Simon Peter Kibira Peter Sebina
ID: UNCST-2019-R000492
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Improving quarantine in Uganda as a key measure to combat COVID-19: Compliance, experiences, gaps and opportunities
REFNo: HS832ES
1. To determine compliance with COVID-19 quarantine measures among self and institutional quarantined persons in Uganda.
2. To determine factors associated with compliance with COVID-19 quarantine measures among self and institutional quarantined persons in Uganda.
3. To explore experiences and coping mechanisms among self and institutional quarantined persons in Uganda.
4. To identify gaps in the management and opportunities for improvement of the quarantine process in Uganda.
 
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Uganda |
2020-10-14 |
2023-10-14 |
Medical and Health Sciences |
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Non-degree Award |
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Victoria Nankabirwa
ID: UNCST-2021-R011871
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A multicenter, phase III, double-blind, randomised, active-controlled study to evaluate the efficacy and safety of VPM1002 in comparison to BCG in prevention of Mycobacterium tuberculosis infection in newborn infants
REFNo: HS838ES
Primary objectives
1. To demonstrate that VPM1002 is non-inferior to BCG SII in providing protection against incident Mtb infection
2. To demonstrate that vaccination with VPM1002 is superior to BCG SII in providing protection against incident Mtb infection
Secondary objectives
1. To compare the safety and tolerability profile of VPM1002 and BCG SII administered as a single dose to newborn infants
2. To compare the protective efficacy of VPM1002 versus BCG SII against TB disease
3. To compare the protective efficacy of VPM1002 versus BCG SII against sustained Mtb infection
Exploratory objectives
1. To evaluate the immunological response to vaccination with a single dose of VPM1002 compared to BCG SII in a subset (immunogenicity cohort) of HIV-exposed and HIV-unexposed newborn infants in terms of the following parameters:
o Concentration of Interferon (IFN)-γ in the supernatant after antigen re-stimulation as determined by ELISA
o CD4+ and CD8+ T-cells after antigen stimulation as determined by Fluorescence-activated cell staining/Intracellular cytokine staining (FACS/ICS)
o Transcriptomics
o Antibody production
2. To evaluate occurrence of QuantiFERON® Gold Plus In-tube test (QFT) conversion, where conversion is defined using alternative QFT thresholds (e.g. > 4 IU/ml); and sustained QFT conversion, where sustained conversion is defined as QFT ≥ 4IU /ml maintained for approximately 6 months following initial QFT conversion, compared across trial arms in all participants.
3. To determine the mortality rate in children receiving VPM1002 compared to BCG SII
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Uganda |
2020-10-14 |
2023-10-14 |
Medical and Health Sciences |
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Non-degree Award |
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Victoria Nankabirwa
ID: UNCST-2021-R011871
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SARS-CoV-2 infection and COVID-19 in women and their infants in Kampala, Uganda
REFNo: HS915ES
Overall aim
To describe how the COVID-19 epidemic and Uganda's countermeasures affect women and their newborns, especially newborns of HIV-1 positive mothers, and to test whether BCG vaccination offers protection against SARS-CoV-2 infection and COVID-19.
Specific objectives
1. To investigate if BCG vaccination of HIV-1 exposed infants at birth or at 14 weeks of age protects them against SARS-CoV-2 infection and COVID-19 until 14 weeks of age or against COVID-19 between 15 and 52 weeks of age, respectively.
2. To estimate the evolving prevalence of SARS-CoV-2 infection and of COVID-19 among HIV-1 positive as well as among HIV-1 negative women who have recently given birth, and describe their association with hospitalization on the day of birth, complications during delivery, low birth weight, and other adverse outcomes
3. To estimate the evolving 14-week cumulative incidence of SARS-CoV-2 infection and of COVID-19 among mothers and babies, and evaluate whether maternal HIV-1 infection affects maternal and infant risk of developing COVID-19 of varying severity
4. To evaluate the impact of wide-ranging preventive measures to control COVID-19 on women giving birth during the epidemic, their children, and their families
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Uganda |
2020-10-14 |
2023-10-14 |
Medical and Health Sciences |
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Non-degree Award |
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Emanuel Peter L
ID:
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Development of Standardized Herbal Formulation: Synergy between Momordica charantia, Aloe vera and Abelmoschus esculentus for Glycemic Control
REFNo: NS119ES
Objectives
1. To establish ethnomedical use of M. charantia and A. esculentus among indigenous community in Tanzania.
2.To establish physicochemical and stability parameters of freeze dried aqueous extracts of the three plant species separately in pre-formulation studies.
3. To evaluate efficacy of combined freeze dried extracts in different ratios of doses of M. charantia, A. esculentus and A. vera in vivo.
4. To establish safety profile of best optimal dose combination of M. charantia, A. esculentus and A. vera on healthy Wistar female rats.
5. To design a solid pharmaceutical dosage form of the optimal dose combination and evaluate its stability, safety and efficacy in vivo.
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Tanzania |
2020-10-12 |
2023-10-12 |
Natural Sciences |
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Degree Award |
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Christine Aanyu
ID:
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EQUITABLE MATERNAL CARE FOR WOMEN WITH DISABILITY (EMeralD) STUDY
REFNo: HS722ES
1) Specific Aim 1. Conduct an analysis of disability, pregnancy and birth outcomes, and maternal health care utilization data for pregnant women with disabilities in Uganda.
2) Specific Aim 2. Understand the needs and perceptions of pregnant women with disabilities and identify availability of, and barriers to accessing, maternal health care services.
3) Specific Aim 3. Formulate and develop a model for disability-friendly services for pregnant women.
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Uganda |
2020-10-07 |
2023-10-07 |
Medical and Health Sciences |
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Non-degree Award |
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David Serwadda -
ID:
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Characterizing community exposure to SARS-CoV-2 in Uganda, and assessing biological determinants of virus spread
REFNo: HS878ES
1.Assess the diagnostic sensitivity and specificity of the CoronaChekTM rapid COVID-19 IgM/IgG lateral flow test (CoronaChekTM by Hangzhou Biotest Biotech Co Ltd) for anti- SARS-CoV-2 antibodies detection in Uganda.
2.Conduct enhanced surveillance of COVID19-like symptoms in the context of an existing population cohort and assess the predictive value of prevailing symptoms for COVID-19 exposure based on rapid serological testing in this region.
3.Determine rates of sero-reactivity/positivity among key health care workers at high-volume health centers III and IV and also among PCR-negative contacts of confirmed COVID-19 cases in the region.
4.Explore ‘prior importation of COVID-19 infection in Ugandaâ€/ pre-existing sero-reactivity (may due to ‘related’ coronavirus strains/shared epitopes) in purposively selected archived sera, prioritizing from truck drivers and commercial sex workers that was collected before the lockdown in Uganda / Rakai region.
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Uganda |
2020-10-06 |
2023-10-06 |
Medical and Health Sciences |
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Non-degree Award |
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Richard Idro
ID: UNCST-2021-R013599
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Dihydroartemisinin-Piperaquine or Sulphadoxine-Pyrimethamine for the Chemoprevention of Malaria in Children with Sickle Cell Anaemia in eastern and southern Africa: a double blind randomised trial (the CHEMCHA trial)
REFNo: HS709ES
Primary objective
The general objective is to determine the efficacy and safety of malaria chemoprevention with weekly single day courses of DP compared to monthly single courses of SP in children with SCA in eastern and southern Africa.
Secondary objectives
1. Assess the feasibility and stakeholder perceptions on the uptake (acceptability) and the potential for future roll-out of weekly DP vs monthly SP.
2. Determine the safety of cumulative dosing of DP, especially on cardiac function.
3. Monitor the development of malaria parasite resistance to DP in clinical isolates over time.
Assess patients’ health-related quality of life, cost-effectiveness, equity and economic implications of using weekly courses of DP vs monthly courses of SP as chemoprevention in SCA.
5. Assess acceptability of weekly courses of DP for malaria chemoprevention in SCA vs monthly courses of SP as chemoprevention in SCA.
6. Conduct policy advocacy to engage key stakeholders on policy decisions on using weekly courses of DP or monthly courses of SP for the chemoprevention of malaria in SCA.
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Uganda |
2020-10-02 |
2023-10-02 |
Medical and Health Sciences |
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Non-degree Award |
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Richard Idro
ID: UNCST-2021-R013599
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Hydroxyurea therapy for Neurological and Cognitive Protection in Pediatric Sickle Cell Anemia in Uganda: A single arm open label trial, “BRAIN SAFE IIâ€
REFNo: HS846ES
The primary objective is to determine the impact of daily oral hydroxyurea therapy, 20- 30mg/kg/day, on the frequency and severity of Sickle Cell Vasculopathy(SCV) in a cohort of children treated for three years, as measured by 3 distinct outcomes: abnormal TCD, neurocognitive impairment and primary stroke, compared with baseline.
Secondary objectives
1.Evaluate the impact of Hydroxyurea therapy on structural SCV using MRI and MRA in a randomly selected subset of this cohort.
2.Assess changes to anemia, CRP and malnutrition status during hydroxyurea therapy, over time, compared with baseline levels.
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Uganda |
2020-10-02 |
2023-10-02 |
Medical and Health Sciences |
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Non-degree Award |
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Sarah Kiguli
ID: UNCST-2021-R013020
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Nutritional Treatment in Pneumonia Trial. (NuTiP)
REFNo: HS911ES
To establish whether supplementary feeding for 56-days (8 weeks) using Ready to Use Therapeutic Feeds (RUTAFA) in children between 6 months and 12 years with respiratory distress complicated by hypoxia versus usual standard care will improve outcome at 90-days.
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Uganda |
2020-10-02 |
2023-10-02 |
Medical and Health Sciences |
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Non-degree Award |
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mariam Namutebi
ID:
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TEENAGE FIRST TIME MOTHERS’ PERCEPTIONS ABOUT THEIR HEALTH CARE NEEDS AND THE GAPS IN POSTPARTUM CARE.
REFNo: HS780ES
General objective:
To explore the teenage first time mothers’ perceptions about their postpartum care needs and the gaps in the facility based postpartum care
Specific Objectives:
1. To explore the teenage first time mothers’ perceptions about their postpartum care needs.
2. To identify the current gaps in the facility based postpartum care provided to teenage first time mothers.
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Uganda |
2020-10-01 |
2023-10-01 |
Medical and Health Sciences |
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Non-degree Award |
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Joseph Kagaayi
ID: UNCST-2024-R015946
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Impact of COVID-19 Lockdown on HIV and Reproductive, Maternal, Neonatal and Child Health services in Masaka region, Uganda
REFNo: HS865ES
1 Goal
The overall goal of the study is to assess the effect of the COVID-19 lockdown on demand and utilization of RMNCH and HIV services and assess coping mechanisms in order to make evidence-based recommendations for mitigation of the impact during the COVID-19 epidemic and future health emergencies and disasters.
Specific aims
1) To determine the effect of COVID-19 lockdown on discontinuation of Antiretroviral therapy (ART) among patients receiving antiretroviral drugs in 12 districts of the Masaka region.
2) To determine the effect of COVID-19 lockdown on Antenatal care (ANC) attendance, facility deliveries, contraception, immunization, EID, HIV testing among all pregnant women and initiation of option B+ among HIV-positive ANC attendees.
3) To determine the effect of the COVID-19 response on viral load monitoring, intensive adherence counseling and HIV viral suppression among clients in the Masaka region,.
4)To explore clients’, district, and health facility knowledge, attitude and experiences (KAE) and coping mechanisms for sustained ART, and RMNCH services. Qualitative exploration of KAE will provide useful pathways for the effect of lockdown measures on demand and utilization of services.
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Uganda |
2020-10-01 |
2023-10-01 |
Medical and Health Sciences |
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Non-degree Award |
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Cissy Kityo
ID: UNCST-2021-R013663
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Validation of SARS-CoV-2 detection by Rapid AirJump RNA Amplification (RARA) COVID Test method
REFNo: HS888ES
We will carry out validation of RARA assay in the laboratory before the field evaluation in testing of SARS-CoV-2.
We intend to understand the inherent characteristics of this assay with regard to accuracy (diagnostic sensitivity, diagnostic specificity), Precision (reproducibility), Limit of detection (LOD), Predictive value (negative and positive), and Assay Efficiency.
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Uganda |
2020-10-01 |
2023-10-01 |
Medical and Health Sciences |
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Non-degree Award |
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KarenBeth Bohan Heikkinen
ID:
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Assessment of Online Modules to Increase Knowledge of Geriatric Care in Health Care Professionals RefNo: MAKSHSREC-2020-6
REFNo: HS727ES
To determine the pharmacists’ satisfaction with pharmacy geriatric online training.,To determine the learning preference in terms of online compared to live educational sessions before and after using the online modules for professional development,To determine the retention of knowledge of geriatric care at three months after completion of all five online educational modules.,To assess the improvement of pharmacy professionals’ knowledge of geriatric care after participating in online educational modules.,
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USA |
2020-09-29 |
2023-09-29 |
Medical and Health Sciences |
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Non-degree Award |
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Ignatius Odongo Odongo
ID:
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Youth Entrepreneurship in South Africa and Uganda: An Investigation of the Influence of Mental Triggers
REFNo: SS487ES
To contribute to the existing discourse on youth entrepreneurship, by introducing a new applied framework from which youth entrepreneurship can be developed based on the influences of mental triggers. The new framework will include, inter alia, a description of the following:
• the environment that can potentially stimulate youth entrepreneurship;
• the kind of entrepreneurship education that will stimulate and provide requisite skills for the nascent youth entrepreneur; and
• the personal characteristics that can be nurtured for entrepreneurial success.
Armed with this new framework, the stakeholders that areresponsible for youth development, particularly in developing countries, will be able to deal with the psychological and other barriers that impede the youth from venturing and succeeding in entrepreneurship.
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Uganda |
2020-09-29 |
2023-09-29 |
Social Science and Humanities |
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Degree Award |
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Victoria Nankabirwa
ID: UNCST-2021-R011871
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Preventing Infant Malnutrition with Early Supplementation (PRIMES)
REFNo: HS825ES
Aim 1. To describe local experiences and beliefs related to breastfeeding, breast milk expression, non-maternal food sources and infant weight and health.
Aim 2. To determine the range of newborn weight changes, the typical age at which a newborn returns to birth weight, and any association of newborn weight change with early dietary intake, clinical and demographic characteristics, and breastfeeding behaviors.
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Uganda |
2020-09-29 |
2023-09-29 |
Medical and Health Sciences |
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Non-degree Award |
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Fred Bulamba
ID: UNCST-2019-R000026
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Mapping perioperative care pathways to support surgical treatment in Low-and-Middle Income Countries
REFNo: HS642ES
The aim of this project is to understand the context of perioperative health systems in Uganda, including the main barriers encountered in the delivery of care.
Objectives:
1. Develop a collaborative approach to perioperative care pathway mapping
2. Carry out a rapid appraisal to map 5 pathways (three “Bellwether procedures and two elective procedures) in Uganda.
3. Refine the process and extend to three low- and middle-income countries
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Uganda |
2020-09-28 |
2023-09-28 |
Medical and Health Sciences |
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Non-degree Award |
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marie nanyanzi
ID: UNCST-2019-R001553
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Point Of Entry Sauti Za Wananchi (Voices of the citizens)Extension Survey
REFNo: SS468ES
To understand the COVID-19 effects on the citizens’ experience and key services they receive during this era of COVID-19 especially
â–ª Establish citizen access to safe water;
â–ª Establish citizen access and usage of health services and knowledge, Attitudes and
Practices (KAPs);
â–ª Find out level of participation/involvement/interaction in development and public
activities /institutions;
â–ª Find out access and usage of financial services amongst citizens;
â–ª Find out how; what and when citizen access different type of information including
government and development information.
â–ª Establish the knowledge, Attitudes and Practices (KAPs) of citizens on different
guidelines, policies; laws and regulations etc
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Uganda |
2020-09-28 |
2023-09-28 |
Social Science and Humanities |
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Non-degree Award |
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mariam Namutebi
ID:
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POSTPARTUM CARE: FACILITY READINESS, MIDWIVES’ PERSPECTIVES AND THE EFFECT OF USING INDIVIDUALIZED CARE PLANS ON POSTPARTUM OUTCOMES.
REFNo: HS773ES
General Objective
To assess the facility readiness for the provision of Postpartum care, explore the midwives’ perspectives about postpartum care and evaluate the effect of using individualized care plans on the postpartum outcomes in the greater Mpigi region.
Specific objectives
1. To assess the facility readiness to provide postpartum care in selected facilities in the greater Mpigi region.
2. To explore the midwives’ perspectives towards postpartum care in the greater Mpigi region.
3. To evaluate the effect of using individualized care plans in the immediate and early postpartum period on the monitoring assessments, physical examination and health education of postpartum women in the greater Mpigi region.
4. To describe the postpartum women’s perspectives and midwives’ experiences of postpartum care provided using individualized care plans
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Uganda |
2020-09-28 |
2023-09-28 |
Medical and Health Sciences |
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Degree Award |
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Esther Buregyeya
ID: UNCST-2020-R014116
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Using the human-centred design model to inform local adaptation of COVID-19 prevention measures among high-risk populations in Malaba and Mutukula points of entry in Uganda
REFNo: HS848ES
1. To determine knowledge and risk-perceptions on COVID-19 measures among high-risk populations in Malaba and Mutukula points of entry.
2. To assess uptake of recommended COVID-19 prevention measures measures among high-risk populations in Malaba and Mutukula points of entry.
3. To explore the facilitators and barriers to uptake of the COVID-19 prevention measures measures among high-risk populations in Malaba and Mutukula points of entry.
4. To design, pilot and evaluate localized behavioural interventions to foster uptake of the COVID-19 prevention measures measures among high-risk populations in Malaba and Mutukula points of entry.
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Uganda |
2020-09-28 |
2023-09-28 |
Medical and Health Sciences |
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Non-degree Award |
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Kirsten Beyer M
ID: UNCST-2021-R013472
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Geospatial Analysis of Kampala Cancer Registry Data
REFNo: HS873ES
Objective 1: Identify spatial and spatiotemporal patterns of cancer in Uganda.
a) Use geospatial mapping techniques to estimate cancer burdens across geographic space and through time.
b) Create visual representations of cancer patterns (maps, graphs).
Objective 2: Examine relationships between social and environmental factors and cancer outcomes in Uganda.
a) Use statistical analysis techniques to determine associations between environmental factors and cancer outcomes.
Objective 3: Pilot the collection of new KCR variables
a) For each new case, we will attempt to acquire marital status, education level, occupation, religion, national Identification number (NIN) (new in Uganda), and precise geographic location information.
Objective 4: Determine the true spatial extent of KCR data collection potential.
a) Identify the number of cases that are discovered and excluded under current practice, as well as the individual’s parish of residence.
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USA |
2020-09-28 |
2023-09-28 |
Medical and Health Sciences |
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Non-degree Award |
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