Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Achilles Katamba
ID: UNCST-2019-R000540
Using human-centered design to develop a novel TB medication adherence technology
REFNo: HS1138ES

1. To design and prototype novel TB medication adherence technologies using research insights gained from previous human-centered design research.
2. To Obtain feedback on novel TB medication adherence technologies from TB patients, caregivers, family members, and health workers using an iterative prototyping approach.

Uganda 2021-01-04 2024-01-04 Medical and Health Sciences Non-degree Award
Sarah Richardson Elizabeth
ID:
A MULTIMETHOD EXAMINATION OF THE STATUS OF EMERGENCY CARE IN UGANDAN HEALTH FACILITIES
REFNo: HS559ES

Broad objective: To maximise the in-depth understanding of the current status of emergency care delivery in Uganda, in order to inform the effective, efficient and sustainable implementation of the components of the WHO ECS toolkit and other emergency care interventions throughout the country. Specific objectives/aims: 1. To describe and establish the current knowledge, attitudes and beliefs of stakeholders towards emergency care. 2. To evaluate barriers and facilitators to the provision of emergency care in Ugandan facilities 3. To evaluate factors that will influence the implementation of emergency care education and implementation packages such as the WHO toolkit 4. To evaluate the current quality and process of the provision of emergency care and the associated total and preventable patient morbidity and mortality in emergency facilities
UK 2020-12-24 2023-12-24 Medical and Health Sciences Degree Award
Nazarius Tumwesigye Mbona
ID: UNCST-2019-R000664
Satisfaction and Knowledge on Emergency Medical services among Health providers and users in facilities implementing a Health System Strengthening project in Masaka and Bukomansimbi districts
REFNo: HS1136ES

ï‚§ To assess the level satisfaction among health providers who were trained in EMS course under strengthening community health care system project in Masaka region
ï‚§ To assess the level knowledge among health providers who were trained in EMS course under strengthening community health care system project in Masaka region
ï‚§ To evaluate the change in the client satisfaction with EMS in facilities that are implementing strengthening community health care system project in Masaka region

Uganda 2020-12-24 2023-12-24 Medical and Health Sciences Non-degree Award
Esther Bayiga Diana Zziwa
ID:
PEDESTRIAN SAFETY AND THE BUILT ENVIRONMENT IN KAMPALA CITY, UGANDA
REFNo: HS960ES

1. To examine the pattern in the spatial and temporal distribution of pedestrian safety in Kampala city, Uganda
2. To examine the influence of the built environment on the distribution pattern of pedestrian safety in Kampala city, Uganda
3. To explore perceptions of different categories of road users in Kampala city, Uganda on the significance of the different built environment variables to pedestrian safety.

Uganda 2020-12-24 2023-12-24 Medical and Health Sciences Degree Award
Mark Kaddumukasa
ID: UNCST-2020-R001798
Prevalence, semiology and risk factors of seizures among elderly patients attending Kiruddu Medical Outpatients in Uganda.
REFNo: HS970ES

Specific objectives
1. To determine the prevalence of seizures among elderly patients attending neurology clinic at Kiruddu hospital.
2. To describe the seizure semiology among elderly patients with seizures.

Secondary objectives
1. To determine the associated risk factors for seizures among elderly patients with cognitive deficts.
2. To determine the cognitive levels of elderly patients attending the neurology clinic at Kiruddu.
3. To explore the stigma associated with dementia among caregivers/families of AD patients.

Uganda 2020-12-24 2023-12-24 Medical and Health Sciences Non-degree Award
Richard Kibombo
ID:
Use of the RMNCAH Scorecard at District and Health Facility Levels
REFNo: HS986ES

i)Assess the extent to which the RMNCAH scorecard has been adopted and utilised in selected districts and health facilities of Uganda;
ii)Examine the strategies and processes or procedures used to implement the RMNCAH scorecard in the selected districts and health facilities;
iii)Investigate the factors that enable and deter use of the RMNCAH scorecard in these districts and health facilities and the lessons learned;
iv)Determine the perceived positive and negative effects of implementing the RMNCAH scorecard in the selected districts and health facilities;
v)Propose practical recommendations for improving the use and institutionalising of the RMNCAH scorecard at the district and health facilities.
Uganda 2020-12-24 2023-12-24 Medical and Health Sciences Non-degree Award
Moses Chemurot
ID:
Exploring stingless bee products for nutritional and medicinal values in Uganda (Bee-Nutri-Medicine project)
REFNo: HS1131ES

Investigate the potency of stingless bee honey and propolis as medicines for wounds and skin infections,Explore antimicrobial properties of honey and propolis collected from stingless bee colonies in Uganda,Determine the nutritional profiles of pollen and honey harvested from two stingless bee species in Uganda. This will guide in the promotion of bee pollen consumption as alternative sources of protein especially for poor rural households.,Explore stingless bee products for nutritional and medicinal purpose in Uganda,
Uganda 2020-12-24 2023-12-24 Medical and Health Sciences Non-degree Award
Margaret Kabahenda
ID:
Strengthening the capacity of teachers to integrate nutrition education in school curricula to improve children’s dietary practices and physical actlivity so as to combat malnutrition [TEACH-Nutrition Project]
REFNo: A93ES

Determine the effectiveness of the proposed intervention model in improving: (a) teachers nutrition knowledge and ability to monitor pupils’ nutritional status; (b) pupils’ dietary practices and physical activity patterns; (c) parents’ knowledge of their children’s nutritional needs and their capacity to provide nutritious foods to their children; and (d) schools management’s commitment to address food and nutrition issues,Determine the barriers and supports for integrating nutrition education in school curricula,Develop an effective nutrition education intervention model that can easily be integrated in lower primary school curricula,Characterize the available nutrition education training programs, materials, and the types and innovation habits of actors engaged in school nutrition education,
Uganda 2020-12-21 2023-12-21 Agricultural Sciences Non-degree Award
Chrispo Maali
ID:
Remuneration and Performance of Teachers in Government Aided Secondary Schools in Kasese District, Western Uganda
REFNo: SS512ES

1.To explore the forms of remuneration in government aided secondary schools in Kasese District.
2.To examine the level of teachers performance in government aided secondary schools in Kasese District
3.To examine the relationship between remuneration and teacher performance in government aided secondary schools in Kasese District.

Uganda 2020-12-21 2023-12-21 Social Science and Humanities Degree Award
Clement Okello Dove
ID: UNCST-2020-R014649
TREATMENT RESPONSE AND TREATMENT RELATED MORTALITY IN PATIENTS WITH ACUTE MYELOID LEUKAEMIA AT THE UGANDA CANCER INSTITUTE
REFNo: HS946ES

1. To describe the clinical characteristics of patients with acute myeloid leukaemia at the Uganda Cancer Institute. 2. To determine the induction treatment response rate in patients with acute myeloid leukaemia at the Uganda Cancer Institute. 3. To determine the rate of induction treatment related mortality in patients with acute myeloid leukaemia at the Uganda Cancer Institute. 4. To determine the predictors of induction related mortality in patients with acute myeloid leukaemia at the Uganda Cancer Institute.
Uganda 2020-12-21 2023-12-21 Medical and Health Sciences Non-degree Award
Lydia Nakiyingi
ID:
Development of large-scale panel of TB patient urine and serum samples to serve as standards for detection of TB LAM in HIV-positive and negative presumptive TB patients
REFNo: HS1006ES

Primary:
•Estimate the sensitivity of the investigational urine LAM test for detection of culture-confirmed Mycobacterium tuberculosis infection among individuals with clinical signs and/or symptoms of TB.
•Examine the effect of HIV infection and CD4 cell level on sensitivity of these assays
•Compare the sensitivity of the existing FujiLAM and AlereLAM assays with new investigational LAM tests

Secondary:
•Use large-scale samples to compare the immunological properties of urinary LAM in different patients, and to perform structural analyses of the urinary LAM antigens
• Develop and distribute aliquots of characterized large-scale urine samples for standardization and optimization of a point-of-care format of the investigational urine LAM assay.


Uganda 2020-12-18 2023-12-18 Medical and Health Sciences Non-degree Award
Janet Nakigudde
ID: UNCST-2019-R000444
Effectiveness and Implementation of an Early Childhood School-Based Mental Health Intervention in Low-Resourced Communities in Hoima and Kampala districts-Uganda
REFNo: HS1057ES

1. To evaluate the short and long term effectiveness of Professional Development (PD alone) and Professional Development plus wellness Training (PDT)
2. To examine the effectiveness mechanisms and theory of change underlying the EBIs
3. To examine implementation contextual factors and mechanisms that contribute to teachers' uptake and sustainment of EBI strategies within PD and PDT schools.
Uganda 2020-12-18 2023-12-18 Medical and Health Sciences Non-degree Award
Carolyne Onyango
ID:
Re-Calibration of Quantitative and Contextual Factors to Predict Child Cognitive Deficits in HIV-Exposed Children in the PROMISE/PROMOTE Study Cohorts (CD PROMOTE Study) Version 2.0, dated 08 March 2020
REFNo: HS795ES

1. To identify clinical, maternal, home-environment factors that are associated with the risk of CD among HIV exposed but uninfected children.
2. To develop a CD risk prediction tool for HIV exposed uninfected children informed by identified risk factors observed in Aim 1 and existing literature

Uganda 2020-12-18 2023-12-18 Medical and Health Sciences Non-degree Award
Bruce Twinamasiko
ID:
FEASIBILITY OF A COMMUNITY HEALTH WORKER-LED INTERVENTION TO CONTROL HIGH BLOOD PRESSURE IN SOUTHWESTERN UGANDA: A PILOT PRAGMATIC CLUSTER RANDOMIZED TRIAL (CHIP TRIAL)
REFNo: HS881ES

1.To test whether a multifaceted intervention program will lead to blood pressure control among patients with uncontrolled blood pressure over a 12-month period compared to usual care.
2.To evaluate whether a multifaceted intervention program will improve hypertension control among hypertensive patients over a 12-month period, compared to usual care.

Uganda 2020-12-18 2023-12-18 Medical and Health Sciences Non-degree Award
Grace Ndeezi
ID: UNCST-2019-R001802
Effect of Vitamin D supplementation on Sickle cell disease hospitalisation and related complications among Children in Mulago Hospital: A randomised clinical trial
REFNo: HS985ES

Objectives
The overarching goal for this study is to evaluate whether vitamin D supplementation can decrease the need for hospitalisations in Ugandan children with SCD
Primary objectives:
1. To determine the frequency of hospitalisation among children with SCD supplemented with vitamin D versus placebo.
2. To determine the effect of vitamin supplementation on serum levels of 25 Hydroxyvitamin D levels in children with SCD

Secondary objectives:
To determine the:
1. Incidence of vaso-occlusive crises (VOC)
2. Incidence of acute severe respiratory illnesses
3. Severe adverse events
4. Requirements for blood transfusion among children supplemented with vitamin D versus Placebo in children with sickle cell anaemia

Uganda 2020-12-18 2023-12-18 Medical and Health Sciences Non-degree Award
Tumuhairwe Juliet
ID:
The Challenge Initiatives Approach to City engagement – Coaching case study
REFNo: SS645ES

This study is meant to explore the successes, challenges and innovations of The Challenge Initiative’s (TCI) coaching model


Specific objectives
1. Document the intensity and focus of TCI coaching to-date, including which high-impact approaches governments most commonly request coaching for, how often, and what their impact has been.
2. Explore how local governments and service providers perceive the TCI coaching model, including, whether they believe it has been beneficial, and if so, how.
3. Understand if TCI’s coaching has led to system strengthening and improvements in the healthcare system both related to family planning and AYSRH service delivery, but also beyond. Additionally, document which system strengthening elements of coaching are most notable to TCI beneficiaries.
4. Document the ways in which TCI’s coaching has worked well and, perhaps, not worked as planned. Use this information to develop recommendations for how TCI can strengthen its coaching model.
5. Understand how the TCI coaching model can be sustained by TCI supported geographies even after a city ‘graduates’ from TCI (i.e., achieves program success and certain milestones, indicating the city no longer needs TCI’s support)

Uganda 2020-12-18 2023-12-18 Social Science and Humanities Non-degree Award
Diana  Ntamu Nandagire
ID:
Small and Growing Businesses: A Segmentation Study in Uganda and Nigeria
REFNo: SS647ES

The purpose of the study is to test Dalberg’s segmentation framework of small and growing businesses (SGBs) by determining the effectiveness of that framework. By testing the framework, “maps” shall be created, funding gaps shall be established and recommendations made for the two African countries (Uganda and Nigeria).
The study will be guided by the following objectives;
a) To determine the extent to which the Dalberg framework defines SGBs in Uganda and Nigeria.
b) To establish the reasons why SGBs seek financing in their operations and the challenges in accessing funding.
c) To identify organisations that invest in SGBs and establish the proportion of their portfolio dedicated to SGBs.
d) To establish the total capital available in funding organisations to SGBs.
e) To establish the challenges of investing in SGBs.


Uganda 2020-12-18 2023-12-18 Social Science and Humanities Non-degree Award
Florence Nassiwa
ID:
Effect of climate variability adaptation strategies on livelihood of smallholder vegetable farmers in Kampala District Uganda
REFNo: SS649ES

i. To establish the effect of technological development adaptation strategies on livelihood of smallholder vegetable farmers.
ii. To determine the effect of government programs and insurance adaptation strategies on livelihood of smallholder vegetable farmers.
iii. To assess the effect of farm production adaptation strategies on livelihood of smallholder vegetable farmers
iv. To establish the effect of farm financial management adaptation strategies on livelihood of smallholder vegetable farmers.
v. To evaluate constraints smallholder vegetable farmers encounter in adapting to climate variability.

Uganda 2020-12-18 2023-12-18 Social Science and Humanities Degree Award
Kamya Moses
ID: UNCST-2020-R014203
Impact of housing modifications combined with piperonyl butoxide (PBO) long-lasting insecticidal nets (LLINs) on the malaria burden in Uganda: a cluster-randomised trial
REFNo: HS1072ES

Primary Objective;
To evaluate the effect of housing modifications plus PBO LLINs, compared to PBO LLINs alone, on the incidence of clinical malaria in Ugandan children aged < 60 months

Secondary Objectives;
1) Epidemiology: To assess the impact of housing modifications + PBO LLINs, compared to PBO LLINs alone, on (1) parasite prevalence, and (2) prevalence of anaemia in children 6m-14y
2) Entomology: To assess the impact of housing modifications + PBO LLINs, compared to PBO LLINs alone, on (1) indoor and outdoor densities of malaria vectors; (2) entomological inoculation rate (EIR); (3) human biting rates (indoor and outdoor); and (4) To evaluate the patterns of insecticide resistance through the phenotypic and molecular detection methods, in mosquito vectors from clusters with housing modification + PBO LLINs, compared to PBO LLINs alone
3) Housing modifications: (1) To understand the local context regarding housing; (2) To assess acceptability of the housing modification interventions quantitatively, among the cohort members and the community, over time; (3) To assess acceptability of the housing modification interventions through qualitative research among the community opinion leaders and members, in both intervention and control clusters, over time; (4) To assess durability of housing modification interventions; (5) To assess environmental measures in houses with modifications + PBO LLINs; (6) To assess feasibility of housing modification including labour and materials, maintenance requirements, time required; (7) To conduct a process evaluation of the interventions, by developing a logic model, assessing the implementation of the housing modifications, and examining the mechanisms of effect
4) Economics: (1) To measure cost-effectiveness of housing modifications + PBO LLINs, compared to PBO LLINs alone, under research conditions; (2) To cost the different components of the interventions and identify factors contributing to major costs; (3) To estimate potential cost of providing housing interventions at scale over longer periods of time.

Uganda 2020-12-18 2023-12-18 Medical and Health Sciences Non-degree Award
Elly Katabira
ID:
REDUCING STROKE BURDEN IN UGANDA USING TARGETED MANAGEMENT INTERVENTION (TEAM). A RANDOMISED, PROSPECTIVE 6 – MONTH CONTROLLED TRIAL.
REFNo: HS1094ES

Objective 1: To refine the TEAM curriculum for optimal acceptability and integration in the Ugandan setting guided by input from stakeholders (patients/family, clinicians, administrators).
Objective 2: To conduct an RCT comparing efficacy of TEAM vs. enhanced treatment as usual (ETAU) in 246 Ugandans (TEAM, N= 123; ETAU, N= 123) at high risk for stroke.
Objective 3: Identify barriers and facilitators to TEAM implementation.

Uganda 2020-12-18 2023-12-18 Medical and Health Sciences Non-degree Award
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