monitoring for children receiving care for leukemia at the UCI
Uganda 2024-03-28 18:56:10 2027-03-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jack Willis
ID:
Health and Livelihood in Uganda: Health Insurance in Uganda
REFNo: SS2328ES

What is the most beneficial structure of a health insurance?,How does the copayment level affect health and financial outcomes? How do these affects compare to those of the premium?,How does the copayment level affect usage of healthcare overall? Indirectly, through its affect on insurance take-up, and directly, through its affect usage of healthcare conditional on purchasing insurance?,How does the copayment level affect insurance demand? Does it affect selection? How does the effect of changing the copay on demand compare to that of changing the premium?,investigate the role of the structure of the Streamline insurance product on household-level outcomes,
UK 2024-03-28 18:51:16 2027-03-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
KANIKA  Jean-Claude MASSAMBA
ID:
effectiveness of vaginal misoprostol versus vaginal dinoprostone among pregnant women undergoing labor induction at Jinja regional Referral Hospital. (REC Approval: BSU-REC-2023-244)
REFNo: HS4007ES

To assess the Peripartum fetal complications as well as the maternal obstetrics outcomes in vaginal misoprostol group versus vaginal dinoprostone group at Jinja Referral Regional Teaching-Hospital maternity ward. ,The main goal of this study is to compare the effectiveness of vaginal misoprostol to vaginal dinoprostone and identify the feto-maternal complications in women undergoing labor induction at Jinja Referral Regional Teaching-maternity Hospital\'s unit.,
Democratic Republic of Congo 2024-03-28 18:36:47 2027-03-28 Medical and Health Sciences Clinical Trial Degree Award
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