Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
Search By Approval Date:
Clear Filter Total: 5,491
Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Denis Muhangi
ID: UNCST-2020-R014258
 Social – Behavioral / Anthropological Study on COVID-19 in Uganda
REFNo: SS700ES

The overall objective of this anthropological study is to generate evidence-based insights on why people behave the way they do in response to COVID-19 and the recommended preventive measures; and to provide recommendations on potential approaches that are culturally and socially acceptable that can be applied to improve compliance and enhance adoption of sustainable behavior change across different groups and the general public in Uganda.

The specific Objectives are:

To assess the extent and how different sections of the population adhere to / comply with the set of desired behaviors / practices as recommended by Government.

To establish trends in behaviour change since the beginning of the COVID-19 crisis.

To establish why people behave the way they do, taking into account the different target groups (individual or group), differences in culture and the immediate context (social economic and structural factors).

To assess the changing community dynamics and the effect of the COVID-19 measures on individual and communal norms that have a bearing on COVID-19 transmission such as - mass gatherings in school set-ups, religious, social and cultural congregations e.g., entertainment, weddings and burial practices.

To establish what each target group thinks would be the prerequisites to protect themselves from COVID-19.

To identify potential culturally and socially acceptable approaches/solutions to health problems which can be applied to improve compliance and enhance adoption of sustainable behavior change - across different groups.
 Uganda 2021-01-25 2024-01-25 Social Science and Humanities Non-degree Award
Innocent Besigye Kabahena
ID: UNCST-2019-R001025
 Evaluating the use of the primary care assessment tool to improve primary care performance in Tororo District, Uganda
REFNo: HS1174ES

1. To adapt and validate the patients'. managers' and health care providers' primary care assessment tools.
2. To measure primary care performance using adapted and validated PCAT tools.
3. To evaluate the implementation of the designed intervention to improve primary care performance.
 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Degree Award
Eddy Walakira Joshua
ID: UNCST-2022-R009077
 Uganda Commercial Sex Exploitation of Children
REFNo: SS724ES

1) Estimate the prevalence of children at of, and engaged in commercial sex exploitation in Karamoja

2) Estimate the proportion of children in Kampala involved in commercial sex exploitation

3) Measure Knowledge, attitudes and practices around CSEC in Karamoja
 Uganda 2021-01-25 2024-01-25 Social Science and Humanities Non-degree Award
Evelyn Avalos
ID:
The impact of protracted refugee displacement and disrupted intergenerational relations on the secure and healthy futures of older people in Uganda
REFNo: SS462ES

-To identify later-life forcibly displaced survival strategies/sustainable livelihoods in a context of family separation
- To understand who covers the needs of aged refugees and to what extent they are covered. Specifically when family relationships and State's social security are disrupted
- To explain the role of place in shaping lives and ageing experiences of aged refugees
-To discover how later-life identities and attachments could be shaped at different social and spatial scales
 El Salvador 2021-01-22 2024-01-22 Social Science and Humanities Non-Clinical Trial Degree Award
Sona Shah
ID:
Adoption of a wireless vital sign monitor for observation of COVID-19 patients
REFNo: HS733ES

1. To evaluate the feasibility of a wireless vital sign monitor for use on critical patients in COVID-19 treatment facilities
2. To assess the accuracy of a wireless vital sign monitor (neoGuard) on adult patients
 USA 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
Christine Nalwadda Kayemba
ID: UNCST-2020-R014220
 Understanding Leadership and Accountability mechanisms in delivering a responsive Maternal and Newborn care in a decentralized health system, Uganda: Lessons for SRHS improvement
REFNo: HS1024ES

Broad objective:

The main objective of this study is to assess leadership and accountability mechanisms for maternal and newborn health in decentralized health systems in Uganda in order to formulate a theory of change for delivering an efficient health services for maternal and newborn health


Specific Objective:

1.Review existing health systems policies in order to highlight leadership and accountability guidelines/policies for maternal and newborn health
2.Explore health systems managers’ understanding and interpretation of leadership and accountability guidelines/policy directives for maternal and newborn health
3.Describe how decentralized health systems managers adapt and implement leadership and accountability policies in maternal and newborn health

 Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
Warren Phipps
ID:
Attitudes and Practices of Antimicrobial Resistance and Stewardship at the Uganda Cancer Institute
REFNo: HS871ES

We will investigate the knowledge, attitudes, and practices about antimicrobial use and antimicrobial resistance among the doctors (including medical officers, fellows, oncologists, and surgeons), nurses, and pharmacists at the Uganda Cancer Institute (UCI).

The aims of the study are;
Aim 1: To examine the current knowledge and attitudes of UCI healthcare providers towards antimicrobial resistance.
Aim 2: To determine the current knowledge and attitudes of UCI healthcare providers towards antimicrobial stewardship.
Aim 3: To understand perceived barriers to the diagnosis and management of infections in patients at UCI

USA 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
Jennifer Serwanga
ID: UNCST-2024-R002056
 Characterising the Global Immune Response to SARS-CoV-2 in COVID-19 Acutely Infected and Recovered Ugandans
REFNo: HS997ES

To describe the frequencies and phenotypes of SARS-CoV2 induced immune
responses in qrt-PCR COVID-19 confirmed Ugandan cases.
b) To describe the evolution and durability of the induced responses.
c) To describe factors associated with COVID-19 disease outcome.
d) To isolate and clone SARS-CoV-2 spike specific human monoclonal antibodies with
potent virus neutralising capabilities
 Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
David Musoke
ID:
A feasibility study for a randomised controlled trial on integrated malaria prevention in Wakiso district, Uganda
REFNo: HS999ES

1. To explore community willingness to participate in an RCT on integrated malaria prevention.
2. To assess stakeholder perspectives on the RCT on integrated malaria prevention.

Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
David Musoke
ID:
Use of Photovoice to explore community members perspectives on health and healthcare challenges in Mukono District, Uganda
REFNo: HS1058ES

To use photovoice as a community-based participatory research method to explore healthcare delivery including barriers and challenges in Mukono district so as to provide information to inform future research and interventions to improve health of the community.
Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
ALEX NDYABAKIRA
ID:
Durability monitoring of Long Lasting Insecticidal Nets in Uganda, distributed during the 2020 mass campaign
REFNo: HS1109ES

Primary objective
1.To assess the physical durability of 5 different brands of nets over a three-year period, estimate median LLIN survival and identify major determinants of field performance
Secondary objectives
1. To describe major behavioral aspects of net care and repair and their impact on physical durability
2. To assess the insecticidal effectiveness (bio-efficacy) and chemical residue of 5 ITN brands during three years of field use

 Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
Philippa Musoke
ID: UNCST-2021-R013523
 Clinical manifestations and Outcomes of SARS-CoV-2 Infection in pregnancy in Africa: Novel Insights from the Democratic Republic of the Congo, Ghana, Kenya, Nigeria, South Africa and Uganda (AFRE-Mom-CoV-19) protocol
REFNo: HS1164ES

To retrospectively investigate the socio-demographic and clinical characteristics and maternal/infant outcomes of pregnant patients with RT-PCR-confirmed SARS‐CoV‐2 infection in six west, east, central and southern African countries: DRC, Ghana, Kenya, Nigeria, South Africa and Uganda.
Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
Amon Nuwahereza
ID: UNCST-2022-R011428
 Ride and Arrive Safe (RAS). A Case study of Mbarara Municipality
REFNo: HS577ES

i. To explore the feasibility of the community facilitation and engagement approach in equipping the Boda-boda cyclists with safety riding knowledge and skills.
ii. To develop a Boda-boda safety user check the mobile application for passengers using Boda-boda a means of transport
iii. To evaluate the effect of Boda-boda cyclist training and community engagement in reducing the number of Boda-boda road traffic accident-related admissions at Mbarara Regional Referral Hospital.

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Denis  Bwayo
ID:
Program Assessment and Implementation Learning for the University Research Co., LLC - Department of Defense HIV Prevention Program – Uganda
REFNo: HS959ES

1.To determine compliance to program set targets for the URC-DHAPP program between October 2018 and September 2021
2.To assess the quality of HIV services delivered at 28 UPDF HIV clinics
3.To determine program outcomes across key program implementation strands in line with 95:95:95 frameworks
4.To share implementation experiences across key program implementation strands including HIV testing, ART services, TB diagnosis and management, PMTCT, OVC and systems strengthening.

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
 ENHANCED ENTOMOLOGICAL SURVEILLANCE(EES) TO INFORM MALARIA CONTROL IN UGANDA
REFNo: HS1059ES

1. To examine the impact of current vector control interventions on malaria vector densities, vector behaviour, and species composition.
2. To monitor the status and intensity of insecticide resistance.
3. To establish the entomological inoculation rates in the selected districts.
4. To build the capacity of districts to conduct routine entomological surveillance

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Philippa Musoke
ID: UNCST-2021-R013523
 Manifestations and Outcomes of Hospitalized African children and Adolescents with SARS-CoV-2 Infection: Insights from the Democratic Republic of the Congo, Ghana, Kenya, Nigeria, South Africa and Uganda (AFRE-Ped-CoV-19) protocol Version November 06 2020. Grant No. 1R25TW011217-01
REFNo: HS1168ES

Study Aims

a) To describe the socio-demographic features; clinical WHO COVID-19 staging at admission, clinical characteristics, laboratory features including inflammatory and
cardiac markers; imaging investigations and associated abnormalities, treatments applied; and comparisons within and across participating African countries.
b) To estimate the prevalence of comorbidities at presentation and recent/current treatment with immunosuppressive drugs and comparisons within and across
participating African countries.
c) To estimate the prevalence of associated tuberculosis (past, current), HIV status (HIV-exposed uninfected or HIV-infected, and type of treatment if HIV-infected), malaria, bacterial infections influenza and other viral infections and comparisons within and
across participating African countries.
d) To assess overall mortality and independent factors associated with mortality and comparisons within and across participating African countries.

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Grace Ndeezi
ID: UNCST-2019-R001802
 A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease IMR-SCD-301
REFNo: HS1130ES

Primary Objectives
To evaluate the HbF response to IMR-687 versus placebo
To evaluate the safety of IMR-687 versus placebo
Secondary Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
To evaluate the effect of IMR-687 versus placebo on indices of red cell hemolysis
To evaluate the effect of IMR-687 versus placebo on indices of WBC adhesion
To evaluate the effect of IMR-687 versus placebo on the incidence of VOCs
To evaluate the effect of IMR-687 versus placebo on quality of life (QoL) measures

Pharmacokinetic Objectives
To evaluate the PK of IMR-687 and any major circulating metabolites
Exploratory Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on changes in RBC characteristics and total Hb
To evaluate the effect of IMR-687 versus placebo on renal function
To evaluate the effect of IMR-687 versus placebo on indices associated with cardiovascular pathophysiology and ischemic stroke risk

Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
FRED SEMITALA COLLINS
ID: UNCST-2020-R014096
 Strengthening Integrated Screening for TB and COVID19 in Kampala, Uganda
REFNo: HS1152ES

The overall goal is to establish the acceptability, feasibility and potential for scaling up the use of COVID19-TB Screening algorithm at Kiruddu National Referral Hospital.
Specific objectives

(1) To explore the perspectives of healthcare providers on the integration of COVID19 and TB screening at Kiruddu National referral Hospital.
(2) To determine the effect of the COVID19-TB algorithm on the proportion of patients screened for TB at Kiruddu National Referral Hospital over a 4-month period.

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Kirsten Beyer M
ID: UNCST-2021-R013472
 Assessing Health Professionals’ Knowledge, Perspectives and Practices Regarding HPV and Cervical Cancer Prevention and Control among Women Living with Human Immunodeficiency Virus Infection in Uganda
REFNo: HS782ES

General Objective The proposed study seeks to examine the role that health professionals play in influencing WHIVs’ perceptions of HPV and cervical cancer and their associated health behaviors in Uganda.

Specific Objective
Interview public health and health care professionals (including clinicians, nurses, counselors, other/public health professionals, and community health workers/village health teams) to examine the following:
1. Knowledge regarding how HPV or cervical cancer impacts WHIV, which populations are impacted most, and frequency of HPV vaccination, screening and treatment. 2. Perspectives regarding barriers/facilitators of cervical cancer and HPV prevention and treatment among WHIV. 3. Practices regarding HIV professionals’ work in cervical cancer and HPV.
USA 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
Emmanuel Sendaula
ID: UNCST-2020-R014767
 Clinical profile of HIV-infected patients receiving a holistic approach of care model attending Reach Out Mbuya facilities in Kampala district
REFNo: HS903ES

Main Objective

To describe the clinical profile and the factors associated with viral suppression status among HIV-infected patients receiving a holistic approach of care model in Kampala District.
Specific objectives

1. To describe the clinical profile of HIV-infected patients receiving a holistic model of care in Kampala District.
2. To determine the socio-demographic factors associated with viral suppression status among HIV-infected patients receiving a holistic model of care in Kampala District.
3. To determine the clinical factors associated with viral suppression status among HIV-infected patients receiving a holistic model of care in Kampala District.

 Uganda 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
View Sort By:

"A prosperous Science and Technology Led Ugandan Society."

NRIMS